Probing the agonist domain of the nicotinic acetylcholine receptor by cysteine scanning mutagenesis reveals residues in proximity to the α- bungarotoxin binding site

Biochemistry

Volumn 38, Issue 16, 1999, Pages 4912-4921

  Spura, Armin ^a   Russin, Tanya S ^b   Freedman, Neal D ^a   Grant, Marianne ^a   McLaughlin, James T ^b   Hawrot, Edward ^a  

^a BROWN UNIVERSITY   (United States)

^b TUFTS UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA BUNGAROTOXIN; AMINO ACID; BROMOACETYLCHOLINE; CYSTEINE; ISOPROTEIN; METHYLAMMONIUM; MUTANT PROTEIN; NICOTINIC RECEPTOR; SULFONIC ACID DERIVATIVE; THIOMESYLIC ACID METHYL ESTER; TRYPTOPHAN;

AMINO ACID SUBSTITUTION; ARTICLE; BINDING COMPETITION; BINDING SITE; CONCENTRATION RESPONSE; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; LIGAND BINDING; MOLECULAR MODEL; PEPTIDE MAPPING; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN PROTEIN INTERACTION; RECEPTOR AFFINITY; SITE DIRECTED MUTAGENESIS; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS; SURFACE CHARGE;

ACETYLCHOLINE; ANIMALS; BUNGAROTOXINS; CYSTEINE; HUMANS; INDICATORS AND REAGENTS; MESYLATES; MICE; MUTAGENESIS, SITE-DIRECTED; NICOTINIC AGONISTS; NICOTINIC ANTAGONISTS; OXIDATION-REDUCTION; PEPTIDE FRAGMENTS; PHENYLALANINE; PROTEIN BINDING; RECEPTORS, NICOTINIC; TORPEDO; TRYPTOPHAN; VALINE;

EID: 0033586727     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi982656z     Document Type: Article

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