Structure-function analysis of water-soluble inhibitors of the catalytic domain of exotoxin A from Pseudomonas aeruginosa

Biochemical Journal

Volumn 385, Issue 3, 2005, Pages 667-675

  Yates, Susan P ^a   Taylor, Patricia L ^a   Jørgensen, René ^b   Ferraris, Dana ^c   Zhang, Jie ^c   Andersen, Gregers R ^b   Merrill, A Rod ^a  

^a UNIVERSITY OF GUELPH   (Canada)

^b AARHUS UNIVERSITY   (Denmark)

^c GUILFORD PHARMACEUTICALS INC   (United States)

Author keywords

Bacterial toxin; Competitive inhibitor; Exotoxin A; Mono ADP ribosyltransferase; Pseudomonas aeruginosa; X ray crystallography

Indexed keywords

AMINES; BACTERIA; BIOCATALYSTS; HYDROGEN BONDS; OXYGEN; PROTEINS; SOLUBILITY; TOXIC MATERIALS;

EXOTOXIN A (ATA); STRUCTURE-FUNCTION ANALYSIS; WATER-SOLUBLE INHIBITORS;

MOLECULAR STRUCTURE;

1 [2 (4 PYRROLIDIN 1 YLMETHYLPHENYL)ETHYL] 8,9 DIHYDRO 7H 2,7,9A TRIAZABENZ[CD]AZULEN 6 ONE; 1 [4 (3 DIEMTHYLAMINOPROPOXY)PHENYL] 8,9 DIHYDRO 7H 2,7,9A TRIAZABENZ[CD]AZULEN 6 ONE; 1 DIMETHYLAMINOMETHYL 8,9 DIHYDRO 7H 1,7,9A TRIAZABENZ[CD]AZULEN 6 ONE; 1,11B DIHYDRO[1]BENZOPYRANO[4,3,2 DE]ISOQUINOLIN 3(2H) ONE 10 SULFONIC ACID; 1,8 NAPHTHALIMIDE; 2 (4 ISOPROPYLPIPERAZIN 1 YL) 5H BENZO[C][1,5]NAPHTHYRIDIN 6 ONE; 2 (4 METHYLPIPERAZIN 1 YL) 5H BENZO[C][1,5]NAPHTHYRIDIN 6 ONE; 3 (MORPHOLIN 4 YLMETHYL) 1,5 DIHYDRO 6H [1,2]DIAZEPINO[4,5,6 CD]INDOL 6 ONE; 5 AMINOISOQUINOLINE; 8 FLUORO 2 (3 PIPERIDIN 1 YLPROPANOYL) 1,3,4,5 2H TETRAHYDROBENZO[C] 1,6 NAPHTHYRIDIN 6 ONE; AMIDE; DIPHTHERIA TOXIN; GLYCINE; HYDROGEN; ISOQUINOLINE DERIVATIVE; KETONE DERIVATIVE; N (5,6 DIHYDRO 6 OXO 2 PHENANTHRIDINYL) 2 DIMETHYLAMINOACETAMIDE; N (6 OXO 5,6 DIHYDROBENZO[C][1,5]NAPHTHYRIDIN 2 YL) 2 (4 PYRROLIDIN 1 YLPIPERIDIN 1 YL)ACETAMIDE; NAPHTHALENE DERIVATIVE; NICOTINAMIDE ADENINE DINUCLEOTIDE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; OXYGEN; PSEUDOMONAS EXOTOXIN; PSEUDOMONAS EXOTOXIN A; UNCLASSIFIED DRUG; WATER;

ARTICLE; CATALYSIS; CONTROLLED STUDY; CRYSTAL STRUCTURE; HYDROGEN BOND; IC 50; INTERMETHOD COMPARISON; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN STRUCTURE; PSEUDOMONAS AERUGINOSA; SOLUBILITY; STRUCTURE ACTIVITY RELATION;

ADP RIBOSE TRANSFERASES; BACTERIAL TOXINS; BINDING SITES; CATALYTIC DOMAIN; ENZYME INHIBITORS; EXOTOXINS; INHIBITORY CONCENTRATION 50; KINETICS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PEPTIDE FRAGMENTS; PROTEIN CONFORMATION; PSEUDOMONAS AERUGINOSA; SOLUBILITY; STRUCTURE-ACTIVITY RELATIONSHIP; VIRULENCE FACTORS; WATER;

BACTERIA (MICROORGANISMS); PSEUDOMONAS; PSEUDOMONAS AERUGINOSA;

EID: 13444274564     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/BJ20041480     Document Type: Article

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