Integrative functional genomics analysis of sustained polyploidy phenotypes in breast cancer cells identifies an oncogenic profile for GINS2

Neoplasia

Volumn 12, Issue 11, 2010, Pages 877-888

  Rantala, Juha K ^a   Edgren, Henrik ^b   Lehtinen, Laura ^a   Wolf, Maija ^b   Kleivi, Kristine ^a,c   Vollan, Hans Kristian Moen ^c,d,e   Aaltola, Anna Riina ^a   Laasola, Petra ^a   Kilpinen, Sami ^b   Saviranta, Petri ^a   Iljin, Kristiina ^a,f   Kallioniemi, Olli ^a,b  

^a VTT TECHNICAL RESEARCH CENTRE OF FINLAND   (Finland)

^b UNIVERSITY OF HELSINKI   (Finland)

^c OSLO UNIVERSITY HOSPITAL   (Norway)

^d ULLEVÅL UNIVERSITY HOSPITAL   (Norway)

^e UNIVERSITY OF OSLO   (Norway)

^f UNIVERSITY OF TURKU   (Finland)

Author keywords

[No Author keywords available]

Indexed keywords

GINS COMPLEX SUBUNIT 2 PROTEIN; HELICASE; UNCLASSIFIED DRUG;

ANEUPLOIDY; ARTICLE; BREAST CANCER; CANCER CELL CULTURE; CELL GROWTH; CELL PROLIFERATION; CONTROLLED STUDY; DNA DAMAGE; DNA REPAIR; FUNCTIONAL GENOMICS; GENE DOSAGE; GENE FUNCTION; GENE IDENTIFICATION; GENE REPRESSION; GENE SILENCING; GROWTH INHIBITION; HUMAN; HUMAN CELL; NUCLEOTIDE SEQUENCE; ONCOGENE; ONCOGENE GINS2; POLYPLOIDY; PRIORITY JOURNAL;

EID: 78149435241     PISSN: 15228002     EISSN: 14765586     Source Type: Journal    
DOI: 10.1593/neo.10548     Document Type: Article

References (48)

