Prostaglandins in action. Indispensable roles of cyclooxygenase-1 and -2 in endothelium-dependent contractions

Advances in Pharmacology

Volumn 60, Issue C, 2010, Pages 61-83

  Wong, Siu Ling ^a   Wong, Wing Tak ^a   Tian, Xiao Yu ^a   Lau, Chi Wai ^a   Huang, Yu ^a  

^a CHINESE UNIVERSITY OF HONG KONG   (Hong Kong)

Author keywords

Contractions; Cyclooxygenase; Endothelium; Prostaglandin; TP receptor

Indexed keywords

ARACHIDONIC ACID; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; ENDOTHELIUM DERIVED CONSTRICTING FACTOR; INDOMETACIN; PROSTACYCLIN; PROSTACYCLIN SYNTHASE; PROSTAGLANDIN; PROSTAGLANDIN E2; PROSTAGLANDIN F2 ALPHA; PROSTAGLANDIN H2; PROSTAGLANDIN SYNTHASE INHIBITOR; ROFECOXIB; THROMBOXANE A2;

BLOOD VESSEL TONE; BOOK; DIABETES MELLITUS; DRUG MECHANISM; HYPERCHOLESTEROLEMIA; HYPERTENSION; PRIORITY JOURNAL; VASCULAR DISEASE; VASODILATATION; ANIMAL; DRUG EFFECT; ENZYMOLOGY; HUMAN; PHYSIOLOGY; REVIEW; VASCULAR ENDOTHELIUM; VASOCONSTRICTION;

ANIMALS; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; CYCLOOXYGENASE INHIBITORS; ENDOTHELIUM, VASCULAR; HUMANS; PROSTAGLANDINS; VASOCONSTRICTION;

EID: 78349266804     PISSN: 10543589     EISSN: None     Source Type: Book Series    
DOI: 10.1016/B978-0-12-385061-4.00003-9     Document Type: Chapter

References (99)

