Novel transcriptional activities of vitamin E: Inhibition of cholesterol biosynthesis

Biochemistry

Volumn 47, Issue 2, 2008, Pages 744-752

  Valastyan, Scott ^a   Thakur, Varsha ^b   Johnson, Amy ^a   Kumar, Karan ^a   Manor, Danny ^a,b  

^a Department of Obstetrics Gynecology   (United States)

^b CASE WESTERN RESERVE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOACTIVITY; BIOSYNTHESIS; CARBON; CHOLESTEROL; OXYGEN; TRANSCRIPTION;

CHOLESTEROL BIOSYNTHESIS; OXIDATIVE DAMAGE;

VITAMINS;

ALPHA TOCOPHEROL; ANTIOXIDANT; CARBON; CHOLESTEROL; FREE RADICAL; OXYGEN; STEROL REGULATORY ELEMENT BINDING PROTEIN 2;

ARTICLE; CHOLESTEROL SYNTHESIS; CONTROLLED STUDY; GENE; GENE CONTROL; GENE EXPRESSION; GENE TARGETING; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; LIVER CELL; OXIDATIVE STRESS; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN PROCESSING; STEROL RESPONSIVE ELEMENT;

ACETYLCYSTEINE; ALPHA-TOCOPHEROL; ANIMALS; CELL LINE; CHO CELLS; CHOLESTEROL; CRICETINAE; CRICETULUS; GENE EXPRESSION REGULATION; GENES, REPORTER; HOMEOSTASIS; HUMANS; LIPID METABOLISM; MULTIGENE FAMILY; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PROTEIN PROCESSING, POST-TRANSLATIONAL; REACTIVE OXYGEN SPECIES; REPRODUCIBILITY OF RESULTS; SERUM RESPONSE ELEMENT; STEROL REGULATORY ELEMENT BINDING PROTEIN 2; TRANSCRIPTION, GENETIC; VITAMIN E;

VERTEBRATA;

EID: 38849126780     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi701432q     Document Type: Article

References (73)

