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Volumn 26, Issue 2, 2010, Pages 146-151

Update on melanocortin interventions for cachexia: Progress toward clinical application

Author keywords

Anorexia; Cachexia; Ghrelin; MC4 R; Melanocortin

Indexed keywords

2 [2 [2 (5 BROMO 2 METHOXYPHENYL)ETHYL] 3 FLUOROPHENYL] 4,5 DIHYDRO 1H IMIDAZOLE; AGOUTI RELATED PROTEIN; CYTOKINE; FAT; HORMONE ANTAGONIST; MELANOCORTIN; MELANOCORTIN 4 RECEPTOR; MELANOCORTIN ANTAGONIST; NBI 12I; NEUROPEPTIDE Y; PIPERAZINE DERIVATIVE; PROOPIOMELANOCORTIN; PYRROLIDINE DERIVATIVE; SNT 207707; SNT 209858; UNCLASSIFIED DRUG;

EID: 73649113084     PISSN: 08999007     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.nut.2009.07.003     Document Type: Review
Times cited : (28)

References (51)
  • 1
    • 0030665384 scopus 로고    scopus 로고
    • Biology of cachexia
    • Tisdale M.J. Biology of cachexia. J Natl Cancer Inst 89 (1997) 1763-1773
    • (1997) J Natl Cancer Inst , vol.89 , pp. 1763-1773
    • Tisdale, M.J.1
  • 2
    • 33747054431 scopus 로고    scopus 로고
    • Therapy insight: Use of melanocortin antagonists in the treatment of cachexia in chronic disease
    • DeBoer M.D., and Marks D.L. Therapy insight: Use of melanocortin antagonists in the treatment of cachexia in chronic disease. Nat Clin Pract Endocrinol Metab 2 (2006) 459-466
    • (2006) Nat Clin Pract Endocrinol Metab , vol.2 , pp. 459-466
    • DeBoer, M.D.1    Marks, D.L.2
  • 3
    • 0035866377 scopus 로고    scopus 로고
    • Role of the central melanocortin system in cachexia
    • Marks D.L., Ling N., and Cone R.D. Role of the central melanocortin system in cachexia. Cancer Res 61 (2001) 1432-1438
    • (2001) Cancer Res , vol.61 , pp. 1432-1438
    • Marks, D.L.1    Ling, N.2    Cone, R.D.3
  • 4
    • 17844401704 scopus 로고    scopus 로고
    • Anatomy and regulation of the central melanocortin system
    • Cone R.D. Anatomy and regulation of the central melanocortin system. Nat Neurosci 8 (2005) 571-578
    • (2005) Nat Neurosci , vol.8 , pp. 571-578
    • Cone, R.D.1
  • 5
    • 30444460361 scopus 로고    scopus 로고
    • Astrocytes in the arcuate nucleus and median eminence that take up a fluorescent dye from the circulation express leptin receptors and neuropeptide Y Y1 receptors
    • Cheunsuang O., and Morris R. Astrocytes in the arcuate nucleus and median eminence that take up a fluorescent dye from the circulation express leptin receptors and neuropeptide Y Y1 receptors. Glia 52 (2005) 228-233
    • (2005) Glia , vol.52 , pp. 228-233
    • Cheunsuang, O.1    Morris, R.2
  • 6
    • 0033200153 scopus 로고    scopus 로고
    • Integration of NPY, AGRP, and melanocortin signals in the hypothalamic paraventricular nucleus: evidence of a cellular basis for the adipostat
    • Cowley M.A., Pronchuk N., Fan W., Dinulescu D.M., Colmers W.F., and Cone R.D. Integration of NPY, AGRP, and melanocortin signals in the hypothalamic paraventricular nucleus: evidence of a cellular basis for the adipostat. Neuron 24 (1999) 155-163
    • (1999) Neuron , vol.24 , pp. 155-163
    • Cowley, M.A.1    Pronchuk, N.2    Fan, W.3    Dinulescu, D.M.4    Colmers, W.F.5    Cone, R.D.6
  • 7
    • 38749123510 scopus 로고    scopus 로고
