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Volumn 31, Issue 8, 2010, Pages 1569-1578

Pharmacology of putative selective hBRS-3 receptor agonists for human bombesin receptors (BnR): Affinities, potencies and selectivity in multiple native and BnR transfected cells

Author keywords

Agonist; Bombesin; Gastrin releasing peptide; Neuromedin B; Receptor

Indexed keywords

BOMBESIN RECEPTOR; BOMBESIN RECEPTOR SUBTYPE 3; BOMBESIN RECEPTOR SUBTYPE 3 AGONIST; HORMONE RECEPTOR STIMULATING AGENT; PHOSPHOLIPASE C; PROTEIN KINASE D; UNCLASSIFIED DRUG;

EID: 78249247696     PISSN: 01969781     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.peptides.2010.04.023     Document Type: Article
Times cited : (21)

References (65)
  • 1
    • 0027963251 scopus 로고
    • Gastrin-releasing peptide receptor-induced internalization, down-regulation, desensitization and growth: Possible role of cAMP
    • Benya RV, Fathi Z, Pradhan T, Battey JF, Kusui T, Jensen RT. Gastrin-releasing peptide receptor-induced internalization, down-regulation, desensitization and growth: possible role of cAMP. Mol Pharmacol 1994; 46(2):235-245
    • (1994) Mol Pharmacol , vol.46 , Issue.2 , pp. 235-245
    • Benya, R.V.1    Fathi, Z.2    Pradhan, T.3    Battey, J.F.4    Kusui, T.5    Jensen, R.T.6
  • 3
    • 0027082327 scopus 로고
    • Neuromedin B receptors retain functional expression when transfected into BALB 3T3 fibroblasts: Analysis of binding, kinetics, stoichiometry, modulation by guanine nucleotide-binding proteins, and signal transduction and comparison with natively expressed receptors
    • Benya RV, Wada E, Battey JF, Fathi Z, Wang LH, Mantey SA, et al. Neuromedin B receptors retain functional expression when transfected into BALB 3T3 fibroblasts: analysis of binding, kinetics, stoichiometry, modulation by guanine nucleotide-binding proteins, and signal transduction and comparison with natively expressed receptors. Mol Pharmacol 1992; 42(6):1058-1068
    • (1992) Mol Pharmacol , vol.42 , Issue.6 , pp. 1058-1068
    • Benya, R.V.1    Wada, E.2    Battey, J.F.3    Fathi, Z.4    Wang, L.H.5    Mantey, S.A.6
  • 4
    • 33947305951 scopus 로고    scopus 로고
    • CCK causes PKD1 activation in pancreatic acini by signaling through PKC-delta and PKCindependent pathways
    • Berna MJ, Hoffmann KM, Tapia JA, Thill M, Pace A, Mantey SA, et al. CCK causes PKD1 activation in pancreatic acini by signaling through PKC-delta and PKCindependent pathways. Biochim Biophys Acta 2007; 1773:483-501.
    • (2007) Biochim Biophys Acta , vol.1773 , pp. 483-501
    • Berna, M.J.1    Hoffmann, K.M.2    Tapia, J.A.3    Thill, M.4    Pace, A.5    Mantey, S.A.6
  • 5
    • 20044376843 scopus 로고    scopus 로고
    • The design of a new potent and selective ligand for the orphan bombesin receptor subtype 3 (BRS3)
    • Boyle RG, Humphries J, Mitchell T, Showell GA, Apaya R, Iijima H, et al. The design of a new potent and selective ligand for the orphan bombesin receptor subtype 3 (BRS3). J Pept Sci 2005; 11:136-141
    • (2005) J Pept Sci , vol.11 , pp. 136-141
    • Boyle, R.G.1    Humphries, J.2    Mitchell, T.3    Showell, G.A.4    Apaya, R.5    Iijima, H.6
  • 6
    • 75149138355 scopus 로고    scopus 로고
    • Treating obesity? It's in the bag!
