메뉴 건너뛰기




Volumn 299, Issue 5, 2010, Pages

Dietary methionine restriction improves colon tight junction barrier function and alters claudin expression pattern

Author keywords

Claudin 3; Mannitol flux; Occludin; Paracellular

Indexed keywords

CLAUDIN; METHIONINE; OCCLUDIN;

EID: 78349255334     PISSN: 03636143     EISSN: 15221563     Source Type: Journal    
DOI: 10.1152/ajpcell.00482.2009     Document Type: Article
Times cited : (45)

References (64)
  • 1
    • 0038054523 scopus 로고    scopus 로고
    • Bacterial invasion by a paracellular route: Divide and conquer
    • DOI 10.1016/S1286-4579(03)00089-3
    • Balkovetz DF, Katz J. Bacterial invasion by a paracellular route: divide and conquer. Microbes Infect 5: 613-619, 2003. (Pubitemid 36645121)
    • (2003) Microbes and Infection , vol.5 , Issue.7 , pp. 613-619
    • Balkovetz, D.F.1    Katz, J.2
  • 2
    • 0037369552 scopus 로고    scopus 로고
    • Intestinal epithelial responses to enteric pathogens: Effects on the tight junction barrier, ion transport, and inflammation
    • DOI 10.1136/gut.52.3.439
    • Berkes J, Viswanathan V, Savkovic S, Hecht G. Intestinal epithelial responses to enteric pathogens: effects on the tight junction barrier, ion transport, and inflammation. Gut 52: 439-451, 2003. (Pubitemid 36253638)
    • (2003) Gut , vol.52 , Issue.3 , pp. 439-451
    • Berkes, J.1    Viswanathan, V.K.2    Savkovic, S.D.3    Hecht, G.4
  • 3
    • 0029759259 scopus 로고    scopus 로고
    • A comparison of proliferation markers (BrdUrd, Ki-67, PCNA) determined at each cell position in the crypts of normal human colonic mucosa
    • Bromley M, Rew D, Becciolini A, Balzi M, Chadwick C, Hewitt D, Li Y, Potten C. A comparison of proliferation markers (BrdUrd, Ki-67, PCNA) determined at each cell position in the crypts of normal human colonic mucosa. Eur J Histochem 40: 89-100, 1996. (Pubitemid 26309951)
    • (1996) European Journal of Histochemistry , vol.40 , Issue.2 , pp. 89-100
    • Bromley, M.1    Rew, D.2    Becciolini, A.3    Balzi, M.4    Chadwick, C.5    Hewitt, D.6    Li, Y.Q.7    Potten, C.S.8
  • 5
    • 43249123912 scopus 로고    scopus 로고
    • Forty percent and eighty percent methionine restriction decrease mitochondrial ROS generation and oxidative stress in rat liver
    • Caro P, Gomez J, Lopez-Torres M, Sanchez I, Naudi A, Jove M, Pamplona R, Barja G. Forty percent and eighty percent methionine restriction decrease mitochondrial ROS generation and oxidative stress in rat liver. Biogerontology 9: 183-196, 2008.
    • (2008) Biogerontology , vol.9 , pp. 183-196
    • Caro, P.1    Gomez, J.2    Lopez-Torres, M.3    Sanchez, I.4    Naudi, A.5    Jove, M.6    Pamplona, R.7    Barja, G.8
  • 7
    • 0034734030 scopus 로고    scopus 로고
    • Modification of tight junction function by protein kinase C isoforms
    • DOI 10.1016/S0169-409X(00)00047-8, PII S0169409X00000478
    • Clarke H, Marano CW, Soler AP, Mullin JM. Modification of tight junction function by protein kinase C isoforms. Adv Drug Deliv Rev 41: 283-301, 2000. (Pubitemid 30347379)
    • (2000) Advanced Drug Delivery Reviews , vol.41 , Issue.3 , pp. 283-301
    • Clarke, H.1    Marano, C.W.2    Peralta Soler, A.3    Mullin, J.M.4
  • 8
    • 0033783241 scopus 로고    scopus 로고
    • Protein kinase C activation leads to dephosphorylation of occludin and tight junction permeability increase in LLC-PK1 epithelial cell sheets
    • Clarke H, Soler AP, Mullin JM. Protein kinase C activation leads to dephosphorylation of occludin and tight junction permeability increase in LLC-PK1 epithelial cell sheets. J Cell Sci 113: 3187-3196, 2000.
