메뉴 건너뛰기




Volumn 12, Issue 12, 2010, Pages 1792-1808

Toxoplasma gondii protease TgSUB1 is required for cell surface processing of micronemal adhesive complexes and efficient adhesion of tachyzoites

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN MPP2; PROTEINASE; PROTOZOAL PROTEIN; TGSUB1 ENZYME; UNCLASSIFIED DRUG;

EID: 78449308526     PISSN: 14625814     EISSN: 14625822     Source Type: Journal    
DOI: 10.1111/j.1462-5822.2010.01509.x     Document Type: Article
Times cited : (62)

References (50)
  • 1
    • 0037124340 scopus 로고    scopus 로고
    • Transepithelial migration of Toxoplasma gondii is linked to parasite motility and virulence
    • Barragan, A., and Sibley, D.L. (2002) Transepithelial migration of Toxoplasma gondii is linked to parasite motility and virulence. J Exp Med 195: 1625-1633.
    • (2002) J Exp Med , vol.195 , pp. 1625-1633
    • Barragan, A.1    Sibley, D.L.2
  • 2
    • 15944368914 scopus 로고    scopus 로고
    • Transepithelial migration of Toxoplasma gondii involves an interaction of intercellular adhesion molecule 1 (ICAM-1) with the parasite adhesin MIC2
    • Barragan, A., Brossier, F., and Sibley, D.L. (2005) Transepithelial migration of Toxoplasma gondii involves an interaction of intercellular adhesion molecule 1 (ICAM-1) with the parasite adhesin MIC2. Cell Microbiol 7: 561-568.
    • (2005) Cell Microbiol , vol.7 , pp. 561-568
    • Barragan, A.1    Brossier, F.2    Sibley, D.L.3
  • 4
    • 49749133184 scopus 로고    scopus 로고
    • The prodomain of Toxoplasma gondii GPI-anchored subtilase TgSUB1 mediates its targeting to micronemes
    • Binder, E.M., Lagal, V., and Kim, K. (2008) The prodomain of Toxoplasma gondii GPI-anchored subtilase TgSUB1 mediates its targeting to micronemes. Traffic 9: 1485-1496.
    • (2008) Traffic , vol.9 , pp. 1485-1496
    • Binder, E.M.1    Lagal, V.2    Kim, K.3
  • 5
    • 0034458967 scopus 로고    scopus 로고
    • Ionophore-resistant mutants of Toxoplasma gondii reveal host cell permeabilization as an early event in egress
    • Black, M., Arrizabalaga, G., and Boothroyd, J. (2000) Ionophore-resistant mutants of Toxoplasma gondii reveal host cell permeabilization as an early event in egress. Mol Cell Biol 20: 9399-9408.
    • (2000) Mol Cell Biol , vol.20 , pp. 9399-9408
    • Black, M.1    Arrizabalaga, G.2    Boothroyd, J.3
  • 7
    • 0035830936 scopus 로고    scopus 로고
    • The toxoplasma micronemal protein MIC4 is an adhesin composed of six conserved apple domains
    • Brecht, S., Carruthers, V.B., Ferguson, P.J.D., Giddings, O.K., Wang, G., Jakle, U., et al. (2001) The toxoplasma micronemal protein MIC4 is an adhesin composed of six conserved apple domains. J Biol Chem 276: 4119-4127.
    • (2001) J Biol Chem , vol.276 , pp. 4119-4127
    • Brecht, S.1    Carruthers, V.B.2    Ferguson, P.J.D.3    Giddings, O.K.4    Wang, G.5    Jakle, U.6
  • 8
    • 0037458587 scopus 로고    scopus 로고
    • C-terminal processing of the toxoplasma protein MIC2 is essential for invasion into host cells
    • Brossier, F., Jewett, T.J., Lovett, J.L., and Sibley, D.L. (2003) C-terminal processing of the toxoplasma protein MIC2 is essential for invasion into host cells. J Biol Chem 278: 6229-6234.