    • Coll AP. Treating Obesity? It's in the Bag! Cell Metab 2010; 11:95-96
    • (2010) Cell Metab , vol.11 , pp. 95-96
    • Coll, A.P.1
  • 7
    • 0027503295 scopus 로고
    • BRS-3: Novel bombesin receptor subtype selectively expressed in testis and lung carcinoma cells
    • Fathi Z, Corjay MH, Shapira H, Wada E, Benya R, Jensen R, et al. BRS-3: novel bombesin receptor subtype selectively expressed in testis and lung carcinoma cells. J Biol Chem 1993; 268(8):5979-5984
    • (1993) J Biol Chem , vol.268 , Issue.8 , pp. 5979-5984
    • Fathi, Z.1    Corjay, M.H.2    Shapira, H.3    Wada, E.4    Benya, R.5    Jensen, R.6
  • 8
    • 0034534349 scopus 로고    scopus 로고
    • Bombesin receptors in distinct tissue compartments of human pancreatic diseases
    • Fleischmann A, Laderach U, Friess H, Buechler MW, Reubi JC. Bombesin receptors in distinct tissue compartments of human pancreatic diseases. Lab Invest 2000; 80:1807-1817
    • (2000) Lab Invest , vol.80 , pp. 1807-1817
    • Fleischmann, A.1    Laderach, U.2    Friess, H.3    Buechler, M.W.4    Reubi, J.C.5
  • 9
    • 38749134845 scopus 로고    scopus 로고
    • Molecular basis for agonist selectivity and activation of the orphan bombesin receptor subtype 3 receptor
    • Gonzalez N, Hocart SJ, Portal-Nunez S, Mantey SA, Nakagawa T, Zudaire E, et al. Molecular basis for agonist selectivity and activation of the orphan bombesin receptor subtype 3 receptor. J Pharmacol Exp Ther 2008; 324:463-474
    • (2008) J Pharmacol Exp Ther , vol.324 , pp. 463-474
    • Gonzalez, N.1    Hocart, S.J.2    Portal-Nunez, S.3    Mantey, S.A.4    Nakagawa, T.5    Zudaire, E.6
  • 10
    • 67650632787 scopus 로고    scopus 로고
    • Characterization of putative GRP- and NMB-receptor antagonist's interaction with human receptors
    • Gonzalez N, Mantey SA, Pradhan TK, Sancho V, Moody TW, Coy DH, et al. Characterization of putative GRP- and NMB-receptor antagonist's interaction with human receptors. Peptides 2009; 30:1473-1486
    • (2009) Peptides , vol.30 , pp. 1473-1486
    • Gonzalez, N.1    Mantey, S.A.2    Pradhan, T.K.3    Sancho, V.4    Moody, T.W.5    Coy, D.H.6
  • 11
    • 38049132623 scopus 로고    scopus 로고
    • Bombesin-related peptides and their receptors: Recent advances in their role in physiology and disease states
    • Gonzalez N, Moody TW, Igarashi H, Ito T, Jensen RT. Bombesin-related peptides and their receptors: recent advances in their role in physiology and disease states. Curr Opin Endocrinol Diabetes Obes 2008; 15:58-64.
    • (2008) Curr Opin Endocrinol Diabetes Obes , vol.15 , pp. 58-64
    • Gonzalez, N.1    Moody, T.W.2    Igarashi, H.3    Ito, T.4    Jensen, R.T.5
  • 12
    • 75149160396 scopus 로고    scopus 로고
    • Regulation of energy homeostasis by bombesin receptor subtype-3: Selective receptor agonists for the treatment of obesity
    • Guan XM, Chen H, Dobbelaar PH, Dong Y, Fong TM, Gagen K, et al. Regulation of energy homeostasis by bombesin receptor subtype-3: selective receptor agonists for the treatment of obesity. Cell Metab 2010; 11:101-112
    • (2010) Cell Metab , vol.11 , pp. 101-112
    • Guan, X.M.1    Chen, H.2    Dobbelaar, P.H.3    Dong, Y.4    Fong, T.M.5    Gagen, K.6
  • 13
    • 33751101651 scopus 로고    scopus 로고
    • Activation of bombesin receptor subtype-3 stimulates adhesion of lung cancer cells
    • Hou X, Wei L, Harada A, Tatamoto K. Activation of bombesin receptor subtype-3 stimulates adhesion of lung cancer cells. Lung Cancer 2006; 54:143-148
    • (2006) Lung Cancer , vol.54 , pp. 143-148
    • Hou, X.1    Wei, L.2    Harada, A.3    Tatamoto, K.4
  • 14
    • 0001289623 scopus 로고
    • Receptors on pancreatic acinar cells
    • Johnson LR, Jacobson ED, Christensen J, Alpers DH, Walsh JH, editors, Third ed. New York: Raven Press
    • Jensen RT. Receptors on pancreatic acinar cells. In: Johnson LR, Jacobson ED, Christensen J, Alpers DH, Walsh JH, editors. Physiology of the gastrointestinal tract, vol.2, Third ed. New York: Raven Press; 1994. p. 377-446.