1. Abdelrahman A.M., Al Suleimani Y.M. Four-week administration of nimesulide, a cyclooxygenase-2 inhibitor, improves endothelial dysfunction in the hindlimb vasculature of streptozotocin-induced diabetic rats. Archives of Pharmacal Research 2008, 31:1584-1589.
2. Abeywardena M.Y., Jablonskis L.T., Head R.J. Age- and hypertension-induced changes in abnormal contractions in rat aorta. Journal of Cardiovascular Pharmacology 2002, 40:930-937.
3. Adeagbo A.S., Zhang X., Patel D., et al. Cyclo-oxygenase-2, endothelium and aortic reactivity during deoxycorticosterone acetate salt-induced hypertension. Journal of Hypertension 2005, 23:1025-1036.
4. Akamine E.H., Urakawa T.A., de Oliveira M.A., et al. Decreased endothelium-dependent vasodilation in diabetic female rats: Role of prostanoids. Journal of Vascular Research 2006, 43:401-410.
5. Alvarez Y., Briones A.M., Balfagón G., et al. Hypertension increases the participation of vasoconstrictor prostanoids from cyclooxygenase-2 in phenylephrine responses. Journal of Hypertension 2005, 23:767-777.
6. Arribas S., Marín J., Ponte A., et al. Norepinephrine-induced relaxations in rat aorta mediated by endothelial beta adrenoceptors. Impairment by ageing and hypertension. Journal of Pharmacology and Experimental Therapeutics 1994, 270:520-527.
7. 2 receptor antagonists inhibit endothelium-dependent contractions. Hypertension 1990, 15:699-703.
8. Auch-Schwelk W., KatusicD́ Z.S., Vanhoutte P.M. Nitric oxide inactivates endothelium-derived contracting factor in the rat aorta. Hypertension 1992, 19:442-445.
9. Auch-Schwelk W., Vanhoutte P.M. Endothelium-derived contracting factor released by serotonin in the aorta of the spontaneously hypertensive rat. American Journal of Hypertension 1991, 4:769-772.
10. Aw T.J., Haas S.J., Liew D., et al. Meta-analysis of cyclooxygenase-2 inhibitors and their effects on blood pressure. Archives of Internal Medicine 2005, 165:490-496.
11. Bogatcheva N.V., Sergeeva M.G., Dudek S.M., et al. Arachidonic acid cascade in endothelial pathobiology. Microvascular Research 2005, 69:107-127.
12. Borg-Capra C., Fournet-Bourguignon M.P., Janiak P., et al. Morphological heterogeneity with normal expression but altered function of G proteins in porcine cultured regenerated coronary endothelial cells. British Journal of Pharmacology 1997, 122:999-1008.
13. Chamorro A. TP receptor antagonism: A new concept in atherothrombosis and stroke prevention. Cerebrovascular Diseases 2009, 27(Suppl 3):20-27.
14. Cheng H.F., Wang C.J., Moeckel G.W., et al. Cyclooxygenase-2 inhibitor blocks expression of mediators of renal injury in a model of diabetes and hypertension. Kidney International 2002, 62:929-939.
15. Cho J., Cooke C.E., Proveaux W. A retrospective review of the effect of COX-2 inhibitors on blood pressure change. American Journal of Therapeutics 2003, 10:311-317.
16. Cohen R.A., Zitnay K.M., Haudenschild C.C., et al. Loss of selective endothelial cell vasoactive functions caused by hypercholesterolemia in pig coronary arteries. Circulation Research 1988, 63:903-910.
17. Cracowski J.L., Devillier P., Durand T., et al. Vascular biology of the isoprostanes. Journal of Vascular Research 2001, 38:93-103.
18. Cyrus T., Ding T., Praticò D. Expression of thromboxane synthase, prostacyclin synthase and thromboxane receptor in atherosclerotic lesions: Correlation with plaque composition. Atherosclerosis 2010, 208:376-381.
19. Dam J.P., Vleeming W., Riezebos J., et al. Effects of hypercholesterolemia on the contractions to angiotensin II in the isolated aorta and iliac artery of the rabbit: Role of arachidonic acid metabolites. Journal of Cardiovascular Pharmacology 1997, 30:118-123.
20. 2 in the vasoconstrictor response induced by 15-E2t-isoprostane in isolated human umbilical vein. Naunyn-Schmiedeberg's Archives of Pharmacology 2006, 373:367-375.
