α-Tocopherol disturbs macrophage LXRα regulation of ABCA1/G1 and cholesterol handling

Biochemical and Biophysical Research Communications

Volumn 369, Issue 3, 2008, Pages 868-872

  Rode, Sabine ^a   Rubic, Tina ^a   Lorenz, Reinhard L ^a  

^a UNIVERSITY OF MUNICH   (Germany)

Author keywords

Tocopherol; ABCA1; ABCG1; Atherosclerosis; CD36; LXR ; PPAR ; Reverse cholesterol transport

Indexed keywords

ABC TRANSPORTER A1; ABC TRANSPORTER G1; ALPHA TOCOPHEROL; CD36 ANTIGEN; CHOLESTEROL; HIGH DENSITY LIPOPROTEIN; LIPID; LIVER X RECEPTOR ALPHA; MESSENGER RNA; OXIDIZED LOW DENSITY LIPOPROTEIN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA;

ARTICLE; ATHEROSCLEROSIS; BLOOD VESSEL WALL; CHOLESTEROL TRANSPORT; CONTROLLED STUDY; FOAM CELL; GENE EXPRESSION; HOMEOSTASIS; HUMAN; HUMAN CELL; LIPID METABOLISM; MACROPHAGE; OXIDATION; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; RECEPTOR UPREGULATION; REPORTER GENE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ALPHA-TOCOPHEROL; ANTIGENS, CD36; ANTIOXIDANTS; ATHEROSCLEROSIS; ATP-BINDING CASSETTE TRANSPORTERS; CHOLESTEROL; CHOLESTEROL, HDL; DNA-BINDING PROTEINS; FOAM CELLS; GENES, REPORTER; HUMANS; LIPOPROTEINS, LDL; RECEPTORS, CYTOPLASMIC AND NUCLEAR; TRANSCRIPTION, GENETIC;

EID: 41149091076     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2008.02.132     Document Type: Article

References (37)

