Mechanisms of disease: Cytokine and adipokine signaling in uremic cachexia

Nature Clinical Practice Nephrology

Volumn 2, Issue 9, 2006, Pages 527-534

  Mak, Robert H ^a   Cheung, Wai ^a   Cone, Roger D ^b   Marks, Daniel L ^a  

^a OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^b OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

Author keywords

Inflammation; Leptin; Melanocortin; Nutrition; Uremia

Indexed keywords

ADIPOCYTOKINE; ADIPONECTIN; AGOUTI RELATED PROTEIN; CYTOKINE; GHRELIN; LEPTIN; MELANOCORTIN; RESISTIN;

ANOREXIA; BODY COMPOSITION; CACHEXIA; CALORIC INTAKE; CANCER; CHRONIC KIDNEY DISEASE; CORRELATION ANALYSIS; DIET SUPPLEMENTATION; DISEASE ASSOCIATION; FOOD INTAKE; HOMEOSTASIS; HUMAN; INFLAMMATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN INTAKE; REVIEW; RISK FACTOR; STATISTICAL DISTRIBUTION; UREMIA;

ADIPOSE TISSUE; CACHEXIA; CYTOKINES; DIETARY SUPPLEMENTS; ENERGY METABOLISM; HOMEOSTASIS; HUMANS; INFLAMMATION; PEPTIDE HORMONES; RENAL INSUFFICIENCY; SIGNAL TRANSDUCTION; UREMIA;

EID: 33748331209     PISSN: 17458323     EISSN: 17458331     Source Type: Journal    
DOI: 10.1038/ncpneph0273     Document Type: Review

References (57)

