Vitamin D3 treatment of Crohns disease patients increases stimulated T cell IL-6 production and proliferation

Alimentary Pharmacology and Therapeutics

Volumn 32, Issue 11-12, 2010, Pages 1364-1372

  Bendix Struve, M ^a   Bartels, L E ^a   Agnholt, J ^a   Dige, A ^a   Jorgensen S P ^a   Dahlerup, J F ^a  

^a AARHUS UNIVERSITY HOSPITAL   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIFEDIOL; COLECALCIFEROL; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 4; INTERLEUKIN 6; PLACEBO; TUMOR NECROSIS FACTOR ALPHA;

ADULT; AGED; ARTICLE; CD4+ T LYMPHOCYTE; CELLULAR IMMUNITY; CLINICAL ARTICLE; CONTROLLED STUDY; CROHN DISEASE; CYTOKINE PRODUCTION; DRUG EFFECT; FEMALE; HUMAN; HUMAN CELL; IMMUNOSTIMULATION; LYMPHOCYTE PROLIFERATION; PERIPHERAL BLOOD MONONUCLEAR CELL; PHENOTYPE; PRIORITY JOURNAL; REGULATORY T LYMPHOCYTE; T LYMPHOCYTE; VITAMIN BLOOD LEVEL;

ADULT; AGED; CHOLECALCIFEROL; CROHN DISEASE; DRUG ADMINISTRATION SCHEDULE; FEMALE; HUMANS; INTERLEUKIN-6; MALE; MIDDLE AGED; STATISTICS AS TOPIC; T-LYMPHOCYTES; YOUNG ADULT;

EID: 78449283236     PISSN: 02692813     EISSN: 13652036     Source Type: Journal    
DOI: 10.1111/j.1365-2036.2010.04463.x     Document Type: Article

References (46)