    • (2000) J Cell Sci , vol.113 , pp. 3187-3196
    • Clarke, H.1    Soler, A.P.2    Mullin, J.M.3
  • 10
    • 34548023972 scopus 로고    scopus 로고
    • Phosphorylation of claudin-4 by PKCepsilon regulates tight junction barrier function in ovarian cancer cells
    • DOI 10.1016/j.yexcr.2007.06.026, PII S0014482707003163
    • D'Souza T, Indig FE, Morin PJ. Phosphorylation of claudin-4 by PKCepsilon regulates tight junction barrier function in ovarian cancer cells. Exp Cell Res 313: 3364-3375, 2007. (Pubitemid 47284066)
    • (2007) Experimental Cell Research , vol.313 , Issue.15 , pp. 3364-3375
    • D'Souza, T.1    Indig, F.E.2    Morin, P.J.3
  • 11
    • 28244466940 scopus 로고    scopus 로고
    • Caloric restriction in humans: Potential pitfalls and health concerns
    • DOI 10.1016/j.mad.2005.09.001, PII S0047637405002186
    • Dirks AJ, Leeuwenburgh C. Caloric restriction in humans: potential pitfalls and health concerns. Mech Ageing Dev 127: 1-7, 2006. (Pubitemid 41713509)
    • (2006) Mechanisms of Ageing and Development , vol.127 , Issue.1 , pp. 1-7
    • Dirks, A.J.1    Leeuwenburgh, C.2
  • 12
    • 0036035189 scopus 로고    scopus 로고
    • Nutrient intake and nutritional indexes in adults with metastatic cancer on a phase I clinical trial of dietary methionine restriction
    • Epner D, Morrow S, Wilcox M, Houghton J. Nutrient intake and nutritional indexes in adults with metastatic cancer on a phase I clinical trial of dietary methionine restriction. Nutr Cancer 42: 158-166, 2002.
    • (2002) Nutr Cancer , vol.42 , pp. 158-166
    • Epner, D.1    Morrow, S.2    Wilcox, M.3    Houghton, J.4
  • 13
    • 33749253359 scopus 로고    scopus 로고
    • Selective amino acid restriction targets mitochondria to induce apoptosis of androgen-independent prostate cancer cells
    • Fu YM, Zhang H, Ding M, Li YQ, Fu X, Yu ZX, Meadows GG. Selective amino acid restriction targets mitochondria to induce apoptosis of androgen-independent prostate cancer cells. J Cell Physiol 209: 522-534, 2006.
    • (2006) J Cell Physiol , vol.209 , pp. 522-534
    • Fu, Y.M.1    Zhang, H.2    Ding, M.3    Li, Y.Q.4    Fu, X.5    Yu, Z.X.6    Meadows, G.G.7
  • 14
    • 49649128839 scopus 로고    scopus 로고
    • Selective amino acid restriction differentially affects the motility and directionality of DU145 and PC3 prostate cancer cells
    • Fu YM, Yu ZX, Lin H, Fu X, Meadows GG. Selective amino acid restriction differentially affects the motility and directionality of DU145 and PC3 prostate cancer cells. J Cell Physiol 217: 184-193, 2008.
    • (2008) J Cell Physiol , vol.217 , pp. 184-193
    • Fu, Y.M.1    Yu, Z.X.2    Lin, H.3    Fu, X.4    Meadows, G.G.5
  • 15
    • 0032559362 scopus 로고    scopus 로고
    • Rho GTPases and the actin cytoskeleton
    • Hall A. Rho GTPases and the actin cytoskeleton. Science 279: 509-514, 1998.