1. Rhodes DR, Yu J, Shanker K, Deshpande N, Varambally R, Ghosh D, Barrette T, Pandey A, and Chinnaiyan AM (2004). Large-scale meta-analysis of cancer microarray data identifies common transcriptional profiles of neoplastic transformation and progression. Proc Natl Acad Sci USA 101, 9309-9314.
2. van't Veer LJ, Dai H, van de Vijver MJ, He YD, Hart AA, Mao M, Peterse HL, van der Kooy K, Marton MJ, Witteveen AT, et al. (2002). Gene expression profiling predicts clinical outcome of breast cancer. Nature 415, 530-536.
3. Kluger HM, Kluger Y, Gilmore-Hebert M, DiVito K, Chang JT, Rodov S, Mironenko O, Kacinski BM, Perkins AS, and Sapi E (2004). cDNA microarray analysis of invasive and tumorigenic phenotypes in a breast cancer model. Lab Invest 84, 320-331.
4. Chen JJ, Peck K, Hong TM, Yang SC, Sher YP, Shih JY, Wu R, Cheng JL, Roffler SR, Wu CW, et al. (2001). Global analysis of gene expression in invasion by a lung cancer model. Cancer Res 61, 5223-5230.
5. Gupta PB, Kuperwasser C, Brunet JP, Ramaswamy S, Kuo WL, Gray JW, Naber SP, andWeinberg RA (2005). The melanocyte differentiation program predisposes to metastasis after neoplastic transformation. Nat Genet 37, 1047-1054.
6. Gupta GP and Massague J (2006). Cancer metastasis: building a framework. Cell 127, 679-695.
7. Huber MA, Kraut N, and Beug H (2005). Molecular requirements for pithelialmesenchymal transition during tumor progression. CurrOpin Cell Biol 17, 548-558.
8. Kopfstein L and Christofori G (2006). Metastasis: cell-autonomous mechanisms versus contributions by the tumor microenvironment. CellMol Life Sci 63, 449-468.
9. Roschke AV, Tonon G, Gehlhaus KS, McTyre N, Bussey KJ, Lababidi S, Scudiero DA, Weinstein JN, and Kirsch IR (2003). Karyotypic complexity of the NCI-60 drug-screening panel. Cancer Res 63(24), 8634-8647.
10. Miller LD, Smeds J, George J, Vega VB, Vergara L, Ploner A, Pawitan Y, Hall P, Klaar S, Liu ET, et al. (2005). An expression signature for p53 status in human breast cancer predicts mutation status, transcriptional effects, and patient survival. Proc Natl Acad Sci USA 102(38), 13550-13555.
11. Kilpinen S, Autio R, Ojala K, Iljin K, Bucher E, Sara H, Pisto T, Saarela M, Skotheim RI, Björkman M, et al. (2008). Systematic bioinformatic analysis of expression levels of 17,330 human genes across 9,783 samples from 175 types of healthy and pathological tissues. Genome Biol 9(9), R139.
12. Muggerud AA, Edgren H, Wolf M, Kleivi K, Dejeux E, Tost J, Sørlie T, and Kallioniemi O (2009). Data integration from two microarray platforms identifies bi-allelic genetic inactivation of RIC8A in a breast cancer cell line. BMC Med Genomics 2, 26.
13. Parker JS, Mullins M, Cheang MC, Leung S, Voduc D, Vickery T, Davies S, Fauron C, He X, Hu Z, et al. (2009). Supervised risk predictor of breast cancer based on intrinsic subtypes. J Clin Oncol 27(8), 1160-1167.
14. Langerød A, Zhao H, Borgan Ø, Nesland JM, Bukholm IR, Ikdahl T, Kåresen R, Børresen-Dale AL, and Jeffrey SS (2009). TP53 mutation status and gene expression profiles are powerful prognostic markers of breast cancer. Breast Cancer Res 9(3), R30.
15. Barrett MT, Scheffer A, Ben-Dor A, Sampas N, Lipson D, Kincaid R, Tsang P, Curry B, Baird K, Meltzer PS, et al. (2004). Comparative genomic hybridization using oligonucleotide microarrays and total genomic DNA. Proc Natl Acad Sci USA 101(51), 17765-17770.
16. Baumbusch LO, Aarøe J, Johansen FE, Hicks J, Sun H, Bruhn L, Gunderson K, Naume B, Kristensen VN, Liestøl K, et al. (2008). Comparison of the Agilent, ROMA/NimbleGen and Illumina platforms for classification of copy number alterations in human breast tumors. BMC Genomics 9, 379.
17. Mousses S, Caplen NJ, Cornelison R, Weaver D, Basik M, Hautaniemi S, Elkahloun AG, Lotufo RA, Choudary A, Dougherty ER, et al. (2003). RNAi microarray analysis in cultured mammalian cells. Genome Res 13(10), 2341-2347.
18. Dennis G Jr, Sherman BT, Hosack DA, Yang J, Gao W, Lane HC, and Lempicki RA (2003). DAVID: database for annotation, visualization, and integrated discovery. Genome Biol 4(5), P3.
19. Huang DW, Sherman BT, and Lempicki RA (2009). Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources. Nat Protoc 4(1), 44-57.
20. Thomassen M, Tan Q, and Kruse TA (2009). Gene expression meta-analysis identifies chromosomal regions and candidate genes involved in breast cancer metastasis. Breast Cancer Res Treat 113(2), 239-249.
21. Adeleide J, Finetti P, Bekhouche I, Repellini L, Geneix J, Sircoulomb F, Charafe-Jauffret E, Cervera N, Desplans D, Parzy D, et al. (2007). Integrated profiling of basal and luminal breast cancers. Cancer Res 67(24), 11565-11575.
22. Neve RM, Chin K, Fridlyand J, Yeh J, Baehner FL, Fevr T, Clark L, Bayani N, Coppe JP, Tong F, et al. (2006). A collection of breast cancer cell lines for the study of functionally distinct cancer subtypes. Cancer Cell 10(6), 515-527.
23. Roschke AV, Glebov OK, Lababidi S, Gehlhaus KS, Weinstein JN, and Kirsch IR (2008). Chromosomal instability is associated with higher expression of genes implicated in epithelial-mesenchymal transition, cancer invasiveness, and metastasis and with lower expression of genes involved in cell cycle checkpoints, DNA repair, and chromatin maintenance. Neoplasia 10(11), 1222-1230.