1. Gruppen MP et al. (2003) Cardiac disease in young adult patients with end-stage renal disease since childhood: a Dutch cohort study. Kidney Int 63: 1058-1065
2. Sarnak MJ and Levey AS (2000) Cardiovascular disease and chronic renal disease: a new paradigm. Am J Kidney Dis 35: S117-S131
3. Cianciaruso B et al. (1995) Cross-sectional comparison of malnutrition in continuous ambulatory peritoneal dialysis and hemodialysis patients. Am J Kidney Dis 26: 475-486
4. Tisdale MJ (1997) Biology of cachexia. J Natl Cancer Inst 89: 1763-1773
5. Kotler DP et al. (1989) Magnitude of body-cell-mass depletion and the timing of death from wasting in AIDS. Am J Clin Nutr 50: 444-447
6. Sherry BA et al. (1989) Anticachectin/tumor necrosis factor-alpha antibodies attenuate development of cachexia in tumor models. FASEB J 3: 1956-1962
7. Fong Y et al. (1989) Cachectin/TNF or IL-1 alpha induces cachexia with redistribution of body proteins. Am J Physiol 256: R659-665
8. Plata-Salaman CR et al. (1996) Anorexia induced by chronic central administration of cytokines at estimated pathophysiological concentrations. Physiol Behav 60: 867-875
9. Scribner BH et al. (1960) The treatment of chronic uremia by means of intermittent hemodialysis: a preliminary report. Trans Am Soc Artif Intern Organs 6: 114-122
10. Anderstam B et al. (1996) Middle-sized molecule fractions isolated from uremic ultrafiltrate and normal urine inhibit ingestive behavior in the rat. J Am Soc Nephrol 7: 2453-2460
11. Mamoun AH et al. (1999) Evidence of splanchnic-brain signaling in inhibition of ingestive behavior by middle molecules. J Am Soc Nephrol 10: 309-314
12. Pecoits-Filho R et al. (2005) Chronic kidney disease and inflammation in pediatric patients: from bench to playground. Pediatr Nephrol 20: 714-720
13. Kaizu Y et al. (2003) Association between inflammatory mediators and muscle mass in long-term hemodialysis patients. Am J Kidney Dis 42: 295-302
14. Bologa RM et al. (1998) Interleukin-6 predicts hypoalbuminemia, hypocholesterolemia, and mortality in hemodialysis patients. Am J Kidney Dis 32: 107-114
15. Goodman MN (1994) Interleukin-6 induces skeletal muscle protein breakdown in rats. Proc Soc Exp Biol Med 205: 182-185
16. Tsujinaka T et al. (1996) Interleukin 6 receptor antibody inhibits muscle atrophy and modulates proteolytic systems in interleukin 6 transgenic mice. J Clin Invest 97: 244-249
17. Aguilera A et al. (1998) Anorexigen (TNF alpha, cholecystokinin) and orexigen (neuropeptide Y) in peritoneal dialysis patients. Their relationship with nutritional parameters. Nephrol Dial Transplant 13: 1476-1483
18. Guttridge DC et al. (2000) NF-κB induced loss of MyoD messenger RNA: Possible role in muscle decay and cachexia. Science 289: 2363-2365
19. Plata-Salaman CR (1998) Cytokines and anorexia: a brief overview. Semin Oncol 25: 4-11
20. Schwartz MW and Morton GJ (2002) Obesity: Keeping hunger at bay. Nature 418: 595-597
21. Ahima RS and Staels B (2000) Leptin. Ann Rev Physiol 62: 413-437
22. Halaas J et al. (1995) Weight-reducing effects of plasma protein encoded by the obese gene. Science 269: 543-549
23. Sharma K et al. (1997) Plasma leptin is partly cleared by the kidney and is elevated in hemodialysis patients. Kidney Int 51: 1980-1985
24. Stenvinkel P et al. (2000) Increases in serum leptin during peritoneal dialysis are associated with inflammation and a decrease in lean body mass. J Am Soc Nephrol 11: 1303-1309
25. Daschner M et al. (1998) Inappropriate elevation of serum leptin in children with chronic renal failure. European Study Group for Nutritional Treatment of Chronic Renal Failure in Chilhood. J Am Soc Nephrol 9: 1074-1079
26. Wolf G et al. (2002) Leptin and renal disease. Am J Kidney Dis 39: 1-11
27. Heimburger O and Stenvinkel P (2005) Adipokines in chronic kidney disease - fat tissue gives nephrologists a message. Perit Dial Int 25: 340-342
28. Qi Y et al. (2004) Adiponectin acts in the brain to decrease body weight. Nature Med 10: 524-529
29. Axelsson J et al. (2006) Elevated resistin levels in chronic kidney disease are associated with decreased glomerular filtration rate and inflammation, but not with insulin resistance. Kidney Int 69: 596-604
30. Gomez-Ambrosi J et al. (2002) Weight loss in tumour-bearing mice is not associated with changes in resistin gene expression in white adipose tissue. Horm Metab Res 34: 674-677
31. Palanivel R and Sweeney G (2005) Regulation of fatty acid uptake and metabolism in L6 skeletal muscle cells by resistin. FEBS Lett 579: 5049-5054
32. Yoshimoto A et al. (2002) Plasma ghrelin and desacyl ghrelin concentrations in renal failure. J Am Soc Nephrol 13: 2748-2752
33. Rodriguez Ayala E et al. (2004) Associations between plasma ghrelin levels and body composition in end-stage renal disease: a longitudinal study. Nephrol Dial Transplant 19: 421-426
34. Wynne K et al. (2005) Subcutaneous ghrelin enhances acute food intake in malnourished patients who receive maintenance peritoneal dialysis: a randomized, placebo-controlled trial. J Am Soc Nephrol 6: 2111-2118
35. Cheung W et al. (2005) Role of leptin and melanocortin signaling in uremia-associated cachexia. J Clin Invest 115: 1659-1665
36. Madiehe AM et al. (2003) Hyperleptinemia and reduced TNF-alpha secretion cause resistance of db/db mice to endotoxin. Am J Physiol Regul Integr Comp Physiol 284: R763-R770
37. Marks DL et al. (2001) Role of central melanocortin system in cachexia. Cancer Res 61: 1432-1438
38. Mitch WE and Goldberg AL (1996) Mechanisms of muscle wasting: the role of the ubiquitin-proteasome pathway. N Engl J Med 335: 1897-1905
39. Mitch WE et al. (1994) Metabolic acidosis stimulates muscle protein degradation by activating the adenosine triphosphate-dependent pathway involving ubiquitin and proteasomes. J Clin Invest 93: 2127-2133
40. Isozaki U et al. (1996) Protein degradation and increased mRNAs encoding proteins of the ubiquitin-proteasome proteolytic pathway in BC3H1 myocytes require an interaction between glucocorticoids and acidification. Proc Natl Acad Sci USA 93: 1967-1971
41. Price SR et al. (1996) Muscle wasting in insulinopenic rats results from activation of the ATP-dependent, ubiquitin-proteasome proteolytic pathway by a mechanism including gene transcription. J Clin Invest 98: 1703-1708
42. Motil KJ et al. (1981) Whole-body leucine and lysine metabolism: response to dietary protein intake in young men. Am J Physiol 240: E712-E721
43. Tom K et al. (1995) Long-term adaptive responses to dietary protein restriction in chronic renal failure. Am J Physiol 268: E668-E677
44. Maroni BJ et al. (1997) Mechanisms permitting nephrotic patients to achieve nitrogen equilibrium with a protein-restricted diet. J Clin Invest 99: 2479-2487
45. Mitch WE (2002) Requirements for protein, calories, and fat in the predialysis patient. In Handbook of Nutrition and the Kidney, 144-165 (Eds Mitch WE and Klahr S) Philadelphia: Lippincott, Williams and Wilkins
46. Simons JP et al. (1999) Weight loss and low body cell mass in males with lung cancer: relationship with systemic inflammation, acute-phase response, resting energy expenditure, and catabolic and anabolic hormones. Clin Sci 97: 215-223
47. Munro R and Capell H (1997) Prevalence of low body mass in rheumatoid arthritis: associations with the acute phase response. Ann Rheum Dis 56: 326-329
48. Stenvinkel P et al. (2000) Are there two types of malnutrition in chronic renal failure? Evidence for relationships between malnutrition, inflammation and atherosclerosis (MIA syndrome). Nephrol Dial Transplant 15: 953-960
49. Pupim LB et al. (2002) Intradialytic parenteral nutrition improves protein and energy homeostasis in chronic hemodialysis patients. J Clin Invest 110: 483-492
50. Betts PR and McGrath G (1974) Growth patterns and dietary intake of children with chronic renal insufficiency. Br Med J 2: 189-193
51. Simmons JM et al. (1971) Relation of calorie deficiency to growth failure in children on hemodialysis and the growth response to calorie supplementation. N Engl J Med 285: 653-656
52. Arnold WC et al. (1983) Effect of calorie supplementation on growth in children with uremia. Kidney Int 24: 205-209
53. Walker S et al. (2003) Catch-up growth with normal parathyroid hormone levels in chronic renal failure. Pediatr Nephrol 18: 1236-1241
54. Jones RW et al. (1982) The effects of chronic renal failure in infancy on growth, nutritional status and body compositioin. Pediatr Res 16: 784-791
55. Markison S et al. (2005) The regulation of feeding and metabolic rate and the prevention of murine cancer cachexia with a small-molecule melanocortin-4 receptor antagonist. Endocrinology 146: 2766-2773
56. Horvath TL (2005) The hardship of obesity: a soft-wired hypothalamus. Nature Neurosci 8: 561-565
57. Cone RD (2005) Anatomy and regulation of the central melanocortin system. Nature Neurosci 8: 571-578