    • (1998) Science , vol.279 , pp. 509-514
    • Hall, A.1
  • 16
    • 0018826448 scopus 로고
    • Electrolyte transport across colonic mucosa from patients with inflammatory bowel disease
    • Hawker PC, McKay JS, Turnberg LA. Electrolyte transport across colonic mucosa from patients with inflammatory bowel disease. Gastroenterology 79: 508-511, 1980.
    • (1980) Gastroenterology , vol.79 , pp. 508-511
    • Hawker, P.C.1    McKay, J.S.2    Turnberg, L.A.3
  • 17
    • 33847127375 scopus 로고    scopus 로고
    • The claudin gene family: Expression in normal and neoplastic tissues
    • Hewitt K, Agarwal R, Morin P. The claudin gene family: expression in normal and neoplastic tissues. BMC Cancer 6: 186, 2006.
    • (2006) BMC Cancer , vol.6 , pp. 186
    • Hewitt, K.1    Agarwal, R.2    Morin, P.3
  • 18
    • 46449107868 scopus 로고    scopus 로고
    • On methionine restriction, suppression of mitochondrial dysfunction and aging
    • Hipkiss AR. On methionine restriction, suppression of mitochondrial dysfunction and aging. Rejuvenation Res 11: 685-688, 2008.
    • (2008) Rejuvenation Res , vol.11 , pp. 685-688
    • Hipkiss, A.R.1
  • 19
    • 0021903915 scopus 로고
    • Altered methionine metabolism and transmethylation in cancer
    • Hoffman RM. Altered methionine metabolism and transmethylation in cancer. Anticancer Res 5: 1-30, 1985.
    • (1985) Anticancer Res , vol.5 , pp. 1-30
    • Hoffman, R.M.1
  • 20
    • 0024267211 scopus 로고
    • Crohn's disease - A permeability disorder of the tight junction?
    • Hollander D. Crohn's disease - a permeability disorder of the tight junction? Gut 29: 1621-1624, 1988.
    • (1988) Gut , vol.29 , pp. 1621-1624
    • Hollander, D.1
  • 21
    • 33644671212 scopus 로고    scopus 로고
    • Methionine-stress: A pleiotropic approach in enhancing the efficacy of chemotherapy
    • Kokkinakis DM. Methionine-stress: a pleiotropic approach in enhancing the efficacy of chemotherapy. Cancer Lett 233: 195-207, 2006.
    • (2006) Cancer Lett , vol.233 , pp. 195-207
    • Kokkinakis, D.M.1
  • 22
    • 0037417428 scopus 로고    scopus 로고
    • Loss of the tight junction protein claudin-7 correlates with histological grade in both ductal carcinoma in situ and invasive ductal carcinoma of the breast
    • Kominsky SL, Argani P, Korz D, Evron E, Raman V, Garrett E, Rein A, Sauter G, Kallioniemi OP, Sukumar S. Loss of the tight junction protein claudin-7 correlates with histological grade in both ductal carcinoma in situ and invasive ductal carcinoma of the breast. Oncogene 22: 2021-2033, 2003.
    • (2003) Oncogene , vol.22 , pp. 2021-2033
    • Kominsky, S.L.1    Argani, P.2    Korz, D.3    Evron, E.4    Raman, V.5    Garrett, E.6    Rein, A.7    Sauter, G.8    Kallioniemi, O.P.9    Sukumar, S.10
  • 24
    • 0018891436 scopus 로고
    • Effect of nutritional and enzymatic methionine deprivation upon human normal and malignant cells in tissue culture
    • Kreis W, Baker A, Ryan V, Bertasso A. Effect of nutritional and enzymatic methionine deprivation upon human normal and malignant cells in tissue culture. Cancer Res 40: 634-641, 1980.