    • Central blockade of melanocortin receptors attenuates the metabolic and locomotor responses to peripheral interleukin-1beta administration
    • Whitaker K.W., and Reyes T.M. Central blockade of melanocortin receptors attenuates the metabolic and locomotor responses to peripheral interleukin-1beta administration. Neuropharmacology 54 (2008) 509-520
    • (2008) Neuropharmacology , vol.54 , pp. 509-520
    • Whitaker, K.W.1    Reyes, T.M.2
  • 8
    • 18844432794 scopus 로고    scopus 로고
    • The regulation of feeding and metabolic rate and the prevention of murine cancer cachexia with a small-molecule melanocortin-4 receptor antagonist
    • Markison S., Foster A.C., Chen C., Brookhart G.B., Hesse A., Hoare S.R., et al. The regulation of feeding and metabolic rate and the prevention of murine cancer cachexia with a small-molecule melanocortin-4 receptor antagonist. Endocrinology 146 (2005) 2766-2773
    • (2005) Endocrinology , vol.146 , pp. 2766-2773
    • Markison, S.1    Foster, A.C.2    Chen, C.3    Brookhart, G.B.4    Hesse, A.5    Hoare, S.R.6
  • 9
    • 58149339706 scopus 로고    scopus 로고
    • Lower metabolic rate in individuals heterozygous for either a frameshift or a functional missense MC4R variant
    • Krakoff J., Ma L., Kobes S., Knowler W.C., Hanson R.L., Bogardus C., and Baier L.J. Lower metabolic rate in individuals heterozygous for either a frameshift or a functional missense MC4R variant. Diabetes 57 (2008) 3267-3272
    • (2008) Diabetes , vol.57 , pp. 3267-3272
    • Krakoff, J.1    Ma, L.2    Kobes, S.3    Knowler, W.C.4    Hanson, R.L.5    Bogardus, C.6    Baier, L.J.7
  • 10
    • 0030614331 scopus 로고    scopus 로고
    • Role of melanocortinergic neurons in feeding and the agouti obesity syndrome
    • Fan W., Boston B.A., Kesterson R.A., Hruby V.J., and Cone R.D. Role of melanocortinergic neurons in feeding and the agouti obesity syndrome. Nature 385 (1997) 165-168
    • (1997) Nature , vol.385 , pp. 165-168
    • Fan, W.1    Boston, B.A.2    Kesterson, R.A.3    Hruby, V.J.4    Cone, R.D.5
  • 11
    • 0037456768 scopus 로고    scopus 로고
    • Clinical spectrum of obesity and mutations in the melanocortin 4 receptor gene
    • Farooqi I.S., Keogh J.M., Yeo G.S., Lank E.J., Cheetham T., and O'Rahilly S. Clinical spectrum of obesity and mutations in the melanocortin 4 receptor gene. N Engl J Med 348 (2003) 1085-1095
    • (2003) N Engl J Med , vol.348 , pp. 1085-1095
    • Farooqi, I.S.1    Keogh, J.M.2    Yeo, G.S.3    Lank, E.J.4    Cheetham, T.5    O'Rahilly, S.6
  • 12
    • 0343953074 scopus 로고    scopus 로고
    • Dominant and recessive inheritance of morbid obesity associated with melanocortin 4 receptor deficiency
    • Farooqi I.S., Yeo G.S., Keogh J.M., Aminian S., Jebb S.A., Butler G., et al. Dominant and recessive inheritance of morbid obesity associated with melanocortin 4 receptor deficiency. J Clin Invest 106 (2000) 271-279
    • (2000) J Clin Invest , vol.106 , pp. 271-279
    • Farooqi, I.S.1    Yeo, G.S.2    Keogh, J.M.3    Aminian, S.4    Jebb, S.A.5    Butler, G.6
  • 13
    • 34250667431 scopus 로고    scopus 로고
    • Melanocortin interventions in cachexia: how soon from bench to bedside?