1. Ingold, K. U., Webb, A. C., Witter, D., Burton, G. W., Metcalfe, T. A., and Muller, D. P. (1987) Vitamin E remains the major lipid-soluble, chain-breaking antioxidant in human plasma even in individuals suffering severe vitamin E deficiency, Arch. Biochem. Biophys. 259, 224-225.
2. Burton, G. W., Cheeseman, K. H., Doba, T., Ingold, K. U., and Slater, T. F. (1983) Vitamin E as an antioxidant in vitro and in vivo, Ciba Found. Symp. 101, 4-18.
3. Traber, M. G., and Arai, H. (1999) Molecular mechanisms of vitamin E transport, Annu. Rev. Nutr. 19, 343-355.
4. Blatt, D. H., Leonard, S. W., and Traber, M. G. (2001) Vitamin E kinetics and the function of tocopherol regulatory proteins, Nutrition 17, 799-805.
5. Kaempf-Rotzoll, D. E., Traber, M. G., and Arai, H. (2003) Vitamin E and transfer proteins, Curr. Opin. Lipidol. 14, 249-254.
6. Sontag, T. J., and Parker, R. S. (2002) Cytochrome P450 omega-hydroxylase pathway of tocopherol catabolism. Novel mechanism of regulation of vitamin E status, J. Biol. Chem. 277, 25290-25296.
7. Azzi, A., Ricciarelli, R., and Zingg, J. M. (2002) Non-antioxidant molecular functions of alpha-tocopherol (vitamin E), FEBS Lett. 519, 8-10.
8. Zingg, J. M., and Azzi, A. (2004) Non-antioxidant activities of vitamin E, Curr. Med. Chem. 11, 1113-1133.
9. Chojkier, M., Houglum, K., Lee, K. S., and Buck, M. (1998) Long-and short-term D-alpha-tocopherol supplementation inhibits liver collagen alpha1(I) gene expression, Am. J. Physiol. 275, G1480-1485.
10. Witt, W., Kolleck, I., Fechner, H., Sinha, P., and Rustow, B. (2000) Regulation by vitamin E of the scavenger receptor BI in rat liver and HepG2 cells, J. Lipid Res. 41, 2009-2016.
11. Devaraj, S., Hugou, I., and Jialal, I. (2001) Alpha-tocopherol decreases CD36 expression in human monocyte-derived macrophages, J. Lipid Res. 42, 521-527.
12. Ricciarelli, R., Zingg, J. M., and Azzi, A. (2000) Vitamin E reduces the uptake of oxidized LDL by inhibiting CD36 scavenger receptor expression in cultured aortic smooth muscle cells, Circulation 102, 82-87.
13. Aratri, E., Spycher, S. E., Breyer, I., and Azzi, A. (1999) Modulation of alpha-tropomyosin expression by alpha-tocopherol in rat vascular smooth muscle cells, FEBS Lett. 447, 91-94.
14. Davies, G. F., McFie, P. J., Khandelwal, R. L., and Roesler, W. J. (2002) Unique ability of troglitazone to up-regulate peroxisome proliferator- activated receptor-gamma expression in hepatocytes, J. Pharmacol. Exp. Ther. 300, 72-77.
15. Zapolska-Downar, D., Zapolski-Downar, A., Markiewski, M., Ciechanowicz, A., Kaczmarczyk, M., and Naruszewicz, M. (2000) Selective inhibition by alpha-tocopherol of vascular cell adhesion molecule-1 expression in human vascular endothelial cells, Biochem. Biophys. Res. Commun. 274, 609-615.
16. Gohil, K., Schock, B. C., Chakraborty, A. A., Terasawa, Y., Raber, J., Farese, R. V., Jr., Packer, L., Cross, C. E., and Traber, M. G. (2003) Gene expression profile of oxidant stress and neurodegeneration in transgenic mice deficient in alpha-tocopherol transfer protein, Free Radical Biol. Med. 35, 1343-1354.
17. Barella, L., Muller, P. Y., Schlachter, M., Hunziker, W., Stocklin, E., Spitzer, V., Meier, N., de Pascual-Teresa, S., Minihane, A. M., and Rimbach, G. (2004) Identification of hepatic molecular mechanisms of action of alpha-tocopherol using global gene expression profile analysis in rats, Biochim. Biophys. Acta 1689, 66-74.
18. Hyland, S., Muller, D., Hayton, S., Stoecklin, E., and Barella, L. (2006) Cortical gene expression in the vitamin E-deficient rat: possible mechanisms for the electrophysiological abnormalities of visual and neural function, Ann. Nutr. Metab. 50, 433-441.
19. Rota, C., Barella, L., Minihane, A. M., Stocklin, E., and Rimbach, G. (2004) Dietary alpha-tocopherol affects differential gene expression in rat testes, IUBMB Life 56, 277-280.