    • (1980) Cancer Res , vol.40 , pp. 634-641
    • Kreis, W.1    Baker, A.2    Ryan, V.3    Bertasso, A.4
  • 25
    • 0033938847 scopus 로고    scopus 로고
    • Claudin-1 and claudin-5 expression and tight junction morphology are altered in blood vessels of human glioblastoma multiforme
    • Liebner S, Fischmann A, Rascher G, Duffner F, Grote EH, Kalbacher H, Wolburg H. Claudin-1 and claudin-5 expression and tight junction morphology are altered in blood vessels of human glioblastoma multiforme. Acta Neuropathol (Berl) 100: 323-331, 2000.
    • (2000) Acta Neuropathol (Berl) , vol.100 , pp. 323-331
    • Liebner, S.1    Fischmann, A.2    Rascher, G.3    Duffner, F.4    Grote, E.H.5    Kalbacher, H.6    Wolburg, H.7
  • 26
    • 0020618323 scopus 로고
    • A freeze fracture study of Crohn's disease of the terminal ileum: Changes in epithelial tight junction organization
    • Marin ML, Greenstein AJ, Geller SA, Gordon RE, Aufses AH. A freeze fracture study of Crohn's disease of the terminal ileum: changes in epithelial tight junction organization. Am J Gastroenterol 78: 537-547, 1983.
    • (1983) Am J Gastroenterol , vol.78 , pp. 537-547
    • Marin, M.L.1    Greenstein, A.J.2    Geller, S.A.3    Gordon, R.E.4    Aufses, A.H.5
  • 27
    • 0014810406 scopus 로고
    • Ultrastructural modifications of intercellular junctions between tumor cells
    • Martinez-Palomo A.Ultrastructural modifications of intercellular junctions between tumor cells. In Vitro 6: 15-20, 1970.
    • (1970) In Vitro , vol.6 , pp. 15-20
    • Martinez-Palomo, A.1
  • 28
    • 32444435024 scopus 로고    scopus 로고
    • Caloric restriction and aging: Controversial issues
    • Masoro EJ. Caloric restriction and aging: controversial issues. J Gerontol A Biol Sci Med Sci 61: 14-19, 2006.
    • (2006) J Gerontol a Biol Sci Med Sci , vol.61 , pp. 14-19
    • Masoro, E.J.1
  • 29
    • 0042698618 scopus 로고    scopus 로고
    • Two poles and a compass
    • Meili R, Firtel RA. Two poles and a compass. Cell 114: 153-156, 2003.
    • (2003) Cell , vol.114 , pp. 153-156
    • Meili, R.1    Firtel, R.A.2
  • 30
    • 23844464540 scopus 로고    scopus 로고
    • Methionine-deficient diet extends mouse lifespan, slows immune and lens aging, alters glucose, T4, IGF-I and insulin levels, and increases hepatocyte MIF levels and stress resistance
    • Miller RA, Buehner G, Chang Y, Harper JM, Sigler R, Smith-Wheelock M. Methionine-deficient diet extends mouse lifespan, slows immune and lens aging, alters glucose, T4, IGF-I and insulin levels, and increases hepatocyte MIF levels and stress resistance. Aging Cell 4: 119-125, 2005.
    • (2005) Aging Cell , vol.4 , pp. 119-125
    • Miller, R.A.1    Buehner, G.2    Chang, Y.3    Harper, J.M.4    Sigler, R.5    Smith-Wheelock, M.6
  • 31
    • 34848911647 scopus 로고    scopus 로고
    • DNA methylation: The nuts and bolts of repression
    • Miranda TB, Jones PA. DNA methylation: the nuts and bolts of repression. J Cell Physiol 213: 384-390, 2007.
    • (2007) J Cell Physiol , vol.213 , pp. 384-390
    • Miranda, T.B.1    Jones, P.A.2
  • 32
    • 1542380399 scopus 로고    scopus 로고
    • Epithelial barriers, compartmentation, and cancer
    • Mullin JM. Epithelial barriers, compartmentation, and cancer. Sci STKE 2004: pe2, 2004.