    • (2003) J Biol Chem , vol.278 , pp. 6229-6234
    • Brossier, F.1    Jewett, T.J.2    Lovett, J.L.3    Sibley, D.L.4
  • 9
    • 15244360655 scopus 로고    scopus 로고
    • A spatially localized rhomboid protease cleaves cell surface adhesins essential for invasion by Toxoplasma
    • Brossier, F., Jewett, T.J., Sibley, D.L., and Urban, S. (2005) A spatially localized rhomboid protease cleaves cell surface adhesins essential for invasion by Toxoplasma. Proc Natl Acad Sci USA 102: 4146-4151.
    • (2005) Proc Natl Acad Sci USA , vol.102 , pp. 4146-4151
    • Brossier, F.1    Jewett, T.J.2    Sibley, D.L.3    Urban, S.4
  • 10
    • 33845681203 scopus 로고    scopus 로고
    • Targeted deletion of MIC5 enhances trimming proteolysis of Toxoplasma invasion proteins
    • Brydges, S.D., Zhou, X.W., Huynh, M.H., Harper, J.M., Mital, J., Adjogble, K.D., et al. (2006) Targeted deletion of MIC5 enhances trimming proteolysis of Toxoplasma invasion proteins. Eukaryot Cell 5: 2174-2183.
    • (2006) Eukaryot Cell , vol.5 , pp. 2174-2183
    • Brydges, S.D.1    Zhou, X.W.2    Huynh, M.H.3    Harper, J.M.4    Mital, J.5    Adjogble, K.D.6
  • 11
    • 77954078996 scopus 로고    scopus 로고
    • Rhomboid 4 (ROM4) affects the processing of surface adhesins and facilitates host cell invasion by Toxoplasma gondii
    • Buguliskis, J.S., Brossier, F., Shuman, J., and Sibley, L.D. (2010) Rhomboid 4 (ROM4) affects the processing of surface adhesins and facilitates host cell invasion by Toxoplasma gondii. PLoS Pathog 6: e1000858.
    • (2010) PLoS Pathog , vol.6
    • Buguliskis, J.S.1    Brossier, F.2    Shuman, J.3    Sibley, L.D.4
  • 12
    • 33646361302 scopus 로고    scopus 로고
    • Proteolysis and Toxoplasma invasion
    • Carruthers, V.B. (2006) Proteolysis and Toxoplasma invasion. Int J Parasitol 36: 595-600.
    • (2006) Int J Parasitol , vol.36 , pp. 595-600
    • Carruthers, V.B.1
  • 13
    • 15944375185 scopus 로고    scopus 로고
    • A new release on life: emerging concepts in proteolysis and parasite invasion
    • Carruthers, V., and Blackman, M. (2005) A new release on life: emerging concepts in proteolysis and parasite invasion. Mol Microbiol 55: 1617-1630.
    • (2005) Mol Microbiol , vol.55 , pp. 1617-1630
    • Carruthers, V.1    Blackman, M.2
  • 14
    • 0030956863 scopus 로고    scopus 로고
    • Sequential protein secretion from three distinct organelles of Toxoplasma gondii accompanies invasion of human fibroblasts
    • Carruthers, V., and Sibley, L. (1997) Sequential protein secretion from three distinct organelles of Toxoplasma gondii accompanies invasion of human fibroblasts. Eur J Cell Biol 73: 114-123.
    • (1997) Eur J Cell Biol , vol.73 , pp. 114-123
    • Carruthers, V.1    Sibley, L.2
  • 15
    • 0033224351 scopus 로고    scopus 로고
    • Secretion of micronemal proteins is associated with toxoplasma invasion of host cells
    • Carruthers, V.B., Giddings, O.K., and Sibley, D.L. (1999a) Secretion of micronemal proteins is associated with toxoplasma invasion of host cells. Cell Microbiol 1: 225-235.
