Role of Toxoplasma gondii myosin a in powering parasite gliding and host cell invasion

Science

Volumn 298, Issue 5594, 2002, Pages 837-840

  Meissner, Markus ^a   Schlüter, Dirk ^a   Soldati, Dominique ^a  

^a IMPERIAL COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CELLS; GENES; TISSUE;

PARASITES;

NATURAL SCIENCES;

MYCOPHENOLIC ACID; MYOSIN;

BIOLOGY; PARASITE CONTROL;

ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; GENE EXPRESSION; GENETIC TRANSCRIPTION; HOST PARASITE INTERACTION; KNOCKOUT GENE; MOUSE; NONHUMAN; PARASITE VIRULENCE; PATHOGENESIS; PLASMODIUM FALCIPARUM; PRIORITY JOURNAL; PROMOTER REGION; TOXOPLASMA GONDII; TOXOPLASMOSIS;

ANIMALS; CALCIMYCIN; CALCIUM; CELL LINE; CELLS, CULTURED; EXOCYTOSIS; GENETIC VECTORS; HUMANS; MICE; MOVEMENT; NONMUSCLE MYOSIN TYPE IIA; ORGANELLES; PROTOZOAN PROTEINS; TETRACYCLINE; TOXOPLASMA; TOXOPLASMOSIS, ANIMAL; TRANS-ACTIVATORS; TRANSFECTION; TRANSGENES; VIRULENCE; VIRULENCE FACTORS;

ANIMALIA; PLASMODIUM FALCIPARUM; PROTOZOA; TOXOPLASMA GONDII;

EID: 0037174664     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.1074553     Document Type: Article

References (19)

1. L D. Sibley, S. Hakansson, V. B. Carruthers, Curr. Biol. 8, 12 (1998).
2. J. M. Dobrowolski, L D. Sibley, Cell 84, 933 (1996).
3. M. B. Heintzeiman, J. D. Schwartzman, J. Mol. Biol. 271, 139 (1997).
4. C. Hettmann et al., Mol. Biol. Cell 11, 1385 (2000).
5. G. Herm-Götz et al., EMBO J. 21, 2149 (2002).
6. E. Wirtz, S. Leal, C. Ochatt, G. A. Cross, Mol. Biochem. Parasitol. 99, 89 (1999).
7. M. Gossen, H. Bujard, Proc. Natl. Acad. Sci. U.S.A. 89, 5547 (1992).
8. M. Meissner et al., Nucleic Acids Res. 29, e115 (2001).
9. Materials and methods are available as supporting material on Science Online.
10. S. Hakansson, H. Morisaki, J. Heuser, L D. Sibley, Mol. Biol. Cell 10, 3539 (1999).
11. M. Black, G. Arrizabalaga, J. C. Boothroyd, Mol. Cell. Biol. 20, 9399 (2000).
12. R. Moudy, T. J. Manning, C. J. Beckers, J. Biol. Chem. 276, 41492 (2001).
13. E. F. Hoff, V. B. Carruthers, Trends Parasitol. 18, 251 (2002).
14. A. A. Sultan et al., Cell 90, 511 (1997).
15. V. B. Carruthers, O. K. Giddings, L D. Sibley, Cell Microbiol. 1, 225 (1999).
16. V. B. Carruthers, S. N. Moreno, L D. Sibley, Biochem. J. 342, 379 (1999).
17. S. Brecht et al., J. Biol. Chem. 276, 4119 (2000).
18. E. R. Pfefferkom, L C. Pfefferkorn, Exp. Parasitol. 39, 365 (1976).
19. Supported by Deutsche Forschungsgerneinschaft grant SO366/1-3. We are grateful to L Y. Kwok, K. Schönig, and A. Herm-Götz for their assistance, and S. Brecht and C. Hettmann for their contributions to the early phase of the project. Special thanks to T. Soldati for his assistance with the microscopy and considerable input in the project, H. Bujard for helpful discussions, and R. Sinden for critical reading of the manuscript.