    • (2004) Sci STKE , vol.2004
    • Mullin, J.M.1
  • 35
    • 0030994411 scopus 로고    scopus 로고
    • Different size limitations for increased transepithelial paracellular solute flux across phorbol ester and tumor necrosis factor-treated epithelial cell sheets
    • Mullin JM, Marano CW, Laughlin KV, Nuciglio M, Stevenson BR, Peralta Soler A. Different size limitations for increased transepithelial paracellular solute flux across phorbol ester and tumor necrosis factor-treated epithelial cell sheets. J Cell Physiol 171: 226-233, 1997.
    • (1997) J Cell Physiol , vol.171 , pp. 226-233
    • Mullin, J.M.1    Marano, C.W.2    Laughlin, K.V.3    Nuciglio, M.4    Stevenson, B.R.5    Peralta Soler, A.6
  • 36
    • 0030601332 scopus 로고    scopus 로고
    • Chronic exposure of LLC-PK1 epithelia to the phorbol ester TPA produces polyp-like foci with leaky tight junctions and altered protein kinase C-alpha expression and localization
    • Mullin JM, Peralta Soler A, Laughlin KV, Kampherstein JA, Russo LM, Saladik DT, George K, Shurina RD, O'Brien TG. Chronic exposure of LLC-PK1 epithelia to the phorbol ester TPA produces polyp-like foci with leaky tight junctions and altered protein kinase C-alpha expression and localization. Exp Cell Res 227: 12-22, 1996.
    • (1996) Exp Cell Res , vol.227 , pp. 12-22
    • Mullin, J.M.1    Peralta Soler, A.2    Laughlin, K.V.3    Kampherstein, J.A.4    Russo, L.M.5    Saladik, D.T.6    George, K.7    Shurina, R.D.8    O'Brien, T.G.9
  • 38
    • 44849092317 scopus 로고    scopus 로고
    • Maternal cocaine administration in mice alters DNA methylation and gene expression in hippocampal neurons of neonatal and prepubertal offspring
    • Novikova SI, He F, Bai J, Cutrufello NJ, Lidow MS, Undieh AS. Maternal cocaine administration in mice alters DNA methylation and gene expression in hippocampal neurons of neonatal and prepubertal offspring. PLoS ONE 3: e1919, 2008.
    • (2008) PLoS ONE , vol.3
    • Novikova, S.I.1    He, F.2    Bai, J.3    Cutrufello, N.J.4    Lidow, M.S.5    Undieh, A.S.6
  • 41
    • 53149144633 scopus 로고    scopus 로고
    • Epigenetic alterations in the brains of Fisher 344 rats induced by long-term administration of folate/methyl-deficient diet
    • Pogribny IP, Karpf AR, James SR, Melnyk S, Han T, Tryndyak VP. Epigenetic alterations in the brains of Fisher 344 rats induced by long-term administration of folate/methyl-deficient diet. Brain Res 1237: 25-34, 2008.
    • (2008) Brain Res , vol.1237 , pp. 25-34
    • Pogribny, I.P.1    Karpf, A.R.2    James, S.R.3    Melnyk, S.4    Han, T.5    Tryndyak, V.P.6
  • 43
    • 0242468133 scopus 로고    scopus 로고
    • Characterization of novel human ovarian cancer-specific transcripts (HOSTs) identified by serial analysis of gene expression
    • Rangel LB, Sherman-Baust CA, Wernyj RP, Schwartz DR, Cho KR, Morin PJ. Characterization of novel human ovarian cancer-specific transcripts (HOSTs) identified by serial analysis of gene expression. Oncogene 22: 7225-7232, 2003.
    • (2003) Oncogene , vol.22 , pp. 7225-7232
    • Rangel, L.B.1    Sherman-Baust, C.A.2    Wernyj, R.P.3    Schwartz, D.R.4    Cho, K.R.5    Morin, P.J.6
  • 46
    • 33745970444 scopus 로고    scopus 로고
    • Methionine restriction decreases mitochondrial oxygen radical generation and leak as well as oxidative damage to mitochondrial DNA and proteins
    • Sanz A, Caro P, Ayala V, Portero-Otin M, Pamplona R, Barja G. Methionine restriction decreases mitochondrial oxygen radical generation and leak as well as oxidative damage to mitochondrial DNA and proteins. FASEB J 20: 1064-1073, 2006.