20. Rota, C., Rimbach, G., Minihane, A. M., Stoecklin, E., and Barella, L. (2005) Dietary vitamin E modulates differential gene expression in the rat hippocampus: potential implications for its neuroprotective properties, Nutr. Neurosci. 8, 21-29.
21. Oommen, S., Vasu, V. T., Leonard, S. W., Traber, M. G., Cross, C. E., and Gohil, K. (2007) Genome wide responses of murine lungs to dietary alpha-tocopherol, Free Radical Res. 41, 98-109.
22. Vasu, V. T., Hobson, B., Gohil, K., and Cross, C. E. (2007) Genome-wide screening of alpha-tocopherol sensitive genes in heart tissue from alpha-tocopherol transfer protein null mice (ATTP(-/-)), FEBS Lett. 581, 1572-1578.
23. Gohil, K., Godzdanker, R., O'Roark, E., Schock, B. C., Kaini, R. R., Packer, L., Cross, C. E., and Traber, M. G. (2004) Alpha-tocopherol transfer protein deficiency in mice causes multi-organ deregulation of gene networks and behavioral deficits with age, Ann. N. Y. Acad Sci. 1031, 109-126.
24. Haddad, J. J. (2004) Oxygen sensing and oxidant/redox-related pathways, Biochem. Biophys. Res. Commun. 316, 969-977.
25. Asmis, R. (1997) Physical partitioning is the main mechanism of alpha-tocopherol and cholesterol transfer between lipoproteins and P388D1 macrophage-like cells, Eur. J. Biochem. 250, 600-607.
26. Qian, J., Atkinson, J., and Manor, D. (2006) Biochemical consequences of heritable mutations in the alpha-tocopherol transfer protein, Biochemistry 45, 8236-8242.
27. Qian, J., Morley, S., Wilson, K., Nava, P., Atkinson, J., and Manor, D. (2005) Intracellular trafficking of vitamin E in hepatocytes: the role of tocopherol transfer protein, J. Lipid Res. 46, 2072-2082.
28. Sladowski, D., Steer, S. J., Clothier, R. H., and Balls, M. (1993) An improved MTT assay, J. Immunol. Methods 157, 203-207.
29. Ellerby, L. M., and Bredesen, D. E. (2000) Measurement of cellular oxidation, reactive oxygen species, and antioxidant enzymes during apoptosis, Methods Enzymol. 322, 413-421.
30. Amoroso, S., Gioielli, A., Cataldi, M., Di Renzo, G., and Annunziato, L. (1999) In the neuronal cell line SH-SY5Y, oxidative stress-induced free radical overproduction causes cell death without any participation of intracellular Ca(2+) increase, Biochim. Biophys. Acta 1452, 151-160.
31. Shin, D. J., and Osborne, T. F. (2003) Thyroid hormone regulation and cholesterol metabolism are connected through sterol regulatory element-binding protein-2 (SREBP-2), J. Biol. Chem. 278, 34114-34118.
32. Schreiber, E., Matthias, P., Muller, M. M., and Schaffner, W. (1989) Rapid detection of octamer binding proteins with 'mini-extracts', prepared from a small number of cells, Nucleic Acids Res. 17, 6419.
33. Sakai, J., Nohturfft, A., Goldstein, J. L., and Brown, M. S. (1998) Cleavage of sterol regulatory element-binding proteins (SREBPs) at site-1 requires interaction with SREBP cleavage-activating protein. Evidence from in vivo competition studies, J. Biol. Chem. 273, 5785-5793.
34. Goldstein, J. L., Basu, S. K., and Brown, M. S. (1983) Receptor-mediated endocytosis of low-density lipoprotein in cultured cells, Methods Enzymol. 98, 241-260.
35. Lee, J. E., Kim, K. M., Cho, J. W., Suh, S. I., Suh, M. H., Kwon, T. K., Park, J. W., Bae, J. H., Song, D. K., Cho, C. H., Bae, I., and Baek, W. K. (2002) Pyrrolidine dithiocarbamate induces cyclooxygenase-2 expression in NIH 3T3 fibroblast cells, Biochem. Biophys. Res. Commun. 298, 230-234.
36. Liou, J. S., Chen, C. Y., Chen, J. S., and Faller, D. V. (2000) Oncogenic ras mediates apoptosis in response to protein kinase C inhibition through the generation of reactive oxygen species, J. Biol. Chem. 275, 39001-39011.
37. Pani, G., Colavitti, R., Bedogni, B., Anzevino, R., Borrello, S., and Galeotti, T. (2000) A redox signaling mechanism for density-dependent inhibition of cell growth, J. Biol. Chem. 275, 38891-38899.
