-
1
-
-
0037119622
-
The calicheamicin gene cluster and its iterative type I enediyne PKS
-
Ahlert J., Shepard E., Lomovskaya N., Zazopoulos E., Staffa A., Bachmann B.O., Huang K., Fonstein L., Czisny A., Whitwam R.E., Farnet C.M., and Thorson J.S. The calicheamicin gene cluster and its iterative type I enediyne PKS. Science 297 (2002) 1173-1176
-
(2002)
Science
, vol.297
, pp. 1173-1176
-
-
Ahlert, J.1
Shepard, E.2
Lomovskaya, N.3
Zazopoulos, E.4
Staffa, A.5
Bachmann, B.O.6
Huang, K.7
Fonstein, L.8
Czisny, A.9
Whitwam, R.E.10
Farnet, C.M.11
Thorson, J.S.12
-
2
-
-
0034111426
-
A novel function of yeast fatty acid synthase-Subunit alpha is capable of self-pantetheinylation
-
Fichtlscherer F., Wellein C., Mittag M., and Schweizer E. A novel function of yeast fatty acid synthase-Subunit alpha is capable of self-pantetheinylation. Eur. J. Biochem. 267 (2000) 2666-2671
-
(2000)
Eur. J. Biochem.
, vol.267
, pp. 2666-2671
-
-
Fichtlscherer, F.1
Wellein, C.2
Mittag, M.3
Schweizer, E.4
-
3
-
-
14844357291
-
Antitumor antibiotics: Bleomycin, enediynes, and mitomycin
-
Galm U., Hager M.H., Van Lanen S.G., Ju J.H., Thorson J.S., and Shen B. Antitumor antibiotics: Bleomycin, enediynes, and mitomycin. Chem. Rev. 105 (2005) 739-758
-
(2005)
Chem. Rev.
, vol.105
, pp. 739-758
-
-
Galm, U.1
Hager, M.H.2
Van Lanen, S.G.3
Ju, J.H.4
Thorson, J.S.5
Shen, B.6
-
4
-
-
41549124102
-
The biosynthetic genes encoding for the production of the dynemicin enediyne core in Micromonospora chersina ATCC53710
-
Gao Q., and Thorson J.S. The biosynthetic genes encoding for the production of the dynemicin enediyne core in Micromonospora chersina ATCC53710. FEMS Microbiol. Lett. 282 (2008) 105-114
-
(2008)
FEMS Microbiol. Lett.
, vol.282
, pp. 105-114
-
-
Gao, Q.1
Thorson, J.S.2
-
5
-
-
0024564576
-
Biosynthesis of NCS chrom A, the chromophore of the antitumor antibiotic neocarzinostatin
-
Hensens O.D., Giner J.L., and Goldberg I.H. Biosynthesis of NCS chrom A, the chromophore of the antitumor antibiotic neocarzinostatin. J. Am. Chem. Soc. 111 (1989) 3295-3299
-
(1989)
J. Am. Chem. Soc.
, vol.111
, pp. 3295-3299
-
-
Hensens, O.D.1
Giner, J.L.2
Goldberg, I.H.3
-
6
-
-
43949138588
-
The role of tandem acyl carrier protein domains in polyunsaturated fatty acid biosynthesis
-
Jiang H., Zirkle R., Metz J.G., Braun L., Richter L., Van Lanen S.G., and Shen B. The role of tandem acyl carrier protein domains in polyunsaturated fatty acid biosynthesis. J. Am. Chem. Soc. 130 (2008) 6336-6337
-
(2008)
J. Am. Chem. Soc.
, vol.130
, pp. 6336-6337
-
-
Jiang, H.1
Zirkle, R.2
Metz, J.G.3
Braun, L.4
Richter, L.5
Van Lanen, S.G.6
Shen, B.7
-
7
-
-
33846676161
-
Single chemical modifications of the C-1027 enediyne core, a radiomimetic antitumor drug, affect both drug potency and the role of ataxia-telangiectasia mutated in cellular responses to DNA double-strand breaks
-
Kennedy D.R., Gawron L.S., Ju J.H., Liu W., Shen B., and Beerman T.A. Single chemical modifications of the C-1027 enediyne core, a radiomimetic antitumor drug, affect both drug potency and the role of ataxia-telangiectasia mutated in cellular responses to DNA double-strand breaks. Cancer Res. 67 (2007) 773-781
-
(2007)
Cancer Res.