    • (2006) FASEB J , vol.20 , pp. 1064-1073
    • Sanz, A.1    Caro, P.2    Ayala, V.3    Portero-Otin, M.4    Pamplona, R.5    Barja, G.6
  • 49
    • 0031959370 scopus 로고    scopus 로고
    • Pentobarbital affects transepithelial electrophysiological parameters regulated by protein kinase C in rat distal colon
    • Simons RM, Laughlin KV, Kampherstein JA, Desai DC, Shurina RD, Mullin JM. Pentobarbital affects transepithelial electrophysiological parameters regulated by protein kinase C in rat distal colon. Dig Dis Sci 43: 632-640, 1998.
    • (1998) Dig Dis Sci , vol.43 , pp. 632-640
    • Simons, R.M.1    Laughlin, K.V.2    Kampherstein, J.A.3    Desai, D.C.4    Shurina, R.D.5    Mullin, J.M.6
  • 50
    • 0942287209 scopus 로고    scopus 로고
    • Epidermal growth factor receptor activation differentially regulates claudin expression and enhances transepithelial resistance in Madin-Darby canine kidney cells
    • Singh AB, Harris RC. Epidermal growth factor receptor activation differentially regulates claudin expression and enhances transepithelial resistance in Madin-Darby canine kidney cells. J Biol Chem 279: 3543-3552, 2004.
    • (2004) J Biol Chem , vol.279 , pp. 3543-3552
    • Singh, A.B.1    Harris, R.C.2
  • 51
    • 34548455766 scopus 로고    scopus 로고
    • Restriction of sulfur-containing amino acids alters claudin composition and improves tight junction barrier function
    • Skrovanek S, Valenzano MC, Mullin JM. Restriction of sulfur-containing amino acids alters claudin composition and improves tight junction barrier function. Am J Physiol Regul Integr Comp Physiol 293: R1046-R1055, 2007.
    • (2007) Am J Physiol Regul Integr Comp Physiol , vol.293
    • Skrovanek, S.1    Valenzano, M.C.2    Mullin, J.M.3
  • 53
    • 58649090901 scopus 로고    scopus 로고
    • Targeted epithelial tight junction dysfunction causes immune activation and contributes to development of experimental colitis
    • Su L, Shen L, Clayburgh D, Nalle S, Sullivan E, Meddings J, Abraham C, Turner J. Targeted epithelial tight junction dysfunction causes immune activation and contributes to development of experimental colitis. Gastroenterology 136: 551-563, 2009.
    • (2009) Gastroenterology , vol.136 , pp. 551-563
    • Su, L.1    Shen, L.2    Clayburgh, D.3    Nalle, S.4    Sullivan, E.5    Meddings, J.6    Abraham, C.7    Turner, J.8
  • 54
    • 0030946344 scopus 로고    scopus 로고
    • Methionine content of dietary proteins affects the molecular species composition of plasma phosphatidylcholine in rats fed a cholesterol-free diet
    • Sugiyama K, Yamakawa A, Kumazawa A, Saeki S. Methionine content of dietary proteins affects the molecular species composition of plasma phosphatidylcholine in rats fed a cholesterol-free diet. J Nutr 127: 600-607, 1997.
    • (1997) J Nutr , vol.127 , pp. 600-607
    • Sugiyama, K.1    Yamakawa, A.2    Kumazawa, A.3    Saeki, S.4
  • 55
    • 67649660052 scopus 로고    scopus 로고
    • Life-span extension in mice by preweaning food restriction and by methionine restriction in middle age
    • Sun L, Sadighi Akha AA, Miller RA, Harper JM. Life-span extension in mice by preweaning food restriction and by methionine restriction in middle age. J Gerontol A Biol Sci Med Sci 64A: 711-722, 2009.