    • (1994) Physiology of the Gastrointestinal Tract , vol.2 , pp. 377-446
    • Jensen, R.T.1
  • 15
    • 41149176081 scopus 로고    scopus 로고
    • Mammalian bombesin receptors: Nomenclature, distribution, pharmacology, signaling and functions in normal and disease states
    • International Union of Pharmacology. LVIII
    • Jensen RT, Battey JF, Spindel ER, Benya RV. International Union of Pharmacology. LVIII. Mammalian bombesin receptors: nomenclature, distribution, pharmacology, signaling and functions in normal and disease states. Pharmacol Rev 2008; 60:1-42.
    • (2008) Pharmacol Rev , vol.60 , pp. 1-42
    • Jensen, R.T.1    Battey, J.F.2    Spindel, E.R.3    Benya, R.V.4
  • 17
    • 0037959899 scopus 로고
    • Interaction of bombesin and litorin with specific membrane receptors on pancreatic acinar cells
    • Jensen RT, Moody T, Pert C, Rivier JE, Gardner JD. Interaction of bombesin and litorin with specific membrane receptors on pancreatic acinar cells. Proc Natl Acad Sci USA 1978; 75:6139-6143
    • (1978) Proc Natl Acad Sci USA , vol.75 , pp. 6139-6143
    • Jensen, R.T.1    Moody, T.2    Pert, C.3    Rivier, J.E.4    Gardner, J.D.5
  • 18
    • 33751189441 scopus 로고    scopus 로고
    • Bombesin-related peptides and neurotensin: Effects on cancer growth/proliferation and cellular signaling in cancer
    • Kastin AJ, editor, Amsterdam: Elsevier
    • Jensen RT, Moody TW. Bombesin-related peptides and neurotensin: effects on cancer growth/proliferation and cellular signaling in cancer. In: Kastin AJ, editor. Handbook of biologically active peptides. Amsterdam: Elsevier; 2006. p. 429-434
    • (2006) Handbook of Biologically Active Peptides , pp. 429-434
    • Jensen, R.T.1    Moody, T.W.2
  • 20
    • 0031953613 scopus 로고    scopus 로고
    • Agonistic properties of alniditan, sumatriptan and dihydroergotamine on human 5-HT1B and 5-HT1D receptors expressed in various mammalian cell lines
    • Lesage AS, Wouters R, Van Gompel P, Heylen L, Vanhoenacker P, Haegeman G, et al. Agonistic properties of alniditan, sumatriptan and dihydroergotamine on human 5-HT1B and 5-HT1D receptors expressed in various mammalian cell lines. Br J Pharmacol 1998; 123:1655-1665
    • (1998) Br J Pharmacol , vol.123 , pp. 1655-1665
    • Lesage, A.S.1    Wouters, R.2    Van Gompel, P.3    Heylen, L.4    Vanhoenacker, P.5    Haegeman, G.6
  • 21
    • 0029116802 scopus 로고
    • Analysis of the role of receptor number in defining the intrinsic activity and potency of partial agonists in neuroblastoma×glioma hybrid NG108-15 cells transfected to express differing levels of the human β2-adrenoceptor
    • MacEwan DJ, Kim GD, Milligan G. Analysis of the role of receptor number in defining the intrinsic activity and potency of partial agonists in neuroblastoma×glioma hybrid NG108-15 cells transfected to express differing levels of the human β2-adrenoceptor. Mol Pharmacol 1995; 48:316-325
    • (1995) Mol Pharmacol , vol.48 , pp. 316-325
    • MacEwan, D.J.1    Kim, G.D.2    Milligan, G.3
  • 22
    • 0035958925 scopus 로고    scopus 로고
    • Bombesin and substance P analogues differentially regulate G-protein coupling to the bombesin receptor. Direct evidence for biased agonism
    • MacKinnon AC, Waters C, Jodrell D, Haslett C, Sethi T. Bombesin and substance P analogues differentially regulate G-protein coupling to the bombesin receptor. Direct evidence for biased agonism. J Biol Chem 2001; 276:28083-28091
    • (2001) J Biol Chem , vol.276 , pp. 28083-28091
    • MacKinnon, A.C.1    Waters, C.2    Jodrell, D.3    Haslett, C.4    Sethi, T.5
  • 23
    • 0027278689 scopus 로고
    • Characterization of bombesin receptors using a novel, potent, radiolabeled antagonist that distinguishes bombesin receptor subtypes
    • Mantey S, Frucht H, Coy DH, Jensen RT. Characterization of bombesin receptors using a novel, potent, radiolabeled antagonist that distinguishes bombesin receptor subtypes. Mol Pharmacol 1993; 45:762-774
    • (1993) Mol Pharmacol , vol.45 , pp. 762-774
    • Mantey, S.1    Frucht, H.2    Coy, D.H.3    Jensen, R.T.4
