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Volumn 91, Issue 4, 2010, Pages

Update on clinical trials of growth factors and anabolic steroids in cachexia and wasting

Author keywords

[No Author keywords available]

Indexed keywords

ANTIRETROVIRUS AGENT; ANABOLIC AGENT; GHRELIN; HUMAN GROWTH HORMONE; MEGESTROL ACETATE; OXANDROLONE; STEROID; TESTOSTERONE;

EID: 77950513120     PISSN: 00029165     EISSN: None     Source Type: Journal    
DOI: 10.3945/ajcn.2010.28608E     Document Type: Review
Times cited : (87)

References (56)
  • 1
    • 33646674302 scopus 로고    scopus 로고
    • Cachexia: Pathophysiology and clinical relevance
    • Morley JE, Thomas DR, Wilson MM. Cachexia: pathophysiology and clinical relevance. Am J Clin Nutr 2006;83:735-743
    • (2006) Am J Clin Nutr , vol.83 , pp. 735-743
    • Morley, J.E.1    Thomas, D.R.2    Wilson, M.M.3
  • 2
    • 67649982995 scopus 로고    scopus 로고
    • Mechanisms of cancer cachexia
    • Tisdale MJ. Mechanisms of cancer cachexia. Physiol Rev 2009;89: 381-410.
    • (2009) Physiol Rev , vol.89 , pp. 381-410
    • Tisdale, M.J.1
  • 3
    • 72449160114 scopus 로고    scopus 로고
    • An update on promising agents for the treatment of cancer cachexia
    • Madeddu C, Mantovani G. An update on promising agents for the treatment of cancer cachexia. Curr Opin Support Palliat Care 2009;3: 258-262
    • (2009) Curr Opin Support Palliat Care , vol.3 , pp. 258-262
    • Madeddu, C.1    Mantovani, G.2
  • 5
    • 65549095939 scopus 로고    scopus 로고
    • Recent insights on chronic heart failure, cachexia and nutrition
    • Miján-de-la-Torre A. Recent insights on chronic heart failure, cachexia and nutrition. Curr Opin Clin Nutr Metab Care 2009;12:251-257
    • (2009) Curr Opin Clin Nutr Metab Care , vol.12 , pp. 251-257
    • Miján-de-la-Torre, A.1
  • 9
    • 0023888048 scopus 로고
    • Metabolic effects of recombinant human growth hormone in patients receiving parenteral nutrition
    • Ziegler TR, Young LS, Manson JMK, Wilmore DW. Metabolic effects of recombinant human growth hormone in patients receiving parenteral nutrition. Ann Surg 1988;208:6-16.
    • (1988) Ann Surg , vol.208 , pp. 6-16
    • Ziegler, T.R.1    Young, L.S.2    Manson, J.M.K.3    Wilmore, D.W.4
  • 11
    • 33644692485 scopus 로고    scopus 로고
    • Recombinant human growth hormone improves muscle amino acid uptake and whole-body protein metabolism in chronic hemodialysis patients
    • Pupim LB, Flakoll PJ, Yu C, Ikizler TA. Recombinant human growth hormone improves muscle amino acid uptake and whole-body protein metabolism in chronic hemodialysis patients. Am J Clin Nutr 2005;82: 1235-1243 (Pubitemid 43779722)
    • (2005) American Journal of Clinical Nutrition , vol.82 , Issue.6 , pp. 1235-1243
    • Pupim, L.B.1    Flakoll, P.J.2    Yu, C.3    Ikizler, T.A.4
  • 12
    • 23844465080 scopus 로고    scopus 로고
    • Growth hormone, glutamine, and an optimal diet reduces parenteral nutrition in patients with short bowel syndrome: A prospective, randomized, placebo-controlled, double-blind clinical trial
    • DOI 10.1097/01.sla.0000186479.53295.14
    • Byrne TA, Wilmore DW, Iyer K, et al. Growth hormone, glutamine, and an optimal diet reduces parenteral nutrition in patients with short bowel syndrome: a prospective, randomized, placebo-controlled, double-blind clinical trial. Ann Surg 2005;242:655-661 (Pubitemid 41567120)
    • (2005) Annals of Surgery , vol.242 , Issue.5 , pp. 655-661
    • Byrne, T.A.1    Wilmore, D.W.2    Iyer, K.3    Dibaise, J.4    Clancy, K.5    Robinson, M.K.6    Chang, P.7    Gertner, J.M.8    Lautz, D.9
  • 13
    • 0025831976 scopus 로고
    • The effect of growth hormone on weight gain and pulmonary function in patients with chronic obstructive lung disease
    • Pape GS, Friedman M, Underwood LE, Clemmons DR. The effect of growth hormone on weight gain and pulmonary function in patients with chronic obstructive lung disease. Chest 1991;99:1495-5000.
