메뉴 건너뛰기




Volumn 5, Issue 10, 2010, Pages

ADAM17 deletion in thymic epithelial cells alters aire expression without affecting T cell developmental progression

Author keywords

[No Author keywords available]

Indexed keywords

AUTOIMMUNE REGULATOR PROTEIN; CRE RECOMBINASE; METALLOPROTEINASE; PROTEIN ADAM17; UNCLASSIFIED DRUG; ADAM PROTEIN; TUMOR NECROSIS FACTOR ALPHA CONVERTING ENZYME; TUMOR NECROSIS FACTOR-ALPHA CONVERTASE;

EID: 78149457953     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0013528     Document Type: Article
Times cited : (7)

References (59)
  • 1
    • 34247882592 scopus 로고    scopus 로고
    • Zoned out: Functional mapping of stromal signaling microenvironments in the thymus
    • Petrie HT, Zuniga-Pflucker JC (2007) Zoned out: functional mapping of stromal signaling microenvironments in the thymus. Annu Rev Immunol 25: 649-679.
    • (2007) Annu Rev Immunol , vol.25 , pp. 649-679
    • Petrie, H.T.1    Zuniga-Pflucker, J.C.2
  • 2
    • 0027153201 scopus 로고
    • A developmental pathway involving four phenotypically and functionally distinct subsets of CD3-CD4- CD8- triple-negative adult mouse thymocytes defined by CD44 and CD25 expression
    • Godfrey DI, Kennedy J, Suda T, Zlotnik A (1993) A developmental pathway involving four phenotypically and functionally distinct subsets of CD3-CD4- CD8- triple-negative adult mouse thymocytes defined by CD44 and CD25 expression. J Immunol 150: 4244-4252.
    • (1993) J Immunol , vol.150 , pp. 4244-4252
    • Godfrey, D.I.1    Kennedy, J.2    Suda, T.3    Zlotnik, A.4
  • 3
    • 33645091616 scopus 로고    scopus 로고
    • Cellular and molecular events during early thymus development
    • Hollander G, Gill J, Zuklys S, Iwanami N, Liu C, et al. (2006) Cellular and molecular events during early thymus development. Immunol Rev 209: 28-46.
    • (2006) Immunol Rev , vol.209 , pp. 28-46
    • Hollander, G.1    Gill, J.2    Zuklys, S.3    Iwanami, N.4    Liu, C.5
  • 4
    • 8044257704 scopus 로고    scopus 로고
    • A metalloproteinase disintegrin that releases tumour-necrosis factor-alpha from cells
    • Black RA, Rauch CT, Kozlosky CJ, Peschon JJ, Slack JL, et al. (1997) A metalloproteinase disintegrin that releases tumour-necrosis factor-alpha from cells. Nature 385: 729-733.
    • (1997) Nature , vol.385 , pp. 729-733
    • Black, R.A.1    Rauch, C.T.2    Kozlosky, C.J.3    Peschon, J.J.4    Slack, J.L.5
  • 5
    • 11244261160 scopus 로고    scopus 로고
    • ADAMs: Key components in EGFR signalling and development
    • Blobel CP (2005) ADAMs: key components in EGFR signalling and development. Nat Rev Mol Cell Biol 6: 32-43.
    • (2005) Nat Rev Mol Cell Biol , vol.6 , pp. 32-43
    • Blobel, C.P.1
  • 7
    • 0036007414 scopus 로고    scopus 로고
    • Shedding light on sheddases: Role in growth and development
    • Kheradmand F, Werb Z (2002) Shedding light on sheddases: role in growth and development. Bioessays 24: 8-12.
    • (2002) Bioessays , vol.24 , pp. 8-12
    • Kheradmand, F.1    Werb, Z.2
  • 8
    • 0034681260 scopus 로고    scopus 로고
    • Regulated intramembrane proteolysis: A control mechanism conserved from bacteria to humans
    • Brown MS, Ye J, Rawson RB, Goldstein JL (2000) Regulated intramembrane proteolysis: a control mechanism conserved from bacteria to humans. Cell 100: 391-398.