, vol.67
, pp. 773-781
-
-
Kennedy, D.R.1
Gawron, L.S.2
Ju, J.H.3
Liu, W.4
Shen, B.5
Beerman, T.A.6
-
8
-
-
36749074497
-
Designer enediynes generate DNA breaks, interstrand cross-links, or both, with concomitant changes in the regulation of DNA damage responses
-
Kennedy D.R., Ju J., Shen B., and Beerman T.A. Designer enediynes generate DNA breaks, interstrand cross-links, or both, with concomitant changes in the regulation of DNA damage responses. Proc. Natl. Acad. Sci. USA 104 (2007) 17632-17637
-
(2007)
Proc. Natl. Acad. Sci. USA
, vol.104
, pp. 17632-17637
-
-
Kennedy, D.R.1
Ju, J.2
Shen, B.3
Beerman, T.A.4
-
9
-
-
0027140085
-
Biosynthesis of esperamicin A1, an enediyne antitumor antibiotic
-
Lam K.S., Veitch J.A., Golik J., Krishnan B., Klohr S.E., Volk K.J., Forenza S., and Doyle T.W. Biosynthesis of esperamicin A1, an enediyne antitumor antibiotic. J. Am. Chem. Soc. 115 (1993) 12340-12345
-
(1993)
J. Am. Chem. Soc.
, vol.115
, pp. 12340-12345
-
-
Lam, K.S.1
Veitch, J.A.2
Golik, J.3
Krishnan, B.4
Klohr, S.E.5
Volk, K.J.6
Forenza, S.7
Doyle, T.W.8
-
10
-
-
0142027815
-
Rapid PCR amplification of minimal enediyne polyketide synthase cassettes leads to a predictive familial classification model
-
Liu W., Ahlert J., Gao Q.J., Wendt-Pienkowski E., Shen B., and Thorson J.S. Rapid PCR amplification of minimal enediyne polyketide synthase cassettes leads to a predictive familial classification model. Proc. Natl. Acad. Sci. USA 100 (2003) 11959-11963
-
(2003)
Proc. Natl. Acad. Sci. USA
, vol.100
, pp. 11959-11963
-
-
Liu, W.1
Ahlert, J.2
Gao, Q.J.3
Wendt-Pienkowski, E.4
Shen, B.5
Thorson, J.S.6
-
11
-
-
0347721776
-
Biosynthesis of the enediyne antitumor antibiotic C-1027
-
Liu W., Christenson S.D., Standage S., and Shen B. Biosynthesis of the enediyne antitumor antibiotic C-1027. Science 297 (2002) 1170-1173
-
(2002)
Science
, vol.297
, pp. 1170-1173
-
-
Liu, W.1
Christenson, S.D.2
Standage, S.3
Shen, B.4
-
12
-
-
20144363202
-
The neocarzinostatin biosynthetic gene cluster from Streptomyces carzinostaticus ATCC 15944 involving two iterative type I polyketide synthases
-
Liu W., Nonaka K., Nie L.P., Zhang J., Christenson S.D., Bae J., Van Lanen S.G., Zazopoulos E., Farnet C.M., Yang C.F., and Shen B. The neocarzinostatin biosynthetic gene cluster from Streptomyces carzinostaticus ATCC 15944 involving two iterative type I polyketide synthases. Chem. Biol. 12 (2005) 293-302
-
(2005)
Chem. Biol.
