-
1
-
-
41149176081
-
-
Jensen RT, Battey JF, Spindel ER, Benya RV. International Union of Pharmacology. LXVIII. Mammalian bombesin receptors: nomenclature, distribution, pharmacology, signaling, and functions in normal and disease states. Pharmacol Rev 2008; 60:1-42. Outstanding comprehensive review of the pharmacology, biology and nomenclature of mammalian bombesin receptors.
-
Jensen RT, Battey JF, Spindel ER, Benya RV. International Union of Pharmacology. LXVIII. Mammalian bombesin receptors: nomenclature, distribution, pharmacology, signaling, and functions in normal and disease states. Pharmacol Rev 2008; 60:1-42. Outstanding comprehensive review of the pharmacology, biology and nomenclature of mammalian bombesin receptors.
-
-
-
-
2
-
-
34547726181
-
-
Sun YG, Chen ZF. A gastrin-releasing peptide receptor mediates the itch sensation in the spinal cord. Nature 2007; 448:700-703. Novel function of GRP as an itch-specific mediator. Chronic itch represents a widespread clinical condition.
-
Sun YG, Chen ZF. A gastrin-releasing peptide receptor mediates the itch sensation in the spinal cord. Nature 2007; 448:700-703. Novel function of GRP as an itch-specific mediator. Chronic itch represents a widespread clinical condition.
-
-
-
-
3
-
-
44349107810
-
Sexually dimorphic gastrin releasing peptide system in the spinal cord controls male reproductive functions
-
This study demonstrates the importance of GRP neurons in the lower spinal cord for penile reflexes
-
Sakamoto H, Matsuda K, Zuloaga DG, et al. Sexually dimorphic gastrin releasing peptide system in the spinal cord controls male reproductive functions. Nat Neurosci 2008; 11:634-636. This study demonstrates the importance of GRP neurons in the lower spinal cord for penile reflexes.
-
(2008)
Nat Neurosci
, vol.11
, pp. 634-636
-
-
Sakamoto, H.1
Matsuda, K.2
Zuloaga, D.G.3
-
4
-
-
0025964088
-
Molecular cloning of the bombesin/ gastrin-releasing peptide receptor from Swiss 3T3 cells
-
Battey JF, Way JM, Corjay MH, et al. Molecular cloning of the bombesin/ gastrin-releasing peptide receptor from Swiss 3T3 cells. Proc Natl Acad Sci U S A 1991; 88:395-399.
-
(1991)
Proc Natl Acad Sci U S A
, vol.88
, pp. 395-399
-
-
Battey, J.F.1
Way, J.M.2
Corjay, M.H.3
-
5
-
-
0026094281
-
Two distinct bombesin receptor subtypes are expressed and functional in human lung carcinoma cells
-
Corjay MH, Dobrzanski DJ, Way JM, et al. Two distinct bombesin receptor subtypes are expressed and functional in human lung carcinoma cells. J Biol Chem 1991; 266:18771-18779.
-
(1991)
J Biol Chem
, vol.266
, pp. 18771-18779
-
-
Corjay, M.H.1
Dobrzanski, D.J.2
Way, J.M.3
-
6
-
-
0025606853
-
Cloning and functional characterization of a complementary DNA encoding the murine fibroblast bombesin/gastrin-releasing peptide receptor
-
Spindel ER, Giladi E, Brehm P, et al. Cloning and functional characterization of a complementary DNA encoding the murine fibroblast bombesin/gastrin-releasing peptide receptor. Mol Endocrinol 1990; 4:1956-1963.
-
(1990)
Mol Endocrinol
, vol.4
, pp. 1956-1963
-
-
Spindel, E.R.1
Giladi, E.2
Brehm, P.3
-
7
-
-
0037118711
-
Molecular basis of the pharmacological difference between rat and human bombesin receptor subtype-3 (BRS-3)
-
Liu J, Lao ZJ, Zhang J, et al. Molecular basis of the pharmacological difference between rat and human bombesin receptor subtype-3 (BRS-3). Biochemistry 2002; 41:8954-8960.
-
(2002)
Biochemistry
, vol.41
, pp. 8954-8960
-
-
Liu, J.1
Lao, Z.J.2
Zhang, J.3
-
8
-
-
0026032388
-
cDNA cloning, characterization, and brain region-specific expression of a neuromedin-B-preferring bombesin receptor
-
Wada E, Way J, Shapira H, et al. cDNA cloning, characterization, and brain region-specific expression of a neuromedin-B-preferring bombesin receptor. Neuron 1991; 6:421-430.
-
(1991)
Neuron
, vol.6
, pp. 421-430
-
-
Wada, E.1
Way, J.2
Shapira, H.3
-
9
-
-
0030662465
-
Mice lacking bombesin receptor subtype-3 develop metabolic defects and obesity
-
Ohki-Hamazaki H, Watase K, Yamamoto K, et al. Mice lacking bombesin receptor subtype-3 develop metabolic defects and obesity. Nature 1997; 390:165-169.
-
(1997)
Nature
, vol.390
, pp. 165-169
-
-
Ohki-Hamazaki, H.1
Watase, K.2
Yamamoto, K.3
-
10
-
-
0032574666
-
Structure and chromosomal localization of the mouse bombesin receptor subtype 3 gene
-
Weber HC, Hampton LL, Jensen RT, Battey JF. Structure and chromosomal localization of the mouse bombesin receptor subtype 3 gene. Gene 1998; 211:125-131.
-
(1998)
Gene
, vol.211
, pp. 125-131
-
-
Weber, H.C.1
Hampton, L.L.2
Jensen, R.T.3
Battey, J.F.4
-
11
-
-
0033974466
-
Molecular organization of the mouse gastrin-releasing peptide receptor gene and its promoter
-
Weber HC, Jensen RT, Battey JF. Molecular organization of the mouse gastrin-releasing peptide receptor gene and its promoter. Gene 2000; 244:137-149.