    • (2000) Cell , vol.100 , pp. 391-398
    • Brown, M.S.1    Ye, J.2    Rawson, R.B.3    Goldstein, J.L.4
  • 9
    • 38749142898 scopus 로고    scopus 로고
    • Clipping, shedding and RIPping keep immunity on cue
    • Murphy G, Murthy A, Khokha R (2008) Clipping, shedding and RIPping keep immunity on cue. Trends Immunol 29: 75-82.
    • (2008) Trends Immunol , vol.29 , pp. 75-82
    • Murphy, G.1    Murthy, A.2    Khokha, R.3
  • 10
    • 8044250278 scopus 로고    scopus 로고
    • Cloning of a disintegrin metalloproteinase that processes precursor tumour-necrosis factoralpha
    • Moss ML, Jin SL, Milla ME, Bickett DM, Burkhart W, et al. (1997) Cloning of a disintegrin metalloproteinase that processes precursor tumour-necrosis factoralpha. Nature 385: 733-736.
    • (1997) Nature , vol.385 , pp. 733-736
    • Moss, M.L.1    Jin, S.L.2    Milla, M.E.3    Bickett, D.M.4    Burkhart, W.5
  • 11
    • 0034640286 scopus 로고    scopus 로고
    • Functional analysis of the domain structure of tumor necrosis factor-alpha converting enzyme
    • Reddy P, Slack JL, Davis R, Cerretti DP, Kozlosky CJ, et al. (2000) Functional analysis of the domain structure of tumor necrosis factor-alpha converting enzyme. J Biol Chem 275: 14608-14614.
    • (2000) J Biol Chem , vol.275 , pp. 14608-14614
    • Reddy, P.1    Slack, J.L.2    Davis, R.3    Cerretti, D.P.4    Kozlosky, C.J.5
  • 12
    • 0032846604 scopus 로고    scopus 로고
    • Cutting edge: A dominant negative form of TNF-alpha converting enzyme inhibits proTNF and TNFRII secretion
    • Solomon KA, Pesti N, Wu G, Newton RC (1999) Cutting edge: a dominant negative form of TNF-alpha converting enzyme inhibits proTNF and TNFRII secretion. J Immunol 163: 4105-4108.
    • (1999) J Immunol , vol.163 , pp. 4105-4108
    • Solomon, K.A.1    Pesti, N.2    Wu, G.3    Newton, R.C.4
  • 13
    • 0033868818 scopus 로고    scopus 로고
    • A novel proteolytic cleavage involved in Notch signaling: The role of the disintegrin-metalloprotease TACE
    • Brou C, Logeat F, Gupta N, Bessia C, LeBail O, et al. (2000) A novel proteolytic cleavage involved in Notch signaling: the role of the disintegrin-metalloprotease TACE. Mol Cell 5: 207-216.
    • (2000) Mol Cell , vol.5 , pp. 207-216
    • Brou, C.1    Logeat, F.2    Gupta, N.3    Bessia, C.4    Lebail, O.5
  • 15
    • 34247363315 scopus 로고    scopus 로고
    • Different ADAMs have distinct influences on Kit ligand processing: Phorbolester- stimulated ectodomain shedding of Kitl1 by ADAM17 is reduced by ADAM19
    • Kawaguchi N, Horiuchi K, Becherer JD, Toyama Y, Besmer P, et al. (2007) Different ADAMs have distinct influences on Kit ligand processing: phorbolester- stimulated ectodomain shedding of Kitl1 by ADAM17 is reduced by ADAM19. J Cell Sci 120: 943-952.