  • 24
    • 4243134905 scopus 로고    scopus 로고
    • Development of bombesin analogs with conformationally restricted amino acid substitutions with enhanced selectivity for the orphan receptor human bombesin receptor subtype 3
    • Mantey SA, Coy DH, Entsuah LK, Jensen RT. Development of bombesin analogs with conformationally restricted amino acid substitutions with enhanced selectivity for the orphan receptor human bombesin receptor subtype 3. J Pharmacol Exp Ther 2004; 310:1161-1170
    • (2004) J Pharmacol Exp Ther , vol.310 , pp. 1161-1170
    • Mantey, S.A.1    Coy, D.H.2    Entsuah, L.K.3    Jensen, R.T.4
  • 25
    • 0035937737 scopus 로고    scopus 로고
    • Rational design of a peptide agonist that interacts selectively with the orphan receptor, bombesin receptor subtype 3
    • Mantey SA, Coy DH, Pradhan TK, Igarashi H, Rizo IM, Shen L, et al. Rational design of a peptide agonist that interacts selectively with the orphan receptor, bombesin receptor subtype 3. J Biol Chem 2001; 276:9219-9229
    • (2001) J Biol Chem , vol.276 , pp. 9219-9229
    • Mantey, S.A.1    Coy, D.H.2    Pradhan, T.K.3    Igarashi, H.4    Rizo, I.M.5    Shen, L.6
  • 26
    • 33751162429 scopus 로고    scopus 로고
    • Identification of bombesin receptor subtype-specific ligands: Effect of N-methyl scanning, truncation, substitution, and evaluation of putative reported selective ligands
    • Mantey SA, Gonzalez N, Schumann M, Pradhan TK, Shen L, Coy DH, et al. Identification of bombesin receptor subtype-specific ligands: effect of N-methyl scanning, truncation, substitution, and evaluation of putative reported selective ligands. J Pharmacol Exp Ther 2006; 319:980-989
    • (2006) J Pharmacol Exp Ther , vol.319 , pp. 980-989
    • Mantey, S.A.1    Gonzalez, N.2    Schumann, M.3    Pradhan, T.K.4    Shen, L.5    Coy, D.H.6
  • 27
    • 0030867843 scopus 로고    scopus 로고
    • Discovery of a high affinity radioligand for thehumanorphan receptor, bombesin receptor subtype 3, which demonstrates it has a unique pharmacology compared to other mammalian bombesin receptors
    • Mantey SA, Weber HC, Sainz E, Akeson M, Ryan RR, Pradhan TK, et al. Discovery of a high affinity radioligand for thehumanorphan receptor, bombesin receptor subtype 3, which demonstrates it has a unique pharmacology compared to other mammalian bombesin receptors. J Biol Chem 1997; 272(41):26062-26071
    • (1997) J Biol Chem , vol.272 , Issue.41 , pp. 26062-26071
    • Mantey, S.A.1    Weber, H.C.2    Sainz, E.3    Akeson, M.4    Ryan, R.R.5    Pradhan, T.K.6
  • 29
    • 2542477191 scopus 로고    scopus 로고
    • Development of high affinity camptothecin-bombesin conjugates that have targeted cytotoxicity for bombesin receptor-containing tumor cells
    • Moody TW, Mantey SA, Pradhan TK, Schumann M, Nakagawa T, Martinez A, et al. Development of high affinity camptothecin-bombesin conjugates that have targeted cytotoxicity for bombesin receptor-containing tumor cells. J BiolChem 2004; 279:23580-23589
    • (2004) J BiolChem , vol.279 , pp. 23580-23589
    • Moody, T.W.1    Mantey, S.A.2    Pradhan, T.K.3    Schumann, M.4    Nakagawa, T.5    Martinez, A.6
  • 31
    • 0030662465 scopus 로고    scopus 로고
    • Mice lacking bombesin receptor subtype-3 develop metabolic defects and obesity
    • Ohki-Hamazaki H, Watase K, Yamamoto K, Ogura H, Yamano M, Yamada K, et al. Mice lacking bombesin receptor subtype-3 develop metabolic defects and obesity. Nature 1997; 390(6656):165-169
    • (1997) Nature , vol.390 , Issue.6656 , pp. 165-169
    • Ohki-Hamazaki, H.1    Watase, K.2    Yamamoto, K.3    Ogura, H.4    Yamano, M.5    Yamada, K.6
  • 32
    • 17444373890 scopus 로고    scopus 로고
    • Bombesin receptor subtype-3 is expressed by the enteric nervous system and by interstitial cells of cajal in the rat gastrointestinal tract
    • Porcher C, Juhem A, Peinnequin A, Bonaz B. Bombesin receptor subtype-3 is expressed by the enteric nervous system and by interstitial cells of Cajal in the rat gastrointestinal tract. Cell Tissue Res 2005; 320:21-31.
