Anorexia induced by cytokine interactions at pathophysiological concentrations

American Journal of Physiology - Regulatory Integrative and Comparative Physiology

Volumn 270, Issue 6 39-6, 1996, Pages

  Sonti, Gayatri ^a   Ilyin, Sergey E ^a   Plata Salamán, Carlos R ^a  

^a UNIVERSITY OF DELAWARE   (United States)

Author keywords

behavior; cerebrospinal fluid; feeding and drinking; food and water intake; growth factor; immune system; immunomodulator; interleukin; intracerebroventricular administration; meal pattern; nervous system; neuroimmunology; rat; synergism; tumor necrosis factor

Indexed keywords

BOVINE SERUM ALBUMIN; CYTOKINE; RECOMBINANT INTERLEUKIN 1BETA; RECOMBINANT INTERLEUKIN 8; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL MODEL; ANOREXIA; ARTICLE; CEREBROSPINAL FLUID; COMPUTER ANALYSIS; CONTROLLED STUDY; DRINKING; EATING; FEEDING BEHAVIOR; FLUID INTAKE; INTRACEREBROVENTRICULAR DRUG ADMINISTRATION; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; SATIETY;

EID: 0029842580     PISSN: 03636119     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpregu.1996.270.6.r1394     Document Type: Article

References (31)