-
(2000)
Gene
, vol.244
, pp. 137-149
-
-
Weber, H.C.1
Jensen, R.T.2
Battey, J.F.3
-
12
-
-
0035819547
-
The human gastrin-releasing peptide receptor gene structure, its tissue expression and promoter
-
Xiao D, Wang J, Hampton LL, Weber HC. The human gastrin-releasing peptide receptor gene structure, its tissue expression and promoter. Gene 2001; 264:95-103.
-
(2001)
Gene
, vol.264
, pp. 95-103
-
-
Xiao, D.1
Wang, J.2
Hampton, L.L.3
Weber, H.C.4
-
13
-
-
0028273910
-
Organization and chromosomal localization of the gene for the human bombesin receptor subtype expressed in pregnant uterus
-
Gorbulev V, Akhundova A, Grzeschik KH, Fahrenholz F. Organization and chromosomal localization of the gene for the human bombesin receptor subtype expressed in pregnant uterus. FEBS Lett 1994; 340:260-264.
-
(1994)
FEBS Lett
, vol.340
, pp. 260-264
-
-
Gorbulev, V.1
Akhundova, A.2
Grzeschik, K.H.3
Fahrenholz, F.4
-
14
-
-
0027291712
-
Comparative mapping of the Grpr locus on the X chromosomes of man and mouse
-
Maslen GL, Boyd Y. Comparative mapping of the Grpr locus on the X chromosomes of man and mouse. Genomics 1993; 17:106-109.
-
(1993)
Genomics
, vol.17
, pp. 106-109
-
-
Maslen, G.L.1
Boyd, Y.2
-
15
-
-
3042820502
-
Transcriptional activation of the human gastrin-releasing peptide receptor gene in gastrointestinal and prostatic epithelial cancer cells
-
Qu X, Xiao D, Weber HC. Transcriptional activation of the human gastrin-releasing peptide receptor gene in gastrointestinal and prostatic epithelial cancer cells. J Mol Neurosci 2004; 22:75-82.
-
(2004)
J Mol Neurosci
, vol.22
, pp. 75-82
-
-
Qu, X.1
Xiao, D.2
Weber, H.C.3
-
16
-
-
3843078730
-
Ets transcriptional regulation of gastrin-releasing peptide receptor in neuroblastomas
-
Qiao J, Cree J, Kang J, et al. Ets transcriptional regulation of gastrin-releasing peptide receptor in neuroblastomas. Surgery 2004; 136:489-494.
-
(2004)
Surgery
, vol.136
, pp. 489-494
-
-
Qiao, J.1
Cree, J.2
Kang, J.3
-
17
-
-
51149106158
-
-
Chinnappan D, Qu X, Xiao D, et al. Human gastrin-releasing peptide receptor gene regulation requires transcription factor binding at two distinct CRE sites. Am J Physiol Gastrointest Liver Physiol 2008; 295:G153-G162. This is the first report to delineate the regulation of the human GRP-R gene by cAMP-dependent signaling pathways. Transcription factors CREB and ATF-1 bind to the human GRP-R promoter and upregulate expression.
-
Chinnappan D, Qu X, Xiao D, et al. Human gastrin-releasing peptide receptor gene regulation requires transcription factor binding at two distinct CRE sites. Am J Physiol Gastrointest Liver Physiol 2008; 295:G153-G162. This is the first report to delineate the regulation of the human GRP-R gene by cAMP-dependent signaling pathways. Transcription factors CREB and ATF-1 bind to the human GRP-R promoter and upregulate expression.
-
-
-
-
18
-
-
0037074018
-
Identification of a signaling network in lateral nucleus of amygdala important for inhibiting memory specifically related to learned fear
-
Shumyatsky GP, Tsvetkov E, Malleret G, et al. Identification of a signaling network in lateral nucleus of amygdala important for inhibiting memory specifically related to learned fear. Cell 2002; 111:905-918.
-
(2002)
Cell
, vol.111
, pp. 905-918
-
-
Shumyatsky, G.P.1
Tsvetkov, E.2
Malleret, G.3
-
19
-
-
34250786168
-
The gastrin-releasing peptide receptor as a therapeutic target in central nervous system disorders
-
Roesler R, Kapczinski F, Quevedo J, et al. The gastrin-releasing peptide receptor as a therapeutic target in central nervous system disorders. Recent Patents CNS Drug Discov 2007; 2:125-129.
-
(2007)
Recent Patents CNS Drug Discov
, vol.2
, pp. 125-129
-
-
Roesler, R.1
Kapczinski, F.2
Quevedo, J.3
-
20
-
-
33746261366
-
Molecular mechanisms mediating gastrin-releasing peptide receptor modulation of memory consolidation in the hippocampus
-
Roesler R, Luft T, Oliveira SH, et al. Molecular mechanisms mediating gastrin-releasing peptide receptor modulation of memory consolidation in the hippocampus. Neuropharmacology 2006; 51:350-357.
-
(2006)
Neuropharmacology
, vol.51
, pp. 350-357
-
-
Roesler, R.1
Luft, T.2
Oliveira, S.H.3
-
21
-
-
33846924787
-
Impairments of social behavior and memory after neonatal gastrin-releasing peptide receptor blockade in rats: Implications for an animal model of neurodevelopmental disorders
-
Presti-Torres J, de Lima MN, Scalco FS, et al. Impairments of social behavior and memory after neonatal gastrin-releasing peptide receptor blockade in rats: Implications for an animal model of neurodevelopmental disorders. Neuropharmacology 2007; 52:724-732.