1. Witztum J.L. The oxidation hypothesis of atherosclerosis. Lancet 344 (1994) 793-795
2. Galle J., Hansen-Hagge T., Wanner C., and Seibold S. Impact of oxidized low density lipoprotein on vascular cells. Atherosclerosis 185 (2006) 219-226
3. Upston J.M., Terentis A.C., and Stocker R. Tocopherol-mediated peroxidation of lipoproteins: implications for vitamin E as a potential antiatherogenic supplement. FASEB J. 13 (1999) 977-994
4. Stampfer M.J., Hennekens C.H., Manson J.E., Colditz G.A., Rosner B., and Willett W.C. Vitamin E consumption and the risk of coronary disease in women. N. Engl. J. Med. 328 (1993) 1444-1449
5. Miller III E.R., Pastor-Barriuso R., Dalal D., Riemersma R.A., Appel L.J., and Guallar E. Meta-analysis: high-dosage vitamin E supplementation may increase all-cause mortality. Ann. Intern. Med. 142 (2005) 37-46
6. Bjelakovic G., Nikolova D., Gluud L.L., Simonetti R.G., and Gluud C. Mortality in randomized trials of antioxidant supplements for primary and secondary prevention: systematic review and meta-analysis. JAMA 297 (2007) 842-857
7. Li A.C., and Glass C.K. PPAR- and LXR-dependent pathways controlling lipid metabolism and the development of atherosclerosis. J. Lipid Res. 45 (2004) 2161-2173
8. Teupser D., Thiery J., and Seidel D. Alpha-tocopherol down-regulates scavenger receptor activity in macrophages. Atherosclerosis 144 (1999) 109-115
9. Ricciarelli R., Zingg J.M., and Azzi A. Vitamin E reduces the uptake of oxidized LDL by inhibiting CD36 scavenger receptor expression in cultured aortic smooth muscle cells. Circulation 102 (2000) 82-87
10. Venugopal S.K., Devaraj S., and Jialal I. RRR-alpha-tocopherol decreases the expression of the major scavenger receptor, CD36, in human macrophages via inhibition of tyrosine kinase (Tyk2). Atherosclerosis 175 (2004) 213-220
11. Pietsch A., Erl W., and Lorenz R.L. Lovastatin reduces expression of the combined adhesion and scavenger receptor CD36 in human monocytic cells. Biochem. Pharmacol. 52 (1996) 433-439
12. Chinetti G., Lestavel S., Bocher V., Remaley A.T., Neve B., Torra I.P., Teissier E., Minnich A., Jaye M., Duverger N., Brewer H.B., Fruchart J.C., Clavey V., and Staels B. PPAR-alpha and PPAR-gamma activators induce cholesterol removal from human macrophage foam cells through stimulation of the ABCA1 pathway. Nat. Med. 7 (2001) 53-58
13. Cignarella A., Engel T., von Eckardstein A., Kratz M., Lorkowski S., Lueken A., Assmann G., and Cullen P. Pharmacological regulation of cholesterol efflux in human monocyte-derived macrophages in the absence of exogenous cholesterol acceptors. Atherosclerosis 179 (2005) 229-236
14. Bustin S.A. Absolute quantification of mRNA using real-time reverse transcription polymerase chain reaction assays. J. Mol. Endocrinol. 25 (2000) 169-193
15. Krotz F., Sohn H.Y., Gloe T., Plank C., and Pohl U. Magnetofection potentiates gene delivery to cultured endothelial cells. J. Vasc. Res. 40 (2003) 425-434
16. Schulz T., Schiffl H., Scheithe R., Hrboticky N., and Lorenz R. Preserved antioxidative defense of lipoproteins in renal failure and during hemodialysis. Am. J. Kidney Dis. 25 (1995) 564-571
17. Quehenberger O., Jurgens G., Zadravec S., and Esterbauer H. Oxidation of human low density lipoprotein initiated by copper (II) chloride. Basic Life Sci. 49 (1988) 387-390
18. Osborne Jr. J.C. Delipidation of plasma lipoproteins. Methods Enzymol. 128 (1986) 213-222
19. Singaraja R.R., Bocher V., James E.R., Clee S.M., Zhang L.H., Leavitt B.R., Tan B., Brooks-Wilson A., Kwok A., Bissada N., Yang Y.Z., Liu G., Tafuri S.R., Fievet C., Wellington C.L., Staels B., and Hayden M.R. Human ABCA1 BAC transgenic mice show increased high density lipoprotein cholesterol and ApoAI-dependent efflux stimulated by an internal promoter containing liver X receptor response elements in intron 1. J. Biol. Chem. 276 (2001) 33969-33979
20. Dimitrov N.V., Meyer C., Gilliland D., Ruppenthal M., Chenoweth W., and Malone W. Plasma tocopherol concentrations in response to supplemental vitamin E. Am. J. Clin. Nutr. 53 (1991) 723-729
21. Oram J.F., Vaughan A.M., and Stocker R. ATP-binding cassette transporter A1 mediates cellular secretion of alpha-tocopherol. J. Biol. Chem. 276 (2001) 39898-39902
22. Brown M.S., and Goldstein J.L. Regulation of the activity of the low density lipoprotein receptor in human fibroblasts. Cell 6 (1975) 307-316
23. Forman B.M., Tontonoz P., Chen J., Brun R.P., Spiegelman B.M., and Evans R.M. 15-Deoxy-delta 12, 14-prostaglandin J2 is a ligand for the adipocyte determination factor PPAR gamma. Cell 83 (1995) 803-812
24. Kliewer S.A., Lenhard J.M., Willson T.M., Patel I., Morris D.C., and Lehmann J.M. A prostaglandin J2 metabolite binds peroxisome proliferator-activated receptor gamma and promotes adipocyte differentiation. Cell 83 (1995) 813-819
25. Boscoboinik D., Szewczyk A., Hensey C., and Azzi A. Inhibition of cell proliferation by alpha-tocopherol. Role of protein kinase C. J. Biol. Chem. 266 (1991) 6188-6194
26. Cachia O., Benna J.E., Pedruzzi E., Descomps B., Gougerot-Pocidalo M.A., and Leger C.L. Alpha-tocopherol inhibits the respiratory burst in human monocytes. Attenuation of p47(phox) membrane translocation and phosphorylation. J. Biol. Chem. 273 (1998) 32801-32805
27. Azzi A., Gysin R., Kempna P., Munteanu A., Villacorta L., Visarius T., and Zingg J.M. Regulation of gene expression by alpha-tocopherol. Biol. Chem. 385 (2004) 585-591
28. Tontonoz P., and Mangelsdorf D.J. Liver X receptor signaling pathways in cardiovascular disease. Mol. Endocrinol. 17 (2003) 985-993
29. Cavelier C., Lorenzi I., Rohrer L., and von Eckardstein A. Lipid efflux by the ATP-binding cassette transporters ABCA1 and ABCG1. Biochim. Biophys. Acta 1761 (2006) 655-666
30. Bowry V.W., Mohr D., Cleary J., and Stocker R. Prevention of tocopherol-mediated peroxidation in ubiquinol-10-free human low density lipoprotein. J. Biol. Chem. 270 (1995) 5756-5763
31. Yang C., McDonald J.G., Patel A., Zhang Y., Umetani M., Xu F., Westover E.J., Covey D.F., Mangelsdorf D.J., Cohen J.C., and Hobbs H.H. Sterol intermediates from cholesterol biosynthetic pathway as liver X receptor ligands. J. Biol. Chem. 281 (2006) 27816-27826
32. Leonard S.W., Joss J.D., Mustacich D.J., Blatt D.H., Lee Y.S., and Traber M.G. Effects of vitamin E on cholesterol levels of hypercholesterolemic patients receiving statins. Am. J. Health Syst. Pharm. 64 (2007) 2257-2266
33. Bowry V.W., Stanley K.K., and Stocker R. High density lipoprotein is the major carrier of lipid hydroperoxides in human blood plasma from fasting donors. Proc. Natl. Acad. Sci. USA 89 (1992) 10316-10320
34. Rimbach G., Minihane A.M., Majewicz J., Fischer A., Pallauf J., Virgli F., and Weinberg P.D. Regulation of cell signalling by vitamin E. Proc. Nutr. Soc. 61 (2002) 415-425
35. Pratico D., Tangirala R.K., Rader D.J., Rokach J., and FitzGerald G.A. Vitamin E suppresses isoprostane generation in vivo and reduces atherosclerosis in ApoE-deficient mice. Nat. Med. 4 (1998) 1189-1192
36. Stephens N.G., Parsons A., Schofield P.M., Kelly F., Cheeseman K., and Mitchinson M.J. Randomised controlled trial of vitamin E in patients with coronary disease: Cambridge Heart Antioxidant Study (CHAOS). Lancet 347 (1996) 781-786
37. Dietary supplementation with n-3 polyunsaturated fatty acids and vitamin E after myocardial infarction: results of the GISSI-Prevenzione trial. Gruppo Italiano per lo Studio della Sopravvivenza nell′Infarto miocardico, Lancet 354 (1999) 447-455.