Blockade of endogenous neurotrophic factors prevents the androgenic rescue of rat spinal motoneurons

Journal of Neuroscience

Volumn 21, Issue 12, 2001, Pages 4366-4372

  Xu, J ^a   Gingras, K M ^a   Bengston, L ^a   Di Marco, A ^a   Forger, N G ^a  

^a UNIVERSITY OF MASSACHUSETTS   (United States)

Author keywords

Androgen; Cell death; Ciliary neurotrophic factor; Motoneuron; Neurotrophin; Trk receptor

Indexed keywords

ANDROGEN; BRAIN DERIVED NEUROTROPHIC FACTOR; BRAIN DERIVED NEUROTROPHIC FACTOR A; BRAIN DERIVED NEUROTROPHIC FACTOR B; BRAIN DERIVED NEUROTROPHIC FACTOR C; HYBRID PROTEIN; IMMUNOGLOBULIN G; NEUROTROPHIC FACTOR; NEUROTROPHIC FACTOR RECEPTOR ALPHA; OIL; TESTOSTERONE PROPIONATE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL INTERACTION; CELL MATURATION; CELL SURVIVAL; CONTROLLED STUDY; NERVE CELL; NONHUMAN; PERINEUM; PRIORITY JOURNAL; PROTEIN BINDING; SPINAL CORD MOTONEURON; SPINAL NERVE;

EID: 0035876290     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.21-12-04366.2001     Document Type: Article

References (60)

1. Brain-derived neurotrophic factor regulates expression of androgen receptors in perineal motoneurons
2. Targeted transduction of CNS neurons with adenoviral vectors carrying neurotrophic factor genes confers neuroprotection that exceeds the transduced population
3. Short- and long-term effects of ciliary neurotrophic factor on androgen-sensitive motoneurons in the lumbar spinal cord
4. Endogenous nerve growth factor regulates the sensitivity of nociceptors in the adult rat
5. Functional interactions of neurotrophins and neurotrophin receptors
6. Cellular analyses of hormone influence on motoneuronal development and function
7. Hormonal control of a developing neuromuscular system. II. Sensitive periods for the androgen-induced masculinization of the rat spinal nucleus of the bulbocavernosus
8. Blockade of endogenous ligands of trkB inhibits formation of ocular dominance columns
9. Involution and hormone-induced persistence of the muscle sphincter (levator) ani in female rats
10. Mice lacking the CNTF receptor, unlike mice lacking CNTF, exhibit profound motor neuron deficits at birth
11. Identification of ciliary neurotrophic factor (CNTF) residues essential for leukemia inhibitory factor receptor binding and generation of CNTF receptor antagonists
12. Motor neuron growth factors
13. CLF associates with CLC to form a functional heteromeric ligand for the CNTF receptor complex
14. Lack of neurotrophin-3 leads to deficiencies in the peripheral nervous system and loss of limb proprioceptive afferents
15. Acetylcholinesterase gene expression in axotomized rat facial motoneurons is differentially regulated by neurotrophins: Correlation with trkB and trkC mRNA levels and isoforms
16. Evidence for androgen receptors in sexually dimorphic perineal muscles of neonatal male rats. Absence of androgen accumulation by the perineal motoneurons
17. Ciliary neurotrophic factor maintains motoneurons and their target muscles in developing rats
18. Ciliary neurotrophic factor arrests muscle and motoneuron degeneration in androgen-insensitive rats
19. Sexual dimorphism in the spinal cord is absent in mice lacking the ciliary neurotrophic factor receptor
20. Androgen spares androgen-insensitive motoneurons from apoptosis in the spinal nucleus of the bulbocavernosus in rats
21. Muscle-derived neurotrophin-4 as an activity-dependent trophic signal for adult motor neurons
22. Expression of neurotrophins in skeletal muscle: Quantitative comparison and significance for motoneuron survival and maintenance of function
23. Motoneuron death and motor unit size during embryonic development of the rat
24. Neurotrophins promote motor neuron survival and are present in embryonic limb bud
25. Neurotrophin signalling
26. Reduction of the naturally occurring motor neuron loss by enlargement of the periphery
27. Naturally occurring and axotomy-induced motoneuron death and its prevention by neurotrophic agents: A comparison between chick and mouse
28. The neurotrophins and CNTF: Two families of collaborative neurotrophic factors
29. Sexual dimorphism and the influence of neonatal androgen in the dorsolateral motor nucleus of the rat lumbar spinal cord
30. Ontogeny of androgen receptor immunoreactivity in lumbar motoneurons and in the sexually dimorphic levator ani muscle of male rats
31. Disruption of the neurotrophin-3 receptor gene trkC eliminates Ia muscle afferents and results in abnormal movements
32. Evidence that brain-derived neurotrophic factor is atrophic factor for motor neurons in vivo
33. Methods for the counting of neurons
34. Reduction of endogenous transforming growth factors β prevents ontogenetic neuron death
35. Motoneuron cell death in the developing lumbar spinal cord of the mouse
36. The effects of growth factors on the survival and differentiation of cultured dentate gyrus neurons
37. Immunohistochemical localization of ciliary neurotrophic factor receptor α expression in the rat nervous system
38. In vivo localization and characterization of functional ciliary neurotrophic factor receptors which utilize JAK-STAT signaling
39. The biological effects of endogenous nerve growth factor on adult sensory neurons revealed by a trkA-IgG fusion molecule
40. Centrally mediated inhibition of local inflammation by ciliary neurotrophic factor
41. Neurotrophic factors and neuromuscular disease. I. General comments, the neurotrophin family, and neuropoietic cytokines
42. Arrest of motor neuron disease in wobbler mice cotreated with CNTF and BDNF
43. Motor neuron columns in the lumbar spinal cord of the rat
44. Androgens prevent normally occurring cell death in a sexually dimorphic spinal nucleus
45. The absence of significant postnatal motoneuron death in the brachial and lumbar spinal cord of the rat
46. Cell death during development of the nervous system
47. Neurotrophic survival molecules for motoneurons: An embarrassment of riches
48. Organization of the motoneurons innervating the pelvic muscles of the male rat
49. Brain-derived neurotrophic factor prevents the death of motoneurons in newborn rats after nerve section
50. Are there more members of the CNTF-GPA family?
51. Human trks: Molecular cloning, tissue distribution, and expression of extracellular domain immunoadhesins
52. TrkB signaling modulates spine density and morphology independent of dendrite structure in cultured neonatal Purkinje cells
53. Synaptic modulation by neurotrophic factors: Differential and synergistic effects of brain-derived neurotrophic factor and ciliary neurotrophic factor
54. The duration of neurotrophic factor independence in early sensory neurons is matched to the time course of target field innervation
55. Localized synaptic actions of neurotrophin-4
56. The role of p75NTR in modulating neurotrophin survival effects in developing motoneurons
57. The neurotrophins BDNF, NT-3 and NT-4/5, but not NGF, up-regulate the cholinergic phenotype of developing motor neurons
58. Expression and androgen regulation of the ciliary neurotrophic factor receptor (CNTFRα) in muscles and spinal cord
59. Brain-derived neurotrophic factor rescues spinal motor neurons from axotomy-induced cell death
60. BDNF regulation of androgen receptor expression in axotomized SNB motoneurons of adult male rats