-
(2007)
Neuropharmacology
, vol.52
, pp. 724-732
-
-
Presti-Torres, J.1
de Lima, M.N.2
Scalco, F.S.3
-
22
-
-
0036142499
-
Gastrin-releasing peptide mediates photic entrainable signals to dorsal subsets of suprachiasmatic nucleus via induction of period gene in mice
-
Aida R, Moriya T, Araki M, et al. Gastrin-releasing peptide mediates photic entrainable signals to dorsal subsets of suprachiasmatic nucleus via induction of period gene in mice. Mol Pharmacol 2002; 61:26-34.
-
(2002)
Mol Pharmacol
, vol.61
, pp. 26-34
-
-
Aida, R.1
Moriya, T.2
Araki, M.3
-
23
-
-
33644748119
-
Diurnal regulation of the gastrin-releasing peptide receptor in the mouse circadian clock
-
Karatsoreos IN, Romeo RD, McEwen BS, Silver R. Diurnal regulation of the gastrin-releasing peptide receptor in the mouse circadian clock. Eur J Neurosci 2006; 23:1047-1053.
-
(2006)
Eur J Neurosci
, vol.23
, pp. 1047-1053
-
-
Karatsoreos, I.N.1
Romeo, R.D.2
McEwen, B.S.3
Silver, R.4
-
24
-
-
0034662327
-
Gastrin-releasing peptide phase-shifts suprachiasmatic nuclei neuronal rhythms in vitro
-
McArthur AJ, Coogan AN, Ajpru S, et al. Gastrin-releasing peptide phase-shifts suprachiasmatic nuclei neuronal rhythms in vitro. J Neurosci 2000; 20:5496-5502.
-
(2000)
J Neurosci
, vol.20
, pp. 5496-5502
-
-
McArthur, A.J.1
Coogan, A.N.2
Ajpru, S.3
-
25
-
-
0029083613
-
Bombesin acts in the suprachiasmatic nucleus to affect circadian changes in tuberoinfundibular dopaminergic neuron activity and prolactin secretion
-
Mai LM, Pan JT. Bombesin acts in the suprachiasmatic nucleus to affect circadian changes in tuberoinfundibular dopaminergic neuron activity and prolactin secretion. Endocrinology 1995; 136:4163-4167.
-
(1995)
Endocrinology
, vol.136
, pp. 4163-4167
-
-
Mai, L.M.1
Pan, J.T.2
-
26
-
-
2442593982
-
Functions of pancreatic beta cells and adipocytes in bombesin receptor subtype-3-deficient mice
-
Nakamichi Y, Wada E, Aoki K, et al. Functions of pancreatic beta cells and adipocytes in bombesin receptor subtype-3-deficient mice. Biochem Biophys Res Commun 2004; 318:698-703.
-
(2004)
Biochem Biophys Res Commun
, vol.318
, pp. 698-703
-
-
Nakamichi, Y.1
Wada, E.2
Aoki, K.3
-
27
-
-
1442301499
-
Leptin resistance and enhancement of feeding facilitation by melanin-concentrating hormone in mice lacking bombesin receptor subtype-3
-
Maekawa F, Quah HM, Tanaka K, Ohki-Hamazaki H. Leptin resistance and enhancement of feeding facilitation by melanin-concentrating hormone in mice lacking bombesin receptor subtype-3. Diabetes 2004; 53:570-576.
-
(2004)
Diabetes
, vol.53
, pp. 570-576
-
-
Maekawa, F.1
Quah, H.M.2
Tanaka, K.3
Ohki-Hamazaki, H.4
-
28
-
-
33745003894
-
Wound repair and proliferation of bronchial epithelial cells enhanced by bombesin receptor subtype 3 activation
-
Tan YR, Qi MM, Qin XQ, et al. Wound repair and proliferation of bronchial epithelial cells enhanced by bombesin receptor subtype 3 activation. Peptides 2006; 27:1852-1858.
-
(2006)
Peptides
, vol.27
, pp. 1852-1858
-
-
Tan, Y.R.1
Qi, M.M.2
Qin, X.Q.3
-
29
-
-
34347209763
-
PPARalpha and AP-2alpha regulate bombesin receptor subtype 3 expression in ozone-stressed bronchial epithelial cells
-
This study examines the regulation of the human BRS-3 gene in bronchial epithelial cells and demonstrates binding of transcription factors PPAR alpha and AP-2 alpha to the promoter and hBRS-3 upregulation
-
Tan YR, Qin XQ, Xiang Y, et al. PPARalpha and AP-2alpha regulate bombesin receptor subtype 3 expression in ozone-stressed bronchial epithelial cells. Biochem J 2007; 405:131-137. This study examines the regulation of the human BRS-3 gene in bronchial epithelial cells and demonstrates binding of transcription factors PPAR alpha and AP-2 alpha to the promoter and hBRS-3 upregulation.
-
(2007)
Biochem J
, vol.405
, pp. 131-137
-
-
Tan, Y.R.1
Qin, X.Q.2
Xiang, Y.3
-
30
-
-
35348968418
-
BRS-3 activation transforms the effect of human bronchial epithelial cells from PGE2 mediated inhibition to TGF-beta1 dependent promotion on proliferation and collagen synthesis of lung fibroblasts
-
Wang Y, Zhang M, Tan Y, et al. BRS-3 activation transforms the effect of human bronchial epithelial cells from PGE2 mediated inhibition to TGF-beta1 dependent promotion on proliferation and collagen synthesis of lung fibroblasts. Cell Biol Int 2007; 31:1495-1500.
