Vitamin E decreases endogenous cholesterol synthesis and apo-AI-mediated cholesterol secretion in Caco-2 cells

Journal of Nutritional Biochemistry

Volumn 21, Issue 12, 2010, Pages 1207-1213

  Landrier, Jean François ^a,b,c   Gouranton, Erwan ^a,b,c   Reboul, Emmanuelle ^a,b,c   Cardinault, Nicolas ^a,b,c   El Yazidi, Claire ^a,b,c   Malezet Desmoulins, Christiane ^a,b,c   André, Marc ^a,b,c   Nowicki, Marion ^a,b,c   Souidi, Maâmar ^d   Borel, Patrick ^a,b,c  

^a INSERM   (France)

^b INSERM   (France)

^c AIX MARSEILLE UNIVERSITY   (France)

^d INSTITUT DE RADIOPROTECTION ET DE SÛRETÉ NUCLÉAIRE IRSN   (France)

Author keywords

Cholesterol; Intestine; Microarrays; Nutrition; Tocopherol; Vitamin

Indexed keywords

ALPHA TOCOPHEROL; APOLIPOPROTEIN A1; CHOLESTANETRIOL 26 MONOOXYGENASE; CHOLESTEROL; GAMMA TOCOPHEROL; LIVER X RECEPTOR; OXYSTEROL;

ARTICLE; CELL STRAIN CACO 2; CHOLESTEROL SYNTHESIS; CONTROLLED STUDY; DOWN REGULATION; ENZYME ACTIVITY; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; NUCLEOTIDE SEQUENCE;

EID: 78249281373     PISSN: 09552863     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jnutbio.2009.10.008     Document Type: Article

References (48)