24. Furuya T, Uchiyama T, Murakami T, Adachi A, Kawauchi S, Oga A, Hirano T, and Sasaki K (2000). Relationship between chromosomal instability and intratumoral regionalDNA ploidy heterogeneity in primary gastric cancers. Clin Cancer Res 6(7), 2815-2820.
25. Risques RA, Moreno V, Ribas M, Marcuello E, Capella G, and Peinado MA (2003). Genetic pathways and genome-wide determinants of clinical outcome in colorectal cancer. Cancer Res 63(21), 7206-7214.
26. Kronenwett U, Huwendiek S, Ostring C, Portwood N, Roblick UJ, Pawitan Y, Alaiya A, Sennerstam R, Zetterberg A, and Auer G (2004). Improved grading of breast adenocarcinomas based on genomic instability. Cancer Res 64(3), 904-909.
27. Carter SL, Eklund AC, Kohane IS, Harris LN, and Szallasi Z (2006). A signature of chromosomal instability inferred from gene expression profiles predicts clinical outcome in multiple human cancers. Nat Genet 38(9), 1043-1048.
28. Walther A, Houlston R, and Tomlinson I (2008).Association between chromosomal instability and prognosis in colorectal cancer: a meta-analysis. Gut 57(7), 941-950.
29. MacNeill SA (2010). Structure and function of the GINS complex, a key component of the eukaryotic replisome. Biochem J 425(3), 489-500.
30. Takayama Y, Kamimura Y, Okawa M, Muramatsu S, Sugino A, and Araki H (2003). GINS, a novel multiprotein complex required for chromosomal DNA replication in budding yeast. Genes Dev 17, 1153-1165.
31. Bauerschmidt C, Pollok S, Kremmer E, Nasheuer HP, and Grosse F (2007). Interactions of human Cdc45 with the Mcm2-7 complex, the GINS complex, and DNA polymerases delta and epsilon during S phase. Genes Cells 12, 745-758.
32. Gambus A, Jones RC, Sanchez-Diaz A, Kanemaki M, van Deursen F, Edmondson RD, and Labib K (2006). GINS maintains association of Cdc45 with MCM in replisome progression complexes at eukaryotic DNA replication forks. Nat Cell Biol 8, 358-366.
33. Kubota Y, Takase Y, Komori Y, Hashimoto Y, Arata T, Kamimura Y, Araki H, and Takisawa H (2003). A novel ring-like complex of Xenopus proteins essential for the initiation of DNA replication. Genes Dev 17, 1141-1152.
34. Kanemaki M, Sanchez-Diaz A, Gambus A, and Labib K (2003). Functional proteomic identification of DNA replication proteins by induced proteolysis in vivo. Nature 423, 720-724.
35. Moyer SE, Lewis PW, and Botchan MR (2006). Isolation of the Cdc45/Mcm2-7/GINS (CMG) complex, a candidate for the eukaryotic DNA replication fork helicase. Proc Natl Acad Sci USA 103, 10236-10241.
36. Pacek M, Tutter AV, Kubota Y, Takisawa H, and Walter JC (2006). Localization of MCM2-7, Cdc45, and GINS to the site of DNA unwinding during eukaryotic DNA replication. Mol Cell 21, 581-587.
37. Chang YP, Wang G, Bermudez V, Hurwitz J, and Chen XS (2007). Crystal structure of the GINS complex and functional insights into its role in DNA replication. Proc Natl Acad Sci USA 104, 12685-12690.
38. De Falco M, Ferrari E, De Felice M, Rossi M, Hubscher U, and Pisani FM (2007). The human GINS complex binds to and specifically stimulates human DNA polymerase α-primase. EMBO Rep 8, 99-103.
39. Boskovic J, Coloma J, Aparicio T, Zhou M, Robinson CV, Méndez J, and Montoya G (2007). Molecular architecture of the human GINS complex. EMBO Rep 8, 678-684.
40. Barkley LR, Song IY, Zou Y, and Vaziri C (2009). Reduced expression of GINS complex members induces hallmarks of pre-malignancy in primary untransformed human cells. Cell Cycle 8, 1577-1588.
41. Matsuoka S, Ballif BA, Smogorzewska A, McDonald ER III, Hurov KE, Luo J, Bakalarski CE, Zhao Z, Solimini N, Lerenthal Y, et al. (2007). ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage. Science 316(5828), 1160-1166.
42. Ryu B, Kim DS, Deluca AM, and Alani RM (2007). Comprehensive expression profiling of tumor cell lines identifies molecular signatures of melanoma progression. PLoS One 2(7), e594.
43. Hayashi R, Arauchi T, Tategu M, Goto Y, and Yoshida K (2006). A combined computational and experimental study on the structure-regulation relationships of putative mammalian DNA replication initiator GINS. Genomics Proteomics Bioinformatics 4, 156-164.
44. Huang HK, Bailis JM, Leverson JD, Gomez EB, Forsburg SL, and Hunter T (2005). Suppressors of Bir1p (Survivin) identify roles for the chromosomal passenger protein Pic1p (INCENP) and the replication initiation factor Psf2p in chromosome segregation. Mol Cell Biol 25, 9000-9015.
45. Lau E, Tsuji T, Guo L, Lu SH, and Jiang W (2007). The role of pre-replicative complex (pre-RC) components in oncogenesis. FASEB J 21, 3786-3794.
46. Giaginis C, Georgiadou M, Dimakopoulou K, Tsourouflis G, Gatzidou E, Kouraklis G, and Theocharis S (2009). Clinical significance of MCM-2 and MCM-5 expression in colon cancer: association with clinicopathological parameters and tumor proliferative capacity. Dig Dis Sci 54, 282-291.
47. Xi Y, Nakajima G, Schmitz JC, Chu E, and Ju J (2006). Multi-level gene expression profiles affected by thymidylate synthase and 5-fluorouracil in colon cancer. BMC Genomics 7, 68.
48. Gavin EJ, Song B, Wang Y, Xi Y, and Ju J (2008). Reduction of Orc6 expression sensitizes human colon cancer cells to 5-fluorouracil and cisplatin. PLoS One 3, e4054.