    • (2005) Cell Tissue Res , vol.320 , pp. 21-31
    • Porcher, C.1    Juhem, A.2    Peinnequin, A.3    Bonaz, B.4
  • 33
    • 0032545948 scopus 로고    scopus 로고
    • Identification of a unique ligand which has high affinity for all four bombesin receptor subtypes
    • Pradhan TK, Katsuno T, Taylor JE, Kim SH, Ryan RR, Mantey SA, et al. Identification of a unique ligand which has high affinity for all four bombesin receptor subtypes. Eur J Pharmacol 1998; 343:275-287
    • (1998) Eur J Pharmacol , vol.343 , pp. 275-287
    • Pradhan, T.K.1    Katsuno, T.2    Taylor, J.E.3    Kim, S.H.4    Ryan, R.R.5    Mantey, S.A.6
  • 34
    • 0036554956 scopus 로고    scopus 로고
    • Bombesin receptor subtypes in human cancers: Detection with the universal radoligand (125)I-[D-TYR(6), beta-ALA(11), PHE(13), NLE(14)] bombesin(6-14)
    • Reubi JC, Wenger S, Schumuckli-Maurer J, Schaer JC, Gugger M. Bombesin receptor subtypes in human cancers: detection with the universal radoligand (125)I-[D-TYR(6), beta-ALA(11), PHE(13), NLE(14)] bombesin(6-14). Clin Cancer Res 2002; 8:1139-1146
    • (2002) Clin Cancer Res , vol.8 , pp. 1139-1146
    • Reubi, J.C.1    Wenger, S.2    Schumuckli-Maurer, J.3    Schaer, J.C.4    Gugger, M.5
  • 36
    • 0036958270 scopus 로고    scopus 로고
    • Gastrointestinal peptide signalling in health and disease
    • Rozengurt E, Guha S, Sinnett-Smith J. Gastrointestinal peptide signalling in health and disease. Eur J Surg Suppl 2002:23-38.
    • (2002) Eur J Surg , Issue.SUPPL. , pp. 23-38
    • Rozengurt, E.1    Guha, S.2    Sinnett-Smith, J.3
  • 37
    • 0032577689 scopus 로고    scopus 로고
    • Ability of various bombesin receptor agonists and antagonists to alter intracellular signaling of the human orphan receptor BRS-3
    • Ryan RR, Weber HC, Hou W, Sainz E, Mantey SA, Battey JF, et al. Ability of various bombesin receptor agonists and antagonists to alter intracellular signaling of the human orphan receptor BRS-3. J Biol Chem 1998; 273:13613-13624
    • (1998) J Biol Chem , vol.273 , pp. 13613-13624
    • Ryan, R.R.1    Weber, H.C.2    Hou, W.3    Sainz, E.4    Mantey, S.A.5    Battey, J.F.6
  • 38
    • 0032455111 scopus 로고    scopus 로고
    • Pharmacology and intracellular signaling mechanisms of the native human orphan receptor BRS-3 in lung cancer cells
    • Ryan RR, Weber HC, Mantey SA, Hou W, Hilburger ME, Pradhan TK, et al. Pharmacology and intracellular signaling mechanisms of the native human orphan receptor BRS-3 in lung cancer cells. J Pharmacol Exp Ther 1998; 287:366-380
    • (1998) J Pharmacol Exp Ther , vol.287 , pp. 366-380
    • Ryan, R.R.1    Weber, H.C.2    Mantey, S.A.3    Hou, W.4    Hilburger, M.E.5    Pradhan, T.K.6
  • 39
    • 2942566069 scopus 로고    scopus 로고
    • Characterization of the bombesin-like peptide receptor family in primates
    • Sano H, Feighner SD, Hreniuk DL, Iwaasa H, Sailer AW, Pan J, et al. Characterization of the bombesin-like peptide receptor family in primates. Genomics 2004; 84:139-146
    • (2004) Genomics , vol.84 , pp. 139-146
    • Sano, H.1    Feighner, S.D.2    Hreniuk, D.L.3    Iwaasa, H.4    Sailer, A.W.5    Pan, J.6
  • 40
    • 33748987928 scopus 로고    scopus 로고
    • Immunohistochemical detection of bombesin receptor subtypes GRP-R and BRS-3 in human tumors using novel antipeptide antibodies
    • Schulz S, Rocken C, Schulz S. Immunohistochemical detection of bombesin receptor subtypes GRP-R and BRS-3 in human tumors using novel antipeptide antibodies. Virchows Arch 2006; 449:421-427
    • (2006) Virchows Arch , vol.449 , pp. 421-427
    • Schulz, S.1    Rocken, C.2    Schulz, S.3
  • 42
    • 33745003894 scopus 로고    scopus 로고
    • Wound repair and proliferation of bronchial epithelial cells enhanced by bombesin receptor subtype 3 activation
    • Tan YR, Qi MM, Qin XQ, Xiang Y, Li X, Wang Y, et al. Wound repair and proliferation of bronchial epithelial cells enhanced by bombesin receptor subtype 3 activation. Peptides 2006; 27:1852-1858
    • (2006) Peptides , vol.27 , pp. 1852-1858
    • Tan, Y.R.1    Qi, M.M.2    Qin, X.Q.3    Xiang, Y.4    Li, X.5    Wang, Y.6
  • 43
    • 34347209763 scopus 로고    scopus 로고
    • PPARalpha and AP-2alpha regulate bombesin receptor subtype 3 expression in ozone-stressed bronchial epithelial cells
    • Tan YR, Qin XQ, Xiang Y, Yang T, Qu F, Wang Y, et al. PPARalpha and AP-2alpha regulate bombesin receptor subtype 3 expression in ozone-stressed bronchial epithelial cells. Biochem J 2007.
