Receptor activator of NF-κB (RANK) ligand induces ectodomain shedding of RANK in murine RAW264.7 macrophages

Journal of Immunology

Volumn 184, Issue 5, 2010, Pages 2442-2448

  Hakozaki, Akihiro ^a   Yoda, Masaki ^a   Tohmonda, Takahide ^a   Furukawa, Mitsuru ^a   Hikata, Tomohiro ^a   Uchikawa, Shinichi ^a   Takaishi, Hironari ^a   Matsumoto, Morio ^a   Chiba, Kazuhiro ^a   Horiuchi, Keisuke ^a   Toyama, Yoshiaki ^a  

^a KEIO UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

MITOGEN ACTIVATED PROTEIN KINASE; MONOMER; RECEPTOR ACTIVATOR OF NUCLEAR FACTOR KAPPA B; TUMOR NECROSIS FACTOR ALPHA CONVERTING ENZYME; TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED FACTOR 6; ADAM PROTEIN; MEMBRANE PROTEIN; NFATC1 PROTEIN, MOUSE; OSTEOCLAST DIFFERENTIATION FACTOR; TRANSCRIPTION FACTOR NFAT; TUMOR NECROSIS FACTOR-ALPHA CONVERTASE;

ANIMAL CELL; ANIMAL CELL CULTURE; ARTICLE; CONTROLLED STUDY; EMBRYO; ENZYME ACTIVITY; MACROPHAGE; MOLECULE; MOUSE; NONHUMAN; OSTEOCLAST; OSTEOCLASTOGENESIS; PRECURSOR; PRIORITY JOURNAL; ANIMAL; BINDING SITE; CELL LINE; CELL STRAIN COS1; CERCOPITHECUS; CHEMISTRY; CYTOLOGY; FLOW CYTOMETRY; GENETIC TRANSFECTION; GENETICS; METABOLISM; MOUSE MUTANT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SOLUBILITY; UPREGULATION; WESTERN BLOTTING;

ADAM PROTEINS; ANIMALS; BINDING SITES; BLOTTING, WESTERN; CELL LINE; CERCOPITHECUS AETHIOPS; COS CELLS; FLOW CYTOMETRY; MACROPHAGES; MEMBRANE PROTEINS; MICE; MICE, KNOCKOUT; MITOGEN-ACTIVATED PROTEIN KINASES; NFATC TRANSCRIPTION FACTORS; OSTEOCLASTS; RANK LIGAND; RECEPTOR ACTIVATOR OF NUCLEAR FACTOR-KAPPA B; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SOLUBILITY; TNF RECEPTOR-ASSOCIATED FACTOR 6; TRANSFECTION; UP-REGULATION;

EID: 77951930123     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.0901188     Document Type: Article

References (37)