    • (1999) Cell Microbiol , vol.1 , pp. 225-235
    • Carruthers, V.B.1    Giddings, O.K.2    Sibley, D.L.3
  • 16
    • 0033198852 scopus 로고    scopus 로고
    • 2+] and stimulate microneme discharge in Toxoplasma gondii
    • 2+] and stimulate microneme discharge in Toxoplasma gondii. Biochem J 342: 379-386.
    • (1999) Biochem J , vol.342 , pp. 379-386
    • Carruthers, V.1    Moreno, S.2    Sibley, L.3
  • 17
    • 0034640516 scopus 로고    scopus 로고
    • The Toxoplasma adhesive protein MIC2 is proteolytically processed at multiple sites by two parasite-derived proteases
    • Carruthers, V.B., Sherman, G.B., and Sibley, D.L. (2000) The Toxoplasma adhesive protein MIC2 is proteolytically processed at multiple sites by two parasite-derived proteases. J Biol Chem 275: 14346-14353.
    • (2000) J Biol Chem , vol.275 , pp. 14346-14353
    • Carruthers, V.B.1    Sherman, G.B.2    Sibley, D.L.3
  • 18
    • 0037013918 scopus 로고    scopus 로고
    • The Toxoplasma gondii protein MIC3 requires pro-peptide cleavage and dimerization to function as adhesin
    • Cerede, O., Dubremetz, J., Bout, D., and Lebrun, M. (2002) The Toxoplasma gondii protein MIC3 requires pro-peptide cleavage and dimerization to function as adhesin. EMBO 21: 2526-2536.
    • (2002) EMBO , vol.21 , pp. 2526-2536
    • Cerede, O.1    Dubremetz, J.2    Bout, D.3    Lebrun, M.4
  • 19
    • 13644269312 scopus 로고    scopus 로고
    • Synergistic role of micronemal proteins in Toxoplasma gondii virulence
    • Cerede, O., Dubremetz, J., Soete, M., Deslee, D., Vial, H., Bout, D., and Lebrun, M. (2005) Synergistic role of micronemal proteins in Toxoplasma gondii virulence. J Exp Med 201: 453-463.
    • (2005) J Exp Med , vol.201 , pp. 453-463
    • Cerede, O.1    Dubremetz, J.2    Soete, M.3    Deslee, D.4    Vial, H.5    Bout, D.6    Lebrun, M.7
  • 21
    • 0345712374 scopus 로고    scopus 로고
    • Serine protease inhibitors block invasion of host cells by Toxoplasma gondii
    • Conseil, V., Soete, M., and Dubremetz, J. (1999) Serine protease inhibitors block invasion of host cells by Toxoplasma gondii. Antimicrob Agents Chemother 43: 1358-1361.
    • (1999) Antimicrob Agents Chemother , vol.43 , pp. 1358-1361
    • Conseil, V.1    Soete, M.2    Dubremetz, J.3
  • 22
    • 0030904788 scopus 로고    scopus 로고
    • Targeted gene disruption shows that knobs enable malaria-infected red cells to cytoadhere under physiological shear stress
    • Crabb, B., Cooke, B., Reeder, J., Waller, R., Caruana, S., Davern, K., et al. (1997) Targeted gene disruption shows that knobs enable malaria-infected red cells to cytoadhere under physiological shear stress. Cell 89: 287-296.
    • (1997) Cell , vol.89 , pp. 287-296
    • Crabb, B.1    Cooke, B.2    Reeder, J.3    Waller, R.4    Caruana, S.5    Davern, K.6
  • 23
    • 0029869791 scopus 로고    scopus 로고
    • Toxoplasma invasion of mammalian cells is powered by the actin cytoskeleton of the parasite
    • Dobrowolski, J., and Sibley, L. (1996) Toxoplasma invasion of mammalian cells is powered by the actin cytoskeleton of the parasite. Cell 84: 933-939.