-
(2007)
Cell Biol Int
, vol.31
, pp. 1495-1500
-
-
Wang, Y.1
Zhang, M.2
Tan, Y.3
-
31
-
-
38049132623
-
Bombesin-related peptides and their receptors: Recent advances in their role in physiology and disease states
-
Gonzalez N, Moody TW, Igarashi H, et al. Bombesin-related peptides and their receptors: recent advances in their role in physiology and disease states. Curr Opin Endocrinol Diabetes Obes 2008; 15:58-64.
-
(2008)
Curr Opin Endocrinol Diabetes Obes
, vol.15
, pp. 58-64
-
-
Gonzalez, N.1
Moody, T.W.2
Igarashi, H.3
-
32
-
-
36048985140
-
Bombesin-like peptides modulate alveolarization and angiogenesis in bronchopulmonary dysplasia
-
Subramaniam M, Bausch C, Twomey A, et al. Bombesin-like peptides modulate alveolarization and angiogenesis in bronchopulmonary dysplasia. Am J Respir Crit Care Med 2007; 176:902-912.
-
(2007)
Am J Respir Crit Care Med
, vol.176
, pp. 902-912
-
-
Subramaniam, M.1
Bausch, C.2
Twomey, A.3
-
33
-
-
33745128353
-
Bombesin inhibits alveolarization and promotes pulmonary fibrosis in newborn mice
-
Ashour K, Shan L, Lee JH, et al. Bombesin inhibits alveolarization and promotes pulmonary fibrosis in newborn mice. Am J Respir Crit Care Med 2006; 173:1377-1385.
-
(2006)
Am J Respir Crit Care Med
, vol.173
, pp. 1377-1385
-
-
Ashour, K.1
Shan, L.2
Lee, J.H.3
-
34
-
-
30344485428
-
Bombesin-like peptides: Modulators of inflammation in acute lung injury?
-
Ganter MT, Pittet JF. Bombesin-like peptides: modulators of inflammation in acute lung injury? Am J Respir Crit Care Med 2006; 173:1-2.
-
(2006)
Am J Respir Crit Care Med
, vol.173
, pp. 1-2
-
-
Ganter, M.T.1
Pittet, J.F.2
-
35
-
-
33745444190
-
Accelerated thymic maturation and autoreactive T cells in bronchopulmonary dysplasia
-
Rosen D, Lee JH, Cuttitta F, et al. Accelerated thymic maturation and autoreactive T cells in bronchopulmonary dysplasia. Am J Respir Crit Care Med 2006; 174:75-83.
-
(2006)
Am J Respir Crit Care Med
, vol.174
, pp. 75-83
-
-
Rosen, D.1
Lee, J.H.2
Cuttitta, F.3
-
36
-
-
30344433265
-
Gastrin-releasing peptide receptor antagonist effects on an animal model of sepsis
-
Dal-Pizzol F, Di Leone LP, Ritter C, et al. Gastrin-releasing peptide receptor antagonist effects on an animal model of sepsis. Am J Respir Crit Care Med 2006; 173:84-90.
-
(2006)
Am J Respir Crit Care Med
, vol.173
, pp. 84-90
-
-
Dal-Pizzol, F.1
Di Leone, L.P.2
Ritter, C.3
-
37
-
-
58849124884
-
Gastrin-releasing peptide mRNA expression in the hypothalamic paraventricular nucleus is altered by melanocortin receptor stimulation and food deprivation
-
Epub ahead of print
-
Ladenheim EE, Behles RR, Bi S, Moran TH. Gastrin-releasing peptide mRNA expression in the hypothalamic paraventricular nucleus is altered by melanocortin receptor stimulation and food deprivation. Endocrinology 2008 [Epub ahead of print).
-
(2008)
Endocrinology
-
-
Ladenheim, E.E.1
Behles, R.R.2
Bi, S.3
Moran, T.H.4
-
38
-
-
34247261452
-
Capsaicin treatment differentially affects feeding suppression by bombesin-like peptides
-
Ladenheim EE, Knipp S. Capsaicin treatment differentially affects feeding suppression by bombesin-like peptides. Physiol Behav 2007; 91:36-41.
-
(2007)
Physiol Behav
, vol.91
, pp. 36-41
-
-
Ladenheim, E.E.1
Knipp, S.2
-
39
-
-
40849145705
-
Factors contributing to obesity in bombesin receptor subtype-3-deficient mice
-
Ladenheim EE, Hamilton NL, Behles RR, et al. Factors contributing to obesity in bombesin receptor subtype-3-deficient mice. Endocrinology 2008; 149:971-978.
-
(2008)
Endocrinology
, vol.149
, pp. 971-978
-
-
Ladenheim, E.E.1
Hamilton, N.L.2
Behles, R.R.3
-
40
-
-
35748978866
-
Expression of neuromedin B in adipose tissue and its regulation by changes in energy balance
-
Hoggard N, Bashir S, Cruickshank M, et al. Expression of neuromedin B in adipose tissue and its regulation by changes in energy balance. J Mol Endocrinol 2007; 39:199-210.
-
(2007)
J Mol Endocrinol
, vol.39
, pp. 199-210
-
-
Hoggard, N.1
Bashir, S.2
Cruickshank, M.3
-
41
-
-
44649197739
-
Bombesin: A possible role in wound repair
-
Baroni A, Perfetto B, Canozo N, et al. Bombesin: a possible role in wound repair. Peptides 2008; 29:1157-1166.
-
(2008)
Peptides
, vol.29
, pp. 1157-1166
-
-
Baroni, A.1
Perfetto, B.2
Canozo, N.3
-
42
-
-
34247242747
-
Bombesin stimulates enterocyte turnover following massive small bowel resection in a rat
-
Sukhotnik I, Slijper N, Karry R, et al. Bombesin stimulates enterocyte turnover following massive small bowel resection in a rat. Pediatr Surg Int 2007; 23:397-404.
