An H-bond between two residues from different loops of the acetylcholine binding site contributes to the activation mechanism of nicotinic receptors

EMBO Journal

Volumn 22, Issue 9, 2003, Pages 1990-2003

  Grutter, Thomas ^a   De Carvalho, Lia Prado ^b   Le Novère, Nicolas ^a   Corringer, Pierre Jean ^a   Edelstein, Stuart ^a,c   Changeux, Jean Pierre ^a  

^a CNRS   (France)

^b SORBONNE UNIVERSITÉ   (France)

^c UNIVERSITY OF GENEVA   (Switzerland)

Author keywords

bungarotoxin binding; Activation mechanism; H bond; Myasthenic mutant; Neuronal nicotinic receptor

Indexed keywords

ACETYLCHOLINE; ALPHA BUNGAROTOXIN; AMINO ACID; BINDING PROTEIN; CHIMERIC PROTEIN; CHOLINERGIC RECEPTOR; EPIBATIDINE; NICOTINE; NICOTINIC RECEPTOR; SEROTONIN 3 RECEPTOR;

AGONIST; ALLOSTERISM; ARTICLE; BINDING AFFINITY; BINDING SITE; COMPETITIVE INHIBITION; CONTROLLED STUDY; CRYSTAL STRUCTURE; DRUG POTENCY; EATON LAMBERT SYNDROME; ELECTROPHYSIOLOGY; HUMAN; HUMAN CELL; HYDROGEN BOND; IC 50; ISOMERISM; KINETICS; MOLECULAR MODEL; MUTANT; PATCH CLAMP; POINT MUTATION; PRIORITY JOURNAL; PROTEIN INTERACTION; REGULATORY MECHANISM; SIMULATION; STATISTICAL ANALYSIS; STATISTICAL SIGNIFICANCE;

ACETYLCHOLINE; AMINO ACID SEQUENCE; BICYCLO COMPOUNDS, HETEROCYCLIC; BINDING SITES; BUNGAROTOXINS; HYDROGEN BONDING; IODINE RADIOISOTOPES; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PYRIDINES; RECEPTORS, NICOTINIC; RECEPTORS, SEROTONIN; RECEPTORS, SEROTONIN, 5-HT3; RECOMBINANT FUSION PROTEINS; SEQUENCE HOMOLOGY, AMINO ACID; TRITIUM;

EID: 0037544107     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1093/emboj/cdg197     Document Type: Article

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