Administration of IL-1β to the 4th ventricle causes anorexia that is blocked by agouti-related peptide and that coincides with activation of tyrosine-hydroxylase neurons in the nucleus of the solitary tract

Peptides

Volumn 30, Issue 2, 2009, Pages 210-218

  DeBoer, Mark D ^a   Scarlett, Jarrad M ^a   Levasseur, Peter R ^a   Grant, Wilmon F ^a   Marks, Daniel L ^a  

^a OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

Author keywords

AgRP; Appetite regulation; Brainstem; Cytokines; IL 1 ; Tyrosine hydroxylase

Indexed keywords

AGOUTI RELATED PROTEIN; INTERLEUKIN 1 RECEPTOR; INTERLEUKIN 1BETA; PROTEIN C FOS; TYROSINE 3 MONOOXYGENASE; PROOPIOMELANOCORTIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANOREXIA; APPETITE; ARTICLE; BRAIN FOURTH VENTRICLE; CACHEXIA; CELL ACTIVATION; CONTROLLED STUDY; FOOD INTAKE; INFLAMMATION; MALE; NEUROMODULATION; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; RAT; SOLITARY TRACT NUCLEUS; ANIMAL; ARCUATE NUCLEUS; BRAIN STEM; CHEMICALLY INDUCED DISORDER; CYTOLOGY; DRUG EFFECT; ENZYMOLOGY; HYPOTHALAMUS; INTRACEREBROVENTRICULAR DRUG ADMINISTRATION; METABOLISM; NERVE CELL; SPRAGUE DAWLEY RAT;

AGOUTI;

AGOUTI-RELATED PROTEIN; ANIMALS; ANOREXIA; ARCUATE NUCLEUS; BRAIN STEM; HYPOTHALAMUS; INFLAMMATION; INJECTIONS, INTRAVENTRICULAR; INTERLEUKIN-1BETA; NEURONS; PRO-OPIOMELANOCORTIN; RATS; RATS, SPRAGUE-DAWLEY; SOLITARY NUCLEUS; TYROSINE 3-MONOOXYGENASE;

EID: 58149503770     PISSN: 01969781     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.peptides.2008.10.019     Document Type: Article

References (47)