    • (2007) J Cell Sci , vol.120 , pp. 943-952
    • Kawaguchi, N.1    Horiuchi, K.2    Becherer, J.D.3    Toyama, Y.4    Besmer, P.5
  • 16
    • 0042858460 scopus 로고    scopus 로고
    • Membraneanchored CD40 is processed by the tumor necrosis factor-alpha-converting enzyme. Implications for CD40 signaling
    • Contin C, Pitard V, Itai T, Nagata S, Moreau JF, et al. (2003) Membraneanchored CD40 is processed by the tumor necrosis factor-alpha-converting enzyme. Implications for CD40 signaling. J Biol Chem 278: 32801-32809.
    • (2003) J Biol Chem , vol.278 , pp. 32801-32809
    • Contin, C.1    Pitard, V.2    Itai, T.3    Nagata, S.4    Moreau, J.F.5
  • 17
  • 18
    • 0035851124 scopus 로고    scopus 로고
    • Tumor necrosis factor-alpha-converting enzyme (ADAM17) mediates the cleavage and shedding of fractalkine (CX3CL1)
    • Garton KJ, Gough PJ, Blobel CP, Murphy G, Greaves DR, et al. (2001) Tumor necrosis factor-alpha-converting enzyme (ADAM17) mediates the cleavage and shedding of fractalkine (CX3CL1). J Biol Chem 276: 37993-38001.
    • (2001) J Biol Chem , vol.276 , pp. 37993-38001
    • Garton, K.J.1    Gough, P.J.2    Blobel, C.P.3    Murphy, G.4    Greaves, D.R.5
  • 19
    • 33846551969 scopus 로고    scopus 로고
    • Metalloproteases regulate T-cell proliferation and effector function via LAG-3
    • Li N, Wang Y, Forbes K, Vignali KM, Heale BS, et al. (2007) Metalloproteases regulate T-cell proliferation and effector function via LAG-3. EMBO J 26: 494-504.
    • (2007) EMBO J , vol.26 , pp. 494-504
    • Li, N.1    Wang, Y.2    Forbes, K.3    Vignali, K.M.4    Heale, B.S.5
  • 20
    • 67649207274 scopus 로고    scopus 로고
    • Ectodomain shedding of FLT3 ligand is mediated by TNF-alpha converting enzyme
    • Horiuchi K, Morioka H, Takaishi H, Akiyama H, Blobel CP, et al. (2009) Ectodomain shedding of FLT3 ligand is mediated by TNF-alpha converting enzyme. J Immunol 182: 7408-7414.
    • (2009) J Immunol , vol.182 , pp. 7408-7414
    • Horiuchi, K.1    Morioka, H.2    Takaishi, H.3    Akiyama, H.4    Blobel, C.P.5
  • 21
    • 0042887604 scopus 로고    scopus 로고
    • TACE is required for fetal murine cardiac development and modeling
    • Shi W, Chen H, Sun J, Buckley S, Zhao J, et al. (2003) TACE is required for fetal murine cardiac development and modeling. Dev Biol 261: 371-380.
    • (2003) Dev Biol , vol.261 , pp. 371-380
    • Shi, W.1    Chen, H.2    Sun, J.3    Buckley, S.4    Zhao, J.5
  • 22
    • 26244464287 scopus 로고    scopus 로고
    • Mammary ductal morphogenesis requires paracrine activation of stromal EGFR via ADAM17-dependent shedding of epithelial amphiregulin
    • Sternlicht MD, Sunnarborg SW, Kouros-Mehr H, Yu Y, Lee DC, et al. (2005) Mammary ductal morphogenesis requires paracrine activation of stromal EGFR via ADAM17-dependent shedding of epithelial amphiregulin. Development 132: 3923-3933.
    • (2005) Development , vol.132 , pp. 3923-3933
    • Sternlicht, M.D.1    Sunnarborg, S.W.2    Kouros-Mehr, H.3    Yu, Y.4    Lee, D.C.5
  • 23
    • 38449086094 scopus 로고    scopus 로고
    • Cutting edge: TNF-alpha-converting enzyme (TACE/ADAM17) inactivation in mouse myeloid cells prevents lethality from endotoxin shock
    • Horiuchi K, Kimura T, Miyamoto T, Takaishi H, Okada Y, et al. (2007) Cutting edge: TNF-alpha-converting enzyme (TACE/ADAM17) inactivation in mouse myeloid cells prevents lethality from endotoxin shock. J Immunol 179: 2686-2689.
