Leptin acts in the periphery to protect thymocytes from glucocorticoid-mediated apoptosis in the absence of weight loss

Endocrinology

Volumn 149, Issue 10, 2008, Pages 5209-5218

  Trotter Mayo, Robert N ^a   Roberts, Margo R ^b  

^a UNIVERSITY OF VIRGINIA   (United States)

^b UNIVERSITY OF VIRGINIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CORTICOSTERONE; GLUCOCORTICOID; LEPTIN;

ADRENALECTOMY; ANIMAL EXPERIMENT; APOPTOSIS; ARTICLE; BONE MARROW; CELL PROTECTION; CONTROLLED STUDY; HYPOTHALAMUS; MOUSE; NONHUMAN; PRIORITY JOURNAL; THYMOCYTE; WEIGHT REDUCTION;

ADRENALECTOMY; AGE FACTORS; ANIMALS; APOPTOSIS; ATROPHY; CHIMERA; CORTICOSTERONE; FLOW CYTOMETRY; LEPTIN; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICE, OBESE; OBESITY; RECEPTORS, LEPTIN; THYMUS GLAND; WEIGHT LOSS;

EID: 53249084263     PISSN: 00137227     EISSN: 00137227     Source Type: Journal    
DOI: 10.1210/en.2008-0476     Document Type: Article

References (46)