1. Berk M.L., Smith S.E., and Mullins L.A. Distribution, parabrachial region projection, and coexistence of neuropeptide and catecholamine cells of the nucleus of the solitary tract in the pigeon. J Comp Neurol 327 (1993) 416-441
2. Blevins J.E., Chelikani P.K., Haver A.C., and Reidelberger R.D. PYY(3-36) induces Fos in the arcuate nucleus and in both catecholaminergic and non-catecholaminergic neurons in the nucleus tractus solitarius of rats. Peptides 29 (2008) 112-119
3. Cheung W., Yu P.X., Little B.M., Cone R.D., Marks D.L., and Mak R.H. Role of leptin and melanocortin signaling in uremia-associated cachexia. J Clin Invest 115 (2005) 1659-1665
4. Cunningham M.J., Scarlett J.M., and Steiner R.A. Cloning and distribution of galanin-like peptide mRNA in the hypothalamus and pituitary of the macaque. Endocrinology 143 (2002) 755-763
5. Davis B.J. Synaptic relationships between the chorda tympani and tyrosine hydroxylase-immunoreactive dendritic processes in the gustatory zone of the nucleus of the solitary tract in the hamster. J Comp Neurol 392 (1998) 78-91
6. DeBoer M.D. Melanocortin interventions in cachexia: how soon from bench to bedside?. Curr Opin Clin Nutr Metab Care 10 (2007) 457-462
7. DeBoer M.D., and Marks D.L. Cachexia: lessons from melanocortin antagonism. Trends Endocrinol Metab: TEM 17 (2006) 199-204
8. DeBoer M.D., and Marks D.L. Therapy insight: use of melanocortin antagonists in the treatment of cachexia in chronic disease. Nat Clin Pract Endocrinol Metab 2 (2006) 459-466
9. Ellacott K.L., Halatchev I.G., and Cone R.D. Characterization of leptin-responsive neurons in the caudal brainstem. Endocrinology 147 (2006) 3190-3195
10. Emond M., Schwartz G.J., and Moran T.H. Meal-related stimuli differentially induce c-Fos activation in the nucleus of the solitary tract. Am J Physiol Regul Integr Comp Physiol 280 (2001) R1315-R1321
11. Fan W., Ellacott K.L., Halatchev I.G., Takahashi K., Yu P., and Cone R.D. Cholecystokinin-mediated suppression of feeding involves the brainstem melanocortin system. Nat Neurosci 7 (2004) 335-336
12. Fu L.Y., and van den Pol A.N. Agouti-related peptide and MC3/4 receptor agonists both inhibit excitatory hypothalamic ventromedial nucleus neurons. J Neurosci 28 (2008) 5433-5449
13. Hagan M.M., Rushing P.A., Pritchard L.M., Schwartz M.W., Strack A.M., Van Der Ploeg L.H., et al. Long-term orexigenic effects of AgRP-(83-132) involve mechanisms other than melanocortin receptor blockade. Am J Physiol Regul Integr Comp Physiol 279 (2000) R47-R52
14. Halatchev I.G., and Cone R.D. Peripheral administration of PYY(3-36) produces conditioned taste aversion in mice. Cell Metab 1 (2005) 159-168
15. Hayakawa T., Takanaga A., Tanaka K., Maeda S., and Seki M. Ultrastructure of the central subnucleus of the nucleus tractus solitarii and the esophageal afferent terminals in the rat. Anat Embryol (Berl) 206 (2003) 273-281
16. Hudson B., and Ritter S. Hindbrain catecholamine neurons mediate consummatory responses to glucoprivation. Physiol Behav 82 (2004) 241-250
17. Jahng J.W., Houpt T.A., Joh T.H., and Son J.H. Differential expression of monoamine oxidase A, serotonin transporter, tyrosine hydroxylase and norepinephrine transporter mRNA by anorexia mutation and food deprivation. Brain Res Dev Brain Res 107 (1998) 241-246
18. Kaplan J.M., Song S., and Grill H.J. Serotonin receptors in the caudal brainstem are necessary and sufficient for the anorectic effect of peripherally administered mCPP. Psychopharmacology 137 (1998) 43-49
19. Laaris N., and Weinreich D. Prostaglandin E2 depresses solitary tract-mediated synaptic transmission in the nucleus tractus solitarius. Neuroscience 146 (2007) 792-801
20. Lam D.D., Zhou L., Vegge A., Xiu P.Y., Christensen B.T., Osundiji M.A., et al. Distribution and neurochemical characterization of neurons within the nucleus of the solitary tract responsive to serotonin agonist-induced hypophagia. Behav Brain Res (2008) (e-pub ahead of print)
21. Lawrence C.B., and Rothwell N.J. Anorexic but not pyrogenic actions of interleukin-1 are modulated by central melanocortin-3/4 receptors in the rat. J Neuroendocrinol 13 (2001) 490-495
22. Linthorst A.C., Flachskamm C., Holsboer F., and Reul J.M. Activation of serotonergic and noradrenergic neurotransmission in the rat hippocampus after peripheral administration of bacterial endotoxin: involvement of the cyclo-oxygenase pathway. Neuroscience 72 (1996) 989-997
