Short-term hepatic effects of depleted uranium on xenobiotic and bile acid metabolizing cytochrome P450 enzymes in the rat

Archives of Toxicology

Volumn 80, Issue 4, 2006, Pages 187-195

  Gueguen Y ^a   Souidi, M ^a   Baudelin, C ^a   Dudoignon, N ^a   Grison, S ^a   Dublineau, I ^a   Marquette, C ^a   Voisin, P ^a   Gourmelon, P ^a   Aigueperse, J ^a  

^a INSTITUT DE RADIOPROTECTION ET DE SÛRETÉ NUCLÉAIRE IRSN   (France)

Author keywords

Bile acids; Cytochromes P450; Depleted uranium; Liver; Xenobiotics

Indexed keywords

7ALPHA HYDROXYCHOLESTEROL; BILE ACID; CYTOCHROME P450; CYTOCHROME P450 7A1; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; UNCLASSIFIED DRUG; URANIUM; XENOBIOTIC AGENT;

ACUTE TOXICITY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BILE ACID METABOLISM; BLOOD ANALYSIS; CHOLESTEROL BLOOD LEVEL; CHOLESTEROL METABOLISM; CONTROLLED STUDY; ENZYME ACTIVITY; EVALUATION; EXPOSURE; GENE EXPRESSION; IN VIVO STUDY; KIDNEY FUNCTION; LIPID METABOLISM; LIVER FUNCTION; LIVER MICROSOME; LIVER TOXICITY; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; STATISTICAL SIGNIFICANCE; UPREGULATION; XENOBIOTIC METABOLISM;

ANIMALS; ARYL HYDROCARBON HYDROXYLASES; BILE ACIDS AND SALTS; CHOLESTEROL; CYTOCHROME P-450 ENZYME SYSTEM; DNA PRIMERS; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HYDROXYCHOLESTEROLS; ISOENZYMES; LIVER; MALE; MEMBRANE PROTEINS; MICROSOMES, LIVER; MITOCHONDRIA, LIVER; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, CYTOPLASMIC AND NUCLEAR; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; URANIUM; XENOBIOTICS;

ANIMALIA;

EID: 33645384017     PISSN: 03405761     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00204-005-0027-3     Document Type: Article

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