, vol.12
, pp. 293-302
-
-
Liu, W.1
Nonaka, K.2
Nie, L.P.3
Zhang, J.4
Christenson, S.D.5
Bae, J.6
Van Lanen, S.G.7
Zazopoulos, E.8
Farnet, C.M.9
Yang, C.F.10
Shen, B.11
-
13
-
-
0035291191
-
SMANCS and polymer-conjugated macromolecular drugs: Advantages in cancer chemotherapy
-
Maeda H. SMANCS and polymer-conjugated macromolecular drugs: Advantages in cancer chemotherapy. Adv. Drug Deliv. Rev. 46 (2001) 169-185
-
(2001)
Adv. Drug Deliv. Rev.
, vol.46
, pp. 169-185
-
-
Maeda, H.1
-
14
-
-
0035854452
-
Production of polyunsaturated fatty acids by polyketide synthases in both prokaryotes and eukaryotes
-
Metz J.G., Roessler P., Facciotti D., Levering C., Dittrich F., Lassner M., Valentine R., Lardizabal K., Domergue F., Yamada A., Yazawa K., Knauf V., et al. Production of polyunsaturated fatty acids by polyketide synthases in both prokaryotes and eukaryotes. Science 293 (2001) 290-293
-
(2001)
Science
, vol.293
, pp. 290-293
-
-
Metz, J.G.1
Roessler, P.2
Facciotti, D.3
Levering, C.4
Dittrich, F.5
Lassner, M.6
Valentine, R.7
Lardizabal, K.8
Domergue, F.9
Yamada, A.10
Yazawa, K.11
Knauf, V.12
-
15
-
-
40849130100
-
Evidence for a novel phosphopantetheinyl transferase domain in the polyketide synthase for enediyne biosynthesis
-
Murugan E., and Liang Z.X. Evidence for a novel phosphopantetheinyl transferase domain in the polyketide synthase for enediyne biosynthesis. FEBS Lett. 582 (2008) 1097-1103
-
(2008)
FEBS Lett.
, vol.582
, pp. 1097-1103
-
-
Murugan, E.1
Liang, Z.X.2
-
16
-
-
0029320145
-
A versatile quick-prep of genomic DNA from gram-positive bacteria
-
Pospiech A., and Neumann B. A versatile quick-prep of genomic DNA from gram-positive bacteria. Trends Genet. 11 (1995) 217-218
-
(1995)
Trends Genet.
, vol.11
, pp. 217-218
-
-
Pospiech, A.1
Neumann, B.2
-
17
-
-
0034930478
-
Cloning and characterization of a phosphopantetheinyl transferase from Streptomyces verticillus ATCC15003, the producer of the hybrid peptide-polyketide antitumor drug bleomycin
-
Sanchez C., Du L.C., Edwards D.J., Toney M.D., and Shen B. Cloning and characterization of a phosphopantetheinyl transferase from Streptomyces verticillus ATCC15003, the producer of the hybrid peptide-polyketide antitumor drug bleomycin. Chem. Biol. 8 (2001) 725-738
-
(2001)
Chem. Biol.
, vol.8
, pp. 725-738
-
-
Sanchez, C.1
Du, L.C.2
Edwards, D.J.3
Toney, M.D.4
Shen, B.5
-
18
-
-
0034753903
-
Mylotarg: Antibody-targeted chemotherapy comes of age
-
Sievers E.L., and Linenberger M. Mylotarg: Antibody-targeted chemotherapy comes of age. Curr. Opin. Oncol. 13 (2001) 522-527
-
(2001)
Curr. Opin. Oncol.
, vol.13
, pp. 522-527
-
-
Sievers, E.L.1
Linenberger, M.2
-
19
-
-
0026681869
-
Biosynthesis of dynemicin A, a 3-Ene-1,5-diyne antitumor antibiotic
-
Tokiwa Y., Miyoshisaitoh M., Kobayashi H., Sunaga R., Konishi M., Oki T., and Iwasaki S. Biosynthesis of dynemicin A, a 3-Ene-1,5-diyne antitumor antibiotic. J. Am. Chem. Soc. 114 (1992) 4107-4110
-
(1992)