38. Sundaresan, M., Yu, Z. X., Ferrans, V. J., Sulciner, D. J., Gutkind, J. S., Irani, K., Goldschmidt-Clermont, P. J., and Finkel, T. (1996) Regulation of reactive-oxygen-species generation in fibroblasts by Rac1, Biochem. J. 318, 379-382.
39. Rodwell, V. W., Nordstrom, J. L., and Mitschelen, J. J. (1976) Regulation of HMG-CoA reductase, Adv. Lipid Res. 14, 1-74.
40. Brown, M. S., and Goldstein, J. L. (1986) A receptor-mediated pathway for cholesterol homeostasis, Science 232, 34-47.
41. Wadkins, R. M., Jares-Erijman, E. A., Klement, R., Rudiger, A., and Jovin, T. M. (1996) Actinomycin D binding to single-stranded DNA: sequence specificity and hemi-intercalation model from fluorescence and 1H NMR spectroscopy, J. Mol. Biol. 262, 53-68.
42. Hua, X., Yokoyama, C., Wu, J., Briggs, M. R., Brown, M. S., Goldstein, J. L., and Wang, X. (1993) SREBP-2, a second basic-helix-loop-helix-leucine zipper protein that stimulates transcription by binding to a sterol regulatory element, Proc. Natl. Acad. Sci. U.S.A. 90, 11603-11607.
43. Liu, J., Zhang, F., Li, C., Lin, M., and Briggs, M. R. (2003) Synergistic activation of human LDL receptor expression by SCAP ligand and cytokine oncostatin M, Arterioscler., Thromb., Vasc. Biol. 23, 90-96.
44. Goldstein, J. L., and Brown, M. S. (1990) Regulation of the mevalonate pathway, Nature 343, 425-430.
45. Amemiya-Kudo, M., Shimano, H., Hasty, A. H., Yahagi, N., Yoshikawa, T., Matsuzaka, T., Okazaki, H., Tamura, Y., Iizuka, Y., Ohashi, K., Osuga, J., Harada, K., Gotoda, T., Sato, R., Kimura, S., Ishibashi, S., and Yamada, N. (2002) Transcriptional activities of nuclear SREBP-1a, -1c, and -2 to different target promoters of lipogenic and cholesterogenic genes, J. Lipid Res. 43, 1220-1235.
46. Sato, R., Inoue, J., Kawabe, Y., Kodama, T., Takano, T., and Maeda, M. (1996) Sterol-dependent transcriptional regulation of sterol regulatory element-binding protein-2, J. Biol. Chem. 271, 26461-26464.
47. Horton, J. D., Goldstein, J. L., and Brown, M. S. (2002) SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver, J. Clin. Invest. 109, 1125-1131.
48. Azzi, A., Boscoboinik, D., Fazzio, A., Marilley, D., Maroni, P., Ozer, N. K., Spycher, S., and Tasinato, A. (1998) RRR-alpha-tocopherol regulation of gene transcription in response to the cell oxidant status, Z. Ernahrungswiss. 37, 21-28.
49. de Nigris, F., Franconi, F., Maida, I., Palumbo, G., Anania, V., and Napoli, C. (2000) Modulation by alpha- and gamma-tocopherol and oxidized low-density lipoprotein of apoptotic signaling in human coronary smooth muscle cells, Biochem. Pharmacol. 59, 1477-1487.
50. Gunawardena, K., Murray, D. K., and Meikle, A. W. (2000) Vitamin E and other antioxidants inhibit human prostate cancer cells through apoptosis, Prostate 44, 287-295.
51. Venkateswaran, V., Fleshner, N. E., and Klotz, L. H. (2002) Modulation of cell proliferation and cell cycle regulators by vitamin E in human prostate carcinoma cell lines, J. Urol. 168, 1578-1582.
52. Clement, S., Tasinato, A., Boscoboinik, D., and Azzi, A. (1997) The effect of alpha-tocopherol on the synthesis, phosphorylation and activity of protein kinase C in smooth muscle cells after phorbol 12- myristate 13-acetate down-regulation, Eur. J. Biochem. 246, 745-749.
53. Ozer, N. K., Palozza, P., Boscoboinik, D., and Azzi, A. (1993) d-alpha-Tocopherol inhibits low density lipoprotein induced proliferation and protein kinase C activity in vascular smooth muscle cells, FEBS Lett. 322, 307-310.
54. Mahoney, C. W., and Azzi, A. (1988) Vitamin E inhibits protein kinase C activity, Biochem. Biophys. Res. Commun. 154, 694-697.
55. Pentland, A. P., Morrison, A. R., Jacobs, S. C., Hruza, L. L., Hebert, J. S., and Packer, L. (1992) Tocopherol analogs suppress arachidonic acid metabolism via phospholipase inhibition, J. Biol. Chem. 267, 15578-15584.