    • (2007) Biochem J
    • Tan, Y.R.1    Qin, X.Q.2    Xiang, Y.3    Yang, T.4    Qu, F.5    Wang, Y.6
  • 44
    • 85047680820 scopus 로고    scopus 로고
    • The human V3 pituitary vasopressin receptor: Ligand binding profile and densitydependent signaling pathways
    • Thibonnier M, Preston JA, Dulin N, Wilkins PL, Berti-Mattera LN, Mattera R. The human V3 pituitary vasopressin receptor: ligand binding profile and densitydependent signaling pathways. Endocrinology 1997; 138:4109-4122
    • (1997) Endocrinology , vol.138 , pp. 4109-4122
    • Thibonnier, M.1    Preston, J.A.2    Dulin, N.3    Wilkins, P.L.4    Berti-Mattera, L.N.5    Mattera, R.6
  • 45
    • 28144441410 scopus 로고    scopus 로고
    • 2+- and PKC-independent mechanism which is partially mediated by the small GTP-binding protein rho
    • Ref Type: Abstract
    • 2+- and PKC-independent mechanism which is partially mediated by the small GTP-binding protein rho. Gastroenterology 1996; 110(A1127). Ref Type: Abstract.
    • (1996) Gastroenterology , vol.110
    • Tsuda, T.1    Jensen, R.T.2
  • 46
    • 0030957917 scopus 로고    scopus 로고
    • Effect of gastrinreleasing peptide receptor number on receptor affinity, coupling, degradation and receptor modulation
    • Tsuda T, Kusui T, Hou W, Benya RV, Akeson MA, Kroog GS, et al. Effect of gastrinreleasing peptide receptor number on receptor affinity, coupling, degradation and receptor modulation. Mol Pharmacol 1997; 51(5):721-732
    • (1997) Mol Pharmacol , vol.51 , Issue.5 , pp. 721-732
    • Tsuda, T.1    Kusui, T.2    Hou, W.3    Benya, R.V.4    Akeson, M.A.5    Kroog, G.S.6
  • 47
    • 0027964870 scopus 로고
    • Molecular cloning and characterization of protein kinase D: A target for diacylglycerol and phorbol esters with a distinctive catalytic domain
    • Valverde AM, Sinnett-Smith J, Van Lint J, Rozengurt E. Molecular cloning and characterization of protein kinase D: a target for diacylglycerol and phorbol esters with a distinctive catalytic domain. Proc Natl Acad Sci USA 1994; 91:8572-8576
    • (1994) Proc Natl Acad Sci USA , vol.91 , pp. 8572-8576
    • Valverde, A.M.1    Sinnett-Smith, J.2    Van Lint, J.3    Rozengurt, E.4
  • 49
    • 0025484209 scopus 로고
    • Gastrinreleasing peptide mRNAs are differentially distributed in the rat nervous system
    • Wada E, Way J, Lebacq-Verheyden AM, Battey JF. Neuromedin B and gastrinreleasing peptide mRNAs are differentially distributed in the rat nervous system. J Neurosci 1990; 10:2917-2930
    • (1990) J Neurosci , vol.10 , pp. 2917-2930
    • Wada, E.1    Way, J.2    Lebacq-Verheyden, A.M.3    Battey, J.F.4    Neuromedin, B.5
  • 50
    • 0035980125 scopus 로고    scopus 로고
    • Activation loop Ser744 and Ser748 in protein kinase D are transphosphorylated in vivo
    • Waldron RT, Rey O, Iglesias T, Tugal T, Cantrell D, Rozengurt E. Activation loop Ser744 and Ser748 in protein kinase D are transphosphorylated in vivo. J Biol Chem 2001; 276:32606-32615
    • (2001) J Biol Chem , vol.276 , pp. 32606-32615
    • Waldron, R.T.1    Rey, O.2    Iglesias, T.3    Tugal, T.4    Cantrell, D.5    Rozengurt, E.6
  • 51
    • 0025021426 scopus 로고