    • DeBoer M.D. Melanocortin interventions in cachexia: how soon from bench to bedside?. Curr Opin Clin Nutr Metab Care 10 (2007) 457-462
    • (2007) Curr Opin Clin Nutr Metab Care , vol.10 , pp. 457-462
    • DeBoer, M.D.1
  • 14
    • 0030729210 scopus 로고    scopus 로고
    • Regulation of hypothalamic proopiomelanocortin mRNA by leptin in ob/ob mice
    • Thornton J.E., Cheung C.C., Clifton D.K., and Steiner R.A. Regulation of hypothalamic proopiomelanocortin mRNA by leptin in ob/ob mice. Endocrinology 138 (1997) 5063-5066
    • (1997) Endocrinology , vol.138 , pp. 5063-5066
    • Thornton, J.E.1    Cheung, C.C.2    Clifton, D.K.3    Steiner, R.A.4
  • 15
    • 0030481802 scopus 로고    scopus 로고
    • Expression of leptin receptor mRNA in the hypothalamic arcuate nucleus-relationship with NPY neurones
    • Hakansson M.L., Hulting A.L., and Meister B. Expression of leptin receptor mRNA in the hypothalamic arcuate nucleus-relationship with NPY neurones. Neuroreport 7 (1996) 3087-3092
    • (1996) Neuroreport , vol.7 , pp. 3087-3092
    • Hakansson, M.L.1    Hulting, A.L.2    Meister, B.3
  • 16
    • 0030775971 scopus 로고    scopus 로고
    • Leptin increases hypothalamic pro-opiomelanocortin mRNA expression in the rostral arcuate nucleus
    • Schwartz M.W., Seeley R.J., Woods S.C., Weigle D.S., Campfield L.A., Burn P., and Baskin D.G. Leptin increases hypothalamic pro-opiomelanocortin mRNA expression in the rostral arcuate nucleus. Diabetes 46 (1997) 2119-2123
    • (1997) Diabetes , vol.46 , pp. 2119-2123
    • Schwartz, M.W.1    Seeley, R.J.2    Woods, S.C.3    Weigle, D.S.4    Campfield, L.A.5    Burn, P.6    Baskin, D.G.7
  • 18
    • 53249125782 scopus 로고    scopus 로고
    • Regulation of agouti-related protein messenger ribonucleic acid transcription and peptide secretion by acute and chronic inflammation
    • Scarlett J.M., Zhu X., Enriori P.J., Bowe D.D., Batra A.K., Levasseur P.R., et al. Regulation of agouti-related protein messenger ribonucleic acid transcription and peptide secretion by acute and chronic inflammation. Endocrinology 149 (2008) 4837-4845
    • (2008) Endocrinology , vol.149 , pp. 4837-4845
    • Scarlett, J.M.1    Zhu, X.2    Enriori, P.J.3    Bowe, D.D.4    Batra, A.K.5    Levasseur, P.R.6
  • 19
    • 0037353349 scopus 로고    scopus 로고
    • Ultrastructure of the central subnucleus of the nucleus tractus solitarii and the esophageal afferent terminals in the rat
    • Hayakawa T., Takanaga A., Tanaka K., Maeda S., and Seki M. Ultrastructure of the central subnucleus of the nucleus tractus solitarii and the esophageal afferent terminals in the rat. Anat Embryol (Berl) 206 (2003) 273-281
    • (2003) Anat Embryol (Berl) , vol.206 , pp. 273-281
    • Hayakawa, T.1    Takanaga, A.2    Tanaka, K.3    Maeda, S.4    Seki, M.5
  • 20
    • 2542497121 scopus 로고    scopus 로고
    • Gastrointestinal mechanisms of satiation for food
    • Ritter R.C. Gastrointestinal mechanisms of satiation for food. Physiol Behav 81 (2004) 249-273
    • (2004) Physiol Behav , vol.81 , pp. 249-273
    • Ritter, R.C.1
  • 21
    • 35548987415 scopus 로고    scopus 로고
    • Identification of rat brainstem neuronal structures activated during cancer-induced anorexia
    • Ruud J., and Blomqvist A. Identification of rat brainstem neuronal structures activated during cancer-induced anorexia. J Comp Neurol 504 (2007) 275-286
    • (2007) J Comp Neurol , vol.504 , pp. 275-286
    • Ruud, J.1    Blomqvist, A.2
  • 22
    • 58149503770 scopus 로고    scopus 로고
    • Administration of IL-1beta to the 4th ventricle causes anorexia that is blocked by agouti-related peptide and that coincides with activation of tyrosine-hydroxylase neurons in the nucleus of the solitary tract
    • DeBoer M.D., Scarlett J.M., Levasseur P.R., Grant W.F., and Marks D.L. Administration of IL-1beta to the 4th ventricle causes anorexia that is blocked by agouti-related peptide and that coincides with activation of tyrosine-hydroxylase neurons in the nucleus of the solitary tract. Peptides 30 (2009) 210-218
    • (2009) Peptides , vol.30 , pp. 210-218
    • DeBoer, M.D.1    Scarlett, J.M.2    Levasseur, P.R.3    Grant, W.F.4    Marks, D.L.5
  • 23