    • (1996) Cell , vol.84 , pp. 933-939
    • Dobrowolski, J.1    Sibley, L.2
  • 24
    • 0032521445 scopus 로고    scopus 로고
    • Gene knock-outs and allelic replacements in Toxoplasma gondii: HXGPRT as a selectable marker for hit and run mutagenesis
    • Donald, R.G.K., and Roos, D.S. (1998) Gene knock-outs and allelic replacements in Toxoplasma gondii: HXGPRT as a selectable marker for hit and run mutagenesis. Mol Biochem Parasitol 91: 295-305.
    • (1998) Mol Biochem Parasitol , vol.91 , pp. 295-305
    • Donald, R.G.K.1    Roos, D.S.2
  • 25
    • 4143127652 scopus 로고    scopus 로고
    • Host cell invasion by the apicomplexans: the significance of microneme protein proteolysis
    • Dowse, T.J., and Soldati, D. (2004) Host cell invasion by the apicomplexans: the significance of microneme protein proteolysis. Curr Opin Microbiol 7: 388-396.
    • (2004) Curr Opin Microbiol , vol.7 , pp. 388-396
    • Dowse, T.J.1    Soldati, D.2
  • 26
    • 19444382777 scopus 로고    scopus 로고
    • Apicomplexa rhomboids have a potential role in microneme protein cleavage during host cell invasion
    • Dowse, T.J., Pascall, J.C., Brown, K.D., and Soldati, D. (2005) Apicomplexa rhomboids have a potential role in microneme protein cleavage during host cell invasion. Int J Parasitol 35: 747-756.
    • (2005) Int J Parasitol , vol.35 , pp. 747-756
    • Dowse, T.J.1    Pascall, J.C.2    Brown, K.D.3    Soldati, D.4
  • 28
    • 0030596197 scopus 로고    scopus 로고
    • The MIC1 microneme protein of Toxoplasma gondii contains a duplicated receptor-like domain and binds to host cell surface
    • Fourmaux, M., Achbarou, A., Mercereau-Puijalon, O., Biderre, C., Briche, I., Loyens, A., et al. (1996) The MIC1 microneme protein of Toxoplasma gondii contains a duplicated receptor-like domain and binds to host cell surface. Mol Biochem Parasitol 83: 201-210.
    • (1996) Mol Biochem Parasitol , vol.83 , pp. 201-210
    • Fourmaux, M.1    Achbarou, A.2    Mercereau-Puijalon, O.3    Biderre, C.4    Briche, I.5    Loyens, A.6
  • 29
    • 76249095009 scopus 로고    scopus 로고
    • Members of a novel protein family containing microneme adhesive repeat domains act as sialic acid-binding lectins during host cell invasion by apicomplexan parasites
    • Friedrich, N., Santos, J.M., Liu, Y., Palma, A.S., Leon, E., Saouros, S., et al. (2010) Members of a novel protein family containing microneme adhesive repeat domains act as sialic acid-binding lectins during host cell invasion by apicomplexan parasites. J Biol Chem 285: 2064-2076.
    • (2010) J Biol Chem , vol.285 , pp. 2064-2076
    • Friedrich, N.1    Santos, J.M.2    Liu, Y.3    Palma, A.S.4    Leon, E.5    Saouros, S.6
  • 30
    • 0342298489 scopus 로고    scopus 로고
    • The microneme protein MIC3 of Toxoplasma gondii is a secretory adhesin that binds to both the surface of the host cells and the surface of the parasite
    • Garcia-Réguet, N., Lebrun, M., Fourmaux, M., Mercereau-Puijalon, O., Mann, T., Beckers, C., et al. (2000) The microneme protein MIC3 of Toxoplasma gondii is a secretory adhesin that binds to both the surface of the host cells and the surface of the parasite. Cell 2: 353-364.