-
(2007)
Pediatr Surg Int
, vol.23
, pp. 397-404
-
-
Sukhotnik, I.1
Slijper, N.2
Karry, R.3
-
43
-
-
48049095209
-
Brain neuronal/inducible nitric oxide synthases and cyclooxygenase-1 are involved in the bombesin-induced activation of central adrenomedullary outflow in rats
-
Lu L, Shimizu T, Nakamura K, Yokotani K. Brain neuronal/inducible nitric oxide synthases and cyclooxygenase-1 are involved in the bombesin-induced activation of central adrenomedullary outflow in rats. Eur J Pharmacol 2008; 590:177-184.
-
(2008)
Eur J Pharmacol
, vol.590
, pp. 177-184
-
-
Lu, L.1
Shimizu, T.2
Nakamura, K.3
Yokotani, K.4
-
44
-
-
39849102477
-
Observations favouring the occurrence of local production and marked effects of bombesin/ gastrin-releasing peptide in the synovial tissue of the human knee joint-comparisons with substance P and the NK-1 receptor
-
Grimsholm O, Rantapaa-Dahlqvist S, Dalen T, Forsgren S. Observations favouring the occurrence of local production and marked effects of bombesin/ gastrin-releasing peptide in the synovial tissue of the human knee joint-comparisons with substance P and the NK-1 receptor. Neuropeptides 2008; 42:133-145.
-
(2008)
Neuropeptides
, vol.42
, pp. 133-145
-
-
Grimsholm, O.1
Rantapaa-Dahlqvist, S.2
Dalen, T.3
Forsgren, S.4
-
45
-
-
52049121600
-
Effects of an antagonist of the bombesin/gastrin-releasing peptide receptor on complete Freund's adjuvant-induced arthritis in rats
-
Oliveira PG, Brenol CV, Edelweiss MI, et al. Effects of an antagonist of the bombesin/gastrin-releasing peptide receptor on complete Freund's adjuvant-induced arthritis in rats. Peptides 2008; 29:1726-1731.
-
(2008)
Peptides
, vol.29
, pp. 1726-1731
-
-
Oliveira, P.G.1
Brenol, C.V.2
Edelweiss, M.I.3
-
47
-
-
35748982434
-
Are neuropeptides important in arthritis? Studies on the importance of bombesin/GRP and substance P in a murine arthritis model
-
Grimsholm O, Guo Y, Ny T, et al. Are neuropeptides important in arthritis? Studies on the importance of bombesin/GRP and substance P in a murine arthritis model. Ann N Y Acad Sci 2007; 1110:525-538.
-
(2007)
Ann N Y Acad Sci
, vol.1110
, pp. 525-538
-
-
Grimsholm, O.1
Guo, Y.2
Ny, T.3
-
48
-
-
33947304019
-
Role of gastrin-releasing peptide and neuromedin B in anxiety and fear-related behavior
-
Bedard T, Mountney C, Kent P, et al. Role of gastrin-releasing peptide and neuromedin B in anxiety and fear-related behavior. Behav Brain Res 2007; 179:133-140.
-
(2007)
Behav Brain Res
, vol.179
, pp. 133-140
-
-
Bedard, T.1
Mountney, C.2
Kent, P.3
-
49
-
-
39749130324
-
Transient disruption of fear-related memory by postretrieval inactivation of gastrin-releasing Peptide or N-methyl-d-aspartate receptors in the hippocampus
-
Luft T, Amaral OB, Schwartsmann G, Roesler R. Transient disruption of fear-related memory by postretrieval inactivation of gastrin-releasing Peptide or N-methyl-d-aspartate receptors in the hippocampus. Curr Neurovasc Res 2008; 5:21-27.
-
(2008)
Curr Neurovasc Res
, vol.5
, pp. 21-27
-
-
Luft, T.1
Amaral, O.B.2
Schwartsmann, G.3
Roesler, R.4
-
50
-
-
34250777689
-
Basic fibroblast growth factor prevents the memory impairment induced by gastrin-releasing peptide receptor antagonism in area CA1 of the rat hippocampus
-
Preissler T, Luft T, Kapczinski F, et al. Basic fibroblast growth factor prevents the memory impairment induced by gastrin-releasing peptide receptor antagonism in area CA1 of the rat hippocampus. Neurochem Res 2007; 32:1381-1386.
-
(2007)
Neurochem Res
, vol.32
, pp. 1381-1386
-
-
Preissler, T.1
Luft, T.2
Kapczinski, F.3
-
51
-
-
38149002950
-
Impaired serum thyrotropin response to hypothyroidism in mice with disruption of neuromedin B receptor
-
Oliveira KJ, Cabanelas A, Veiga MA, et al. Impaired serum thyrotropin response to hypothyroidism in mice with disruption of neuromedin B receptor. Regul Pept 2008; 146:213-217.
-
(2008)
Regul Pept
, vol.146
, pp. 213-217
-
-
Oliveira, K.J.1
Cabanelas, A.2
Veiga, M.A.3
-
52
-
-
34548459014
-
Gastrin-releasing peptide receptor as a molecular target in experimental anticancer therapy
-
Cornelio DB, Roesler R, Schwartsmann G. Gastrin-releasing peptide receptor as a molecular target in experimental anticancer therapy. Ann Oncol 2007; 18:1457-1466.
-
(2007)
Ann Oncol
, vol.18
, pp. 1457-1466
-
-
Cornelio, D.B.1
Roesler, R.2
Schwartsmann, G.3
-
54
-
-
25444521559
-
Biologic relevance of mammalian bombesin-like peptides and their receptors in human malignancies
-
Qu X, Xiao D, Weber HC. Biologic relevance of mammalian bombesin-like peptides and their receptors in human malignancies. Curr Opin Endocrinol Diab 2003; 10:60-71.