    • 45349083684 scopus 로고    scopus 로고
    • Dual modulation of synaptic transmission in the nucleus tractus solitarius by prostaglandin E2 synthesized downstream of IL-1beta
    • Marty V., El Hachmane M., and Amedee T. Dual modulation of synaptic transmission in the nucleus tractus solitarius by prostaglandin E2 synthesized downstream of IL-1beta. Eur J Neurosci 27 (2008) 3132-3150
    • (2008) Eur J Neurosci , vol.27 , pp. 3132-3150
    • Marty, V.1    El Hachmane, M.2    Amedee, T.3
  • 24
    • 21044433027 scopus 로고    scopus 로고
    • Brain stem melanocortinergic modulation of meal size and identification of hypothalamic POMC projections
    • Zheng H., Patterson L.M., Phifer C.B., and Berthoud H.R. Brain stem melanocortinergic modulation of meal size and identification of hypothalamic POMC projections. Am J Physiol Regul Integr Comp Physiol 289 (2005) R247-R258
    • (2005) Am J Physiol Regul Integr Comp Physiol , vol.289
    • Zheng, H.1    Patterson, L.M.2    Phifer, C.B.3    Berthoud, H.R.4
  • 25
    • 38549149911 scopus 로고    scopus 로고
    • Ghrelin treatment of chronic kidney disease: improvements in lean body mass and cytokine profile
    • DeBoer M.D., Zhu X., Levasseur P.R., Inui A., Hu Z., Han G., et al. Ghrelin treatment of chronic kidney disease: improvements in lean body mass and cytokine profile. Endocrinology 149 (2008) 827-835
    • (2008) Endocrinology , vol.149 , pp. 827-835
    • DeBoer, M.D.1    Zhu, X.2    Levasseur, P.R.3    Inui, A.4    Hu, Z.5    Han, G.6
  • 26
    • 34250888937 scopus 로고    scopus 로고
    • Ghrelin treatment causes increased food intake and retention of lean body mass in a rat model of cancer cachexia
    • DeBoer M.D., Zhu X.X., Levasseur P., Meguid M.M., Suzuki S., Inui A., et al. Ghrelin treatment causes increased food intake and retention of lean body mass in a rat model of cancer cachexia. Endocrinology 148 (2007) 3004-3012
    • (2007) Endocrinology , vol.148 , pp. 3004-3012
    • DeBoer, M.D.1    Zhu, X.X.2    Levasseur, P.3    Meguid, M.M.4    Suzuki, S.5    Inui, A.6
  • 27
    • 49749111114 scopus 로고    scopus 로고
    • Emergence of ghrelin as a treatment for cachexia syndromes
    • DeBoer M.D. Emergence of ghrelin as a treatment for cachexia syndromes. Nutrition 24 (2008) 806-814
    • (2008) Nutrition , vol.24 , pp. 806-814
    • DeBoer, M.D.1
  • 28
    • 42949133797 scopus 로고    scopus 로고
    • Val103Ile polymorphism of the melanocortin-4 receptor gene (MC4R) in cancer cachexia
    • Knoll S., Zimmer S., Hinney A., Scherag A., Neubauer A., and Hebebrand J. Val103Ile polymorphism of the melanocortin-4 receptor gene (MC4R) in cancer cachexia. BMC Cancer 8 (2008) 85
    • (2008) BMC Cancer , vol.8 , pp. 85
    • Knoll, S.1    Zimmer, S.2    Hinney, A.3    Scherag, A.4    Neubauer, A.5    Hebebrand, J.6
  • 29
    • 0034610311 scopus 로고    scopus 로고
    • Molecular determinants of ligand binding to the human melanocortin-4 receptor
    • Yang Y.K., Fong T.M., Dickinson C.J., Mao C., Li J.Y., Tota M.R., et al. Molecular determinants of ligand binding to the human melanocortin-4 receptor. Biochemistry 39 (2000) 14900-14911
    • (2000) Biochemistry , vol.39 , pp. 14900-14911
    • Yang, Y.K.1    Fong, T.M.2    Dickinson, C.J.3    Mao, C.4    Li, J.Y.5    Tota, M.R.6
  • 30
    • 34547608426 scopus 로고    scopus 로고
    • Contribution of the conserved amino acids of the melanocortin-4 receptor in [corrected] [Nle4, D-Phe7]-alpha-melanocyte-stimulating [corrected] hormone binding and signaling
    • Chen M., Cai M., Aprahamian C.J., Georgeson K.E., Hruby V., Harmon C.M., and Yang Y. Contribution of the conserved amino acids of the melanocortin-4 receptor in [corrected] [Nle4, D-Phe7]-alpha-melanocyte-stimulating [corrected] hormone binding and signaling. J Biol Chem 282 (2007) 21712-21719
    • (2007) J Biol Chem , vol.282 , pp. 21712-21719
    • Chen, M.1    Cai, M.2    Aprahamian, C.J.3    Georgeson, K.E.4    Hruby, V.5    Harmon, C.M.6    Yang, Y.7
  • 31
    • 37349116252 scopus 로고    scopus 로고
    • The continuum of translation research in genomic medicine: how can we accelerate the appropriate integration of human genome discoveries into health care and disease prevention?
