Wild blueberry-rich diets affect the contractile machinery of the vascular smooth muscle in the Sprague-Dawley rat

Journal of Medicinal Food

Volumn 8, Issue 1, 2005, Pages 8-13

  Norton, Cynthia ^a   Kalea, Anastasia Z ^a   Harris, Patrick D ^b   Klimis Zacas, Dorothy J ^a  

^a UNIVERSITY OF MAINE   (United States)

^b University of Louisville School of Medicine   (United States)

Author keywords

Blueberries; Contractile properties; Diet; Vascular smooth muscle

Indexed keywords

ACETYLCHOLINE; ALPHA 1 ADRENERGIC RECEPTOR STIMULATING AGENT; BLUEBERRY EXTRACT; PHENYLEPHRINE; PLANT EXTRACT; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; AORTA; ARTICLE; BLUEBERRY; CONTROLLED STUDY; DIET SUPPLEMENTATION; DOSE RESPONSE; DRUG EFFECT; DRUG MECHANISM; MALE; MUSCLE CONTRACTILITY; NONHUMAN; PRIORITY JOURNAL; RAT; RECEPTOR SENSITIVITY; VASCULAR ENDOTHELIUM; VASCULAR RING; VASCULAR SMOOTH MUSCLE;

ACETYLCHOLINE; ANALYSIS OF VARIANCE; ANIMALS; AORTA; BLUEBERRY PLANT; CROSS-OVER STUDIES; DOSE-RESPONSE RELATIONSHIP, DRUG; MALE; MUSCLE CONTRACTION; MUSCLE, SMOOTH, VASCULAR; PHENYLEPHRINE; RANDOM ALLOCATION; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, ADRENERGIC, ALPHA-1; VASOCONSTRICTION; VASOCONSTRICTOR AGENTS;

ANIMALIA; VACCINIUM;

EID: 18144387591     PISSN: 1096620X     EISSN: None     Source Type: Journal    
DOI: 10.1089/jmf.2005.8.8     Document Type: Article

References (43)

