Analysis of undeclared synthetic phosphodiesterase-5 inhibitors in dietary supplements and herbal matrices by LC-ESI-MS and LC-UV

Journal of Pharmaceutical and Biomedical Analysis

Volumn 36, Issue 3, 2004, Pages 525-533

  Gratz, Samuel R ^a   Flurer, Cheryl L ^a   Wolnik, Karen A ^a  

^a CENTER FOR DRUG EVALUATION AND RESEARCH   (United States)

Author keywords

Dietary supplements; Electrospray; Mass spectrometry; Phosphodiesterase 5; Reversed phase liquid chromatography; Sildenafil; Tadalafil; Vardenafil

Indexed keywords

ACETONITRILE; HERBACEOUS AGENT; PHOSPHODIESTERASE V INHIBITOR; SILDENAFIL; TADALAFIL; VARDENAFIL; WATER;

ACCURACY; ANALYTIC METHOD; ARTICLE; DIET SUPPLEMENTATION; DRUG CAPSULE; DRUG FORMULATION; DRUG IDENTIFICATION; DRUG ISOLATION; ELECTROSPRAY MASS SPECTROMETRY; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; REPRODUCIBILITY; REVERSED PHASE LIQUID CHROMATOGRAPHY; TABLET FORMULATION; ULTRASOUND;

3',5'-CYCLIC-GMP PHOSPHODIESTERASE; CHROMATOGRAPHY, LIQUID; DIETARY SUPPLEMENTS; MASS SPECTROMETRY; PHOSPHODIESTERASE INHIBITORS; PHOSPHORIC DIESTER HYDROLASES; PLANT PREPARATIONS; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; SPECTROPHOTOMETRY, ULTRAVIOLET;

EID: 7444221111     PISSN: 07317085     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jpba.2004.07.004     Document Type: Article

References (14)

1. H.D. Langtry, and A. Markham Drugs 57 1999 967 989
2. C.L. Kruger, and S.W. Mann Food Chem. Toxicol. 41 2003 793 805
3. C.G. Stief, S. Uckert, A.J. Becker, M.C. Truss, and U. Jonas J. Urol. 159 1998 1390 1393
4. M.C. Tseng, and J.H. Lin J. Food Drug Anal. 10 2002 112 119
5. M.H. Shin, M.K. Hong, W.S. Kim, Y.J. Lee, and Y.C. Jeoung Food Add. Contam. 20 2003 793 796
6. E. Mikami, T. Ohno, and H. Matsumoto Forensic Sci. Int. 130 2002 140 146
7. J.Y. Cho, H.S. Lim, K.S. Yu, H.J. Shim, I.J. Jang, and S.G. Shin J. Chromatogr. B 795 2003 179 186
8. A. Eerkes, T. Addison, and W. Naidong J. Chromatogr. B 768 2002 277 284
9. Y. Qui, S. Bhattacharjee, P. Kraft, T. John, E. Craig, D. Haynes-Johnson, J. Guan, W. Jiang, M. Macielag, Z. Sui, J. Clancy, and S. Lundeen Eur. J. Pharmacol. 472 2003 73 80
10. M. Sheu, A. Wu, G. Yeh, A. Hsia, and H. Ho J. Chromatogr. B 791 2003 255 262
11. N. Daraghmeh, M. Al-Omari, A. Badwan, and A. Jaber J. Pharm. Biomed. Anal. 25 2001 483 492
12. Pharmaceutical Forum (USP), Sildenafil Citrate and Sildenafil Citrate Tablets Monographs, vol. 24, 1998, pp. 7182-7185.
13. J.D.H. Cooper, D.C. Muirhead, J.E. Taylor, and P.R. Baker J. Chromatogr. B 701 1997 87 95
14. M. Takino Determination of the metabolites of nitrofuran antibacterial drugs in chicken tissue by LC-ESI-MS 2003 Agilent Technologies (application note)