    • Khoury M.J., Gwinn M., Yoon P.W., Dowling N., Moore C.A., and Bradley L. The continuum of translation research in genomic medicine: how can we accelerate the appropriate integration of human genome discoveries into health care and disease prevention?. Genet Med 9 (2007) 665-674
    • (2007) Genet Med , vol.9 , pp. 665-674
    • Khoury, M.J.1    Gwinn, M.2    Yoon, P.W.3    Dowling, N.4    Moore, C.A.5    Bradley, L.6
  • 33
    • 72949084933 scopus 로고    scopus 로고
    • Blockade of central melanocortin signaling promotes accumulation of lean body mass in rodent models of chronic heart failure
    • Bowe D.D., Scarlett J.M., Basra A.K., Steiner R.A., and Marks D.L. Blockade of central melanocortin signaling promotes accumulation of lean body mass in rodent models of chronic heart failure. J Investig Med 55 (2007) S77
    • (2007) J Investig Med , vol.55
    • Bowe, D.D.1    Scarlett, J.M.2    Basra, A.K.3    Steiner, R.A.4    Marks, D.L.5
  • 34
    • 72949120917 scopus 로고    scopus 로고
    • Central melanocortin blockade attenuates cardiac cachexia in a rat model of chronic heart failure
    • Basra A.K., Scarlett J.M., Bowe D.D., Steiner R.A., and Marks D.L. Central melanocortin blockade attenuates cardiac cachexia in a rat model of chronic heart failure. J Investig Med 56 (2008) 229-230
    • (2008) J Investig Med , vol.56 , pp. 229-230
    • Basra, A.K.1    Scarlett, J.M.2    Bowe, D.D.3    Steiner, R.A.4    Marks, D.L.5
  • 35
    • 33846807457 scopus 로고    scopus 로고
    • Central infusion of the melanocortin receptor antagonist agouti-related peptide (AgRP(83-132)) prevents cachexia-related symptoms induced by radiation and colon-26 tumors in mice
    • Joppa M.A., Gogas K.R., Foster A.C., and Markison S. Central infusion of the melanocortin receptor antagonist agouti-related peptide (AgRP(83-132)) prevents cachexia-related symptoms induced by radiation and colon-26 tumors in mice. Peptides 28 (2007) 636-642
    • (2007) Peptides , vol.28 , pp. 636-642
    • Joppa, M.A.1    Gogas, K.R.2    Foster, A.C.3    Markison, S.4
  • 37
    • 0031025867 scopus 로고    scopus 로고
    • The influence of muscle mass, strength, fatigability and blood flow on exercise capacity in cachectic and non-cachectic patients with chronic heart failure
    • Anker S.D., Swan J.W., Volterrani M., Chua T.P., Clark A.L., Poole-Wilson P.A., and Coats A.J. The influence of muscle mass, strength, fatigability and blood flow on exercise capacity in cachectic and non-cachectic patients with chronic heart failure. Eur Heart J 18 (1997) 259-269
    • (1997) Eur Heart J , vol.18 , pp. 259-269
    • Anker, S.D.1    Swan, J.W.2    Volterrani, M.3    Chua, T.P.4    Clark, A.L.5    Poole-Wilson, P.A.6    Coats, A.J.7
  • 39
    • 38049183243 scopus 로고    scopus 로고
    • 2007 Focused update of the ACC/AHA 2004 guidelines for the management of patients with ST-elevation myocardial infarction: a report of the American College of Cardiology/American Heart Association task force on practice guidelines: developed in collaboration with the Canadian Cardiovascular Society endorsed by the American Academy of Family Physicians