-
(2003)
Curr Opin Endocrinol Diab
, vol.10
, pp. 60-71
-
-
Qu, X.1
Xiao, D.2
Weber, H.C.3
-
55
-
-
35848943698
-
Mitogenic signaling pathways induced by G protein-coupled receptors
-
Rozengurt E. Mitogenic signaling pathways induced by G protein-coupled receptors. J Cell Physiol 2007; 213:589-602.
-
(2007)
J Cell Physiol
, vol.213
, pp. 589-602
-
-
Rozengurt, E.1
-
56
-
-
34248591612
-
Targeting the Raf-MEK-ERK mitogen-activated protein kinase cascade for the treatment of cancer
-
Roberts PJ, Der CJ. Targeting the Raf-MEK-ERK mitogen-activated protein kinase cascade for the treatment of cancer. Oncogene 2007; 26:3291-3310.
-
(2007)
Oncogene
, vol.26
, pp. 3291-3310
-
-
Roberts, P.J.1
CJ, D.2
-
57
-
-
40849147041
-
EGFR antagonists in cancer treatment
-
Ciardiello F, Tortora G. EGFR antagonists in cancer treatment. N Engl J Med 2008; 358:1160-1174.
-
(2008)
N Engl J Med
, vol.358
, pp. 1160-1174
-
-
Ciardiello, F.1
Tortora, G.2
-
59
-
-
0033599039
-
EGF receptor transactivation by G-protein-coupled receptors requires metalloproteinase cleavage of proHB-EGF
-
Prenzel N, Zwick E, Daub H, et al. EGF receptor transactivation by G-protein-coupled receptors requires metalloproteinase cleavage of proHB-EGF. Nature 1999; 402:884-888.
-
(1999)
Nature
, vol.402
, pp. 884-888
-
-
Prenzel, N.1
Zwick, E.2
Daub, H.3
-
60
-
-
0038107752
-
Activation of extracellular signal-regulated kinase mediates bombesin-induced mitogenic responses in prostate cancer cells
-
Xiao D, Qu X, Weber HC. Activation of extracellular signal-regulated kinase mediates bombesin-induced mitogenic responses in prostate cancer cells. Cell Signal 2003; 15:945-953.
-
(2003)
Cell Signal
, vol.15
, pp. 945-953
-
-
Xiao, D.1
Qu, X.2
Weber, H.C.3
-
61
-
-
0142025133
-
Mitogenic effects of gastrin-releasing peptide in head and neck squamous cancer cells are mediated by activation of the epidermal growth factor receptor
-
Lui VW, Thomas SM, Zhang Q, et al. Mitogenic effects of gastrin-releasing peptide in head and neck squamous cancer cells are mediated by activation of the epidermal growth factor receptor. Oncogene 2003; 22:6183-6193.
-
(2003)
Oncogene
, vol.22
, pp. 6183-6193
-
-
Lui, V.W.1
Thomas, S.M.2
Zhang, Q.3
-
62
-
-
18644367044
-
Gastrin-releasing peptide receptor mediates activation of the epidermal growth factor receptor in lung cancer cells
-
Thomas SM, Grandis JR, Wentzel AL, et al. Gastrin-releasing peptide receptor mediates activation of the epidermal growth factor receptor in lung cancer cells. Neoplasia 2005; 7:426-431.
-
(2005)
Neoplasia
, vol.7
, pp. 426-431
-
-
Thomas, S.M.1
Grandis, J.R.2
Wentzel, A.L.3
-
63
-
-
38449087529
-
Crosstalk between G-protein-coupled receptors and epidermal growth factor receptor in cancer
-
Bhola NE, Grandis JR. Crosstalk between G-protein-coupled receptors and epidermal growth factor receptor in cancer. Front Biosci 2008; 13:1857-1865.
-
(2008)
Front Biosci
, vol.13
, pp. 1857-1865
-
-
Bhola, N.E.1
Grandis, J.R.2
-
64
-
-
11244261160
-
-
Blobel CP. ADAMs: key components in EGFR signalling and development. Nat Rev Mol Cell Biol 2005; 6:32-43.
-
Blobel CP. ADAMs: key components in EGFR signalling and development. Nat Rev Mol Cell Biol 2005; 6:32-43.
-
-
-
-
66
-
-
33745714456
-
ADAMs as mediators of EGF receptor transactivation by G protein-coupled receptors
-
Ohtsu H, Dempsey PJ, Eguchi S. ADAMs as mediators of EGF receptor transactivation by G protein-coupled receptors. Am J Physiol Cell Physiol 2006; 291:C1-10.
-
(2006)
Am J Physiol Cell Physiol
, vol.291
-
-
Ohtsu, H.1
Dempsey, P.J.2
Eguchi, S.3
-
67
-
-
33947727520
-
Gastrin-releasing peptide activates Akt through the epidermal growth factor receptor pathway and abrogates the effect of gefitinib
-
This study shows that PI3 kinase is downstream target of EGF-R transactivation
-
Liu X, Carlisle DL, Swick MC, et al. Gastrin-releasing peptide activates Akt through the epidermal growth factor receptor pathway and abrogates the effect of gefitinib. Exp Cell Res 2007; 313:1361-1372. This study shows that PI3 kinase is downstream target of EGF-R transactivation.