    • (2007) J Immunol , vol.179 , pp. 2686-2689
    • Horiuchi, K.1    Kimura, T.2    Miyamoto, T.3    Takaishi, H.4    Okada, Y.5
  • 24
    • 57349182490 scopus 로고    scopus 로고
    • Deficiency of TNFalpha converting enzyme (TACE/ADAM17) causes a lean, hypermetabolic phenotype in mice
    • Gelling RW, Yan W, Al-Noori S, Pardini A, Morton GJ, et al. (2008) Deficiency of TNFalpha converting enzyme (TACE/ADAM17) causes a lean, hypermetabolic phenotype in mice. Endocrinology 149: 6053-6064.
    • (2008) Endocrinology , vol.149 , pp. 6053-6064
    • Gelling, R.W.1    Yan, W.2    Al-Noori, S.3    Pardini, A.4    Morton, G.J.5
  • 25
    • 33947629847 scopus 로고    scopus 로고
    • Non-Cell Autonomous Expression of TNF-{alpha}-Converting Enzyme ADAM17 Is Required for Normal Lymphocyte Development
    • Li N, Boyd K, Dempsey PJ, Vignali DA (2007) Non-Cell Autonomous Expression of TNF-{alpha}-Converting Enzyme ADAM17 Is Required for Normal Lymphocyte Development. J Immunol 178: 4214-4221.
    • (2007) J Immunol , vol.178 , pp. 4214-4221
    • Li, N.1    Boyd, K.2    Dempsey, P.J.3    Vignali, D.A.4
  • 26
    • 77957853390 scopus 로고    scopus 로고
    • Inhibition of proteolysis of Delta-like-1 does not promote or reduce T-cell developmental potential
    • Gravano DM, Manilay JO (2010) Inhibition of proteolysis of Delta-like-1 does not promote or reduce T-cell developmental potential. Immunol Cell Biol.
    • (2010) Immunol Cell Biol
    • Gravano, D.M.1    Manilay, J.O.2
  • 27
    • 34447104270 scopus 로고    scopus 로고
    • Specific expression of lacZ and cre recombinase in fetal thymic epithelial cells by multiplex gene targeting at the Foxn1 locus
    • Gordon J, Xiao S, Hughes B, 3rd, Su DM, Navarre SP, et al. (2007) Specific expression of lacZ and cre recombinase in fetal thymic epithelial cells by multiplex gene targeting at the Foxn1 locus. BMC Dev Biol 7: 69.
    • (2007) BMC Dev Biol , vol.7 , pp. 69
    • Gordon, J.1    Xiao, S.2    Hughes III, B.3    Su, D.M.4    Navarre, S.P.5
  • 28
    • 58149151302 scopus 로고    scopus 로고
    • Delta-like 4 is the essential, nonredundant ligand for Notch1 during thymic T cell lineage commitment
    • Koch U, Fiorini E, Benedito R, Besseyrias V, Schuster-Gossler K, et al. (2008) Delta-like 4 is the essential, nonredundant ligand for Notch1 during thymic T cell lineage commitment. J Exp Med 205: 2515-2523.
    • (2008) J Exp Med , vol.205 , pp. 2515-2523
    • Koch, U.1    Fiorini, E.2    Benedito, R.3    Besseyrias, V.4    Schuster-Gossler, K.5
  • 30
    • 22344449972 scopus 로고    scopus 로고
    • Promiscuous gene expression in thymic epithelial cells is regulated at multiple levels
    • Derbinski J, Gabler J, Brors B, Tierling S, Jonnakuty S, et al. (2005) Promiscuous gene expression in thymic epithelial cells is regulated at multiple levels. J Exp Med 202: 33-45.