    • Antman E.M., Hand M., Armstrong P.W., Bates E.R., Green L.A., Halasyamani L.K., et al. 2007 Focused update of the ACC/AHA 2004 guidelines for the management of patients with ST-elevation myocardial infarction: a report of the American College of Cardiology/American Heart Association task force on practice guidelines: developed in collaboration with the Canadian Cardiovascular Society endorsed by the American Academy of Family Physicians: 2007 writing group to review new evidence and update the ACC/AHA 2004 guidelines for the management of patients with ST-elevation myocardial infarction, writing on behalf of the 2004 writing committee. Circulation 117 (2008) 296-329
    • (2008) Circulation , vol.117 , pp. 296-329
    • Antman, E.M.1    Hand, M.2    Armstrong, P.W.3    Bates, E.R.4    Green, L.A.5    Halasyamani, L.K.6
  • 40
    • 20444497662 scopus 로고    scopus 로고
    • Role of leptin and melanocortin signaling in uremia-associated cachexia
    • Cheung W., Yu P.X., Little B.M., Cone R.D., Marks D.L., and Mak R.H. Role of leptin and melanocortin signaling in uremia-associated cachexia. J Clin Invest 115 (2005) 1659-1665
    • (2005) J Clin Invest , vol.115 , pp. 1659-1665
    • Cheung, W.1    Yu, P.X.2    Little, B.M.3    Cone, R.D.4    Marks, D.L.5    Mak, R.H.6
  • 42
    • 0034919731 scopus 로고    scopus 로고
    • Reversal of cancer anorexia by blockade of central melanocortin receptors in rats
    • Wisse B.E., Frayo R.S., Schwartz M.W., and Cummings D.E. Reversal of cancer anorexia by blockade of central melanocortin receptors in rats. Endocrinology 142 (2001) 3292-3301
    • (2001) Endocrinology , vol.142 , pp. 3292-3301
    • Wisse, B.E.1    Frayo, R.S.2    Schwartz, M.W.3    Cummings, D.E.4
  • 43
    • 63349100316 scopus 로고    scopus 로고
    • Orally available selective melanocortin-4 receptor antagonists stimulate food intake and reduce cancer-induced cachexia in mice
    • Weyermann P., Dallmann R., Magyar J., Anklin C., Hufschmid M., Dubach-Powell J., et al. Orally available selective melanocortin-4 receptor antagonists stimulate food intake and reduce cancer-induced cachexia in mice. PLoS One 4 (2009) e4774
    • (2009) PLoS One , vol.4
    • Weyermann, P.1    Dallmann, R.2    Magyar, J.3    Anklin, C.4    Hufschmid, M.5    Dubach-Powell, J.6
  • 44
    • 34548502188 scopus 로고    scopus 로고
    • Peripheral administration of the melanocortin-4 receptor antagonist NBI-12i ameliorates uremia-associated cachexia in mice
    • Cheung W.W., Kuo H.J., Markison S., Chen C., Foster A.C., Marks D.L., and Mak R.H. Peripheral administration of the melanocortin-4 receptor antagonist NBI-12i ameliorates uremia-associated cachexia in mice. J Am Soc Nephrol 18 (2007) 2517-2524
    • (2007) J Am Soc Nephrol , vol.18 , pp. 2517-2524
    • Cheung, W.W.1    Kuo, H.J.2    Markison, S.3    Chen, C.4    Foster, A.C.5    Marks, D.L.6    Mak, R.H.7
  • 45
    • 37049016920 scopus 로고    scopus 로고
    • Design, synthesis, in vitro, and in vivo characterization of phenylpiperazines and pyridinylpiperazines as potent and selective antagonists of the melanocortin-4 receptor
    • Tran J.A., Jiang W., Tucci F.C., Fleck B.A., Wen J., Sai Y., et al. Design, synthesis, in vitro, and in vivo characterization of phenylpiperazines and pyridinylpiperazines as potent and selective antagonists of the melanocortin-4 receptor. J Med Chem 50 (2007) 6356-6366