23. Lynn R.B., Hyde T.M., Cooperman R.R., and Miselis R.R. Distribution of bombesin-like immunoreactivity in the nucleus of the solitary tract and dorsal motor nucleus of the rat and human: colocalization with tyrosine hydroxylase. J Comp Neurol 369 (1996) 552-570
24. Marks D.L., Butler A.A., Turner R., Brookhart G.B., and Cone R.D. Differential role of melanocortin receptor subtypes in cachexia. Endocrinology 144 (2003) 1513-1523
25. Marks D.L., Ling N., and Cone R.D. Role of the central melanocortin system in cachexia. Cancer Res 61 (2001) 1432-1438
26. Marty V., El Hachmane M., and Amedee T. Dual modulation of synaptic transmission in the nucleus tractus solitarius by prostaglandin E2 synthesized downstream of IL-1beta. Eur J Neurosci 27 (2008) 3132-3150
27. Moga M.M., Saper C.B., and Gray T.S. Neuropeptide organization of the hypothalamic projection to the parabrachial nucleus in the rat. J Comp Neurol 295 (1990) 662-682
28. Paues J., Mackerlova L., and Blomqvist A. Expression of melanocortin-4 receptor by rat parabrachial neurons responsive to immune and aversive stimuli. Neuroscience 141 (2006) 287-297
29. Paxinos G, Watson C. The rat brain in stereotaxic coordinates, 5th ed.; 2007.
30. Perello M., Stuart R.C., and Nillni E.A. Differential effects of fasting and leptin on proopiomelanocortin peptides in the arcuate nucleus and in the nucleus of the solitary tract. Am J Physiol Endocrinol Metab 292 (2007) E1348-E1357
31. Pritchard L.E., and White A. Agouti-related protein: more than a melanocortin-4 receptor antagonist?. Peptides 26 (2005) 1759-1770
32. Reyes T.M., and Sawchenko P.E. Involvement of the arcuate nucleus of the hypothalamus in interleukin-1-induced anorexia. J Neurosci 22 (2002) 5091-5099
33. Rinaman L. Hindbrain noradrenergic lesions attenuate anorexia and alter central cFos expression in rats after gastric viscerosensory stimulation. J Neurosci 23 (2003) 10084-10092
34. Ritter R.C. Gastrointestinal mechanisms of satiation for food. Physiol Behav 81 (2004) 249-273
35. Ritter S., Bugarith K., and Dinh T.T. Immunotoxic destruction of distinct catecholamine subgroups produces selective impairment of glucoregulatory responses and neuronal activation. J Comp Neurol 432 (2001) 197-216
36. Rogers R.C., Travagli R.A., and Hermann G.E. Noradrenergic neurons in the rat solitary nucleus participate in the esophageal-gastric relaxation reflex. Am J Physiol Regul Integr Comp Physiol 285 (2003) R479-R489
37. Ruud J., and Blomqvist A. Identification of rat brainstem neuronal structures activated during cancer-induced anorexia. J Comp Neurol 504 (2007) 275-286
38. Scarlett J.M., Jobst E.E., Enriori P.J., Bowe D.D., Batra A.K., Grant W.F., et al. Regulation of central melanocortin signaling by interleukin-1{beta}. Endocrinology 148 (2007) 4217-4225
39. Shintani F., Kanba S., Nakaki T., Nibuya M., Kinoshita N., Suzuki E., et al. Interleukin-1 beta augments release of norepinephrine, dopamine, and serotonin in the rat anterior hypothalamus. J Neurosci 13 (1993) 3574-3581
40. Sim L.J., and Joseph S.A. Arcuate nucleus projections to brainstem regions which modulate nociception. J Chem Neuroanat 4 (1991) 97-109
41. Taylor K., Lester E., Hudson B., and Ritter S. Hypothalamic and hindbrain NPY, AGRP and NE increase consummatory feeding responses. Physiol Behav 90 (2007) 744-750
42. Tisdale M.J. Biology of cachexia. J Natl Cancer Inst 89 (1997) 1763-1773
43. Van Bockstaele E.J., Peoples J., and Telegan P. Efferent projections of the nucleus of the solitary tract to peri-locus coeruleus dendrites in rat brain: evidence for a monosynaptic pathway. J Comp Neurol 412 (1999) 410-428
44. Williams D.L., Bowers R.R., Bartness T.J., Kaplan J.M., and Grill H.J. Brainstem melanocortin 3/4 receptor stimulation increases uncoupling protein gene expression in brown fat. Endocrinology 144 (2003) 4692-4697
45. Williams D.L., Kaplan J.M., and Grill H.J. The role of the dorsal vagal complex and the vagus nerve in feeding effects of melanocortin-3/4 receptor stimulation. Endocrinology 141 (2000) 1332-1337
46. Zheng H., Patterson L.M., Morrison C., Banfield B.W., Randall J.A., Browning K.N., et al. Melanin concentrating hormone innervation of caudal brainstem areas involved in gastrointestinal functions and energy balance. Neuroscience 135 (2005) 611-625
47. Zheng H., Patterson L.M., Phifer C.B., and Berthoud H.R. Brain stem melanocortinergic modulation of meal size and identification of hypothalamic POMC projections. Am J Physiol Regul Integr Comp Physiol 289 (2005) R247-R258