    • (2000) Cell , vol.2 , pp. 353-364
    • Garcia-Réguet, N.1    Lebrun, M.2    Fourmaux, M.3    Mercereau-Puijalon, O.4    Mann, T.5    Beckers, C.6
  • 31
    • 0343162619 scopus 로고    scopus 로고
    • Time-lapse video microscopy of gliding motility in Toxoplasma gondii reveals a novel, biphasic mechanism of cell locomotion
    • Hakansson, S., Morisaki, H., Heuser, J., and Sibley, L.D. (1999) Time-lapse video microscopy of gliding motility in Toxoplasma gondii reveals a novel, biphasic mechanism of cell locomotion. Mol Biol Cell 10: 3539-3547.
    • (1999) Mol Biol Cell , vol.10 , pp. 3539-3547
    • Hakansson, S.1    Morisaki, H.2    Heuser, J.3    Sibley, L.D.4
  • 32
    • 1542375192 scopus 로고    scopus 로고
    • Multimerization of the Toxoplasma gondii MIC2 integrin-like A-domain is required for binding to heparin and human cells
    • Harper, J., Hoff, E., and Carruthers, V. (2004) Multimerization of the Toxoplasma gondii MIC2 integrin-like A-domain is required for binding to heparin and human cells. Mol Biochem Parasitol 134: 201-212.
    • (2004) Mol Biochem Parasitol , vol.134 , pp. 201-212
    • Harper, J.1    Hoff, E.2    Carruthers, V.3
  • 33
    • 33749484972 scopus 로고    scopus 로고
    • A cleavable propeptide influences Toxoplasma infection by facilitating the trafficking and secretion of the TgMIC2-M2AP invasion complex
    • Harper, J., Huynh, M., Coppens, I., Parussini, F., Moreno, S., and Carruthers, V.B. (2006) A cleavable propeptide influences Toxoplasma infection by facilitating the trafficking and secretion of the TgMIC2-M2AP invasion complex. Mol Biol Cell 17: 4551-4563.
    • (2006) Mol Biol Cell , vol.17 , pp. 4551-4563
    • Harper, J.1    Huynh, M.2    Coppens, I.3    Parussini, F.4    Moreno, S.5    Carruthers, V.B.6
  • 34
    • 33748066307 scopus 로고    scopus 로고
    • Toxoplasma MIC2 is a major determinant of invasion and virulence
    • e84. doi:10.1371/journal.ppat.0020084
    • Huynh, M.-H., and Carruthers, V.B. (2006) Toxoplasma MIC2 is a major determinant of invasion and virulence. PLoS Pathog 2: e84. doi:10.1371/journal.ppat.0020084
    • (2006) PLoS Pathog , vol.2
    • Huynh, M.1    Carruthers, V.B.2
  • 35
    • 0038558167 scopus 로고    scopus 로고
    • Rapid invasion of host cells by Toxoplasma requires secretion of the MIC2-M2AP adhesive protein complex
    • Huynh, M., Rabenau, K., Harper, J., Beatty, W., Sibley, L., and Carruthers, V. (2003) Rapid invasion of host cells by Toxoplasma requires secretion of the MIC2-M2AP adhesive protein complex. EMBO J 22: 2082-2090.
    • (2003) EMBO J , vol.22 , pp. 2082-2090
    • Huynh, M.1    Rabenau, K.2    Harper, J.3    Beatty, W.4    Sibley, L.5    Carruthers, V.6
  • 36
    • 1542364495 scopus 로고    scopus 로고
    • The toxoplasma proteins MIC2 and M2AP form a hexameric complex necessary for intracellular survival
    • Jewett, T.J., and Sibley, L.D. (2004) The toxoplasma proteins MIC2 and M2AP form a hexameric complex necessary for intracellular survival. J Biol Chem 279: 9362-9369.
    • (2004) J Biol Chem , vol.279 , pp. 9362-9369
    • Jewett, T.J.1    Sibley, L.D.2
  • 37
    • 58849087549 scopus 로고    scopus 로고
    • Rapid membrane disruption by a perforin-like protein facilitates parasite exit from host cells
    • Kafsack, B.F., Pena, J.D., Coppens, I., Ravindran, S., Boothroyd, J.C., and Carruthers, V.B. (2009) Rapid membrane disruption by a perforin-like protein facilitates parasite exit from host cells. Science 323: 530-533.