    • (2009) J Gerontol A Biol Sci Med Sci , vol.64 A , pp. 711-722
    • Sun, L.1    Sadighi Akha, A.A.2    Miller, R.A.3    Harper, J.M.4
  • 56
    • 61449339872 scopus 로고    scopus 로고
    • DNA methylation: An introduction to the biology and the disease-associated changes of a promising biomarker
    • Tost J. DNA methylation: an introduction to the biology and the disease-associated changes of a promising biomarker. Methods Mol Biol 507: 3-20, 2009.
    • (2009) Methods Mol Biol , vol.507 , pp. 3-20
    • Tost, J.1
  • 58
    • 33644506738 scopus 로고    scopus 로고
    • Calorie restriction increases life span: A molecular mechanism
    • Wolf G. Calorie restriction increases life span: a molecular mechanism. Nutr Rev 64: 89-92, 2006.
    • (2006) Nutr Rev , vol.64 , pp. 89-92
    • Wolf, G.1
  • 59
    • 33845459705 scopus 로고    scopus 로고
    • Applying proteomic methodologies to analyze the effect of methionine restriction on proliferation of human gastric cancer SGC7901 cells
    • Xin L, Cao WX, Fei XF, Wang Y, Liu WT, Liu BY, Zhu ZG. Applying proteomic methodologies to analyze the effect of methionine restriction on proliferation of human gastric cancer SGC7901 cells. Clin Chim Acta 377: 206-212, 2007.
    • (2007) Clin Chim Acta , vol.377 , pp. 206-212
    • Xin, L.1    Cao, W.X.2    Fei, X.F.3    Wang, Y.4    Liu, W.T.5    Liu, B.Y.6    Zhu, Z.G.7
  • 60
    • 4344700784 scopus 로고    scopus 로고
    • Downregulation of epithelial apoptosis and barrier repair in active Crohn's disease by tumour necrosis factor alpha antibody treatment
    • Zeissig S, Bojarski C, Buergel N, Mankertz J, Zeitz M, Fromm M, Schulzke JD. Downregulation of epithelial apoptosis and barrier repair in active Crohn's disease by tumour necrosis factor alpha antibody treatment. Gut 52: 1295-1302, 2004.
    • (2004) Gut , vol.52 , pp. 1295-1302
    • Zeissig, S.1    Bojarski, C.2    Buergel, N.3    Mankertz, J.4    Zeitz, M.5    Fromm, M.6    Schulzke, J.D.7
  • 61
    • 33845995125 scopus 로고    scopus 로고
    • Changes in expression and distribution of claudin-2, -5 and -8 lead to discontinuous tight junctions and barrier dysfunction in active Crohn's disease
    • Zeissig S, Burgel N, Gunzel D, Richter J, Mankertz J, Wahnschaffe U, Kroesen AJ, Zeitz M, Fromm M, Schulzke JD. Changes in expression and distribution of claudin-2, -5 and -8 lead to discontinuous tight junctions and barrier dysfunction in active Crohn's disease. Gut 56: 61-72, 2007.
    • (2007) Gut , vol.56 , pp. 61-72
    • Zeissig, S.1    Burgel, N.2    Gunzel, D.3    Richter, J.4    Mankertz, J.5    Wahnschaffe, U.6    Kroesen, A.J.7    Zeitz, M.8    Fromm, M.9    Schulzke, J.D.10
  • 63
    • 0028331789 scopus 로고
    • Sequential decrease in tight junctions as revealed by 7H6 tight junction-associated protein during rat hepatocarcinogenesis
    • Zhong Y, Enomoto K, Tobioka H, Konishi Y, Satoh M, Mori M. Sequential decrease in tight junctions as revealed by 7H6 tight junction-associated protein during rat hepatocarcinogenesis. Jpn J Cancer Res 85: 351-356, 1994. (Pubitemid 24129614)
    • (1994) Japanese Journal of Cancer Research , vol.85 , Issue.4 , pp. 351-356
    • Zhong, Y.1    Enomoto, K.2    Tobioka, H.3    Konishi, Y.4    Satoh, M.5    Mori, M.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.