    • Desmethionine alkylamide bombesin analogues: A new class of bombesin receptor antagonists with a potent antisecretory activity in pancreatic acini and antimitotic activity in Swiss 3T3 cells
    • Wang LH, Coy DH, Taylor JE, Jiang NY, Kim SH, Moreau JP, et al. Desmethionine alkylamide bombesin analogues: a new class of bombesin receptor antagonists with a potent antisecretory activity in pancreatic acini and antimitotic activity in Swiss 3T3 cells. Biochemistry (Mosc) 1990; 29(3):616-622
    • (1990) Biochemistry (Mosc) , vol.29 , Issue.3 , pp. 616-622
    • Wang, L.H.1    Coy, D.H.2    Taylor, J.E.3    Jiang, N.Y.4    Kim, S.H.5    Moreau, J.P.6
  • 52
    • 0025063157 scopus 로고
    • Des-Met carboxyl-terminally modified analogues of bombesin function as potent bombesin receptor antagonists, partial agonists, or agonists
    • Wang LH, Coy DH, Taylor JE, Jiang NY, Moreau JP, Huang SC, et al. Des-Met carboxyl-terminally modified analogues of bombesin function as potent bombesin receptor antagonists, partial agonists, or agonists. J Biol Chem 1990; 265(26):15695-15703
    • (1990) J Biol Chem , vol.265 , Issue.26 , pp. 15695-15703
    • Wang, L.H.1    Coy, D.H.2    Taylor, J.E.3    Jiang, N.Y.4    Moreau, J.P.5    Huang, S.C.6
  • 53
    • 35348968418 scopus 로고    scopus 로고
    • BRS-3 activation transforms the effect of human bronchial epithelial cells from PGE2 mediated inhibition to TGF-beta1 dependent promotion on proliferation and collagen synthesis of lung fibroblasts
    • Wang Y, Zhang M, Tan Y, Xiang Y, Liu H, Qu F, et al. BRS-3 activation transforms the effect of human bronchial epithelial cells from PGE2 mediated inhibition to TGF-beta1 dependent promotion on proliferation and collagen synthesis of lung fibroblasts. Cell Biol Int 2007; 31:1495-1500
    • (2007) Cell Biol Int , vol.31 , pp. 1495-1500
    • Wang, Y.1    Zhang, M.2    Tan, Y.3    Xiang, Y.4    Liu, H.5    Qu, F.6
  • 54
    • 0038754759 scopus 로고    scopus 로고
    • Design of selective peptidomimetic agonists for the human orphan receptor BRS-3
    • Weber D, Berger C, Eickelmann P, Antel J, Kessler H. Design of selective peptidomimetic agonists for the human orphan receptor BRS-3. J Med Chem 2003; 46:1918-1930
    • (2003) J Med Chem , vol.46 , pp. 1918-1930
    • Weber, D.1    Berger, C.2    Eickelmann, P.3    Antel, J.4    Kessler, H.5
  • 55
    • 0035993847 scopus 로고    scopus 로고
    • Systematic optimization of a lead-structure identities for a selective short peptide agonist for the human orphan receptor BRS-3
    • Weber D, Berger C, Heinrich T, Eickelmann P, Antel J, Kessler H. Systematic optimization of a lead-structure identities for a selective short peptide agonist for the human orphan receptor BRS-3. J Pept Sci 2002; 8:461-475
    • (2002) J Pept Sci , vol.8 , pp. 461-475
    • Weber, D.1    Berger, C.2    Heinrich, T.3    Eickelmann, P.4    Antel, J.5    Kessler, H.6
  • 56
    • 58849153281 scopus 로고    scopus 로고
    • Regulation and signaling of human bombesin receptors and their biological effects
    • Weber HC. Regulation and signaling of human bombesin receptors and their biological effects. Curr Opin Endocrinol Diabetes Obes 2009; 16:66-71.