    • (2005) J Exp Med , vol.202 , pp. 33-45
    • Derbinski, J.1    Gabler, J.2    Brors, B.3    Tierling, S.4    Jonnakuty, S.5
  • 31
    • 0032578456 scopus 로고    scopus 로고
    • Interdependence of cortical thymic epithelial cell differentiation and T-lineage commitment
    • Klug DB, Carter C, Crouch E, Roop D, Conti CJ, et al. (1998) Interdependence of cortical thymic epithelial cell differentiation and T-lineage commitment. Proc Natl Acad Sci U S A 95: 11822-11827.
    • (1998) Proc Natl Acad Sci U S A , vol.95 , pp. 11822-11827
    • Klug, D.B.1    Carter, C.2    Crouch, E.3    Roop, D.4    Conti, C.J.5
  • 32
    • 77952302980 scopus 로고    scopus 로고
    • Biphasic Aire expression in early embryos and in medullary thymic epithelial cells before end-stage terminal differentiation
    • Nishikawa Y, Hirota F, Yano M, Kitajima H, Miyazaki J, et al. (2010) Biphasic Aire expression in early embryos and in medullary thymic epithelial cells before end-stage terminal differentiation. J Exp Med 207: 963-971.
    • (2010) J Exp Med , vol.207 , pp. 963-971
    • Nishikawa, Y.1    Hirota, F.2    Yano, M.3    Kitajima, H.4    Miyazaki, J.5
  • 33
    • 35748941369 scopus 로고    scopus 로고
    • Proliferative arrest and rapid turnover of thymic epithelial cells expressing Aire
    • Gray D, Abramson J, Benoist C, Mathis D (2007) Proliferative arrest and rapid turnover of thymic epithelial cells expressing Aire. J Exp Med 204: 2521-2528.
    • (2007) J Exp Med , vol.204 , pp. 2521-2528
    • Gray, D.1    Abramson, J.2    Benoist, C.3    Mathis, D.4
  • 34
    • 45949094459 scopus 로고    scopus 로고
    • The lymphotoxin pathway regulates Aire-independent expression of ectopic genes and chemokines in thymic stromal cells
    • Seach N, Ueno T, Fletcher AL, Lowen T, Mattesich M, et al. (2008) The lymphotoxin pathway regulates Aire-independent expression of ectopic genes and chemokines in thymic stromal cells. J Immunol 180: 5384-5392.
    • (2008) J Immunol , vol.180 , pp. 5384-5392
    • Seach, N.1    Ueno, T.2    Fletcher, A.L.3    Lowen, T.4    Mattesich, M.5
  • 35
    • 34247170523 scopus 로고    scopus 로고
    • A unique thymic fibroblast population revealed by the monoclonal antibody MTS-15
    • Gray DH, Tull D, Ueno T, Seach N, Classon BJ, et al. (2007) A unique thymic fibroblast population revealed by the monoclonal antibody MTS-15. J Immunol 178: 4956-4965.
    • (2007) J Immunol , vol.178 , pp. 4956-4965
    • Gray, D.H.1    Tull, D.2    Ueno, T.3    Seach, N.4    Classon, B.J.5
  • 37
    • 0029942722 scopus 로고    scopus 로고
    • Epidermal growth factor can replace thymic mesenchyme in induction of embryonic thymus morphogenesis in vitro
    • Shinohara T, Honjo T (1996) Epidermal growth factor can replace thymic mesenchyme in induction of embryonic thymus morphogenesis in vitro. Eur J Immunol 26: 747-752.
    • (1996) Eur J Immunol , vol.26 , pp. 747-752
    • Shinohara, T.1    Honjo, T.2
  • 38
    • 0030951076 scopus 로고    scopus 로고
    • Fibroblast dependency during early thymocyte development maps to the CD25+ CD44+ stage and involves interactions with fibroblast matrix molecules
    • Anderson G, Anderson KL, Tchilian EZ, Owen JJ, Jenkinson EJ (1997) Fibroblast dependency during early thymocyte development maps to the CD25+ CD44+ stage and involves interactions with fibroblast matrix molecules. Eur J Immunol 27: 1200-1206.
