Structure elucidation of a novel analogue of sildenafil detected as an adulterant in an herbal dietary supplement

Journal of Pharmaceutical and Biomedical Analysis

Volumn 43, Issue 5, 2007, Pages 1615-1621

  Reepmeyer, John C ^a   Woodruff, Jeffrey T ^a   d'Avignon, D André ^b  

^a CENTER FOR DRUG EVALUATION AND RESEARCH   (United States)

^b WASHINGTON UNIVERSITY   (United States)

Author keywords

Dietary supplements; Liquid chromatography mass spectrometry (LC MS); Methisosildenafil; Nuclear magnetic resonance (NMR); Sildenafil analogue

Indexed keywords

1 METHYLPIPERAZINE; 2,6 DIMETHYLPIPERAZINE; AMINE; METHISOSILDENAFIL; METHYL GROUP; NITROGEN; PIPERAZINE DERIVATIVE; SILDENAFIL; SULFONIC ACID DERIVATIVE; SULFUR; TADALAFIL; UNCLASSIFIED DRUG; VARDENAFIL;

ARTICLE; CHEMICAL BOND; DERIVATIZATION; DIET SUPPLEMENTATION; DRUG MARKETING; DRUG STRUCTURE; HERBAL MEDICINE; INTERNET; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; NUCLEAR MAGNETIC RESONANCE; PRIORITY JOURNAL; SEXUAL FUNCTION; SPECTROPHOTOMETER;

CHROMATOGRAPHY, LIQUID; DESIGNER DRUGS; DIETARY SUPPLEMENTS; FOOD CONTAMINATION; HUMANS; IMPOTENCE; MAGNETIC RESONANCE SPECTROSCOPY; MALE; MASS SPECTROMETRY; MOLECULAR STRUCTURE; PHOSPHODIESTERASE INHIBITORS; PIPERAZINES; PLANT EXTRACTS; PLANT PREPARATIONS; PURINES; SPECTROPHOTOMETRY, ULTRAVIOLET; SULFONES;

EID: 33947498162     PISSN: 07317085     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jpba.2006.11.037     Document Type: Article

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