J. Am. Chem. Soc.
, vol.114
, pp. 4107-4110
-
-
Tokiwa, Y.1
Miyoshisaitoh, M.2
Kobayashi, H.3
Sunaga, R.4
Konishi, M.5
Oki, T.6
Iwasaki, S.7
-
20
-
-
35848971002
-
Characterization of the maduropeptin biosynthetic gene cluster from Actinomadura madurae ATCC 39144 supporting a unifying paradigm for enediyne biosynthesis
-
Van Lanen S.G., Oh T.J., Liu W., Wendt-Pienkowski E., and Shen B. Characterization of the maduropeptin biosynthetic gene cluster from Actinomadura madurae ATCC 39144 supporting a unifying paradigm for enediyne biosynthesis. J. Am. Chem. Soc. 129 (2007) 13082-13094
-
(2007)
J. Am. Chem. Soc.
, vol.129
, pp. 13082-13094
-
-
Van Lanen, S.G.1
Oh, T.J.2
Liu, W.3
Wendt-Pienkowski, E.4
Shen, B.5
-
21
-
-
44649201476
-
Biosynthesis of enediyne antitumor antibiotics
-
Van Lanen S.G., and Shen B. Biosynthesis of enediyne antitumor antibiotics. Curr. Top. Med. Chem. 8 (2008) 448-459
-
(2008)
Curr. Top. Med. Chem.
, vol.8
, pp. 448-459
-
-
Van Lanen, S.G.1
Shen, B.2
-
22
-
-
0032843973
-
C-1027. Antineoplastic antibiotic
-
Wang X.W., and Xie H. C-1027. Antineoplastic antibiotic. Drugs Future 24 (1999) 847-852
-
(1999)
Drugs Future
, vol.24
, pp. 847-852
-
-
Wang, X.W.1
Xie, H.2
-
23
-
-
0347717823
-
Identification of a phosphopantetheinyl transferase for erythromycin biosynthesis in Saccharopolyspora erythraea
-
Weissman K.J., Hong H., Oliynyk M., Siskos A.P., and Leadlay P.F. Identification of a phosphopantetheinyl transferase for erythromycin biosynthesis in Saccharopolyspora erythraea. ChemBioChem 5 (2004) 116-125
-
(2004)
ChemBioChem
, vol.5
, pp. 116-125
-
-
Weissman, K.J.1
Hong, H.2
Oliynyk, M.3
Siskos, A.P.4
Leadlay, P.F.5
-
24
-
-
0037318402
-
A genomics-guided approach for discovering and expressing cryptic metabolic pathways
-
Zazopoulos E., Huang K.X., Staffa A., Liu W., Bachmann B.O., Nonaka K., Ahlert J., Thorson J.S., Shen B., and Farnet C.M. A genomics-guided approach for discovering and expressing cryptic metabolic pathways. Nat. Biotechnol. 21 (2003) 187-190
-
(2003)
Nat. Biotechnol.
, vol.21
, pp. 187-190
-
-
Zazopoulos, E.1
Huang, K.X.2
Staffa, A.3
Liu, W.4
Bachmann, B.O.5
Nonaka, K.6
Ahlert, J.7
Thorson, J.S.8
Shen, B.9
Farnet, C.M.10
-
25
-
-
39549096803
-
A phosphopantetheinylating polyketide synthase producing a linear polyene to initiate enediyne antitumor antibiotic biosynthesis
-
Zhang J., Van Lanen S.G., Ju J.H., Liu W., Dorrestein P.C., Li W.L., Kelleher N.L., and Shen B. A phosphopantetheinylating polyketide synthase producing a linear polyene to initiate enediyne antitumor antibiotic biosynthesis. Proc. Natl. Acad. Sci. USA 105 (2008) 1460-1465
-
(2008)
Proc. Natl. Acad. Sci. USA
, vol.105
, pp. 1460-1465
-
-
Zhang, J.1
Van Lanen, S.G.2
Ju, J.H.3
Liu, W.4
Dorrestein, P.C.5
Li, W.L.6
Kelleher, N.L.7
Shen, B.8
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