    • (1991) Chest , vol.99 , pp. 1495-5000
    • Pape, G.S.1    Friedman, M.2    Underwood, L.E.3    Clemmons, D.R.4
  • 14
    • 0031436628 scopus 로고    scopus 로고
    • Administration of growth hormone to underweight patients with chronic obstructive pulmonary disease: A prospective, randomized, controlled study
    • Burdet L, de Muralt B, Schutz Y, Pichard C, Fitting JW. Administration of growth hormone to underweight patients with chronic obstructive pulmonary disease. A prospective, randomized, controlled study. Am J Respir Crit Care Med 1997;156:1800-1806 (Pubitemid 28011785)
    • (1997) American Journal of Respiratory and Critical Care Medicine , vol.156 , Issue.6 , pp. 1800-1806
    • Burdet, L.1    De Muralt, B.2    Schutz, Y.3    Pichard, C.4    Fitting, J.-W.5
  • 16
    • 0037599468 scopus 로고    scopus 로고
    • Growth hormone resistance in chronic heart failure and its therapeutic implications
    • DOI 10.1054/jcaf.2003.23
    • Cicoira M, Kalra PR, Anker SD. Growth hormone resistance in chronic heart failure and its therapeutic implications. J Card Fail 2003;9:219-226 (Pubitemid 36734319)
    • (2003) Journal of Cardiac Failure , vol.9 , Issue.3 , pp. 219-226
    • Cicoira, M.1    Kalra, P.R.2    Anker, S.D.3
  • 20
    • 69949126965 scopus 로고    scopus 로고
    • Growth hormone deficiency in patients with chronic heart failure and beneficial effects of its correction
    • July 7 (Epub ahead of print)
    • Cittadini A, Saldamarco L, Marra AM, et al. Growth hormone deficiency in patients with chronic heart failure and beneficial effects of its correction. J Clin Endocrinol Metab 2009;July 7 (Epub ahead of print).
    • (2009) J Clin Endocrinol Metab
    • Cittadini, A.1    Saldamarco, L.2    Marra, A.M.3
  • 21
    • 37349034238 scopus 로고    scopus 로고
    • Role of recombinant human growth hormone in HIV-associated wasting and cachexia: Pathophysiology and rationale for treatment
    • DOI 10.1016/j.clinthera.2007.11.004, PII S0149291807003530
    • Gelato M, McNurlan M, Freedland E. Role of recombinant human growth hormone in HIV-associated wasting and cachexia: pathophysiology and rationale for treatment. Clin Ther 2007;29:2269-2288 (Pubitemid 350298124)
    • (2007) Clinical Therapeutics , vol.29 , Issue.11 , pp. 2269-2288
    • Gelato, M.1    McNurlan, M.2    Freedland, E.3
  • 22
    • 0030319368 scopus 로고    scopus 로고
    • Recombinant human growth hormone in patients with HIV-associated wasting. a randomized, placebo-controlled trial
    • Serostim Study Group.