21. 2α is increased in hypercholesterolemia. Arteriosclerosis, Thrombosis, and Vascular Biology 1997, 17:3230-3235.
22. 2α and platelet activation in diabetes mellitus: Effects of improved metabolic control and vitamin E supplementation. Circulation 1999, 99:224-229.
23. Flavahan N.A. Balancing prostanoid activity in the human vascular system. Trends in Pharmacological Sciences 2007, 28:106-110.
24. Flórez A., de Haro J., Martínez E., et al. Selective cyclooxygenase-2 inhibition reduces endothelial dysfunction and improves inflammatory status in patients with intermittent claudication. Revista Española de Cardiología 2009, 62:851-857.
25. Foudi N., Norel X., Rienzo M., et al. Altered reactivity to norepinephrine through COX-2 induction by vascular injury in hypercholesterolemic rabbits. American Journal of Physiology. Heart and Circulatory Physiology 2009, 297:H1882-H1888.
26. Fujii K., Ohmori S., Tominaga M., et al. Age-related changes in endothelium-dependent hyperpolarization in the rat mesenteric artery. The American Journal of Physiology 1993, 265:H509-H516.
27. 2α, an F2-isoprostane, on endothelin-1 release. Journal of Cardiovascular Pharmacology 1995, 26(Suppl 3):S51-S52.
28. Garcia-Cohen E.C., Marin J., Diez-Picazo L.D., et al. Oxidative stress induced by tert-butyl hydroperoxide causes vasoconstriction in the aorta from hypertensive and aged rats: Role of cyclooxygenase-2 isoform. The Journal of Pharmacology and Experimental Therapeutics 2000, 293:75-81.
29. 2 in the SHR aorta. Circulation Research 1995, 76:1003-1010.
30. Ghanam K., Lavagna C., Burgaud J.L., et al. Involvement of cyclooxygenase 2 in the protective effect of 17β-estradiol on hypercholesterolemic rabbit aorta. Biochemical and Biophysical Research Communications 2000, 275:696-703.
31. Gluais P., Lonchampt M., Morrow J.D., et al. Acetylcholine-induced endothelium-dependent contractions in the SHR aorta: The Janus face of prostacyclin. British Journal of Pharmacology 2005, 146:834-845.
32. 2 as endothelium-derived contracting factors. American Journal of Physiology. Heart and Circulatory Physiology 2006, 291:H2255-H2264.
33. Griffoni C., Spisni E., Strillacci A., et al. Selective inhibition of prostacyclin synthase activity by rofecoxib. Journal of Cellular and Molecular Medicine 2007, 11:327-338.
34. Hart J.L., Sobey C.G., Woodman O.L. Cholesterol feeding enhances vasoconstrictor effects of products from rabbit polymorphonuclear leukocytes. The American Journal of Physiology 1995, 269:H1-H6.
35. Hashimoto M., Akishita M., Eto M., et al. The impairment of flow-mediated vasodilatation in obese men with visceral fat accumulation. International Journal of Obesity and Related Metabolic Disorders 1998, 22:477-484.
36. Hermann M., Camici G., Fratton A., et al. Differential effects of selective cyclooxygenase-2 inhibitors on endothelial function in salt-induced hypertension. Circulation 2003, 108:2308-2311.
37. Hla T., Neilson K. Human cyclooxygenase-2 cDNA. Proceedings of the National Academy of Sciences of the United States of America 1992, 89:7384-7388.
38. Ibarra M., López-Guerrero J.J., Mejía-Zepeda R., et al. Endothelium-dependent inhibition of the contractile response is decreased in aorta from aged and spontaneously hypertensive rats. Archives of Medical Research 2006, 37:334-341.
39. Ihlemann N., Stokholm K.H., Eskildsen P.C. Impaired vascular reactivity is present despite normal levels of von Willebrand factor in patients with uncomplicated type 2 diabetes. Diabetic Medicine 2002, 19:476-481.
40. 2) receptor agonist enhances ICAM-1, VCAM-1 or ELAM-1 expression by human vascular endothelial cells. Clinical and Experimental Immunology 1998, 112:464-470.
41. Jerez S., Sierra L., Coviello A., et al. Endothelial dysfunction and improvement of the angiotensin II-reactivity in hypercholesterolemic rabbits: Role of cyclooxygenase metabolites. European Journal of Pharmacology 2008, 580:182-189.