    • (2009) Science , vol.323 , pp. 530-533
    • Kafsack, B.F.1    Pena, J.D.2    Coppens, I.3    Ravindran, S.4    Boothroyd, J.C.5    Carruthers, V.B.6
  • 38
    • 4644345259 scopus 로고    scopus 로고
    • The glideosome: a molecular machine powering motility and host-cell invasion by Apicomplexa
    • Keeley, A., and Soldati, D. (2004) The glideosome: a molecular machine powering motility and host-cell invasion by Apicomplexa. Trends Cell Biol 14: 528-532.
    • (2004) Trends Cell Biol , vol.14 , pp. 528-532
    • Keeley, A.1    Soldati, D.2
  • 39
    • 73349142319 scopus 로고    scopus 로고
    • Phenotypic and gene expression changes among clonal type I strains of Toxoplasma gondii
    • Khan, A., Behnke, M.S., Dunay, I.R., White, M.W., and Sibley, L.D. (2009) Phenotypic and gene expression changes among clonal type I strains of Toxoplasma gondii. Eukaryot Cell 8: 1828-1836.
    • (2009) Eukaryot Cell , vol.8 , pp. 1828-1836
    • Khan, A.1    Behnke, M.S.2    Dunay, I.R.3    White, M.W.4    Sibley, L.D.5
  • 41
    • 0036473089 scopus 로고    scopus 로고
    • A family of transmembrane microneme proteins of Toxoplasma gondii contain EGF-like domains and function as escorters
    • Meissner, M., Reiss, M., Viebig, N., Carruthers, V.B., Toursel, C., Tomavo, S., et al. (2002a) A family of transmembrane microneme proteins of Toxoplasma gondii contain EGF-like domains and function as escorters. J Cell Sci 115: 563-574.
    • (2002) J Cell Sci , vol.115 , pp. 563-574
    • Meissner, M.1    Reiss, M.2    Viebig, N.3    Carruthers, V.B.4    Toursel, C.5    Tomavo, S.6
  • 42
    • 0037174664 scopus 로고    scopus 로고
    • Role of Toxoplasma gondii myosin A in powering parasite gliding and host cell invasion
    • Meissner, M., Schluter, D., and Soldati, D. (2002b) Role of Toxoplasma gondii myosin A in powering parasite gliding and host cell invasion. Science 298: 837-840.
    • (2002) Science , vol.298 , pp. 837-840
    • Meissner, M.1    Schluter, D.2    Soldati, D.3
  • 43
    • 0035976961 scopus 로고    scopus 로고
    • A conserved subtilisin-like protein TgSUB1 in microneme organelles of Toxoplasma gondii
    • Miller, S.A., Binder, E.M., Blackman, M.J., Carruthers, V.B., and Kim, K. (2001) A conserved subtilisin-like protein TgSUB1 in microneme organelles of Toxoplasma gondii. J Biol Chem 276: 45341-45348.
    • (2001) J Biol Chem , vol.276 , pp. 45341-45348
    • Miller, S.A.1    Binder, E.M.2    Blackman, M.J.3    Carruthers, V.B.4    Kim, K.5
  • 44
    • 0034883267 scopus 로고    scopus 로고
    • TgM2AP participates in Toxoplasma gondii invasion of host cells and is tightly associated with the adhesive protein TgMIC2
    • Rabenau, K.E., Sohrabi, A., Tripathy, A., Reitter, C., Ajioka, J.W., Tomley, F.M., and Carruthers, V.B. (2001) TgM2AP participates in Toxoplasma gondii invasion of host cells and is tightly associated with the adhesive protein TgMIC2. Mol Microbiol 41: 537-547.