    • Schambelan M, Mulligan K, Grunfeld C, et al. Recombinant human growth hormone in patients with HIV-associated wasting. A randomized, placebo-controlled trial. Serostim Study Group. Ann Intern Med 1996;125:873-882
    • (1996) Ann Intern Med , vol.125 , pp. 873-882
    • Schambelan, M.1    Mulligan, K.2    Grunfeld, C.3
  • 23
    • 0031724708 scopus 로고    scopus 로고
    • Effects of chronic growth hormone treatment on energy intake and resting energy metabolism in patients with human immunodeficiency virus-associated wasting - A clinical research center study
    • DOI 10.1210/jc.83.5.1542
    • Mulligan K, Tai VW, Schambelan M. Effects of chronic growth hormone treatment on energy intake and resting energy metabolism in patients with human immunodeficiency virus-associated wasting-a clinical research center study. J Clin Endocrinol Metab 1998;83: 1542-1547 (Pubitemid 28501017)
    • (1998) Journal of Clinical Endocrinology and Metabolism , vol.83 , Issue.5 , pp. 1542-1547
    • Mulligan, K.1    Tai, V.W.2    Schambelan, M.3
  • 24
    • 0032811563 scopus 로고    scopus 로고
    • Short-term growth hormone administration at the time of opportunistic infections in HIV-positive patients
    • Paton NI, Newton PJ, Sharpstone DR, et al. Short-term growth hormone administration at the time of opportunistic infections in HIV-positive patients. AIDS 1999;13:1195-1202
    • (1999) AIDS , vol.13 , pp. 1195-1202
    • Paton, N.I.1    Newton, P.J.2    Sharpstone, D.R.3
  • 25
    • 6344250692 scopus 로고    scopus 로고
    • Growth hormone treatment improves peripheral muscle oxygen extraction-utilization during exercise in patients with human immunodeficiency virus-associated wasting: A randomized controlled trial
    • DOI 10.1210/jc.2004-0451
    • Esposito JG, Thomas SG, Kingdon L, Ezzat S. Growth hormone treatment improves peripheral muscle oxygen extraction-utilization during exercise in patients with human immunodeficiency virus-associated wasting: a randomized controlled trial. J Clin Endocrinol Metab 2004; 89:5124-5131 (Pubitemid 39391459)
    • (2004) Journal of Clinical Endocrinology and Metabolism , vol.89 , Issue.10 , pp. 5124-5131
    • Esposito, J.G.1    Thomas, S.G.2    Kingdon, L.3    Ezzat, S.4
  • 26
    • 23944463887 scopus 로고    scopus 로고
    • Anabolic growth hormone action improves submaximal measures of physical performance in patients with HIV-associated wasting
    • DOI 10.1152/ajpendo.00013.2005
    • Esposito JG, Thomas SG, Kingdon L, Ezzat S. Anabolic growth hormone action improves submaximal measures of physical performance in patients with HIV-associated wasting. Am J Physiol Endocrinol Metab 2005;289:E494-503. (Pubitemid 41192705)
    • (2005) American Journal of Physiology - Endocrinology and Metabolism , vol.289 , Issue.3
    • Esposito, J.G.1    Thomas, S.G.2    Kingdon, L.3    Ezzat, S.4
  • 27
    • 1542723602 scopus 로고    scopus 로고
    • Growth hormone improves lean body mass, physical performance, and quality of life in subjects with HIV-associated weight loss or wasting on highly active antiretroviral therapy
    • Moyle GJ, Daar ES, Gertner JM, et al. Growth hormone improves lean body mass, physical performance, and quality of life in subjects with HIV-associated weight loss or wasting on highly active antiretroviral therapy. J Acquir Immune Defic Syndr 2004;35:367-375
    • (2004) J Acquir Immune Defic Syndr , vol.35 , pp. 367-375