42. Kamgar M., Nobakhthaghighi N., Shamshirsaz A.A., et al. Impaired fibrinolytic activity in type II diabetes: Correlation with urinary albumin excretion and progression of renal disease. Kidney International 2006, 69:1899-1903.
43. Kimmel S.E., Berlin J.A., Reilly M., et al. Patients exposed to rofecoxib and celecoxib have different odds of nonfatal myocardial infarction. Annals of Internal Medicine 2005, 142:157-164.
44. Komers R., Lindsley J.N., Oyama T.T., et al. Immunohistochemical and functional correlations of renal cyclooxygenase-2 in experimental diabetes. Journal of Clinical Investigation 2001, 107:889-898.
45. Komers R., Zdychová J., Cahová M., et al. Renal cyclooxygenase-2 in obese Zucker (fatty) rats. Kidney International 2005, 67:2151-2158.
46. Küng C.F., Lüscher T.F. Different mechanisms of endothelial dysfunction with aging and hypertension in rat aorta. Hypertension 1995, 25:194-200.
47. Lagaud G.J., Masih-Khan E., Kai S., et al. Influence of type II diabetes on arterial tone and endothelial function in murine mesenteric resistance arteries. Journal of Vascular Research 2001, 38:578-589.
48. Lee M.Y., Tse H.F., Siu C.W., et al. Genomic changes in regenerated porcine coronary arterial endothelial cells. Arteriosclerosis, Thrombosis, and Vascular Biology 2007, 27:2443-2449.
49. Liu C.Q., Leung F.P., Wong S.L., et al. Thromboxane prostanoid receptor activation impairs endothelial nitric oxide-dependent vasorelaxations: The role of Rho kinase. Biochemical Pharmacology 2009, 78:374-381.
50. Liu C.Q., Wong S.L., Leung F.P., et al. Prostanoid TP receptor-mediated impairment of cyclic AMP-dependent vasorelaxation is reversed by phosphodiesterase inhibitors. European Journal of Pharmacology 2010, 632:45-51.
51. Lüscher T.F., Aarhus L.L., Vanhoutte P.M. Indomethacin improves the impaired endothelium-dependent relaxations in small mesenteric arteries of the spontaneously hypertensive rat. American Journal of Hypertension 1990, 3:55-58.
52. Lüscher T.F., Vanhoutte P.M. Endothelium-dependent contractions to acetylcholine in the aorta of the spontaneously hypertensive rat. Hypertension 1986, 8:344-348.
53. Marnett L.J. The COXIB experience: A look in the rearview mirror. Annual Review of Pharmacology and Toxicology 2009, 49:65-90.
54. Matsumoto T., Ishida K., Kobayashi T., et al. Pyrrolidine dithiocarbamate reduces vascular prostanoid-induced responses in aged type 2 diabetic rat model. Journal of Pharmacological Sciences 2009, 110:326-333.
55. Matsumoto T., Kakami M., Noguchi E., et al. Imbalance between endothelium-derived relaxing and contracting factors in mesenteric arteries from aged OLETF rats, a model of type 2 diabetes. American Journal of Physiology. Heart and Circulatory Physiology 2007, 293:H1480-H1490.
56. Matsumoto T., Nakayama N., Ishida K., et al. Eicosapentaenoic acid improves imbalance between vasodilator and vasoconstrictor actions of endothelium-derived factors in mesenteric arteries from rats at chronic stage of type 2 diabetes. The Journal of Pharmacology and Experimental Therapeutics 2009, 329:324-334.
57. Matsumoto T., Noguchi E., Ishida K., et al. Metformin normalizes endothelial function by suppressing vasoconstrictor prostanoids in mesenteric arteries from OLETF rats, a model of type 2 diabetes. American Journal of Physiology. Heart and Circulatory Physiology 2008, 295:H1165-H1176.
58. 2 synthase inhibitor. Atherosclerosis 2009, 205:87-95.
59. McGettigan P., Henry D. Cardiovascular risk and inhibition of cyclooxygenase: A systematic review of the observational studies of selective and nonselective inhibitors of cyclooxygenase 2. JAMA 2006, 296:1633-1644.
60. Mogensen C.E., Schmitz O. The diabetic kidney: From hyperfiltration and microalbuminuria to end-stage renal failure. The Medical Clinics of North America 1988, 72:1465-1492.
61. Mombouli J.V., Vanhoutte P.M. Purinergic endothelium-dependent and -independent contractions in rat aorta. Hypertension 1993, 22:577-583.
