Identification of a nonaketide product for the iterative polyketide synthase in biosynthesis of the nine-membered enediyne C-1027

Angewandte Chemie - International Edition

Volumn 49, Issue 43, 2010, Pages 7926-7928

  Chen, Xiaolei ^a   Guo, Zu Feng ^a   Lai, Pok Man ^b   Sze, Kong Hung ^b   Guo, Zhihong ^a  

^a HONG KONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Hong Kong)

^b UNIVERSITY OF HONG KONG   (Hong Kong)

Author keywords

Biosynthesis; Enediynes; Enzyme catalysis; Natural products; Polyketides

Indexed keywords

CATALYTIC FUNCTIONS; ENEDIYNES; ENZYME CATALYSIS; NATURAL PRODUCTS; POLYKETIDE SYNTHASES; POLYKETIDES; SYNTHASES; THIOESTERASES;

BIOCHEMISTRY; CATALYSIS; ENZYMES;

BIOSYNTHESIS;

AMINOGLYCOSIDE; ANTIBIOTIC C 1027; ANTINEOPLASTIC ANTIBIOTIC; BACTERIAL PROTEIN; ENEDIYNE; POLYKETIDE SYNTHASE;

ARTICLE; BACTERIUM; ENZYMOLOGY; ESCHERICHIA COLI; GENE EXPRESSION; GENETICS; METABOLISM;

AMINOGLYCOSIDES; ANTIBIOTICS, ANTINEOPLASTIC; BACTERIA; BACTERIAL PROTEINS; ENEDIYNES; ESCHERICHIA COLI; GENE EXPRESSION; POLYKETIDE SYNTHASES;

EID: 78349264615     PISSN: 14337851     EISSN: 15213773     Source Type: Journal    
DOI: 10.1002/anie.201003369     Document Type: Article

References (18)

1. A. L. Smith, K. C. Nicolaou, J. Med. Chem. 1996, 39, 2103 - 2117.
2. W. Liu, S. D. Christenson, S. Standage, B. Shen, Science 2002, 297, 1170 - 1173.
3. J. Ahlert, E. Shepard, N. Lomovskaya, E. Zazopoulos, A. Staffa, B. O. Bachmann, K. Huang, L. Fonstein, A. Czisny, R. E. Whitwam, C. M. Farnet, J. S. Thorson, Science 2002, 297, 1173 - 1176.
4. W. Liu, K. Nonaka, L. Nie, J. Zhang, S. D. Christenson, J. Bae, S. G. Van Lanen, E. Zazopoulos, C. M. Farnet, C. F. Yang, B. Shen, Chem. Biol. 2005, 12, 293 - 302.
5. S. G. Van Lanen, T. Oh, W. Liu, E. Wendt-Pienkowski, B. Shen, J. Am. Chem. Soc. 2007, 129, 13082 - 13094.
6. Q. Gao, J. S. Thorson, FEMS Microbiol. Lett. 2008, 282, 105 - 114.
7. W. Liu, J. Ahlert, Q. Gao, E. Wendt-Pienkowski, B. Shen, J. S. Thorson, Proc. Natl. Acad. Sci. USA 2003, 100, 11959 - 11963.
8. E. Zazopoulos, K. Huang, A. Staffa, W. Liu, B. O. Bachmann, K. Nonaka, J. Ahlert, J. S. Thorson, B. Shen, C. M. Farnet, Nat. Biotechnol. 2003, 21, 187 - 190.
9. G. P. Horsman, S. G. Van Lanen, B. Shen, Methods Enzymol. 2009, 459, 97 - 112.
10. J. Zhang, S. G. Van Lanen, J. Ju, W. Liu, P. C. Dorrestein, W. Li, N. L. Kelleher, B. Shen, Proc. Natl. Acad. Sci. USA 2008, 105, 1460 - 1465.
11. R. Kong, L. P. Goh, C. W. Liew, Q. S. Ho, E. Murugan, B. Li, K. Tang, Z.-X. Liang, J. Am. Chem. Soc. 2008, 130, 8142 - 8143.
12. H. Sun, R. Kong, D. Zhu, M. Lu, Q. Ji, C. W. Liew, J. Lescar, G. Zhong, Z.-X. Liang, Chem. Commun. 2009, 7399 - 7401.
13. K. Belecki, J. M. Crawford, C. A. Townsend, J. Am. Chem. Soc. 2009, 131, 12564 - 12566.
14. G. P. Horsman, Y. Chen, J. S. Thorson, B. Shen, Proc. Natl. Acad. Sci. USA 2010, 107, 11331 - 11335.
15. B. S. Kim, T. A. Cropp, B. J. Beck, D. H. Sherman, K. A. Reynolds, J. Biol. Chem. 2002, 277, 48028 - 48034.
16. Z.-F. Guo, Y. Sun, S. Zheng, Z. Guo, Biochemistry 2009, 48, 1712 - 1722.
17. Z.-X. Liang, Nat. Prod. Rep. 2010, 27, 499 - 528.
18. O. D. Hensens, J. L. Giner, I. H. Goldberg, J. Am. Chem. Soc. 1989, 111, 3295 - 3299.