Separation and structural elucidation of a novel analogue of vardenafil included as an adulterant in a dietary supplement by liquid chromatography-electrospray ionization mass spectrometry, infrared spectroscopy and nuclear magnetic resonance spectroscopy

Journal of Pharmaceutical and Biomedical Analysis

Volumn 54, Issue 3, 2011, Pages 491-496

  Lee, Hwa Mi ^a,b   Kim, Chang Soo ^b   Jang, Young Mi ^b   Kwon, Sung Won ^a   Lee, Bong Jin ^a  

^a Seoul National University   (South Korea)

^b Korea Food and Drug Administration   (South Korea)

Author keywords

Dietary supplement; Hongdenafil (acetildenafil); Mass spectrometry (MS); Sildenafil; Vardenafil

Indexed keywords

2 [2 ETHOXY 5 [2 (4 ETHYLPIPERAZIN 1 YL)ACETYL]PHENYL] 5 METHYL 7 PROPYLIMIDAZO(5,1 F)(1,2,4)TRIAZIN 4(3H) ONE; ACETIC ACID DERIVATIVE; HOMOSILDENAFIL; HONGDENAFIL; MEGATON; PIPERAZINE DERIVATIVE; PRESCRIPTION DRUG; PYRAZOLOPYRIMIDINE DERIVATIVE; SILDENAFIL; TADALAFIL; UNCLASSIFIED DRUG; VARDENAFIL;

ARTICLE; CHEMICAL COMPOSITION; CONTROLLED STUDY; DIET SUPPLEMENTATION; DRUG STRUCTURE; ELECTROSPRAY MASS SPECTROMETRY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; INFRARED SPECTROSCOPY; MOLECULE; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PRIORITY JOURNAL; SEPARATION TECHNIQUE; STRUCTURE ANALYSIS;

CARBOLINES; CHROMATOGRAPHY, LIQUID; DIETARY SUPPLEMENTS; DRUG CONTAMINATION; ERECTILE DYSFUNCTION; HUMANS; IMIDAZOLES; MAGNETIC RESONANCE SPECTROSCOPY; MALE; PHOSPHODIESTERASE 5 INHIBITORS; PIPERAZINES; PURINES; SACCHAROMYCES CEREVISIAE; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; SPECTROPHOTOMETRY, INFRARED; SULFONES; TRIAZINES;

EID: 78149500732     PISSN: 07317085     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jpba.2010.09.022     Document Type: Article

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