Synthesis of dihydrouracils spiro-fused to pyrrolidines: Druglike molecules based on the 2-arylethyl amine scaffold

Molecules

Volumn 15, Issue 4, 2010, Pages 2269-2301

  Blanco Ania, Daniel ^a   Valderas Cortina, Carolina ^a   Hermkens, Pedro H H ^b   Sliedregt, Leo A J M ^c   Scheeren, Hans W ^a   Rutjes, Floris P J T ^a  

^a RADBOUD UNIVERSITY NIJMEGEN   (Netherlands)

^b MSD   (Netherlands)

^c Solvay Pharmaceuticals Inc   (Netherlands)

Author keywords

1 3 dipolar cycloaddition; Azomethine ylide; Knoevenagel condensation; Parallel synthesis; Spiro dihydrouracils

Indexed keywords

DIHYDROURACIL; DRUG DERIVATIVE; PYRROLIDINE DERIVATIVE; SPIRO COMPOUND; URACIL;

ARTICLE; CHEMISTRY; COMBINATORIAL CHEMISTRY; MOLECULAR LIBRARY; SYNTHESIS;

COMBINATORIAL CHEMISTRY TECHNIQUES; PYRROLIDINES; SMALL MOLECULE LIBRARIES; SPIRO COMPOUNDS; URACIL;

EID: 77951791126     PISSN: None     EISSN: 14203049     Source Type: Journal    
DOI: 10.3390/molecules15042269     Document Type: Article

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