    • (1997) Eur J Immunol , vol.27 , pp. 1200-1206
    • Anderson, G.1    Anderson, K.L.2    Tchilian, E.Z.3    Owen, J.J.4    Jenkinson, E.J.5
  • 39
    • 0034689058 scopus 로고    scopus 로고
    • An essential role for thymic mesenchyme in early T cell development
    • Suniara RK, Jenkinson EJ, Owen JJ (2000) An essential role for thymic mesenchyme in early T cell development. J Exp Med 191: 1051-1056.
    • (2000) J Exp Med , vol.191 , pp. 1051-1056
    • Suniara, R.K.1    Jenkinson, E.J.2    Owen, J.J.3
  • 40
    • 49149124183 scopus 로고    scopus 로고
    • Contribution of neural crest-derived cells in the embryonic and adult thymus
    • Foster K, Sheridan J, Veiga-Fernandes H, Roderick K, Pachnis V, et al. (2008) Contribution of neural crest-derived cells in the embryonic and adult thymus. J Immunol 180: 3183-3189.
    • (2008) J Immunol , vol.180 , pp. 3183-3189
    • Foster, K.1    Sheridan, J.2    Veiga-Fernandes, H.3    Roderick, K.4    Pachnis, V.5
  • 41
    • 77952961847 scopus 로고    scopus 로고
    • Neural crest-derived pericytes promote egress of mature thymocytes at the corticomedullary junction
    • Zachariah MA, Cyster JG (2010) Neural crest-derived pericytes promote egress of mature thymocytes at the corticomedullary junction. Science 328: 1129-1135.
    • (2010) Science , vol.328 , pp. 1129-1135
    • Zachariah, M.A.1    Cyster, J.G.2
  • 42
    • 0034049874 scopus 로고    scopus 로고
    • Glucocorticoids in T cell development and function*
    • Ashwell JD, Lu FW, Vacchio MS (2000) Glucocorticoids in T cell development and function*. Annu Rev Immunol 18: 309-345.
    • (2000) Annu Rev Immunol , vol.18 , pp. 309-345
    • Ashwell, J.D.1    Lu, F.W.2    Vacchio, M.S.3
  • 43
    • 0032741972 scopus 로고    scopus 로고
    • Leptin protects mice from starvation-induced lymphoid atrophy and increases thymic cellularity in ob/ob mice
    • Howard JK, Lord GM, Matarese G, Vendetti S, Ghatei MA, et al. (1999) Leptin protects mice from starvation-induced lymphoid atrophy and increases thymic cellularity in ob/ob mice. J Clin Invest 104: 1051-1059.
    • (1999) J Clin Invest , vol.104 , pp. 1051-1059
    • Howard, J.K.1    Lord, G.M.2    Matarese, G.3    Vendetti, S.4    Ghatei, M.A.5
  • 44
    • 53249084263 scopus 로고    scopus 로고
    • Leptin acts in the periphery to protect thymocytes from glucocorticoid-mediated apoptosis in the absence of weight loss
    • Trotter-Mayo RN, Roberts MR (2008) Leptin acts in the periphery to protect thymocytes from glucocorticoid-mediated apoptosis in the absence of weight loss. Endocrinology 149: 5209-5218.
    • (2008) Endocrinology , vol.149 , pp. 5209-5218
    • Trotter-Mayo, R.N.1    Roberts, M.R.2
  • 45
    • 0037084784 scopus 로고    scopus 로고
    • Aire deficient mice develop multiple features of APECED phenotype and show altered immune response
    • Ramsey C, Winqvist O, Puhakka L, Halonen M, Moro A, et al. (2002) Aire deficient mice develop multiple features of APECED phenotype and show altered immune response. Hum Mol Genet 11: 397-409.