    • (2009) Curr Opin Endocrinol Diabetes Obes , vol.16 , pp. 66-71
    • Weber, H.C.1
  • 57
    • 0035910373 scopus 로고    scopus 로고
    • A bombesin receptor subtype-3 peptide increases nuclear oncogene expression in a MEK-1 dependent manner in human lung cancer cells
    • Weber HC, Walters J, Leyton J, Casibang M, Purdom S, Jensen RT, et al. A bombesin receptor subtype-3 peptide increases nuclear oncogene expression in a MEK-1 dependent manner in human lung cancer cells. Eur J Pharmacol 2001; 412:13-20.
    • (2001) Eur J Pharmacol , vol.412 , pp. 13-20
    • Weber, H.C.1    Walters, J.2    Leyton, J.3    Casibang, M.4    Purdom, S.5    Jens6
  • 58
    • 0028098167 scopus 로고
    • Bombesin receptors in a human duodenal tumor cell line: Binding properties and function
    • Williams BY, Schonbrunn A. Bombesin receptors in a human duodenal tumor cell line: binding properties and function. Cancer Res 1994; 54(3):818-824
    • (1994) Cancer Res , vol.54 , Issue.3 , pp. 818-824
    • Williams, B.Y.1    Schonbrunn, A.2
  • 59
    • 0028956089 scopus 로고
    • Differential activation of human gastrinreleasing peptide receptor-mediated responses by bombesin analogs
    • Wu JM, Hoang DO, Feldman RI. Differential activation of human gastrinreleasing peptide receptor-mediated responses by bombesin analogs. Mol Pharmacol 1995; 47(4):871-881
    • (1995) Mol Pharmacol , vol.47 , Issue.4 , pp. 871-881
    • Wu, J.M.1    Hoang, D.O.2    Feldman, R.I.3
  • 60
    • 0029807965 scopus 로고    scopus 로고
    • Discovery of high affinity bombesin receptor subtype 3 agonists
    • Wu JM, Nitecki DE, Biancalana S, Feldman RI. Discovery of high affinity bombesin receptor subtype 3 agonists. Mol Pharmacol 1996; 50(5):1355-1363
    • (1996) Mol Pharmacol , vol.50 , Issue.5 , pp. 1355-1363
    • Wu, J.M.1    Nitecki, D.E.2    Biancalana, S.3    Feldman, R.I.4
  • 61
    • 0034011010 scopus 로고    scopus 로고
    • Differential effects of social isolation upon body weight, food consumption, and responsiveness to novel and social environment in bombesin receptor subtype-3 (BRS-3) deficient mice
    • Yamada K, Ohki-Hamazaki H, Wada K. Differential effects of social isolation upon body weight, food consumption, and responsiveness to novel and social environment in bombesin receptor subtype-3 (BRS-3) deficient mice. Physiol Behav 2000; 68:555-561
    • (2000) Physiol Behav , vol.68 , pp. 555-561
    • Yamada, K.1    Ohki-Hamazaki, H.2    Wada, K.3
  • 62
    • 0036150790 scopus 로고    scopus 로고
    • Role of bombesin (BN)-like peptides/receptors in emotional behavior by comparison of three strains of BN-like peptide receptor knockout mice
    • Yamada K, Santo-Yamada Y, Wada E, Wada K. Role of bombesin (BN)-like peptides/receptors in emotional behavior by comparison of three strains of BN-like peptide receptor knockout mice. Mol Psychiatry 2002; 7(113-7):6.
    • (2002) Mol Psychiatry , vol.7 , Issue.113-117 , pp. 6
    • Yamada, K.1    Santo-Yamada, Y.2    Wada, E.3    Wada, K.4
  • 63
    • 0033013213 scopus 로고    scopus 로고
    • Hyperresponsiveness to palatable and aversive taste stimuli in genetically obese (bombesin receptor subtype-3-deficient) mice
    • Yamada K, Wada E, Imaki J, Ohki-Hamazaki H, Wada K. Hyperresponsiveness to palatable and aversive taste stimuli in genetically obese (bombesin receptor subtype-3-deficient) mice. Physiol Behav 1999; 66:863-867
    • (1999) Physiol Behav , vol.66 , pp. 863-867
    • Yamada, K.1    Wada, E.2    Imaki, J.3    Ohki-Hamazaki, H.4    Wada, K.5
  • 64
    • 67949109456 scopus 로고    scopus 로고
    • Pharmacological characterization of a selective agonist for bombesin receptor subtype-3
    • Zhang L, Nothacker HP, Wang Z, Bohn LM, Civelli O. Pharmacological characterization of a selective agonist for bombesin receptor subtype-3. Biochem Biophys Res Commun 2009; 387:283-288
    • (2009) Biochem Biophys Res Commun , vol.387 , pp. 283-288
    • Zhang, L.1    Nothacker, H.P.2    Wang, Z.3    Bohn, L.M.4    Civelli, O.5


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