1. Wilson J.D. The quantification of cholesterol excretion and degradation in the isotopic steady state in the rat: the influence of dietary cholesterol. J Lipid Res 1964, 5:409-417.
2. Dietschy J.M., Weis H.J. Cholesterol synthesis by the gastrointestinal tract. Am J Clin Nutr 1971, 24:70-76.
3. Perrodin M., Lutton C. In vivo cholesterol synthesis by the rat digestive tract: I. A topological study. Reprod Nutr Dev 1985, 25:647-657.
4. 14C-acetate for measuring in vivo rat cholesterol synthesis. Reprod Nutr Dev 1990, 30:71-84.
5. Repa J.J., Lund E.G., Horton J.D., Leitersdorf E., Russell D.W., Dietschy J.M., et al. Disruption of the sterol 27-hydroxylase gene in mice results in hepatomegaly and hypertriglyceridemia. Reversal by cholic acid feeding. J Biol Chem 2000, 275:39685-39692.
6. Plosch T., Kosters A., Groen A.K., Kuipers F. The ABC of hepatic and intestinal cholesterol transport. Handb Exp Pharmacol 2005, 465-482.
7. Brunham L.R., Kruit J.K., Iqbal J., Fievet C., Timmins J.M., Pape T.D., et al. Intestinal ABCA1 directly contributes to HDL biogenesis in vivo. J Clin Invest 2006, 116:1052-1062.
8. Tall A.R., Yvan-Charvet L., Terasaka N., Pagler T., Wang N. HDL, ABC transporters, and cholesterol efflux: implications for the treatment of atherosclerosis. Cell Metab 2008, 7:365-375.
9. Oram J.F. Tangier disease and ABCA1. Biochim Biophys Acta 2000, 1529:321-330.
10. Wu A.L., Windmueller H.G. Relative contributions by liver and intestine to individual plasma apolipoproteins in the rat. J Biol Chem 1979, 254:7316-7322.
11. Traber M.G. Vitamin e regulatory mechanisms. Annu Rev Nutr 2007, 27:347-362.
12. Bietrix F., Yan D., Nauze M., Rolland C., Bertrand-Michel J., Comera C., et al. Accelerated lipid absorption in mice overexpressing intestinal SR-BI. J Biol Chem 2006, 281:7214-7219.
13. Reboul E., Klein A., Bietrix F., Gleize B., Malezet-Desmoulins C., Schneider M., et al. Scavenger receptor class B type I (SR-BI) is involved in vitamin E transport across the enterocyte. J Biol Chem 2006, 281:4739-4745.
14. Narushima K., Takada T., Yamanashi Y., Suzuki H. Niemann-pick C1-like 1 mediates alpha-tocopherol transport. Mol Pharmacol 2008, 74:42-49.
15. Anwar K., Kayden H.J., Hussain M.M. Transport of vitamin E by differentiated Caco-2 cells. J Lipid Res 2006, 47:1261-1273.
16. Reboul E., Trompier D., Moussa M., Klein A., Landrier J.F., Chimini G., et al. ATP-Binding cassette transporter A1 is significantly involved in the intestinal absorption of alpha- and gamma-tocopherol but not in that of retinyl palmitate in mice. Am J Clin Nutr 2009, 89:177-184.
17. Valastyan S., Thakur V., Johnson A., Kumar K., Manor D. Novel transcriptional activities of vitamin E: inhibition of cholesterol biosynthesis. Biochemistry 2008, 47:744-752.
18. Horton J.D., Goldstein J.L., Brown M.S. SREBPs: Activators of the complete program of cholesterol and fatty acid synthesis in the liver. J Clin Invest 2002, 109:1125-1131.
19. Staggers J.E., Hernell O., Stafford R.J., Carey M.C. Physical-chemical behavior of dietary and biliary lipids during intestinal digestion and absorption: 1. Phase behavior and aggregation states of model lipid systems patterned after aqueous duodenal contents of healthy adult human beings. Biochemistry 1990, 29:2028-2040.
20. Landrier J.F., Malezet-Desmoulins C., Reboul E., Marie Lorec A., Josephe Amiot M., Borel P. Comparison of different vehicles to study the effect of tocopherols on gene expression in intestinal cells. Free Radic Res 2008, 42:523-530.
21. Borel P., Pasquier B., Armand M., Tyssandier V., Grolier P., Alexandre-Gouabau M.C., et al. Processing of vitamin A and E in the human gastrointestinal tract. Am J Physiol Gastrointest Liver Physiol 2001, 280:G95-G103.
22. Salvini S., Charbonnier M., Defoort C., Alquier C., Lairon D. Functional characterization of three clones of the human intestinal Caco-2 cell line for dietary lipid processing. Br J Nutr 2002, 87:211-217.
23. Chantret I., Rodolosse A., Barbat A., Dussaulx E., Brot-Laroche E., Zweibaum A., et al. Differential expression of sucrase-isomaltase in clones isolated from early and late passages of the cell line Caco-2: evidence for glucose-dependent negative regulation. J Cell Sci 1994, 107(Pt 1):213-225.
24. Li T., Chen W., Chiang J.Y. PXR induces CYP27A1 and regulates cholesterol metabolism in the intestine. J Lipid Res 2007, 48:373-384.
25. Gueguen Y., Souidi M., Baudelin C., Dudoignon N., Grison S., Dublineau I., et al. Short-term hepatic effects of depleted uranium on xenobiotic and bile acid metabolizing cytochrome P450 enzymes in the rat. Arch Toxicol 2006, 80:187-195.