    • Moyle, G.J.1    Daar, E.S.2    Gertner, J.M.3
  • 28
    • 54049121817 scopus 로고    scopus 로고
    • The role of ghrelin and ghrelin analogues in wasting disease
    • Kamiji MM, Inui A. The role of ghrelin and ghrelin analogues in wasting disease. Curr Opin Clin Nutr Metab Care 2008;11:443-451
    • (2008) Curr Opin Clin Nutr Metab Care , vol.11 , pp. 443-451
    • Kamiji, M.M.1    Inui, A.2
  • 29
    • 49749111114 scopus 로고    scopus 로고
    • Emergence of ghrelin as a treatment for cachexia syndromes
    • DeBoer MD. Emergence of ghrelin as a treatment for cachexia syndromes. Nutrition 2008;24:806-814
    • (2008) Nutrition , vol.24 , pp. 806-814
    • Deboer, M.D.1
  • 30
    • 2942670638 scopus 로고    scopus 로고
    • Ghrelin increases energy intake in cancer patients with impaired appetite: Acute, randomized, placebo-controlled trial
    • Neary NM, Small CJ, Wren AM, et al. Ghrelin increases energy intake in cancer patients with impaired appetite: acute, randomized, placebo-controlled trial. J Clin Endocrinol Metab 2004;89:2832-2836
    • (2004) J Clin Endocrinol Metab , vol.89 , pp. 2832-2836
    • Neary, N.M.1    Small, C.J.2    Wren, A.M.3
  • 34
    • 20844460120 scopus 로고    scopus 로고
    • Effects of ghrelin administration on left ventricular function, exercise capacity, and muscle wasting in patients with chronic heart failure
    • DOI 10.1161/01.CIR.0000149746.62908.BB
    • Nagaya N, Moriya J, Yasumura Y, et al. Effects of ghrelin administration on left ventricular function, exercise capacity, and muscle wasting in patients with chronic heart failure. Circulation 2004;110: 3674-3679 (Pubitemid 39665256)
    • (2004) Circulation , vol.110 , Issue.24 , pp. 3674-3679
    • Nagaya, N.1    Moriya, J.2    Yasumura, Y.3    Uematsu, M.4    Ono, F.5    Shimizu, W.6    Ueno, K.7    Kitakaze, M.8    Miyatake, K.9    Kangawa, K.10
  • 35
    • 35549012275 scopus 로고    scopus 로고
    • Effect on body weight and safety of RC-1291, a novel, orally available ghrelin mimetic and growth hormone secretagogue: Results of a phase I, randomized, placebo-controlled, multiple-dose study in healthy volunteers
    • Garcia JM, Polvino WJ. Effect on body weight and safety of RC-1291, a novel, orally available ghrelin mimetic and growth hormone secretagogue: results of a phase I, randomized, placebo-controlled, multiple-dose study in healthy volunteers. Oncologist 2007;12:594-600.
    • (2007) Oncologist , vol.12 , pp. 594-600
    • Garcia, J.M.1    Polvino, W.J.2
  • 36
    • 67349182900 scopus 로고    scopus 로고
    • Pharmacodynamic hormonal effects of anamorelin, a novel oral ghrelin mimetic and growth hormone secretagogue in healthy volunteers
    • Garcia JM, Polvino WJ. Pharmacodynamic hormonal effects of anamorelin, a novel oral ghrelin mimetic and growth hormone secretagogue in healthy volunteers. Growth Horm IGF Res 2009;19:267-277
    • (2009) Growth Horm IGF Res , vol.19 , pp. 267-277
    • Garcia, J.M.1    Polvino, W.J.2
  • 37
    • 37649021033 scopus 로고    scopus 로고
    • Phase II, randomized, placebo-controlled, double blind study of the efficacy and safety of RC-1291 for the treatment of cancer cachexia
    • abstract
    • Garcia JM, Graham C, Kumor R, Polvino WA. Phase II, randomized, placebo-controlled, double blind study of the efficacy and safety of RC-1291 for the treatment of cancer cachexia. J Clin Oncol 2007;25:S25 (abstract).