    • (2002) Hum Mol Genet , vol.11 , pp. 397-409
    • Ramsey, C.1    Winqvist, O.2    Puhakka, L.3    Halonen, M.4    Moro, A.5
  • 46
    • 25144432460 scopus 로고    scopus 로고
    • Modifier loci condition autoimmunity provoked by Aire deficiency
    • Jiang W, Anderson MS, Bronson R, Mathis D, Benoist C (2005) Modifier loci condition autoimmunity provoked by Aire deficiency. J Exp Med 202: 805-815.
    • (2005) J Exp Med , vol.202 , pp. 805-815
    • Jiang, W.1    Anderson, M.S.2    Bronson, R.3    Mathis, D.4    Benoist, C.5
  • 47
    • 13544262691 scopus 로고    scopus 로고
    • Development of autoimmunity against transcriptionally unrepressed target antigen in the thymus of Aire-deficient mice
    • Kuroda N, Mitani T, Takeda N, Ishimaru N, Arakaki R, et al. (2005) Development of autoimmunity against transcriptionally unrepressed target antigen in the thymus of Aire-deficient mice. J Immunol 174: 1862-1870.
    • (2005) J Immunol , vol.174 , pp. 1862-1870
    • Kuroda, N.1    Mitani, T.2    Takeda, N.3    Ishimaru, N.4    Arakaki, R.5
  • 49
    • 0041884736 scopus 로고    scopus 로고
    • Thymic medullary epithelial cell differentiation, thymocyte emigration, and the control of autoimmunity require lympho-epithelial cross talk via LTbetaR
    • Boehm T, Scheu S, Pfeffer K, Bleul CC (2003) Thymic medullary epithelial cell differentiation, thymocyte emigration, and the control of autoimmunity require lympho-epithelial cross talk via LTbetaR. J Exp Med 198: 757-769.
    • (2003) J Exp Med , vol.198 , pp. 757-769
    • Boehm, T.1    Scheu, S.2    Pfeffer, K.3    Bleul, C.C.4
  • 50
    • 0032754773 scopus 로고    scopus 로고
    • Expression and alternative splicing of the mouse autoimmune regulator gene (Aire)
    • Ruan QG, Wang CY, Shi JD, She JX (1999) Expression and alternative splicing of the mouse autoimmune regulator gene (Aire). J Autoimmun 13: 307-313.
    • (1999) J Autoimmun , vol.13 , pp. 307-313
    • Ruan, Q.G.1    Wang, C.Y.2    Shi, J.D.3    She, J.X.4
  • 51
    • 77951930123 scopus 로고    scopus 로고
    • Receptor activator of NF-kappaB (RANK) ligand induces ectodomain shedding of RANK in murine RAW264.7 macrophages
    • Hakozaki A, Yoda M, Tohmonda T, Furukawa M, Hikata T, et al. (2010) Receptor activator of NF-kappaB (RANK) ligand induces ectodomain shedding of RANK in murine RAW264.7 macrophages. J Immunol 184: 2442-2448.
    • (2010) J Immunol , vol.184 , pp. 2442-2448
    • Hakozaki, A.1    Yoda, M.2    Tohmonda, T.3    Furukawa, M.4    Hikata, T.5
  • 52
    • 51349111243 scopus 로고    scopus 로고
    • The tumor necrosis factor family receptors RANK and CD40 cooperatively establish the thymic medullary microenvironment and self-tolerance
    • Akiyama T, Shimo Y, Yanai H, Qin J, Ohshima D, et al. (2008) The tumor necrosis factor family receptors RANK and CD40 cooperatively establish the thymic medullary microenvironment and self-tolerance. Immunity 29: 423-437.
    • (2008) Immunity , vol.29 , pp. 423-437
    • Akiyama, T.1    Shimo, Y.2    Yanai, H.3    Qin, J.4    Ohshima, D.5
  • 53
    • 51349092893 scopus 로고    scopus 로고
    • The cytokine RANKL produced by positively selected thymocytes fosters medullary thymic epithelial cells that express autoimmune regulator
    • Hikosaka Y, Nitta T, Ohigashi I, Yano K, Ishimaru N, et al. (2008) The cytokine RANKL produced by positively selected thymocytes fosters medullary thymic epithelial cells that express autoimmune regulator. Immunity 29: 438-450.