1. Baumgart DC, Carding SR,. Inflammatory bowel disease: cause and immunobiology. Lancet 2007; 369: 1627 - 40.
2. Shivananda S, Lennard-Jones J, Logan R, et al. Incidence of inflammatory bowel disease across Europe: is there a difference between north and south? Results of the European Collaborative Study on Inflammatory Bowel Disease (EC-IBD). Gut 1996; 39: 690 - 7.
3. McCarthy D, Duggan P, OBrien M, et al. Seasonality of vitamin D status and bone turnover in patients with Crohns disease. Aliment Pharmacol Ther 2005; 21: 1073 - 83.
4. Zeng L, Anderson FH,. Seasonal change in the exacerbations of Crohns disease. Scand J Gastroenterol 1996; 31: 79 - 82.
5. Leslie WD, Miller N, Rogala L, Bernstein CN,. Vitamin D status and bone density in recently diagnosed inflammatory bowel disease: the Manitoba IBD Cohort Study. Am J Gastroenterol 2008; 103: 1451 - 9.
6. Jorgensen SP, Agnholt J, Glerup H, et al. Clinical trial: vitamin D3 treatment in Crohns disease - a randomised double-blind placebo-controlled study. Aliment Pharmacol Ther 2010; 32: 377 - 83.
7. Niessner M, Volk BA,. Altered Th1/Th2 cytokine profiles in the intestinal mucosa of patients with inflammatory bowel disease as assessed by quantitative reversed transcribed polymerase chain reaction (RT-PCR). Clin Exp Immunol 1995; 101: 428 - 35.
8. Weiner HL,. Oral tolerance: immune mechanisms and the generation of Th3-type TGF-beta-secreting regulatory cells. Microbes Infect 2001; 3: 947 - 54.
9. Veny M, Esteller M, Ricart E, Pique JM, Panes J, Salas A,. Late Crohns disease patients present an increase in peripheral Th17 cells and cytokine production compared with early patients. Aliment Pharmacol Ther 2010; 31: 561 - 72.
10. Fujino S, Andoh A, Bamba S, et al. Increased expression of interleukin 17 in inflammatory bowel disease. Gut 2003; 52: 65 - 70.
11. Mangan PR, Harrington LE, OQuinn DB, et al. Transforming growth factor-beta induces development of the T(H)17 lineage. Nature 2006; 441: 231 - 4.
12. Langrish CL, Chen Y, Blumenschein WM, et al. IL-23 drives a pathogenic T cell population that induces autoimmune inflammation. J Exp Med 2005; 201: 233 - 40.
13. Aggarwal S, Ghilardi N, Xie MH, De Sauvage FJ, Gurney AL,. Interleukin-23 promotes a distinct CD4 T cell activation state characterized by the production of interleukin-17. J Biol Chem 2003; 278: 1910 - 4.
14. Duerr RH, Taylor KD, Brant SR, et al. A genome-wide association study identifies IL23R as an inflammatory bowel disease gene. Science 2006; 314: 1461 - 3.
15. OConnor W Jr, Kamanaka M, Booth CJ, et al. A protective function for interleukin 17A in T cell-mediated intestinal inflammation. Nat Immunol 2009; 10: 603 - 9.
16. Jones G, Strugnell SA, DeLuca HF,. Current understanding of the molecular actions of vitamin D. Physiol Rev 1998; 78: 1193 - 231.
17. Bouillon R, Carmeliet G, Verlinden L, et al. Vitamin D and human health: lessons from vitamin D receptor null mice. Endocr Rev 2008; 29: 726 - 76.
18. Yu S, Bruce D, Froicu M, Weaver V, Cantorna MT,. Failure of T cell homing, reduced CD4/CD8alphaalpha intraepithelial lymphocytes, and inflammation in the gut of vitamin D receptor KO mice. Proc Natl Acad Sci U S A 2008; 105: 20834 - 9.
19. Froicu M, Weaver V, Wynn TA, McDowell MA, Welsh JE, Cantorna MT,. A crucial role for the vitamin D receptor in experimental inflammatory bowel diseases. Mol Endocrinol 2003; 17: 2386 - 92.
20. Cantorna MT, Mahon BD,. Mounting evidence for vitamin D as an environmental factor affecting autoimmune disease prevalence. Exp Biol Med 2004; 229: 1136 - 42.
21. Cantorna MT, Munsick C, Bemiss C, Mahon BD., 1,25- Dihydroxycholecalciferol prevents and ameliorates symptoms of experimental murine inflammatory bowel disease. J Nutr 2000; 130: 2648 - 52.
22. Ardizzone S, Cassinotti A, Trabattoni D, et al. Immunomodulatory effects of 1,25-dihydroxyvitamin D3 on TH1/TH2 cytokines in inflammatory bowel disease: an in vitro study. Int J Immunopathol Pharmacol 2009; 22: 63 - 71.
23. Stio M, Martinesi M, Bruni S, et al. Interaction among vitamin D(3) analogue KH 1060, TNF-alpha, and vitamin D receptor protein in peripheral blood mononuclear cells of inflammatory bowel disease patients. Int Immunopharmacol 2006; 6: 1083 - 92.