    • (2007) J Clin Oncol , vol.25
    • Garcia, J.M.1    Graham, C.2    Kumor, R.3    Polvino, W.A.4
  • 38
    • 0029437656 scopus 로고
    • Pathophysiology and treatment of the AIDS wasting syndrome
    • Kotler DP, Grunfeld C. Pathophysiology and treatment of the AIDS wasting syndrome. AIDS Clin Rev 1995-1996;229-275
    • (1995) AIDS Clin Rev , pp. 229-275
    • Kotler, D.P.1    Grunfeld, C.2
  • 39
    • 0036206076 scopus 로고    scopus 로고
    • Megestrol acetate stimulates weight gain and ventilation in underweight COPD patients
    • DOI 10.1378/chest.121.4.1070
    • Weisberg J,Wanger J, Olson J, et al. Megestrol acetate stimulates weight gain and ventilation in underweight COPD patients. Chest 2002;121: 1070-1078 (Pubitemid 34280424)
    • (2002) Chest , vol.121 , Issue.4 , pp. 1070-1078
    • Weisberg, J.1    Wanger, J.2    Olson, J.3    Streit, B.4    Fogarty, C.5    Martin, T.6    Casaburi, R.7
  • 40
    • 21844436308 scopus 로고    scopus 로고
    • Megestrol acetate for the treatment of anorexiacachexia syndrome
    • CD004310
    • Berenstein EG, Ortiz Z. Megestrol acetate for the treatment of anorexiacachexia syndrome. Cochrane Database Syst Rev 2005:CD004310.
    • (2005) Cochrane Database Syst Rev
    • Berenstein, E.G.1    Ortiz, Z.2
  • 41
    • 0038683837 scopus 로고    scopus 로고
    • Megestrol acetate in pediatric oncology patients may lead to severe, symptomatic adrenal suppression
    • Orme LM, Bond JD, Humphrey MS, et al. Megestrol acetate in pediatric oncology patients may lead to severe, symptomatic adrenal suppression. Cancer 2003;98:397-400.
    • (2003) Cancer , vol.98 , pp. 397-400
    • Orme, L.M.1    Bond, J.D.2    Humphrey, M.S.3
  • 42
    • 0032955902 scopus 로고    scopus 로고
    • Thrombotic events associated with megestrol acetate in patients with AIDS cachexia
    • DOI 10.1016/S0899-9007(99)00007-6, PII S0899900799000076
    • Koller E, Gibert C, Green L, Mann M, Bernstein B. Thrombotic events associated with megestrol acetate in patients with AIDS cachexia. Nutrition 1999;15:294-298 (Pubitemid 29201096)
    • (1999) Nutrition , vol.15 , Issue.4 , pp. 294-298
    • Koller, E.1    Gibert, C.2    Green, L.3    Mann, M.4    Bernstein, B.5
  • 43
    • 59849116257 scopus 로고    scopus 로고
    • Advances in testosterone replacement therapy
    • Gooren LJ. Advances in testosterone replacement therapy. Front Horm Res 2009;37:32-51.
    • (2009) Front Horm Res , vol.37 , pp. 32-51
    • Gooren, L.J.1
  • 44
    • 61449151964 scopus 로고    scopus 로고
    • Effect of testosterone and a nutritional supplement, alone and in combination, on hospital admissions in undernourished older men and women
    • Chapman IM, Visvanathan R, Hammond AJ, et al. Effect of testosterone and a nutritional supplement, alone and in combination, on hospital admissions in undernourished older men and women. Am J Clin Nutr 2009;89:880-889
    • (2009) Am J Clin Nutr , vol.89 , pp. 880-889
    • Chapman, I.M.1    Visvanathan, R.2    Hammond, A.J.3
  • 45
    • 1842689292 scopus 로고    scopus 로고
    • The anabolic androgenic steroid oxandrolone in the treatment of wasting and catabolic disorders: Review of efficacy and safety
    • DOI 10.2165/00003495-200464070-00004
    • Orr R, Fiatarone Singh M. The anabolic androgenic steroid oxandrolone in the treatment of wasting and catabolic disorders: review of efficacy and safety. Drugs 2004;64:725-750 (Pubitemid 38471373)
    • (2004) Drugs , vol.64 , Issue.7 , pp. 725-750
    • Orr, R.1    Fiatarone Singh, M.2
  • 46
    • 0033983480 scopus 로고    scopus 로고
    • Testosterone replacement and resistance exercise in HIV-infected men with weight loss and low testosterone levels
    • Bhasin S, Storer TW, Javanbakht M, et al. Testosterone replacement and resistance exercise in HIV-infected men with weight loss and low testosterone levels. JAMA 2000;283:763-770
    • (2000) JAMA , vol.283 , pp. 763-770
    • Bhasin, S.1    Storer, T.W.2    Javanbakht, M.3
  • 49
    • 47549114457 scopus 로고    scopus 로고
    • Effects of a supraphysiological dose of testosterone on physical function, muscle performance, mood, and fatigue in men with HIV-associated weight loss
    • Knapp PE, Storer TW, Herbst KL, et al. Effects of a supraphysiological dose of testosterone on physical function, muscle performance, mood, and fatigue in men with HIV-associated weight loss. Am J Physiol Endocrinol Metab 2008;294:E1135-43.