62. Morrow J.D., Hill K.E., Burk R.F., et al. A series of prostaglandin F2-like compounds are produced in vivo in humans by a non-cyclooxygenase, free radical-catalyzed mechanism. Proceedings of the National Academy of Sciences of the United States of America 1990, 87:9383-9387.
63. Mullen M.J., Kharbanda R.K., Cross J., et al. Heterogenous nature of flow-mediated dilatation in human conduit arteries in vivo: Relevance to endothelial dysfunction in hypercholesterolemia. Circulation Research 2001, 88:145-151.
64. Noon J.P., Walker B.R., Hand M.F., et al. Impairment of forearm vasodilatation to acetylcholine in hypercholesterolemia is reversed by aspirin. Cardiovascular Research 1998, 38:480-484.
65. Park S.J., Lee J.J., Kirchengast M., et al. The combined 5-HT2 receptor and calcium channel inhibitor LU49938 restores endothelium dependent responses in the regenerated endothelium of the porcine coronary artery. Cardiovascular Research 1995, 29:95-101.
66. Peredo H.A., Rodríguez R., Susemihl M.C., et al. Long-term streptozotocin-induced diabetes alters prostanoid production in rat aorta and mesenteric bed. Autonomic & Autacoid Pharmacology 2006, 26:355-360.
67. Pérez-Sala D., Lamas S. Regulation of cyclooxygenase-2 expression by nitric oxide in cells. Antioxidants and Redox Signaling 2001, 3:231-248.
68. Pfister S.L., Campbell W.B. Contribution of arachidonic acid metabolites to reduced norepinephrine-induced contractions in hypercholesterolemic rabbit aortas. Journal of Cardiovascular Pharmacology 1996, 28:784-791.
69. Rovati G.E., Sala A., Capra V., et al. Dual COXIB/TP antagonists: A possible new twist in NSAID pharmacology and cardiovascular risk. Trends in Pharmacological Sciences 2010, 31:102-107.
70. 2 EP1 receptor increases arteriolar tone and blood pressure in mice with type 2 diabetes. Cardiovascular Research 2009, 83:148-154.
71. 2α: An endothelium-derived contractile factor acting independently of other endothelium-derived contractile factors via vascular thromboxane receptors. Circulation Research 2009, 104:141-143.
72. Shi Y., Feletou M., Ku D.D., et al. The calcium ionophore A23187 induces endothelium-dependent contractions in femoral arteries from rats with streptozotocin-induced diabetes. British Journal of Pharmacology 2007, 150:624-632.
73. Shi Y., Man R.Y., Vanhoutte P.M. Two isoforms of cyclooxygenase contribute to augmented endothelium-dependent contractions in femoral arteries of 1-year-old rats. Acta Pharmacologica Sinica 2008, 29:185-192.
74. Shibano T., Codina J., Birnbaumer L., et al. Pertussis toxin-sensitive G proteins in regenerated endothelial cells of porcine coronary artery. The American Journal of Physiology 1994, 267:H979-H981.
75. Shimokawa H., Aarhus L.L., Vanhoutte P.M. Porcine coronary arteries with regenerated endothelium have a reduced endothelium-dependent responsiveness to aggregating platelets and serotonin. Circulation Research 1987, 61:256-270.
76. Shimokawa H., Vanhoutte P.M. Impaired endothelium-dependent relaxation to aggregating platelets and related vasoactive substances in porcine coronary arteries in hypercholesterolemia and atherosclerosis. Circulation Research 1989, 64:900-914.
77. Shimokawa H., Vanhoutte P.M. Angiographic demonstration of hyperconstriction induced by serotonin and aggregating platelets in porcine coronary arteries with regenerated endothelium. Journal of the American College of Cardiology 1991, 17:1197-1202.
78. Silverstein F.E., Faich G., Goldstein J.L., et al. Gastrointestinal toxicity with celecoxib vs nonsteroidal anti-inflammatory drugs for osteoarthritis and rheumatoid arthritis: The CLASS study: A randomized controlled trial. Celecoxib Long-term Arthritis Safety Study. JAMA 2000, 284:1247-1255.
79. Smith W.L., DeWitt D.L., Garavito R.M. Cyclooxygenases: Structural, cellular, and molecular biology. Annual Review of Biochemistry 2000, 69:145-182.