-
(2007)
Exp Cell Res
, vol.313
, pp. 1361-1372
-
-
Liu, X.1
Carlisle, D.L.2
Swick, M.C.3
-
68
-
-
34248193845
-
Antitumor mechanisms of combined gastrin-releasing peptide receptor and epidermal growth factor receptor targeting in head and neck cancer
-
Important study to show that a combination of GRP-R and EGF-R inhibition results in enhanced tumor cell blockade
-
Zhang Q, Bhola NE, Lui VW, et al. Antitumor mechanisms of combined gastrin-releasing peptide receptor and epidermal growth factor receptor targeting in head and neck cancer. Mol Cancer Ther 2007; 6:1414-1424. Important study to show that a combination of GRP-R and EGF-R inhibition results in enhanced tumor cell blockade.
-
(2007)
Mol Cancer Ther
, vol.6
, pp. 1414-1424
-
-
Zhang, Q.1
Bhola, N.E.2
Lui, V.W.3
-
69
-
-
45249112170
-
Gastrin-releasing peptide receptors regulate proliferation of C6 glioma cells through a phosphatidylinositol 3-kinase-dependent mechanism
-
Flores DG, de Farias CB, Leites J, et al. Gastrin-releasing peptide receptors regulate proliferation of C6 glioma cells through a phosphatidylinositol 3-kinase-dependent mechanism. Curr Neurovasc Res 2008; 5:99-105.
-
(2008)
Curr Neurovasc Res
, vol.5
, pp. 99-105
-
-
Flores, D.G.1
de Farias, C.B.2
Leites, J.3
-
70
-
-
34247248710
-
Phosphatidylinositol 3-kinase regulation of gastrin-releasing peptide-induced cell cycle progression in neuroblastoma cells
-
Ishola TA, Kang J, Qiao J, et al. Phosphatidylinositol 3-kinase regulation of gastrin-releasing peptide-induced cell cycle progression in neuroblastoma cells. Biochim Biophys Acta 2007; 1770:927-932.
-
(2007)
Biochim Biophys Acta
, vol.1770
, pp. 927-932
-
-
Ishola, T.A.1
Kang, J.2
Qiao, J.3
-
71
-
-
51349137154
-
Gastrin-releasing peptide receptor silencing suppresses the tumorigenesis and metastatic potential of neuroblastoma
-
Qiao J, Kang J, Ishola TA, et al. Gastrin-releasing peptide receptor silencing suppresses the tumorigenesis and metastatic potential of neuroblastoma. Proc Natl Acad Sci U S A 2008; 105:12891-12896.
-
(2008)
Proc Natl Acad Sci U S A
, vol.105
, pp. 12891-12896
-
-
Qiao, J.1
Kang, J.2
Ishola, T.A.3
-
72
-
-
49849099579
-
Stimulation of proliferation of U138-MG glioblastoma cells by gastrin-releasing peptide in combination with agents that enhance cAMP signaling
-
Farias CB, Lima RC, Lima LO, et al. Stimulation of proliferation of U138-MG glioblastoma cells by gastrin-releasing peptide in combination with agents that enhance cAMP signaling. Oncology 2008; 75:27-31.
-
(2008)
Oncology
, vol.75
, pp. 27-31
-
-
Farias, C.B.1
Lima, R.C.2
Lima, L.O.3
-
73
-
-
0037063323
-
Human gastrin-releasing peptide receptor mediates sustained CREB phosphorylation and transactivation in HuTu 80 duodenal cancer cells
-
Qu X, Xiao D, Weber HC. Human gastrin-releasing peptide receptor mediates sustained CREB phosphorylation and transactivation in HuTu 80 duodenal cancer cells. FEBS Lett 2002; 527:109-113.
-
(2002)
FEBS Lett
, vol.527
, pp. 109-113
-
-
Qu, X.1
Xiao, D.2
Weber, H.C.3
-
74
-
-
0035051948
-
The case for gastrin-releasing peptide acting as a morphogen when it and its receptor are aberrantly expressed in cancer
-
Jensen JA, Carroll RE, Benya RV. The case for gastrin-releasing peptide acting as a morphogen when it and its receptor are aberrantly expressed in cancer. Peptides 2001; 22:689-699.
-
(2001)
Peptides
, vol.22
, pp. 689-699
-
-
Jensen, J.A.1
Carroll, R.E.2
Benya, R.V.3
-
75
-
-
33846194960
-
Gastrin-releasing peptide mediates its morphogenic properties in human colon cancer by upregulating intracellular adhesion protein-1 (ICAM-1) via focal adhesion kinase
-
Taglia L, Matusiak D, Matkowskyj KA, Benya RV. Gastrin-releasing peptide mediates its morphogenic properties in human colon cancer by upregulating intracellular adhesion protein-1 (ICAM-1) via focal adhesion kinase. Am J Physiol Gastrointest Liver Physiol 2007; 292:G182-G190.
-
(2007)
Am J Physiol Gastrointest Liver Physiol
, vol.292
-
-
Taglia, L.1
Matusiak, D.2
Matkowskyj, K.A.3
Benya, R.V.4
-
76
-
-
33749176646
-
Neuropeptide-stimulated cell migration in prostate cancer cells is mediated by RhoA kinase signaling and inhibited by neutral endopeptidase
-
Zheng R, Iwase A, Shen R, et al. Neuropeptide-stimulated cell migration in prostate cancer cells is mediated by RhoA kinase signaling and inhibited by neutral endopeptidase. Oncogene 2006; 25:5942-5952.
-
(2006)
Oncogene
, vol.25
, pp. 5942-5952
-
-
Zheng, R.1
Iwase, A.2
Shen, R.3
-
77
-
-
33847039876
-
-
Corral RS, Iniguez MA, Duque J, et al. Bombesin induces cyclooxygenase-2 expression through the activation of the nuclear factor of activated T cells and enhances cell migration in Caco-2 colon carcinoma cells. Oncogene 2007; 26:958-969. Novel mechanism by which bombesin targets COX-2 and mediates cell migration.