26. Souidi M., Parquet M., Ferezou J., Lutton C. Modulation of cholesterol 7alpha-hydroxylase and sterol 27-hydroxylase activities by steroids and physiological conditions in hamster. Life Sci 1999, 64:1585-1593.
27. Li X., Pandak W.M., Erickson S.K., Ma Y., Yin L., Hylemon P., et al. Biosynthesis of the regulatory oxysterol, 5-cholesten-3beta,25-diol 3-sulfate, in hepatocytes. J Lipid Res 2007, 48:2587-2596.
28. Xu J., Gingras K.M., Bengston L., Di Marco A., Forger N.G. Blockade of endogenous neurotrophic factors prevents the androgenic rescue of rat spinal motoneurons. J Neurosci 2001, 21:4366-4372.
29. Oram J.F., Lawn R.M. ABCA1. The gatekeeper for eliminating excess tissue cholesterol. J Lipid Res 2001, 42:1173-1179.
30. Santamarina-Fojo S., Remaley A.T., Neufeld E.B., Brewer H.B. Regulation and intracellular trafficking of the ABCA1 transporter. J Lipid Res 2001, 42:1339-1345.
31. Venkateswaran A., Laffitte B.A., Joseph S.B., Mak P.A., Wilpitz D.C., Edwards P.A., et al. Control of cellular cholesterol efflux by the nuclear oxysterol receptor LXR alpha. Proc Natl Acad Sci U S A 2000, 97:12097-12102.
32. Janowski B.A., Willy P.J., Devi T.R., Falck J.R., Mangelsdorf D.J. An oxysterol signalling pathway mediated by the nuclear receptor LXR alpha. Nature 1996, 383:728-731.
33. Barella L., Muller P.Y., Schlachter M., Hunziker W., Stocklin E., Spitzer V., et al. Identification of hepatic molecular mechanisms of action of alpha-tocopherol using global gene expression profile analysis in rats. Biochim Biophys Acta 2004, 1689:66-74.
34. Javitt N.B. Biologic role(s) of the 25(R),26-hydroxycholesterol metabolic pathway. Biochim Biophys Acta 2000, 1529:136-141.
35. Yang C., McDonald J.G., Patel A., Zhang Y., Umetani M., Xu F., et al. Sterol intermediates from cholesterol biosynthetic pathway as liver X receptor ligands. J Biol Chem 2006, 281:27816-27826.
36. Li Y., Bolten C., Bhat B.G., Woodring-Dietz J., Li S., Prayaga S.K., et al. Induction of human liver X receptor alpha gene expression via an autoregulatory loop mechanism. Mol Endocrinol 2002, 16:506-514.
37. Murthy S., Born E., Mathur S.N., Field F.J. LXR/RXR activation enhances basolateral efflux of cholesterol in CaCo-2 cells. J Lipid Res 2002, 43:1054-1064.
38. Wang N., Lan D., Chen W., Matsuura F., Tall A.R. ATP-Binding cassette transporters G1 and G4 mediate cellular cholesterol efflux to high-density lipoproteins. Proc Natl Acad Sci U S A 2004, 101:9774-9779.
39. Marcil V., Delvin E., Sane A.T., Tremblay A., Levy E. Oxidative stress influences cholesterol efflux in THP-1 macrophages: role of ATP-binding cassette A1 and nuclear factors. Cardiovasc Res 2006, 72:473-482.
40. Chen M., Li W., Wang N., Zhu Y., Wang X. ROS and NF-kappaB but not LXR mediate IL-1beta signaling for the downregulation of ATP-binding cassette transporter A1. Am J Physiol Cell Physiol 2007, 292:C1493-C1501.
41. Wang X., Liao D., Bharadwaj U., Li M., Yao Q., Chen C. C-Reactive protein inhibits cholesterol efflux from human macrophage-derived foam cells. Arterioscler Thromb Vasc Biol 2008, 28:519-526.
42. Rode S., Rubic T., Lorenz R.L. alpha-Tocopherol disturbs macrophage LXRalpha regulation of ABCA1/G1 and cholesterol handling. Biochem Biophys Res Commun 2008, 369:868-872.
43. Wong J., Quinn C.M., Brown A.J. Statins inhibit synthesis of an oxysterol ligand for the liver x receptor in human macrophages with consequences for cholesterol flux. Arterioscler Thromb Vasc Biol 2004, 24:2365-2371.
44. Wong J., Quinn C.M., Brown A.J. SREBP-2 positively regulates transcription of the cholesterol efflux gene, ABCA1, by generating oxysterol ligands for LXR. Biochem J 2006, 400:485-491.
45. Cheung M.C., Zhao X.Q., Chait A., Albers J.J., Brown B.G. Antioxidant supplements block the response of HDL to simvastatin-niacin therapy in patients with coronary artery disease and low HDL. Arterioscler Thromb Vasc Biol 2001, 21:1320-1326.
46. Pirat B., Korkmaz M.E., Eroglu S., Tayfun E., Yildirir A., Ulucam M., et al. The effects of simvastatin combined with different antioxidant vitamin regimens on serum lipid profile in patients with low HDL cholesterol levels. Anadolu Kardiyol Derg 2004, 4:318-322.
47. Leonard S.W., Joss J.D., Mustacich D.J., Blatt D.H., Lee Y.S., Traber M.G. Effects of vitamin E on cholesterol levels of hypercholesterolemic patients receiving statins. Am J Health Syst Pharm 2007, 64:2257-2266.
48. Hsieh J., Hayashi A.A., Webb J., Adeli K. Postprandial dyslipidemia in insulin resistance: mechanisms and role of intestinal insulin sensitivity. Atheroscler Suppl 2008, 9:7-13.