    • (2008) Immunity , vol.29 , pp. 438-450
    • Hikosaka, Y.1    Nitta, T.2    Ohigashi, I.3    Yano, K.4    Ishimaru, N.5
  • 54
    • 34250336454 scopus 로고    scopus 로고
    • RANK signals from CD4(+)3(-) inducer cells regulate development of Aireexpressing epithelial cells in the thymic medulla
    • Rossi SW, Kim MY, Leibbrandt A, Parnell SM, Jenkinson WE, et al. (2007) RANK signals from CD4(+)3(-) inducer cells regulate development of Aireexpressing epithelial cells in the thymic medulla. J Exp Med 204: 1267-1272.
    • (2007) J Exp Med , vol.204 , pp. 1267-1272
    • Rossi, S.W.1    Kim, M.Y.2    Leibbrandt, A.3    Parnell, S.M.4    Jenkinson, W.E.5
  • 55
    • 61449111905 scopus 로고    scopus 로고
    • Conditional inactivation of TACE by a Sox9 promoter leads to osteoporosis and increased granulopoiesis via dysregulation of IL-17 and G-CSF
    • Horiuchi K, Kimura T, Miyamoto T, Miyamoto K, Akiyama H, et al. (2009) Conditional inactivation of TACE by a Sox9 promoter leads to osteoporosis and increased granulopoiesis via dysregulation of IL-17 and G-CSF. J Immunol 182: 2093-2101.
    • (2009) J Immunol , vol.182 , pp. 2093-2101
    • Horiuchi, K.1    Kimura, T.2    Miyamoto, T.3    Miyamoto, K.4    Akiyama, H.5
  • 56
    • 77950889362 scopus 로고    scopus 로고
    • Pathological neovascularization is reduced by inactivation of ADAM17 in endothelial cells but not in pericytes
    • Weskamp G, Mendelson K, Swendeman S, Le Gall S, Ma Y, et al. (2010) Pathological neovascularization is reduced by inactivation of ADAM17 in endothelial cells but not in pericytes. Circ Res 106: 932-940.
    • (2010) Circ Res , vol.106 , pp. 932-940
    • Weskamp, G.1    Mendelson, K.2    Swendeman, S.3    le Gall, S.4    Ma, Y.5
  • 57
    • 33845239216 scopus 로고    scopus 로고
    • Developmental kinetics, turnover, and stimulatory capacity of thymic epithelial cells
    • Gray DH, Seach N, Ueno T, Milton MK, Liston A, et al. (2006) Developmental kinetics, turnover, and stimulatory capacity of thymic epithelial cells. Blood 108: 3777-3785.
    • (2006) Blood , vol.108 , pp. 3777-3785
    • Gray, D.H.1    Seach, N.2    Ueno, T.3    Milton, M.K.4    Liston, A.5
  • 58
    • 41949087056 scopus 로고    scopus 로고
    • Notch target Hes5 ensures appropriate Notch induced T- versus B-cell choices in the thymus
    • Varnum-Finney B, Dallas MH, Kato K, Bernstein ID (2008) Notch target Hes5 ensures appropriate Notch induced T- versus B-cell choices in the thymus. Blood 111: 2615-2620.
    • (2008) Blood , vol.111 , pp. 2615-2620
    • Varnum-Finney, B.1    Dallas, M.H.2    Kato, K.3    Bernstein, I.D.4
  • 59
    • 54049121774 scopus 로고    scopus 로고
    • Alterations of the medullary epithelial compartment in the Aire-deficient thymus: Implications for programs of thymic epithelial differentiation
    • Dooley J, Erickson M, Farr AG (2008) Alterations of the medullary epithelial compartment in the Aire-deficient thymus: implications for programs of thymic epithelial differentiation. J Immunol 181: 5225-5232.
    • (2008) J Immunol , vol.181 , pp. 5225-5232
    • Dooley, J.1    Erickson, M.2    Farr, A.G.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.