Isolation and identification of a sildenafil analogue illegally added in dietary supplements

Journal of Food and Drug Analysis

Volumn 14, Issue 1, 2006, Pages 19-23

  Lai, Kuo Chih ^a   Liu, Yi Chu ^a   Tseng, Mu Chang ^a   Lin, Jer Huei ^a  

^a Executive Yuan   (Taiwan)

Author keywords

Identified; Isolated; LC MS MS; NMR; Sildenafil analogue

Indexed keywords

HOMOSILDENAFIL; PHOSPHODIESTERASE V INHIBITOR; SILDENAFIL; UNCLASSIFIED DRUG;

ARTICLE; CORRELATION ANALYSIS; DIET SUPPLEMENTATION; DRUG DETERMINATION; DRUG IDENTIFICATION; DRUG ISOLATION; DRUG PURIFICATION; DRUG STRUCTURE; LIQUID CHROMATOGRAPHY; LIQUID LIQUID EXTRACTION; MASS SPECTROMETRY; NUCLEAR MAGNETIC RESONANCE; STRUCTURE ANALYSIS; TAIWAN;

EID: 33646718358     PISSN: 10219498     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (9)

1. Jeffecoate, W. J. 1991. The investigation of impotence. Br. J. Urol. 68: 449-453.
2. Goldstein, I. 2000. Male sexual circuitry. Sci. Am. 283: 56-61.
3. Terrett, N. K., Bell, A. K., Brown, D. and Ellis, P. 1996. Sildenafil (Viagra) a potent and selective inhibitor of type-5 cyclic GMP phosphodiesterase with utility for the treatment of male erectile dysfunction. Bioorg. Med. Chem. Lett. 6: 1819-1824.
4. Boolell, M., Allen, M. J., Ballard, S. A., Gepi-Attee, S., Muirhead, G. J., Naylor, A. M., Osterloh, I. H. and Gingell, C. 1996. Sildenafil: an orally active type-5 cyclic GMP specific phosphodiesterase inhibitor for treatment of penile erectile dysfunction. Int. J. Impot. Res. 8: 47-52.
5. Beavo, J. A. 1995. Cyclic nucleotide phosphodiesterases functional implication of multiple isoforms. Physiol. Rev. 75: 725-748.
6. Takako, M., Sutemi, S., Kiyoko, K., Fusako, I., Jyunichi, N., Hisashi, K. and Ichiro, Y. 2001. Identification system for sildenafil in health foods. Yakugaku Zasshi 121: 765-769.
7. Tseng, M. C. and Lin, J. H. 2002. Determination of sildenafil citrate adulterated in a dietary supplement capsule by LC/MS/MS. J. Food Drug Anal. 10: 112-119.
8. Shin, M. H., Hong, M. K., Kim, W. S., Lee, Y. J. and Jeoung, Y. C. 2003. Identification of a new analogue of sildenafil added illegally to a functional food marketed for penile erectile dysfunction. Food Addit. Contam. 20: 793-796.
9. Hong, M. K., Chio, D., Lim, M. H. and Park, G. S. 2004. Structure Determination of Sildenafil Analogues Found in Chinese Herb Drinks. 118th AOAC poster Abstracts. p. 154.