1. Theoleyre, S., Y. Wittrant, S. K. Tat, Y. Fortun, F. Redini, and D. Heymann. 2004. The molecular triad OPG/RANK/RANKL: involvement in the orchestration of pathophysiological bone remodeling. Cytokine Growth Factor Rev. 15: 457-475. (Pubitemid 39550455)
2. Boyle, W. J., W. S. Simonet, and D. L. Lacey. 2003. Osteoclast differentiation and activation. Nature 423: 337-342.
3. Asagiri, M., and H. Takayanagi. 2007. The molecular understanding of osteoclast differentiation. Bone 40: 251-264.
4. Wada, T., T. Nakashima, N. Hiroshi, and J. M. Penninger. 2006. RANKL-RANK signaling in osteoclastogenesis and bone disease. Trends Mol. Med. 12: 17-25.
5. Simonet, W. S., D. L. Lacey, C. R. Dunstan, M. Kelley, M. S. Chang, R. Lüthy, H. Q. Nguyen, S. Wooden, L. Bennett, T. Boone, et al. 1997. Osteoprotegerin: a novel secreted protein involved in the regulation of bone density. Cell 89: 309-319.
6. Kong, Y. Y., H. Yoshida, I. Sarosi, H. L. Tan, E. Timms, C. Capparelli, S. Morony, A. J. Oliveira-dos-Santos, G. Van, A. Itie, et al. 1999. OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesis. Nature 397: 315-323.
7. Dougall, W. C., M. Glaccum, K. Charrier, K. Rohrbach, K. Brasel, T. De Smedt, E. Daro, J. Smith, M. E. Tometsko, C. R. Maliszewski, et al. 1999. RANK is essential for osteoclast and lymph node development. Genes Dev. 13: 2412-2424.
8. Murphy, G., A. Murthy, and R. Khokha. 2008. Clipping, shedding and RIPping keep immunity on cue. Trends Immunol. 29: 75-82.
9. Kheradmand, F., and Z. Werb. 2002. Shedding light on sheddases: role in growth and development. Bioessays 24: 8-12. (Pubitemid 34108414)
10. Overall, C. M., and C. P. Blobel. 2007. In search of partners: linking extracellular proteases to substrates. Nat. Rev. Mol. Cell Biol. 8: 245-257.
11. Blobel, C. P. 2000. Remarkable roles of proteolysis on and beyond the cell surface. Curr. Opin. Cell Biol. 12: 606-612.
12. Hikita, A., I. Yana, H. Wakeyama, M. Nakamura, Y. Kadono, Y. Oshima, K. Nakamura, M. Seiki, and S. Tanaka. 2006. Negative regulation of osteoclastogenesis by ectodomain shedding of receptor activator of NF-kappaB ligand. J. Biol. Chem. 281: 36846-36855.
13. Lum, L., B. R. Wong, R. Josien, J. D. Becherer, H. Erdjument-Bromage, J. Schlöndorff, P. Tempst, Y. Choi, and C. P. Blobel. 1999. Evidence for a role of a tumor necrosis factor-α (TNF-α)-converting enzyme-like protease in shedding of TRANCE, a TNF family member involved in osteoclastogenesis and dendritic cell survival. J. Biol. Chem. 274: 13613-13618.
14. Hikita, A., Y. Kadono, H. Chikuda, A. Fukuda, H. Wakeyama, H. Yasuda, K. Nakamura, H. Oda, T. Miyazaki, and S. Tanaka. 2005. Identification of an alternatively spliced variant of Ca2+-promoted Ras inactivator as a possible regulator of RANKL shedding. J. Biol. Chem. 280: 41700-41706.
15. Horiuchi, K., T. Miyamoto, H. Takaishi, A. Hakozaki, N. Kosaki, Y. Miyauchi, M. Furukawa, J. Takito, H. Kaneko, K. Matsuzaki, et al. 2007. Cell surface colony-stimulating factor 1 can be cleaved by TNF-α converting enzyme or endocytosed in a clathrin-dependent manner. J. Immunol. 179: 6715-6724.
16. Rovida, E., A. Paccagnini, M. Del Rosso, J. Peschon, and P. Dello Sbarba. 2001. TNF-α-converting enzyme cleaves the macrophage colony-stimulating factor receptor in macrophages undergoing activation. J. Immunol. 166: 1583-1589. (Pubitemid 32114638)
17. Horiuchi, K., and Y. Toyama. 2008. Posttranslational regulation of cell-surface colony-stimulating factor-1. Crit. Rev. Immunol. 28: 215-227.
18. Weskamp, G., H. Cai, T. A. Brodie, S. Higashyama, K. Manova, T. Ludwig, and C. P. Blobel. 2002. Mice lacking the metalloprotease-disintegrin MDC9 (ADAM9) have no evident major abnormalities during development or adult life. Mol. Cell. Biol. 22: 1537-1544.
19. Horiuchi, K., T. Kimura, T. Miyamoto, H. Takaishi, Y. Okada, Y. Toyama, and C. P. Blobel. 2007. Cutting edge: TNF-a-converting enzyme (TACE/ADAM17) inactivation in mouse myeloid cells prevents lethality from endotoxin shock. J. Immunol. 179: 2686-2689.
20. Sahin, U., G. Weskamp, Y. Zheng, V. Chesneau, K. Horiuchi, and C. P. Blobel. 2006. A sensitive method to monitor ectodomain shedding of ligands of the epidermal growth factor receptor. Methods Mol. Biol. 327: 99-113.