1. Akalin, H., A. C. Akdis, R. Mistik, S. Helvaci, and K. Kilicturgay. Cerebrospinal fluid interleukin-1β/interleukin-1 receptor antagonist balance and tumor necrosis factor-α concentrations in tuberculous, viral and acute bacterial meningitis. Scand. J. Infect. Dis. 26: 667-674, 1994.
2. Aloisi, F., A. Care, G. Borsellino, P. Gallo, S. Rosa, A. Bassani, A. Cabibbo, U. Testa, G. Levi, and C. Peschle. Production of hemoiymphopoietic cytokines (IL-6, IL-8, colony-stimulating factors) by normal human astrocytes in response to IL-1β and tumor necrosis factor-α. J. Immunol. 149: 2358-2366, 1992.
3. Baggiolini, M., and I. Clark-Lewis. Interleukin-8, a chemotactic and inflammatory cytokine. FEBS Lett. 307: 97-101, 1992.
4. Banks, W. A., L. Ortiz, S. R. Plotkin, and A. J. Kastin. Human interleukin (EL) 1α, murine IL-1α and murine IL-1β are transported from blood to brain in the mouse by a shared saturable mechanism. J. Pharmacol. Exp. Ther. 259: 988-996, 1991.
5. Baudrie, V., J. B. Roullet, Y. Goureau, F. Chaouloff, and J. L. Elghozi. Determination of cerebrospinal fluid production rate using a push-pull perfusion procedure in the conscious rat. Fundam. Clin. Pharmacol. 4: 269-274, 1990.
6. Dorovini-Zis, K., P. D. Bowman, and R. Prameya. Adhesion and migration of human polymorphonuclear leukocytes across cultured bovine brain microvessel endothelial cells. J. Neuropathol. Exp. Neural. 51: 194-205, 1992.
7. Giulian, D., and M. Corpuz. Microglial secretion products and their impact on the nervous system. Adv. Neural. 59: 315-320, 1993.
8. Glimåker, M., P. Kragsbjerg, M. Forsgren, and P. Olcén. Tumor necrosis factor-α (TNFα) in cerebrospinal fluid from patients with bacterial meningitis of different etiologies: high levels of TNFα indicate bacterial meningitis. J. Infect. Dis. 167: 882-889, 1993.
9. Gutierrez, E. G., W. A. Banks, and A. J. Kastin. Murine tumor necrosis factor alpha is transported from blood to brain in the mouse. J. Neuroimmunol. 47: 169-176, 1993.
10. Halstensen, A., M. Ceska, P. Brandtzaeg, H. Redl, A. Naess, and A. Waage. Interleukin-8 in serum and cerebrospinal fluid from patients with meningococcal disease. J. Infect. Dis. 167: 471-475, 1993.
11. Hashimoto, M., T. Ueno, and M. Iriki. What roles does the organum vasculosum laminae terminalis play in fever in rabbits? Eur. J. Physiol. 429: 50-57, 1994.
12. Hickey, W. F., B. L. Hsu, and H. Kimura. T-lymphocyte entry into the central nervous system. J. Neurosci. Res. 28: 254-260, 1991.
13. Jacobs, R. F., and D. R. Tabor. The immunology of sepsis and meningitis - cytokine biology. Scand. J. Infect. Dis. Suppl. 73: 7-15, 1990.
14. Lai, Y. L., P. M. Smith, W. J. E. Lamm, and J. Hildebrandt. Sampling and analysis of cerebrospinal fluid for chronic studies in awake rats. J. Appl. Physiol. 54: 1754-1757, 1983.
15. López-Cortés, L. F., M. Cruz-Ruiz, J. Gómez-Mateos, D. Jiménez-Hernández, J. Palomino, and E. Jiménez. Measurement of levels of tumor necrosis factor-α and interleukin-1β in the CSF of patients with meningitis of different etiologies: utility in the differential diagnosis. Clin. Infect. Dis. 16: 534-539, 1993.
16. Mann, J. D., A. B. Butler, J. E. Rosenthal, C. J. Maffeo, R. N. Johnson, and N. H. Bass. Regulation of intracranial pressure in rat, dog and man. Ann. Neural. 3: 156-165, 1978.
17. Merrill, J. E., Y. Koyanagi, J. Zack, L. Thomas, F. Martin, and I. S. Y. Chen. Induction of interleukin-1 and tumor necrosis factor alpha in brain cultures by human immunodeficiency virus type 1. J. Virol. 66: 2217-2225, 1992.
18. Molenaar, G. J., F. Berkenbosch, A.-M. van Dam, and C. M. J. E. Lugard. Distribution of interleukin 1β immunoreactivity within the porcine hypothalamus. Brain Res. 608: 169-174, 1993.
19. Ohga, S., T. Aoki, K. Okada, H. Akeda, K. Fujioka, A. Ohshima, T. Mori, I. Minamishima, and K. Ueda. Cerebrospinal fluid concentrations of interleukin-1β, tumor necrosis factor-α, and interferon gamma in bacterial meningitis. Arch. Dis. Child. 70: 123-125, 1994.
20. Plata-Salamán, C. R. Immunomodulators and feeding regulation: a humoral link between the immune and nervous systems. Brain Behav. Immun. 3: 193-213, 1989.
21. Plata-Salamán, C. R. Immunoregulators in the nervous system. Neurosci. Biobehav. Rev. 15: 185-215, 1991.
22. Plata-Salamán, C. R. Meal patterns in response to the intrace-rebroventricular administration of interleukin-1β in rats. Physiol. Behav. 55: 727-733, 1994.
23. Plata-Salamán, C. R., and J. P. Borkoski. Interleukin-8 modulates feeding by direct action in the central nervous system. Am. J. Physiol. 265 (Regulatory Integrative Comp. Physiol. 34): R877-R882, 1993.
24. Plata-Salamán, C. R., Y. Oomura, and Y. Kai. Tumor necrosis factor and interleukin-1β: suppression of food intake by direct action in the central nervous system. Brain Res. 448: 106-114, 1988.
25. 2-microglobulin, a marker of immune activation. Am. J. Physiol. 268 (Regulatory Integrative Comp. Physiol. 37): R1513-R1519, 1995.
26. Symons, J. A., R. V. Bundick, A. J. Suckling, and M. G. Rumsby. Cerebrospinal fluid interleukin 1 like activity during chronic relapsing experimental allergic encephalomyelitis. Clin. Exp. Immunol. 68: 648-654, 1987.
27. Thomas, W. E. Brain macrophages: evaluation of microglia and their functions. Brain Res. Rev. 17 :61-74, 1992.
28. Van der Meer, M. J. M., C. G. J. F. Sweep, G. J. Pesman, G. F. Bonn, and A. R. M. M. Hermus. Synergism between IL-1β and TNF-α on the activity of the pituitary-adrenal axis and on food intake of rats. Am. J. Physiol. 268 (Endocrinol. Metab. 31): E551-E557, 1995.
29. Van Deuren, M., J. van der Ven-Jongekrijg, A. K. M. Bartelink, R. van Dalen, R. W. Sauerwein, and J. W. M. van der Meer. Correlation between proinflammatory cytokines and antiinflammatory mediators and the severity of disease in meningococcal infections. J. Infect. Dis. 172: 433-439, 1995.
30. Waage, A., A. Halstensen, T. Espevik, and P. Brandtzaeg. Compartmentalization of TNF and IL-6 in meningitis and septic shock. Mediat. Inflamm. 2: 23-25, 1993.
31. Yang, Z.-J., M. Koseki, M. M. Meguid, J. R. Gleason, and D. Debonis. Synergistic effect of rhTNF-α and rhIL-1α in inducing anorexia in rats. Am. J. Physiol. 267 (Regulatory Integrative Comp. Physiol. 36): R1056-R1064, 1994.