56. Muller, P. Y., Netscher, T., Frank, J., Stoecklin, E., Rimbach, G., and Barella, L. (2005) Comparative quantification of pharmacodynamic parameters of chiral compounds (RRR- vs. all-rac-alpha tocopherol) by global gene expression profiling, J. Plant Physiol. 162, 811-817.
57. Gius, D., Botero, A., Shah, S., and Curry, H. A. (1999) Intracellular oxidation/reduction status in the regulation of transcription factors NF-kappaB and AP-1, Toxicol. Lett. 106, 93-106.
58. Nguyen, T., Sherratt, P. J., and Pickett, C. B. (2003) Regulatory mechanisms controlling gene expression mediated by the antioxidant response element, Annu. Rev. Pharmacol. Toxicol. 43, 233-260.
59. Nguyen, T., Sherratt, P. J., Huang, H. C., Yang, C. S., and Pickett, C. B. (2003) Increased protein stability as a mechanism that enhances Nrf2-mediated transcriptional activation of the antioxidant response element. Degradation of Nrf2 by the 26 S proteasome, J. Biol. Chem. 278, 4536-4541.
60. Radhakrishnan, A., Sun, L. P., Kwon, H. J., Brown, M. S., and Goldstein, J. L. (2004) Direct binding of cholesterol to the purified membrane region of SCAP: mechanism for a sterol-sensing domain, Mol. Cell 15, 259-268.
61. Goldstein, J. L., DeBose-Boyd, R. A., and Brown, M. S. (2006) Protein sensors for membrane sterols, Cell 124, 35-46.
62. Chen, L. H., Liao, S., and Packett, L. V. (1972) Interaction of dietary vitamin E and protein level of lipid source with serum cholesterol level in rats, J. Nutr. 102, 729-732.
63. Jack Yang, N. Y., and Desai, I. D. (1977) Effect of high levels of dietary vitamin E on liver and plasma lipids and fat soluble vitamins in rats, J. Nutr. 107, 1418-1426.
64. Morrissey, R. B., and Donaldson, W. E. (1979) Cholesteremia in Japanese quail: response to a mixture of vitamins C and E and choline chloride, Artery 5, 182-192.
65. Komaratat, P., Chupukcharoen, N., and Wilairat, P. (1985) Effect of vitamin E on cholesterol plasma lipoprotein distribution and metabolism in rabbit, Int. J. Vitam. Nutr. Res. 55, 167-171.
66. Phonpanichrasamee, C., Komaratat, P., and Wilairat, P. (1990) Hypocholesterolemic effect of vitamin E on cholesterol-fed rabbit, Int. J. Vitam. Nutr. Res. 60, 240-244.
67. Wilson, R. B., Middleton, C. C., and Sun, G. Y. (1978) Vitamin E, antioxidants and lipid peroxidation in experimental atherosclerosis of rabbits, J. Nutr. 108, 1858-1867.
68. Stephens, N. G., Parsons, A., Schofield, P. M., Kelly, F., Cheeseman, K., and Mitchinson, M. J. (1996) Randomised controlled trial of vitamin E in patients with coronary disease: Cambridge Heart Antioxidant Study (CHAOS), Lancet 347, 781-786.
69. de Gaetano, G. (2001) Low-dose aspirin and vitamin E in people at cardiovascular risk: a randomised trial in general practice. Collaborative Group of the Primary Prevention Project, Lancet 357, 89-95.
70. Boaz, M., Smetana, S., Weinstein, T., Matas, Z., Gafter, U., Iaina, A., Knecht, A., Weissgarten, Y., Brunner, D., Fainaru, M., and Green, M. S. (2000) Secondary prevention with antioxidants of cardiovascular disease in endstage renal disease (SPACE): randomised placebo-controlled trial, Lancet 356, 1213-1218.
71. Rapola, J. M., Virtamo, J., Haukka, J. K., Heinonen, O. P., Albanes, D., Taylor, P. R., and Huttunen, J. K. (1996) Effect of vitamin E and beta carotene on the incidence of angina pectoris. A randomized, double-blind, controlled trial, JAMA, J. Am. Med. Assoc. 275, 693-698.
72. Marchioli, R. (1999) Dietary supplementation with n-3 polyunsaturated fatty acids and vitamin E after myocardial infarction: results of the GISSI-Prevenzione trial. Gruppo Italiano per lo Studio della Sopravvivenza nell'Infarto miocardico, Lancet 354, 447-455.
73. Miller, E. R., 3rd, Pastor-Barriuso, R., Dalal, D., Riemersma, R. A., Appel, L. J., and Guallar, E. (2005) Meta-analysis: high-dosage vitamin E supplementation may increase all-cause mortality, Ann. Intern. Med. 142, 37-46.