1. Zhang Y, Proenca R, Maffei M, Barone M, Leopold L, Friedman JM 1994 Positional cloning of the mouse obese gene and its human homologue. Nature 372:425-432
2. Gaucher EA, Miyamoto MM, Benner SA 2003 Evolutionary, structural and biochemical evidence for a new interaction site of the leptin obesity protein. Genetics 163:1549-1553
3. Tartaglia LA 1997 The leptin receptor. J Biol Chem 272:6093-6096
4. Considine RV, Sinha MK, Heiman ML, Kriauciunas A, Stephens TW, Nyce MR, Ohannesian JP, Marco CC, McKee LJ, Bauer TL, Caro JF 1996 Serum immunoreactive-leptin concentrations in normal-weight and obese humans. N Engl J Med 334:292-295
5. Maffei M, Halaas J, Ravussin E, Pratley RE, Lee GH, Zhang Y, Fei H, Kim S, Lallone R, Ranganathan S, Kern PA, Friedman JM 1995 Leptin levels in human and rodent: measurement of plasma leptin and ob RNA in obese and weight-reduced subjects. Nat Med 1:1155-1161
6. Pelleymounter MA, Cullen MJ, Baker MB, Hecht R, Winters D, Boone T, Collins F 1995 Effects of the obese gene product on body weight regulation in ob/ob mice. Science 269:540-543
7. Halaas JL, Gajiwala KS, Maffei M, Cohen SL, Chait BT, Rabinowitz D, Lallone RL, Burley SK, Friedman JM 1995 Weight-reducing effects of the plasma protein encoded by the obese gene. Science 269:543-546
8. Frederich RC, Hamann A, Anderson S, Lollmann B, Lowell BB, Flier JS 1995 Leptin levels reflect body lipid content in mice: evidence for diet-induced resistance to leptin action. Nat Med 1:1311-1314
9. Scarpace PJ, Matheny M 1998 Leptin induction of UCP1 gene expression is dependent on sympathetic innervation. Am J Physiol 275:E259-E264
10. Takeda S, Elefteriou F, Karsenty G 2003 Common endocrine control of body weight, reproduction, and bone mass. Annu Rev Nutr 23:403-411
11. Bajari TM, Nimpf J, Schneider WJ 2004 Role of leptin in reproduction. Curr Opin Lipidol 15:315-319
12. Proulx K, Clavel S, Nault G, Richard D, Walker CD 2001 High neonatal leptin exposure enhances brain GR expression and feedback efficacy on the adrenocortical axis of developing rats. Endocrinology 142:4607-4616
13. Huang Q, Timofeeva E, Richard D 2006 Regulation of corticotropin-releasing factor and its types 1 and 2 receptors by leptin in rats subjected to treadmill running-induced stress. J Endocrinol 191:179-188
14. Chehab FF, Qiu J, Ogus S 2004 The use of animal models to dissect the biology of leptin. Recent Prog Horm Res 59:245-266
15. Thomas T 2004 The complex effects of leptin on bone metabolism through multiple pathways. Curr Opin Pharmacol 4:295-300
16. Bornstein SR, Uhlmann K, Haidan A, Ehrhart-Bornstein M, Scherbaum WA 1997 Evidence for a novel peripheral action of leptin as a metabolic signal to the adrenal gland: leptin inhibits cortisol release directly. Diabetes 46:1235-1238
17. Bjorbaek C, Kahn BB 2004 Leptin signaling in the central nervous system and the periphery. Recent Prog Horm Res 59:305-331
18. Matarese G, Moschos S, Mantzoros CS 2005 Leptin in immunology. J Immunol 174:3137-3142
19. Ahima RS, Prabakaran D, Mantzoros C, Qu D, Lowell B, Maratos-Flier E, Flier JS 1996 Role of leptin in the neuroendocrine response to fasting. Nature 382:250-252
20. Boden G, Chen X, Mozzoli M, Ryan I 1996 Effect of fasting on serum leptin in normal human subjects. J Clin Endocrinol Metab 81:3419-3423
21. Weigle DS, Duell PB, Connor WE, Steiner RA, Soules MR, Kuijper JL 1997 Effect of fasting, refeeding, and dietary fat restriction on plasma leptin levels. J Clin Endocrinol Metab 82:561-565
22. Neumann CG, Gewa C, Bwibo NO 2004 Child nutrition in developing countries. Pediatr Ann 33:658-674
23. Chandra RK 1980 Cell-mediated immunity in genetically obese C57BL/6J ob/ob) mice. Am J Clin Nutr 33:13-16
24. Meade CJ, Sheena J, Mertin J 1979 Effects of the obese (ob/ob) genotype on spleen cell immune function. Int Arch Allergy Appl Immunol 58:121-127
25. Howard JK, Lord GM, Matarese G, Vendetti S, Ghatei MA, Ritter MA, Lechler RI, Bloom SR 1999 Leptin protects mice from starvation-induced lymphoid atrophy and increases thymic cellularity in ob/ob mice. J Clin Invest 104:1051-1059
26. Hick RW, Gruver AL, Ventevogel MS, Haynes BF, Sempowski GD 2006 Leptin selectively augments thymopoiesis in leptin deficiency and lipopolysaccharide-induced thymic atrophy. J Immunol 177:169-176
27. Fujita Y, Murakami M, Ogawa Y, Masuzaki H, Tanaka M, Ozaki S, Nakao K, Mimori T 2002 Leptin inhibits stress-induced apoptosis of T lymphocytes. Clin Exp Immunol 128:21-26
28. Savino W 2002 The thymus gland is a target in malnutrition. Eur J Clin Nutr 56(Suppl 3):S46-S49
29. Prentice AM 1999 The thymus: a barometer of malnutrition. Br J Nutr 81:345-347
30. Montez JM, Soukas A, Asilmaz E, Fayzikhodjaeva G, Fantuzzi G, Friedman JM 2005 Acute leptin deficiency, leptin resistance, and the physiologic response to leptin withdrawal. Proc Natl Acad Sci USA 102:2537-2542
31. Garthwaite TL, Martinson DR, Tseng LF, Hagen TC, Menahan LA 1980 A longitudinal hormonal profile of the genetically obese mouse. Endocrinology 107:671-676
32. Shimomura Y, Bray GA, Lee M 1987 Adrenalectomy and steroid treatment in obese (ob/ob) and diabetic (db/db) mice. Horm Metab Res 19:295-299
33. Chen H, Charlat O, Tartaglia LA, Woolf EA, Weng X, Ellis SJ, Lakey ND, Culpepper J, Moore KJ, Breitbart RE, Duyk GM, Tepper RI, Morgenstern JP 1996 Evidence that the diabetes gene encodes the leptin receptor: identification of a mutation in the leptin receptor gene in db/db mice. Cell 84:491-495
34. Chowers I, Einat R, Feldman S 1969 Effects of starvation on levels of corticotrophin releasing factor, corticotrophin and plasma corticosterone in rats. Acta Endocrinol (Copenh) 61:687-694
35. Barone KS, O'Brien PC, Stevenson JR 1993 Characterization and mechanisms of thymic atrophy in protein-malnourished mice: role of corticosterone. Cell Immunol 148:226-233
36. Trotter RN, Stornetta RL, Guyenet PG, Roberts MR 2007 Transneuronal mapping of the CNS network controlling sympathetic outflow to the rat thymus. Auton Neurosci 131:9-20
37. Sennello JA, Fayad R, Pini M, Gove ME, Fantuzzi G 2006 Transplantation of wild-type white adipose tissue normalizes metabolic, immune and inflammatory alterations in leptin-deficient ob/ob mice. Cytokine 36:261-266
38. Pruett SB, Padgett EL 2004 Thymus-derived glucocorticoids are insufficient for normal thymus homeostasis in the adult mouse. BMC Immunol 5:24
39. Zediak VP, Bhandoola A 2005 Aging and T cell development: interplay between progenitors and their environment. Semin Immunol 17:337-346
40. Dixit VD, Yang H, Sun Y, Weeraratna AT, Youm YH, Smith RG, Taub DD 2007 Ghrelin promotes thymopoiesis during aging. J Clin Invest 117:2778-2790
41. Almeida AR, Borghans JA, Freitas AA 2001 T cell homeostasis: thymus regeneration and peripheral T cell restoration in mice with a reduced fraction of competent precursors. J Exp Med 194:591-599
42. Prockop SE, Petrie HT 2004 Regulation of thymus size by competition for stromal niches among early T cell progenitors. J Immunol 173:1604-1611
43. Bennett BD, Solar GP, Yuan JQ, Mathias J, Thomas GR, Matthews W 1996 A role for leptin and its cognate receptor in hematopoiesis. Curr Biol 6:1170-1180
44. Kim GS, Hong JS, Kim SW, Koh JM, An CS, Choi JY, Cheng SL 2003 Leptin induces apoptosis via ERK/cPLA2/cytochrome c pathway in human bone marrow stromal cells. J Biol Chem 278:21920-21929
45. Thomas T, Gori F, Khosla S, Jensen MD, Burguera B, Riggs BL 1999 Leptin acts on human marrow stromal cells to enhance differentiation to osteoblasts and to inhibit differentiation to adipocytes. Endocrinology 140:1630-1638
46. Palmer G, Aurrand-Lions M, Contassot E, Talabot-Ayer D, Ducrest-Gay D, Vesin C, Chobaz-Peclat V, Busso N, Gabay C 2006 Indirect effects of leptin receptor deficiency on lymphocyte populations and immune response in db/db mice. J Immunol 177:2899-2907