Bombesin and substance P analogues differentially regulate G-protein coupling to the bombesin receptor: Direct evidence for biased agonism

Journal of Biological Chemistry

Volumn 276, Issue 30, 2001, Pages 28083-28091

  MacKinnon, Alison C ^a   Waters, Catherine ^a   Jodrell, Duncan ^a,b   Haslett, Christopher ^a   Sethi, Tariq ^a  

^a UNIVERSITY OF EDINBURGH   (United Kingdom)

^b WESTERN GENERAL HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CELLS; DRUG PRODUCTS; ENZYME INHIBITION; GROWTH KINETICS; ONCOLOGY; PHYSIOLOGY;

SIGNAL TRANSDUCTION;

ENZYMES;

ANTINEOPLASTIC AGENT; BOMBESIN; BOMBESIN RECEPTOR; CALCIUM ION; EPIDERMAL GROWTH FACTOR RECEPTOR; GASTRIN RELEASING PEPTIDE RECEPTOR; GUANINE NUCLEOTIDE BINDING PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; NEUROPEPTIDE; PERTUSSIS TOXIN; RECEPTOR; STRESS ACTIVATED PROTEIN KINASE; SUBSTANCE P [1 DEXTRO ARGININE 5 DEXTRO PHENYLALANINE 7,9 DEXTRO TRYPTOPHAN 11 LEUCINE]; SUBSTANCE P DERIVATIVE; UNCLASSIFIED DRUG; 4 (3 CHLOROANILINO) 6,7 DIMETHOXYQUINAZOLINE; BORDETELLA VIRULENCE FACTOR; CALCIUM; DRUG DERIVATIVE; ENZYME INHIBITOR; LIGAND; SUBSTANCE P; TYRPHOSTIN;

AGONIST; ANIMAL CELL; ARTICLE; BINDING SITE; CALCIUM CELL LEVEL; CANCER INHIBITION; CONTROLLED STUDY; DRUG DESIGN; DRUG RECEPTOR BINDING; DRUG SELECTIVITY; ENZYME ACTIVATION; LUNG SMALL CELL CANCER; MITOGENESIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RAT; RECEPTOR SENSITIVITY; SIGNAL TRANSDUCTION; ANIMAL; BAGG ALBINO MOUSE; CELL CULTURE; CELL LINE; CELL STRAIN 3T3; CELL STRAIN COS1; CHEMISTRY; DOMINANT GENE; DOSE RESPONSE; HUMAN; METABOLISM; MOUSE; PHOSPHORYLATION; PROTEIN BINDING; THEORETICAL MODEL; TIME; WESTERN BLOTTING;

ANIMALIA;

3T3 CELLS; ANIMALS; BINDING SITES; BLOTTING, WESTERN; BOMBESIN; CALCIUM; CELL LINE; COS CELLS; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME ACTIVATION; ENZYME INHIBITORS; GENES, DOMINANT; GTP-BINDING PROTEINS; HUMANS; LIGANDS; MICE; MICE, INBRED BALB C; MITOGEN-ACTIVATED PROTEIN KINASES; MODELS, THEORETICAL; PERTUSSIS TOXIN; PHOSPHORYLATION; PROTEIN BINDING; RATS; RECEPTORS, BOMBESIN; SIGNAL TRANSDUCTION; SUBSTANCE P; TIME FACTORS; TUMOR CELLS, CULTURED; TYRPHOSTINS; VIRULENCE FACTORS, BORDETELLA;

EID: 0035958925     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M009772200     Document Type: Article

References (52)

