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Hataya Y, Akamizu T, Hosoda H, et al. Alterations of plasma ghrelin levels in rats with lipopolysaccharide-induced wasting syndrome and effects of ghrelin treatment on the syndrome. Endocrinology 2003; 144:5365-5371.
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Hataya, Y.1
Akamizu, T.2
Hosoda, H.3
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55
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Ghrelin treatment of chronic kidney disease: Improvements in lean body mass and cytokine profile
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Deboer MD, Zhu X, Levasseur PR, et al. Ghrelin treatment of chronic kidney disease: Improvements in lean body mass and cytokine profile. Endocrinology 2008; 149:827-835.
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Deboer, M.D.1
Zhu, X.2
Levasseur, P.R.3
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56
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Ghrelin treatment causes increased food intake and retention of lean body mass in a rat model of cancer cachexia
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DeBoer MD, Zhu XX, Levasseur P, et al. Ghrelin treatment causes increased food intake and retention of lean body mass in a rat model of cancer cachexia. Endocrinology 2007; 148:3004-3012.
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DeBoer, M.D.1
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Levasseur, P.3
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57
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Chronic administration of ghrelin improves left ventricular dysfunction and attenuates development of cardiac cachexia in rats with heart failure
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Nagaya N, Uematsu M, Kojima M, et al. Chronic administration of ghrelin improves left ventricular dysfunction and attenuates development of cardiac cachexia in rats with heart failure. Circulation 2001; 104:1430-1435.
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Nagaya, N.1
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Kojima, M.3
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58
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No effects of human ghrelin on cardiac function despite profound effects on body composition in a rat model of heart failure
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These experiments demonstrated that chronic ghrelin treatment improves lean body mass retention in a rat model of chronic heart failure, in the absence of any significant improvements in cardiac function
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Akashi YJ, Palus S, Datta R, et al. No effects of human ghrelin on cardiac function despite profound effects on body composition in a rat model of heart failure. Int J Cardiol 2009; 137:267-275. These experiments demonstrated that chronic ghrelin treatment improves lean body mass retention in a rat model of chronic heart failure, in the absence of any significant improvements in cardiac function.
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Int J Cardiol
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Akashi, Y.J.1
Palus, S.2
Datta, R.3
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59
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Combined effects of ghrelin and higher food intake enhance skeletal muscle mitochondrial oxidative capacity and AKT phosphorylation in rats with chronic kidney disease
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Exogenous ghrelin treatment improves metabolic function in the skeletal muscle of nephrectomized rats, at least in part via mechanisms that operate independently of ghrelin-induced food intake
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Barazzoni R, Zhu X,Deboer M, et al.Combined effects of ghrelin and higher food intake enhance skeletal muscle mitochondrial oxidative capacity and AKT phosphorylation in rats with chronic kidney disease. Kidney Int 2010; 77:23-28. Exogenous ghrelin treatment improves metabolic function in the skeletal muscle of nephrectomized rats, at least in part via mechanisms that operate independently of ghrelin-induced food intake.
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Kidney Int
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Barazzoni, R.1
Zhu, X.2
Deboer, M.3
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60
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Update on clinical trials of growth factors and anabolic steroids in cachexia and wasting
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Gullett NP, Hebbar G, Ziegler TR. Update on clinical trials of growth factors and anabolic steroids in cachexia and wasting. Am J Clin Nutr 2010; 91:1143S-1147S.
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Am J Clin Nutr
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Gullett, N.P.1
Hebbar, G.2
Ziegler, T.R.3
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61
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Effect on body weight and safety of RC-1291, a novel, orally available ghrelin mimetic and growth hormone secretagogue: Results of a phase I, randomized, placebo-controlled, multiple-dose study in healthy volunteers
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Garcia JM, Polvino WJ. Effect on body weight and safety of RC-1291, a novel, orally available ghrelin mimetic and growth hormone secretagogue: Results of a phase I, randomized, placebo-controlled, multiple-dose study in healthy volunteers. Oncologist 2007; 12:594-600.
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Garcia, J.M.1
Polvino, W.J.2
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62
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A Phase II randomized, placebocontrolled, double blind study of the efficacy and safety of RC-1291 for the treatment of cancer-cachexia
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[abstract]
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Garcia JM, Graham C, Kumor K, Polvino W. A Phase II, randomized, placebocontrolled, double blind study of the efficacy and safety of RC-1291 for the treatment of cancer-cachexia. J Clin Oncol 2007; 25:9133 [abstract].