    • (2008) Am J Physiol Endocrinol Metab , vol.294
    • Knapp, P.E.1    Storer, T.W.2    Herbst, K.L.3
  • 51
    • 0033553201 scopus 로고    scopus 로고
    • Resistance exercise and supraphysiologic androgen therapy in eugonadal men with HIV related weight loss
    • Strawford A, Barbieri T, VanLoan M, et al. Resistance exercise and supraphysiologic androgen therapy in eugonadal men with HIV related weight loss. JAMA 1999;281:1282-1290
    • (1999) JAMA , vol.281 , pp. 1282-1290
    • Strawford, A.1    Barbieri, T.2    Vanloan, M.3
  • 52
    • 33645108179 scopus 로고    scopus 로고
    • Oxandrolone in the treatment of HIV-associated weight loss in men: A randomized, double-blind, placebo-controlled study
    • Grunfeld C, Kotler DP, Dobs A, Glesby M, Bhasin S. Oxandrolone in the treatment of HIV-associated weight loss in men: a randomized, double-blind, placebo-controlled study. J Acquir Immune Defic Syndr 2006;41:304-311
    • (2006) J Acquir Immune Defic Syndr , vol.41 , pp. 304-311
    • Grunfeld, C.1    Kotler, D.P.2    Dobs, A.3    Glesby, M.4    Bhasin, S.5
  • 53
    • 0036036456 scopus 로고    scopus 로고
    • Reversal of COPD-associated weight loss using the anabolic agent oxandrolone
    • M012 Study Group.
    • Yeh SS, DeGuzman B, Kramer T. M012 Study Group. Reversal of COPD-associated weight loss using the anabolic agent oxandrolone. Chest 2002;122:421-428
    • (2002) Chest , vol.122 , pp. 421-428
    • Yeh, S.S.1    Deguzman, B.2    Kramer, T.3
  • 54
    • 14844287053 scopus 로고    scopus 로고
    • Effect of nandrolone decanoate therapy on weight and lean body mass in HIV-infected women with weight loss: A randomized, double-blind, placebo-controlled, multicenter trial
    • DOI 10.1001/archinte.165.5.578
    • Mulligan K, Zackin R, Clark RA, et al. Effect of nandrolone decanoate therapy on weight and lean body mass in HIV-infected women with weight loss: a randomized, double-blind, placebo-controlled, multicenter trial. Arch Intern Med 2005;165:578-588 (Pubitemid 40344392)
    • (2005) Archives of Internal Medicine , vol.165 , Issue.5 , pp. 578-585
    • Mulligan, K.1    Zackin, R.2    Clark, R.A.3    Alston-Smith, B.4    Liu, T.5    Sattler, F.R.6    Delvers, T.B.7    Currier, J.S.8
  • 56
    • 65549087111 scopus 로고    scopus 로고
    • Selective androgen receptor modulators as function promoting therapies
    • Bhasin S, Jasuja R. Selective androgen receptor modulators as function promoting therapies. Curr Opin Clin Nutr Metab Care 2009;12:232-234
    • (2009) Curr Opin Clin Nutr Metab Care , vol.12 , pp. 232-234
    • Bhasin, S.1    Jasuja, R.2


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