-
Corral RS, Iniguez MA, Duque J, et al. Bombesin induces cyclooxygenase-2 expression through the activation of the nuclear factor of activated T cells and enhances cell migration in Caco-2 colon carcinoma cells. Oncogene 2007; 26:958-969. Novel mechanism by which bombesin targets COX-2 and mediates cell migration.
-
-
-
-
78
-
-
46449100403
-
Synergistic regulation of COX-2 expression by bombesin and transforming growth factor-beta
-
Guo YS, Chen Z, Wen XD, et al. Synergistic regulation of COX-2 expression by bombesin and transforming growth factor-beta. Dig Dis Sci 2008; 53:2045-2052.
-
(2008)
Dig Dis Sci
, vol.53
, pp. 2045-2052
-
-
Guo, Y.S.1
Chen, Z.2
Wen, X.D.3
-
79
-
-
34347348018
-
Bombesin induces angiogenesis and neuroblastoma growth
-
Kang J, Ishola TA, Baregamian N, et al. Bombesin induces angiogenesis and neuroblastoma growth. Cancer Lett 2007; 253:273-281.
-
(2007)
Cancer Lett
, vol.253
, pp. 273-281
-
-
Kang, J.1
Ishola, T.A.2
Baregamian, N.3
-
80
-
-
34247850950
-
Alterations of EGFR/HER, angiogenesis and apoptosis pathways after therapy with antagonists of growth hormone releasing hormone and bombesin in nonsmall cell lung cancer
-
Kanashiro CA, Schally AV, Zarandi M, et al. Alterations of EGFR/HER, angiogenesis and apoptosis pathways after therapy with antagonists of growth hormone releasing hormone and bombesin in nonsmall cell lung cancer. Int J Oncol 2007; 30:1019-1028.
-
(2007)
Int J Oncol
, vol.30
, pp. 1019-1028
-
-
Kanashiro, C.A.1
Schally, A.V.2
Zarandi, M.3
-
81
-
-
34547888717
-
Overexpression of gastrin-releasing peptide receptors in tumor-associated blood vessels of human ovarian neoplasms
-
This study shows strong GRP-R expression in tumor vessels suggesting an important function for GRP in angiogenesis
-
Fleischmann A, Waser B, Reubi JC. Overexpression of gastrin-releasing peptide receptors in tumor-associated blood vessels of human ovarian neoplasms. Cell Oncol 2007; 29:421-433. This study shows strong GRP-R expression in tumor vessels suggesting an important function for GRP in angiogenesis.
-
(2007)
Cell Oncol
, vol.29
, pp. 421-433
-
-
Fleischmann, A.1
Waser, B.2
Reubi, J.C.3
-
82
-
-
33751267275
-
Inappropriate activation of the androgen receptor by nonsteroids: Involvement of the Src kinase pathway and its therapeutic implications
-
Desai SJ, Ma AH, Tepper CG, et al. Inappropriate activation of the androgen receptor by nonsteroids: involvement of the Src kinase pathway and its therapeutic implications. Cancer Res 2006; 66:10449-10459.
-
(2006)
Cancer Res
, vol.66
, pp. 10449-10459
-
-
Desai, S.J.1
Ma, A.H.2
Tepper, C.G.3
-
83
-
-
0035204477
-
Neuropeptide-induced androgen independence in prostate cancer cells: Roles of nonreceptor tyrosine kinases Etk/Bmx, Src, and focal adhesion kinase
-
Lee LF, Guan J, Qiu Y, Kung HJ. Neuropeptide-induced androgen independence in prostate cancer cells: roles of nonreceptor tyrosine kinases Etk/Bmx, Src, and focal adhesion kinase. Mol Cell Biol 2001; 21:8385-8397.
-
(2001)
Mol Cell Biol
, vol.21
, pp. 8385-8397
-
-
Lee, L.F.1
Guan, J.2
Qiu, Y.3
Kung, H.J.4
-
84
-
-
57149116951
-
Modulation of 11 beta-Hydroxysteroid dehydrogenase expression by bombesin: A possible mechanism for glucocorticoid resistance in androgen independent prostate cancer
-
Lee JG, Ge R, Hardy DO, et al. Modulation of 11 beta-Hydroxysteroid dehydrogenase expression by bombesin: a possible mechanism for glucocorticoid resistance in androgen independent prostate cancer. Horm Metab Res 2008; 40:772-778.
-
(2008)
Horm Metab Res
, vol.40
, pp. 772-778
-
-
Lee, J.G.1
Ge, R.2
Hardy, D.O.3
-
85
-
-
27544467453
-
Bombesin regulates cyctin D1 expression through the early growth response protein Egr-1 in prostate cancer cells
-
Xiao D, Chinnappan D, Pestell R, et al. Bombesin regulates cyctin D1 expression through the early growth response protein Egr-1 in prostate cancer cells. Cancer Res 2005; 65:9934-9942.
-
(2005)
Cancer Res
, vol.65
, pp. 9934-9942
-
-
Xiao, D.1
Chinnappan, D.2
Pestell, R.3
-
86
-
-
35448985707
-
Transcriptional regulation of human protease-activated receptor 1 : A role for the early growth response-1 protein in prostate cancer
-
Bombesin-dependent Egr-1 activation has multiple downstream targets in prostate cancer
-
Salah Z, Maoz M, Pizov G, Bar-Shavit R. Transcriptional regulation of human protease-activated receptor 1 : a role for the early growth response-1 protein in prostate cancer. Cancer Res 2007; 67:9835-9843. Bombesin-dependent Egr-1 activation has multiple downstream targets in prostate cancer.
-
(2007)
Cancer Res
, vol.67
, pp. 9835-9843
-
-
Salah, Z.1
Maoz, M.2
Pizov, G.3
Bar-Shavit, R.4
|