    • (2001) Mol Microbiol , vol.41 , pp. 537-547
    • Rabenau, K.E.1    Sohrabi, A.2    Tripathy, A.3    Reitter, C.4    Ajioka, J.W.5    Tomley, F.M.6    Carruthers, V.B.7
  • 45
    • 0242474092 scopus 로고    scopus 로고
    • Comparison of two DNA targets for the diagnosis of Toxoplasmosis by real-time PCR using fluorescence resonance energy transfer hybridization probes
    • Reischl, U., Bretagne, S., Kruger, D., Ernault, P., and Costa, J.M. (2003) Comparison of two DNA targets for the diagnosis of Toxoplasmosis by real-time PCR using fluorescence resonance energy transfer hybridization probes. BMC Infect Dis 3: 7.
    • (2003) BMC Infect Dis , vol.3 , pp. 7
    • Reischl, U.1    Bretagne, S.2    Kruger, D.3    Ernault, P.4    Costa, J.M.5
  • 46
    • 0035809213 scopus 로고    scopus 로고
    • Identification and characterization of an escorter for two secretory adhesins in Toxoplasma gondii
    • Reiss, M., Viebig, N., Brecht, S., Fourmaux, M., Soete, M., Di Cristina, M., et al. (2001) Identification and characterization of an escorter for two secretory adhesins in Toxoplasma gondii. J Cell Biol 152: 563-578.
    • (2001) J Cell Biol , vol.152 , pp. 563-578
    • Reiss, M.1    Viebig, N.2    Brecht, S.3    Fourmaux, M.4    Soete, M.5    Di Cristina, M.6
  • 47
    • 33644666110 scopus 로고    scopus 로고
    • A novel galectin-like domain from Toxoplasma gondii micronemal protein 1 assists the folding, assembly, and transport of a cell adhesion complex
    • Saouros, S., Edwards-Jones, B., Reiss, M., Sawmynaden, K., Cota, E., Simpson, P., et al. (2005) A novel galectin-like domain from Toxoplasma gondii micronemal protein 1 assists the folding, assembly, and transport of a cell adhesion complex. J Biol Chem 280: 38583-38591.
    • (2005) J Biol Chem , vol.280 , pp. 38583-38591
    • Saouros, S.1    Edwards-Jones, B.2    Reiss, M.3    Sawmynaden, K.4    Cota, E.5    Simpson, P.6
  • 48
    • 33748189347 scopus 로고    scopus 로고
    • Cell-surface association between matrix metalloproteinases and integrins: role of the complexes in leukocyte migration and cancer progression
    • Stefanidakis, M., and Koivunen, E. (2006) Cell-surface association between matrix metalloproteinases and integrins: role of the complexes in leukocyte migration and cancer progression. Blood 108: 1441-1450.
    • (2006) Blood , vol.108 , pp. 1441-1450
    • Stefanidakis, M.1    Koivunen, E.2
  • 49
    • 33846561051 scopus 로고    scopus 로고
    • Cysteine protease inhibitors block Toxoplasma gondii microneme secretion and cell invasion
    • Teo, C., Zhou, X., Bogyo, M., and Carruthers, V. (2007) Cysteine protease inhibitors block Toxoplasma gondii microneme secretion and cell invasion. Antimicrob Agents Chemother 51: 679-688.
    • (2007) Antimicrob Agents Chemother , vol.51 , pp. 679-688
    • Teo, C.1    Zhou, X.2    Bogyo, M.3    Carruthers, V.4
  • 50
    • 2442690776 scopus 로고    scopus 로고
    • Proteomic analysis of cleavage events reveals a dynamic two-step mechanism for proteolysis of a key parasite adhesive complex
    • Zhou, X.W., Blackman, M.J., Howell, S.A., and Carruthers, V.B. (2004) Proteomic analysis of cleavage events reveals a dynamic two-step mechanism for proteolysis of a key parasite adhesive complex. Mol Cell Proteomics 3: 565-576.
    • (2004) Mol Cell Proteomics , vol.3 , pp. 565-576
    • Zhou, X.W.1    Blackman, M.J.2    Howell, S.A.3    Carruthers, V.B.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.