24. Bartels LE, Jorgensen SP, Agnholt J, Kelsen J, Hvas CL, Dahlerup JF,. 1,25-dihydroxyvitamin D3 and dexamethasone increase interleukin-10 production in CD4+ T cells from patients with Crohns disease. Int Immunopharmacol 2007; 7: 1755 - 64.
25. Boonstra A, Barrat FJ, Crain C, Heath VL, Savelkoul HF, OGarra A,. 1alpha,25-Dihydroxyvitamin d3 has a direct effect on naive CD4(+) T cells to enhance the development of Th2 cells. J Immunol 2001; 167: 4974 - 80.
26. Barrat FJ, Cua DJ, Boonstra A, et al. In vitro generation of interleukin 10-producing regulatory CD4(+) T cells is induced by immunosuppressive drugs and inhibited by T helper type 1 (Th1)-and Th2-inducing cytokines. J Exp Med 2002; 195: 603 - 16.
27. Urry Z, Xystrakis E, Richards DF, et al. Ligation of TLR9 induced on human IL-10-secreting Tregs by 1alpha,25-dihydroxyvitamin D3 abrogates regulatory function. J Clin Invest 2009; 119: 387 - 98.
28. Penna G, Roncari A, Amuchastegui S, et al. Expression of the inhibitory receptor ILT3 on dendritic cells is dispensable for induction of CD4+ Foxp3+ regulatory T cells by 1,25-dihydroxyvitamin D3. Blood 2005; 106: 3490 - 7.
29. Mahon BD, Wittke A, Weaver V, Cantorna MT,. The targets of vitamin D depend on the differentiation and activation status of CD4 positive T cells. J Cell Biochem 2003; 89: 922 - 32.
30. Stio M, Treves C, Martinesi M, DAlbasio G, Bagnoli S, Bonanomi AG,. Effect of anti-TNF therapy and vitamin D derivatives on the proliferation of peripheral blood mononuclear cells in Crohns disease. Dig Dis Sci 2004; 49: 328 - 35.
31. Von Essen MR, Kongsbak M, Schjerling P, Olgaard K, Odum N, Geisler C,. Vitamin D controls T cell antigen receptor signaling and activation of human T cells. Nat Immunol 2010; 11: 344 - 9.
32. Griffin MD, Xing N, Kumar R,. Vitamin D and its analogs as regulators of immune activation and antigen presentation. Annu Rev Nutr 2003; 23: 117 - 45.
33. Mora JR, Iwata M, Von Andrian UH,. Vitamin effects on the immune system: vitamins A and D take centre stage. Nat Rev Immunol 2008; 8: 685 - 98.
34. Van Etten E, Mathieu C,. Immunoregulation by 1,25-dihydroxyvitamin D3: basic concepts. J Steroid Biochem Mol Biol 2005; 97: 93 - 101.
35. Jeng L, Yamshchikov AV, Judd SE, et al. Alterations in vitamin D status and anti-microbial peptide levels in patients in the intensive care unit with sepsis. J Transl Med 2009; 7: 28.
36. Adorini L, Penna G,. Dendritic cell tolerogenicity: a key mechanism in immunomodulation by vitamin D receptor agonists. Hum Immunol 2009; 70: 345 - 52.
37. Maunsell Z, Wright DJ, Rainbow SJ,. Routine isotope-dilution liquid chromatography-tandem mass spectrometry assay for simultaneous measurement of the 25-hydroxy metabolites of vitamins D2 and D3. Clin Chem 2005; 51: 1683 - 90.
38. Heijink IH, Vellenga E, Borger P, Postma DS, De Monchy JG, Kauffman HF,. Interleukin-6 promotes the production of interleukin-4 and interleukin-5 by interleukin-2-dependent and -independent mechanisms in freshly isolated human T cells. Immunology 2002; 107: 316 - 24.
39. Thien R, Baier K, Pietschmann P, Peterlik M, Willheim M,. Interactions of 1 alpha,25-dihydroxyvitamin D3 with IL-12 and IL-4 on cytokine expression of human T lymphocytes. J Allergy Clin Immunol 2005; 116: 683 - 9.
40. Diehl S, Rincon M,. The two faces of IL-6 on Th1/Th2 differentiation. Mol Immunol 2002; 39: 531 - 6.
41. Steensberg A, Fischer CP, Keller C, Moller K, Pedersen BK,. IL-6 enhances plasma IL-1ra, IL-10, and cortisol in humans. Am J Physiol Endocrinol Metab 2003; 285: E433 - 7.
42. Pedersen BK,. IL-6 signalling in exercise and disease. Biochem Soc Trans 2007; 35: 1295 - 7.
43. Holtta V, Klemetti P, Sipponen T, et al. IL-23/IL-17 immunity as a hallmark of Crohns disease. Inflamm Bowel Dis 2008; 14: 1175 - 84.
44. Yuk JM, Shin DM, Lee HM, et al. Vitamin D3 induces autophagy in human monocytes/macrophages via cathelicidin. Cell Host Microbe 2009; 6: 231 - 43.
45. Cui G, Zhang Y, Gong Z, Zhang JZ, Zang YQ,. Induction of CD4+ CD25+ Foxp3+ regulatory T cell response by glatiramer acetate in type 1 diabetes. Cell Res 2009; 19: 574 - 83.
46. Ghoreishi M, Bach P, Obst J, Komba M, Fleet JC, Dutz JP,. Expansion of antigen-specific regulatory T cells with the topical vitamin d analog calcipotriol. J Immunol 2009; 182: 6071 - 8.