Eicosapentaenoic acid improves imbalance between vasodilator and vasoconstrictor actions of endothelium- derived factors in mesenteric arteries from rats at chronic stage of type 2 diabetes

Journal of Pharmacology and Experimental Therapeutics

Volumn 329, Issue 1, 2009, Pages 324-334

  Matsumoto, Takayuki ^a   Nakayama, Naoaki ^a   Ishida, Keiko ^a   Kobayashi, Tsuneo ^a   Kamata, Katsuo ^a  

^a HOSHI UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCHOLINE; ARACHIDONIC ACID; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; ENDOTHELIUM DERIVED HYPERPOLARIZING FACTOR; ICOSAPENTAENOIC ACID; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; NITRIC OXIDE; PROSTANOID;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD CHEMISTRY; BLOOD PRESSURE; BODY WEIGHT; CONTROLLED STUDY; DRUG MECHANISM; ENDOTHELIAL DYSFUNCTION; ENZYME ACTIVITY; MALE; MESENTERIC ARTERY; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; VASOCONSTRICTION; VASODILATATION;

ANIMALS; BLOOD CHEMICAL ANALYSIS; BLOOD PRESSURE; BLOTTING, WESTERN; CHRONIC DISEASE; DIABETES MELLITUS, TYPE 2; DIABETIC ANGIOPATHIES; EICOSAPENTAENOIC ACID; ENDOTHELINS; ENDOTHELIUM, VASCULAR; ENDOTHELIUM-DEPENDENT RELAXING FACTORS; ENZYME-LINKED IMMUNOSORBENT ASSAY; ISOMETRIC CONTRACTION; MALE; MESENTERIC ARTERIES; MITOGEN-ACTIVATED PROTEIN KINASE 1; MUSCLE, SMOOTH, VASCULAR; NF-KAPPA B; NITRATES; NITRITES; PHOSPHORYLATION; PROSTAGLANDINS; RATS; RATS, INBRED OLETF;

EID: 63849336996     PISSN: 00223565     EISSN: 15210103     Source Type: Journal    
DOI: 10.1124/jpet.108.148718     Document Type: Article

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