21. Weskamp, G., J. Schlöndorff, L. Lum, J. D. Becherer, T. W. Kim, P. Saftig, D. Hartmann, G. Murphy, and C. P. Blobel. 2004. Evidence for a critical role of the tumor necrosis factor a convertase (TACE) in ectodomain shedding of the p75 neurotrophin receptor (p75NTR). J. Biol. Chem. 279: 4241-4249.
22. Kanazawa, K., and A. Kudo. 2005. Self-assembled RANK induces osteoclastogenesis ligand-independently. J. Bone Miner. Res. 20: 2053-2060.
23. Horiuchi, K., S. Le Gall, M. Schulte, T. Yamaguchi, K. Reiss, G. Murphy, Y. Toyama, D. Hartmann, P. Saftig, and C. P. Blobel. 2007. Substrate selectivity of epidermal growth factor-receptor ligand sheddases and their regulation by phorbol esters and calcium influx. Mol. Biol. Cell 18: 176-188.
24. Swendeman, S., K. Mendelson, G. Weskamp, K. Horiuchi, U. Deutsch, P. Scherle, A. Hooper, S. Rafii, and C. P. Blobel. 2008. VEGF-A stimulates ADAM17-dependent shedding of VEGFR2 and crosstalk between VEGFR2 and ERK signaling. Circ. Res. 103: 916-918.
25. Ye, H., J. R. Arron, B. Lamothe, M. Cirilli, T. Kobayashi, N. K. Shevde, D. Segal, O. K. Dzivenu, M. Vologodskaia, M. Yim, et al. 2002. Distinct molecular mechanism for initiating TRAF6 signalling. Nature 418: 443-447.
26. Azuma, Y., K. Kaji, R. Katogi, S. Takeshita, and A. Kudo. 2000. Tumor necrosis factor-α induces differentiation of and bone resorption by osteoclasts. J. Biol. Chem. 275: 4858-4864.
27. Murakami, D., I. Okamoto, O. Nagano, Y. Kawano, T. Tomita, T. Iwatsubo, B. De Strooper, E. Yumoto, and H. Saya. 2003. Presenilin-dependent γ-secretase activity mediates the intramembranous cleavage of CD44. Oncogene 22: 1511-1516. (Pubitemid 36390600)
28. Nagano, O., and H. Saya. 2004. Mechanism and biological significance of CD44 cleavage. Cancer Sci. 95: 930-935. (Pubitemid 40089583)
29. Mumm, J. S., E. H. Schroeter, M. T. Saxena, A. Griesemer, X. Tian, D. J. Pan, W. J. Ray, and R. Kopan. 2000. A ligand-induced extracellular cleavage regulates γ-secretase-like proteolytic activation of Notch1. Mol. Cell 5: 197-206.
30. Pinckard, J. K., K. C. Sheehan, C. D. Arthur, and R. D. Schreiber. 1997. Constitutive shedding of both p55 and p75 murine TNF receptors in vivo. J. Immunol. 158: 3869-3873.
31. McDermott, M. F., I. Aksentijevich, J. Galon, E. M. McDermott, B. W. Ogunkolade, M. Centola, E. Mansfield, M. Gadina, L. Karenko, T. Pettersson, et al. 1999. Germline mutations in the extracellular domains of the 55 kDa TNF receptor, TNFR1, define a family of dominantly inherited autoinflammatory syndromes. Cell 97: 133-144.
32. Xanthoulea, S., M. Pasparakis, S. Kousteni, C. Brakebusch, D.Wallach, J. Bauer, H. Lassmann, and G. Kollias. 2004. Tumor necrosis factor (TNF) receptor shedding controls thresholds of innate immune activation that balance opposing TNF functions in infectious and inflammatory diseases. J. Exp. Med. 200: 367-376.
33. Nakagawa, N., M. Kinosaki, K. Yamaguchi, N. Shima, H. Yasuda, K. Yano, T. Morinaga, and K. Higashio. 1998. RANK is the essential signaling receptor for osteoclast differentiation factor in osteoclastogenesis. Biochem. Biophys. Res. Commun. 253: 395-400.
34. Oyajobi, B. O., D. M. Anderson, K. Traianedes, P. J. Williams, T. Yoneda, and G. R. Mundy. 2001. Therapeutic efficacy of a soluble receptor activator of nuclear factor kappaB-IgG Fc fusion protein in suppressing bone resorption and hypercalcemia in a model of humoral hypercalcemia of malignancy. Cancer Res. 61: 2572-2578.
35. Sordillo, E. M., and R. N. Pearse. 2003. RANK-Fc: a therapeutic antagonist for RANK-L in myeloma. Cancer 97(3, Suppl.)802-812.
36. Zhang, J., J. Dai, Z. Yao, Y. Lu, W. Dougall, and E. T. Keller. 2003. Soluble receptor activator of nuclear factor kappaB Fc diminishes prostate cancer progression in bone. Cancer Res. 63: 7883-7890. (Pubitemid 37466723)
37. Shipman, C. M., and P. I. Croucher. 2003. Osteoprotegerin is a soluble decoy receptor for tumor necrosis factor-related apoptosis-inducing ligand/Apo2 ligand and can function as a paracrine survival factor for human myeloma cells. Cancer Res. 63: 912-916.