    • (2007) J Med Chem , vol.50 , pp. 6356-6366
    • Tran, J.A.1    Jiang, W.2    Tucci, F.C.3    Fleck, B.A.4    Wen, J.5    Sai, Y.6
  • 46
    • 34548563715 scopus 로고    scopus 로고
    • Pyrrolidinones as potent functional antagonists of the human melanocortin-4 receptor
    • Jiang W., Tucci F.C., Tran J.A., Fleck B.A., Wen J., Markison S., et al. Pyrrolidinones as potent functional antagonists of the human melanocortin-4 receptor. Bioorg Med Chem Lett 17 (2007) 5610-5613
    • (2007) Bioorg Med Chem Lett , vol.17 , pp. 5610-5613
    • Jiang, W.1    Tucci, F.C.2    Tran, J.A.3    Fleck, B.A.4    Wen, J.5    Markison, S.6
  • 47
    • 43749088040 scopus 로고    scopus 로고
    • Pharmacological and pharmacokinetic characterization of 2-piperazine-alpha-isopropyl benzylamine derivatives as melanocortin-4 receptor antagonists
    • Chen C., Tucci F.C., Jiang W., Tran J.A., Fleck B.A., Hoare S.R., et al. Pharmacological and pharmacokinetic characterization of 2-piperazine-alpha-isopropyl benzylamine derivatives as melanocortin-4 receptor antagonists. Bioorg Med Chem 16 (2008) 5606-5618
    • (2008) Bioorg Med Chem , vol.16 , pp. 5606-5618
    • Chen, C.1    Tucci, F.C.2    Jiang, W.3    Tran, J.A.4    Fleck, B.A.5    Hoare, S.R.6
  • 48
    • 33645889660 scopus 로고    scopus 로고
    • Peripheral administration of a melanocortin 4-receptor inverse agonist prevents loss of lean body mass in tumor-bearing mice
    • Nicholson J.R., Kohler G., Schaerer F., Senn C., Weyermann P., and Hofbauer K.G. Peripheral administration of a melanocortin 4-receptor inverse agonist prevents loss of lean body mass in tumor-bearing mice. J Pharmacol Exp Ther 317 (2006) 771-777
    • (2006) J Pharmacol Exp Ther , vol.317 , pp. 771-777
    • Nicholson, J.R.1    Kohler, G.2    Schaerer, F.3    Senn, C.4    Weyermann, P.5    Hofbauer, K.G.6
  • 49
    • 12144285830 scopus 로고    scopus 로고
    • Identification of 2-[2-[2-(5-bromo-2-methoxyphenyl)-ethyl]-3-fluorophenyl]-4,5-dihydro-1H- imidazole (ML00253764), a small molecule melanocortin 4 receptor antagonist that effectively reduces tumor-induced weight loss in a mouse model
    • Vos T.J., Caracoti A., Che J.L., Dai M., Farrer C.A., Forsyth N.E., et al. Identification of 2-[2-[2-(5-bromo-2-methoxyphenyl)-ethyl]-3-fluorophenyl]-4,5-dihydro-1H- imidazole (ML00253764), a small molecule melanocortin 4 receptor antagonist that effectively reduces tumor-induced weight loss in a mouse model. J Med Chem 47 (2004) 1602-1604
    • (2004) J Med Chem , vol.47 , pp. 1602-1604
    • Vos, T.J.1    Caracoti, A.2    Che, J.L.3    Dai, M.4    Farrer, C.A.5    Forsyth, N.E.6
  • 50
    • 73649083758 scopus 로고    scopus 로고
    • Available at:, Accessed June 30, 2009
    • Trials for cachexia treatment. Available at: http://clinicaltrials.gov/ct2/results?term=cachexia&pg=4. Accessed June 30, 2009.
    • Trials for cachexia treatment
  • 51
    • 33745643143 scopus 로고    scopus 로고
    • Cachexia: lessons from melanocortin antagonism
    • DeBoer M.D., and Marks D.L. Cachexia: lessons from melanocortin antagonism. Trends Endocrinol Metab 17 (2006) 199-204
    • (2006) Trends Endocrinol Metab , vol.17 , pp. 199-204
    • DeBoer, M.D.1    Marks, D.L.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.