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J Clin Oncol
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Garcia, J.M.1
Graham, C.2
Kumor, K.3
Polvino, W.4
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63
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Effects of single and chronic intracerebroventricular administration of the orexins on feeding in the rat
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Haynes AC, Jackson B, Overend P, et al. Effects of single and chronic intracerebroventricular administration of the orexins on feeding in the rat. Peptides 1999; 20:1099-1105.
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Peptides
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Haynes, A.C.1
Jackson, B.2
Overend, P.3
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64
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Chronic intracerebroventricular administration of orexin-A to rats increases food intake in daytime, but has no effect on body weight
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Yamanaka A, Sakurai T, Katsumoto T, et al. Chronic intracerebroventricular administration of orexin-A to rats increases food intake in daytime, but has no effect on body weight. Brain Res 1999; 849:248-252.
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Yamanaka, A.1
Sakurai, T.2
Katsumoto, T.3
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65
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70449927248
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Hypothalamic orexin stimulates feeding-associated glucose utilization in skeletal muscle via sympathetic nervous system
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This paper reveals a role for hypothalamic orexin neurons in skeletal muscle glucose metabolism
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Shiuchi T, Haque MS, Okamoto S, et al. Hypothalamic orexin stimulates feeding-associated glucose utilization in skeletal muscle via sympathetic nervous system. Cell Metab 2009; 10:466-480. This paper reveals a role for hypothalamic orexin neurons in skeletal muscle glucose metabolism.
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Cell Metab
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, pp. 466-480
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Shiuchi, T.1
Haque, M.S.2
Okamoto, S.3
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66
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Orexin/hypocretin and histamine: Distinct roles in the control of wakefulness demonstrated using knock-out mouse models
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Anaclet C, Parmentier R, Ouk K, et al. Orexin/hypocretin and histamine: Distinct roles in the control of wakefulness demonstrated using knock-out mouse models. J Neurosci 2009; 29:14423-14438.
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Anaclet, C.1
Parmentier, R.2
Ouk, K.3
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67
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70349108442
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Lipopolysaccharide challenge-induced suppression of Fos in hypothalamic orexin neurons: Their potential role in sickness behavior
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These experiments hint at a potential role of reduced activity of hypothalamic orexin neurons in illness-induced lethargy
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Gaykema RP, Goehler LE. Lipopolysaccharide challenge-induced suppression of Fos in hypothalamic orexin neurons: Their potential role in sickness behavior. Brain Behav Immun 2009; 23:926-930. These experiments hint at a potential role of reduced activity of hypothalamic orexin neurons in illness-induced lethargy.
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(2009)
Brain Behav Immun
, vol.23
, pp. 926-930
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Gaykema, R.P.1
Goehler, L.E.2
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68
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Central interleukin-10 attenuates lipopolysaccharide-induced changes in food intake, energy expenditure and hypothalamic Fos expression
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Hollis JH, Lemus M, Evetts MJ, Oldfield BJ. Central interleukin-10 attenuates lipopolysaccharide-induced changes in food intake, energy expenditure and hypothalamic Fos expression. Neuropharmacology 2010; 58:730-738.
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Neuropharmacology
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Hollis, J.H.1
Lemus, M.2
Evetts, M.J.3
Oldfield, B.J.4
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69
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66749125910
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Apilot study evaluating the safety and efficacy of modafinil for cancer-related fatigue
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This small study in humansubjectsdemonstrated thatmodafinil (aCNSstimulant that increases orexin activity) reduces fatigue and improves quality of life in cancer patients
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Blackhall L, Petroni G, Shu J, et al.Apilot study evaluating the safety and efficacy of modafinil for cancer-related fatigue. J Palliat Med 2009; 12:433-439. This small study in humansubjectsdemonstrated thatmodafinil (aCNSstimulant that increases orexin activity) reduces fatigue and improves quality of life in cancer patients.
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(2009)
J Palliat Med
, vol.12
, pp. 433-439
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Blackhall, L.1
Petroni, G.2
Shu, J.3
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70
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65949103861
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Modafinil for the treatment of fatigue in lung cancer: A pilot study
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Another pilot study that tested the safety and efficacy of modafinil in cancer patients. Modafinil lessened fatigue, perhaps by virtue of its ability to stimulate hypothalamic orexin neuronal activity
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Spathis A, Dhillan R, Booden D, et al. Modafinil for the treatment of fatigue in lung cancer: A pilot study. Palliat Med 2009; 23:325-331. Another pilot study that tested the safety and efficacy of modafinil in cancer patients. Modafinil lessened fatigue, perhaps by virtue of its ability to stimulate hypothalamic orexin neuronal activity.
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(2009)
Palliat Med
, vol.23
, pp. 325-331
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Spathis, A.1
Dhillan, R.2
Booden, D.3
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