1. Cardiovascular Disease Facts, Disease Prevention and Treatment Strategies, http://www.healingwithnutrition.com (accessed November 2003).
2. Association Member Benefits Advisors First Diagnosis Heart Attack and Surgery Page, http://www.amba-info.com/heartinfo.html (accessed November 2003).
3. Palo Alto Medical Foundation, Department of Cardiovascular Biology. http://www.pamf.org (accessed November 2003).
4. The France Foundation-Cardiovascular Disease. http://www. francefoundation.com/cardio.htm (accessed November 2003).
5. Lefer D, Granger N: Oxidative stress and cardiac disease. Am J Med 2000;109:315-323.
6. Milnor W: Cardiovascular Physiology, Oxford University Press, Oxford, 1990.
7. Kalea AZ, Norton C, Harris PD, Klimis-Zacas D: Whole wild blueberries suppress alpha-1 adrenergic agonist-induced contraction in rat aorta, [abstract]. FASEB J 2003;17(4):A335.
8. Klabunde RE: Cardiovascular Physiology Web Resource. http://www.oucom. ohiou.edu/CVPhysiology/BF011.htm (accessed April 2002).
9. Brown AA, Hu FB: Dietary modulation of endothelial function: Implications for cardiovascular disease. Am J Clin Nutr 2000;73:673-686.
10. Cohen RA: The role of nitric oxide and other endothelium-derived vasoactive substances in vascular disease. Prog Cardiovasc Dis 1995;38:105-129.
11. Selemidis S, Cocks TM: Endothelium-dependent hyperpolarization as a remote anti-atherogenic mechanism. Trends Pharmacol Sci 2002;23:213-219.
12. Beach PK, Spain DA, Kawabe T, Harris PD, Garrison RN: Sepsis increases NOS-2 activity and decreases non-NOS-mediated acetylcholine-induced dilation in rat aorta. J Surg Res 2001;96:17-22.
13. Guimaraes S, Moura D: Vascular adrenoreceptors: An update. Pharmacol Rev 2001;53:319-356.
14. Vogel RA: Coronary risk factors, endothelial function and atherosclerosis: A review. Clin Cardiol 1997;20:426-432.
15. Kalt W, Ryan D, Duy J, Prior R, Ehlenfeldt A, Kloet V: Interspecific variation in anthocyanins, phenolics and antioxidant capacity among genotypes of highbush and lowbush blueberries. J Agric Food Chem 2001;49:4761-4767.
16. Prior RL, Cao G, Martin A, et al.: Antioxidant capacity as influenced by total phenolic and anthocyanin content, maturity and variety of Vaccinium species. J Agric Food Chem 1998;46:2686-2693.
17. Harborne JB, Williams CA: Advances in flavonoid research since 1992. Phytochemistry 2000;55:481-504.
18. Ross R: Atherosclerosis-an inflammatory disease. Mech Dis 1993;340:115-126.
19. Morton LW, Caccetta RAA, Puddey IB, Croft KD: Chemistry and biological effects of dietary phenolic compounds: Relevance to cardiovascular disease. Clin Exp Pharmacol Physiol 2000;27:152-159.
20. Tapiero H, Tew KD, Nguyen B, Mathe G: Polyphenols: Do they play a role in the prevention of human pathologies? Biomed Pharmacother 2002;56:1-8.
21. Schramm DD, German JB: Potential effects of flavenoids on the etiology of vascular disease. J Nutr Biochem 1998;9:560-566.
22. Camire ME: Phytochemicals in the Vaccinium family: Bilberries, blueberries and cranberries. In: Phytochemicals in Nutrition and Health (Meskin M, Bidlack W, Davies A, Omaye S, eds.), CRC Press, Boca Raton, FL, 2002, pp. 20-30.
23. Andriambeloson E, Kleschyov A, Muller B, Beretz A, Stoclet JC, Andriantsitohaina R: Nitric oxide production and endothelium-dependent vasorelaxation induced by wine polyphenols in rat aorta. Br J Pharmacol 1997;120:1053-1058.
24. Andriambeloson E, Magnier C, Haan-Archipoff G, et al.: Natural dietary polyphenolic compounds cause endothelium-dependent vasorelaxation in rat thoracic aorta. J Nutr 1998;128:2324-2333.
25. Youdim K, Martin A, Joseph J: Incorporation of the elderberry anthocyanins by endothelial cells increases protection against oxidative stress. Free Radic Biol Med 2000;29:51-60.
26. Fitzpatrick DF, Hirschfield SL, Coffey RG: Endothelium-dependent vasorelaxing activity of wine and other grape products. Am J Physiol 1993;265:H774-H778.
27. Mendes A, Desgranges C, Cheze C, Vercauteren J, Freslon J-T: Vasorelaxant effects of grape polyphenols in rat isolated aorta. Possible involvement of a nurinergic pathway. Fundam Clin Pharmacol 2003;17:673-681.
28. Benito S, Lopez D, Saiz MP, et al.: A flavonoid-rich diet increases nitric oxide production in rat aorta. Br J Pharmacol 2002;135:910-916.
29. Vanhoutte PM: How to assess endothelial function in human blood vessels. J Hypertens 1999;17:1047-1058.
30. Kawabe T, Harris PD, Zakaria R, Garrison N: Sepsis alters vessel contraction by adrenoceptor-induced nitric oxide and prostanoid. J Surg Res 2003;10:352-359.
31. Angus JA, Wright CE: Techniques to study the pharmacodynamics of isolated large and small blood vessels. J Pharmacol Toxicol Methods 2000;44:395-407.
32. Furchgott RF, Vanhoutte PM: Endothelium derived relaxing and contracting factors. FASEB J 1989;3:2007-2018.
33. Dora KA, Hinton JM, Walker SD, Garland CJ: An indirect influence of phenylephrine on the release of endothelium-derived vasodilators in rat small mesenteric artery. Br J Pharmacol 2000;129:381-387.
34. Kalea AZ, Harris PD, Klimis-Zacas DJ: Dietary manganese suppresses alpha-1 adrenergic receptor-mediated vascular contraction. J Nutr Biochem 2005;16:44-49.
35. Illames AG, Correa RC, Martinez PJ: Effects of a vasorelaxing factor liberated by the rat isolated atria on rat aortic rings with and without endothelium. Gen Pharmacol 1999;32:179-184.
36. Asbun-Bojalil J, Castillo EF, Escalante BA, Castillo C: Does segmental difference in α 1 adrenoreceptor subtype explain contractile difference in rat abdominal and thoracic aortae? Vasc Pharmacol 2002;38:169-175.
37. Adeagbo ASO, Triggle CR: Interactions of nitric oxide synthase inhibitors and dexamethasone with alpha-adrenoreceptor-mediated responses in rat aorta. Br J Pharmacol 1993;109:495-501.
38. Wallerath T, Poleo D, Fortsmann U: Red wine increases the expression of human endothelial nitric oxide synthase. J Am Coll Cardiol 2003;41:471-478.
39. Weiping F, Conklin, BS, Lin PH, et al.: Red wine prevents homocysteine-induced endothelial dysfunction in porcine coronary arteries. J Surg Rex 2003;115:82-91.
40. Kay CD, Holub BJ: The effect of wild blueberry (Vaccinium angustifolium) consumption on postprandial serum antioxidant status in human subjects. Br J Nutr 2002;88:389-397.
41. Wu X, Cao G, Prior RL: Absorption and metabolism of anthocyanins in elderly women after consumption of elderberry and blueberry. J Nutr 2002;132:1865-1871.
42. Paganga G, Rice-Evans CA: The identification of flavonoids as glycosides in human plasma. FEBS Lett 1997;401:78-82.
43. Mazza G, Kay C, Cottrell T, Holub B: Absorption of anthocyanins from blueberries and serum antioxidant status in human subjects. J Agric Food Chem 2002;50:7731-7737.