80. Smith W., Garavito R., DeWitt D. Prostaglandin endoperoxide H synthases (cyclooxygenases)-1 and -2. The Journal of Biological Chemistry 1996, 271:33157-33160.
81. 2. Journal of Cardiovascular Pharmacology 1993, 22(Suppl. 8):S328-S331.
82. Taddei S., Virdis A., Ghiadoni L., et al. Cyclooxygenase inhibition restores nitric oxide activity in essential hypertension. Hypertension 1997, 29:274-279.
83. Taddei S., Virdis A., Mattei P., et al. Hypertension causes premature aging of endothelial function in humans. Hypertension 1997, 29:736-743.
84. Tang E.H., Leung F.P., Huang Y., et al. Calcium and reactive oxygen species increase in endothelial cells in response to releasers of endothelium-derived contracting factor. British Journal of Pharmacology 2007, 151:15-23.
85. Tang E.H., Vanhoutte P.M. Gene expression changes of prostanoid synthases in endothelial cells and prostanoid receptors in vascular smooth muscle cells caused by aging and hypertension. Physiological Genomics 2008, 32:409-418.
86. Tesfamariam B., Brown M.L., Cohen R.A. 15-Hydroxyeicosatetraenoic acid and diabetic endothelial dysfunction in rabbit aorta. Journal of Cardiovascular Pharmacology 1995, 25:748-755.
87. Tesfamariam B., Brown M.L., Deykin D., et al. Elevated glucose promotes generation of endothelium-derived vasoconstrictor prostanoids in rabbit aorta. Journal of Clinical Investigation 1990, 85:929-932.
88. 2. The American Journal of Physiology 1989, 257:H1327-H1333.
89. Thollon C., Bidouard J.P., Cambarrat C., et al. Alteration of endothelium-dependent hyperpolarizations in porcine coronary arteries with regenerated endothelium. Circulation Research 1999, 84:371-377.
90. Topper J.N., Cai J., Falb D., et al. Identification of vascular endothelial genes differentially responsive to fluid mechanical stimuli: Cyclooxygenase-2, manganese superoxide dismutase, and endothelial cell nitric oxide synthase are selectively up-regulated by steady laminar shear stress. Proceedings of the National Academy of Sciences of the United States of America 1996, 93:10417-10422.
91. Van Diest M.J., Herman A.G., Verbeuren T.J. Influence of hypercholesterolaemia on the reactivity of isolated rabbit arteries to 15-lipoxygenase metabolites of arachidonic acid: Comparison with platelet-derived agents and vasodilators. Prostaglandins Leukotrienes and Essential Fatty Acids 1996, 54:135-145.
92. White W.B., West C.R., Borer J.S., et al. Risk of cardiovascular events in patients receiving celecoxib: A meta-analysis of randomized clinical trials. The American Journal of Cardiology 2007, 99:91-98.
93. Williams C.S., Mann M., DuBois R.N. The role of cyclooxygenases in inflammation, cancer and development. Oncogene 1999, 18:7908-7916.
94. 2α mediates endothelium-dependent contractions in the aortae of hamsters with increased impact during aging. Circulation Research 2009, 104:228-235.
95. 2 plays a key role in the endothelium-dependent contractions to acetylcholine in the aorta of the spontaneously hypertensive rat. American Journal of Physiology. Heart and Circulatory Physiology 2010, 298:H1260-H1266.
96. Yang D., Félétou M., Boulanger C.M., et al. Oxygen-derived free radicals mediate endothelium-dependent contractions to acetylcholine in aortas from spontaneously hypertensive rats. British Journal of Pharmacology 2002, 136:104-110.
97. Yang D., Gluais P., Zhang J.N., et al. Nitric oxide and inactivation of the endothelium-dependent contracting factor released by acetylcholine in spontaneously hypertensive rat. Journal of Cardiovascular Pharmacology 2004, 43:815-820.
98. Yura T., Fukunaga M., Khan R., et al. Free-radical-generated F2-isoprostane stimulates cell proliferation and endothelin-1 expression on endothelial cells. Kidney International 1999, 56:471-478.
99. 2 and involves upregulation of thromboxane receptor mRNA. Circulation 1998, 97:589-595.