1. Rozengurt, E. (1998) Am. J. Physiol. 275, G177-G182
2. Moody, T. W., and Cuttitta, F. (1993) Life Sci. 52, 1161-1173
3. Wang, Q. J., Knezetic, J. A., Schally, A. V., Pour, P. M., and Adrian, T. E. (1996) Int. J. Cancer. 68, 528-534
4. Moody, T. W., Pert, C. B., Gazdar, A. F., Carney, D. N., and Minna, J. D. (1981) Science 214, 1246-1248
5. Cuttitta, F., Carney, J., Mulshine, J., Moody, T. W., Fedorko, J., Fischler, A., and Minna, J. D. (1985) Nature 316, 823-826
6. Sethi, T., and Rozengurt, E. (1991) Cancer Res. 51, 3621-3623
7. Sethi, T., Langdon, S. P., Smyth, J. S., and Rozengurt, E. (1992) Cancer Res. 52, (suppl.) 2737-2742
8. Offermans, S., Heiler, E., Spicher, K., and Schultz, G. (1994) FEBS Lett. 349, 201-204
9. Jian, X., Sainz, E., Clark, W. A., Jensen, R. T., Battey, J. K., and Northup, J. K. (1999) J. Biol. Chem. 274, 11573-11581
10. Charlesworth, A., Broad, S., and Rozengurt, E. (1996) Oncogene 12, 1337-1345
11. Ridley, A. J., and Hall, A. (1992) Cell 70, 389-399
12. Buhl, A. M., Johnson, N. L., Dhanasekaran, N., and Johnson, G. L. (1995) J. Biol. Chem. 270, 24631-24634
13. Needham, L. K., and Rozengurt, E. (1998) J. Biol. Chem. 273, 14626-14632
14. Gohla, A., Offermanns, S., Wilkie, T. M., and Schultz, G. (1999) J. Biol. Chem. 274, 17901-17907
15. Rozengurt, E., and Sinnet-Smith, J. (1988) Prog. Nucleic Acid Res. Mol. Biol. 35, 261-295
16. Slice, L., Walsh, J. H., and Rozengurt, E. (1999) J. Biol. Chem. 274, 27562-27566
17. Seckl, M. J., Newman, R. H., Freemont, P. S., and Rozengurt, E. (1995) J. Cell. Physiol. 163, 87-95
18. Seckl, M. J., Higgins, T., and Rozengurt, E. (1996) J. Biol. Chem. 271, 29453-29460
19. Seckl, M. J., Higgins, T., Widmer, F., and Rozengurt, E. (1997) Cancer Res. 57, 51-54
20. Woll, P. J., and Rozengurt, E. (1988) Proc. Nat. Acad. Sci. U. S. A. 85, 1859-1863
21. MacKinnon, A. C., Armstrong, R. A., Waters, C., Cummings, J., Smyth, J. F., Haslett, C., and Sethi, T. (1999) Br. J. Cancer 80, 1026-1034
22. Reeve, J. G., and Bleehen, N. M. (1994) Biochem. Biophys. Res. Commun. 199, 1313-1319
23. MacKinnon, A. C., Waters, C., Rahman, I., Harani, N., Rintoul, R., Haslett, C., and Sethi, T. (2000) Br. J. Cancer 83, 941-948
24. Jarpe, M. B., Knall, C., Mitchell, F. M., Buhl, A., Duzic, E., and Johnson, G. L. (1998) J. Biol. Chem. 273, 3097-3104
25. Mitchell, F. M., Heasley, L. E., Qian, N. X., Zamarripa, J., and Johnson, G. L. (1995) J. Biol. Chem. 270, 8623-8628
26. Kenakin, T. (1995) Trends. Pharmacol. Sci. 16, 232-238
27. Berg, K. A., Maayani, S., Goldfarb, J., Scaramellini, C., Leff, P., and Clarke, W. P. (1998) Mol. Pharmacol. 54, 94-104
28. Sinnett-Smith, J., Santiskulvong, C., Duque, J., and Rozengurt, E.(2000) J. Biol. Chem. 275, 30644-30652
29. Tsien, R. Y., Pozzan, T., and Rink, T. J. (1992) Nature 295, 68-71
30. Scatchard, G. (1949) Ann. N. Y. Acad. Sci. 51, 660-666
31. Cheng, Y. C., and Prusoff, W. H. (1973) Biochem. Pharmacol. 22, 3099-3108
32. Koppan, M., Halmos, G., Arencibia, J. M., Lamharzi, N., and Schally, A. V. (1998) Cancer 83, 1335-1343
33. Akeson, M., Sainz, E., Mantey, S. A., Jensen, R. T., and Battey, J. F. (1997) J. Biol. Chem. 272, 17405-17409
34. Donohue, P. J., Sainz, E., Akeson, M., Kroog, G. S., Mantey, S. A., Battey, J. F., Jensen, R. T., and Northup, J. K. (1999) Biochemistry 38, 9366-9372
35. Tsuda, T., Kusui, T., Hou, W., Benya, R. V., Akeson, M. A., Kroog, G. S., Battey, J. F., and Jensen, R. T. (1997) Mol. Pharmacol. 51, 721-732
36. Collins, L. R., Minden, A., Karin, M., and Brown, J. H. (1996) J. Biol. Chem. 271, 17349-17353
37. Prasad, M. V., Dermott, J. M., Heasley, L. E., Johnson, G. L., and Dhanasekaran, N. (1995) J. Biol. Chem. 270, 18655-18659
38. Gohla, A., Schultz, G., and Offermanns, S. (2000) Circ. Res. 87, 221-227
39. Luttrell, L. M., Daaka, Y., Della Rocca, G. J., and Leikowitz, R. J. (1997) J. Biol. Chem. 272, 31648-31656
40. Charlesworth, A., and Rozengurt, E. (1997) Oncogene 14, 2323-2329
41. Della Rocca, G. J., Maudsley, S., Daaka, Y., Lefkowitz, R. J., and Luttrell, L. M. (1999) J. Biol. Chem. 274, 13978-13984
42. Kelley, M. J., Linnoila, R. I., Avis, I. L., Georgiadis, M. S., Cuttitta, F., Mulshine, J. L., and Johnson, B. E. (1997) Chest 112, 256-261
43. Zachary, I., Sinnett-Smith, J. W., and Rozengurt, E. (1986) J. Cell Biol. 102, 2211-2222
44. Hawes, B. E., Luttrel, L. M., van Biesen, T., and Lefkowitz, R. J. (1996) J. Biol. Chem. 271, 12133-12136
45. Hedin, K. E., Bell, M. P., Huntoon, C. J., Karnitz, L. M., and McKean, D. J. (1999) J. Biol. Chem. 274, 19992-20001
46. Kozasa, T., and Gilman, A. G. (1995) J. Biol. Chem. 270, 1734-1741
47. Watson, C., Chen, G., Irving, P., Way, J., Chen, W., and Kenakin, T. (2000) Mol. Pharmacol. 58, 1230-1238
48. Perez, D. M., Hwa, J., Gaivin, R., Mather, M., Brown, F., and Graham, R. M. (1996) Mol. Pharmacol. 49, 112-122
49. Shyu, J. F., Inove, D., Baron, R., and Horne, W. C. (1996) J. Biol. Chem. 271, 31127-31134
50. Kosugi, S., Okajima, F., Ban, T., Hidaka, A., Shenker, A., and Kohn, L. D. (1992) J. Biol. Chem. 267, 24153-24156
51. Gether, U., Ballesteros, J. A., Seifert, R., Sanders-Bush, E., Weinstein, H., and Kobilka, B. K. (1997) J. Biol. Chem. 272, 2587-2590
52. Weiss, J. M. Morgan, P. H., Lutz, M. W., and Kenakin, T. P. (1996) J. Theor. Biol. 178, 151-167