메뉴 건너뛰기




Volumn 216, Issue 1, 2011, Pages 220-228

Comparative neuroprotective profile of statins in quinolinic acid induced neurotoxicity in rats

Author keywords

Huntington; Mitochondrial dysfunction; Neurotoxicity; Oxidative stress; Statins

Indexed keywords

ATORVASTATIN; CATALASE; FLUINDOSTATIN; NITRITE; QUINOLINIC ACID; SIMVASTATIN; SUPEROXIDE DISMUTASE; TUMOR NECROSIS FACTOR ALPHA;

EID: 78149408231     PISSN: 01664328     EISSN: 18727549     Source Type: Journal    
DOI: 10.1016/j.bbr.2010.07.040     Document Type: Article
Times cited : (16)

References (69)
  • 1
    • 60349111588 scopus 로고    scopus 로고
    • Specific inhibition of kynurenate synthesis enhances extracellular dopamine levels in the rodent striatum
    • Amori L., Wu H.Q., Marinozzi M., Pellicciari R., Guidetti P., Schwarcz R. Specific inhibition of kynurenate synthesis enhances extracellular dopamine levels in the rodent striatum. Neuroscience 2009, 159:196-203.
    • (2009) Neuroscience , vol.159 , pp. 196-203
    • Amori, L.1    Wu, H.Q.2    Marinozzi, M.3    Pellicciari, R.4    Guidetti, P.5    Schwarcz, R.6
  • 2
    • 0033674862 scopus 로고    scopus 로고
    • Deficits in striatal dopamine D(2) receptors and energy metabolism detected by in vivo microPET imaging in a rat model of Huntington's disease
    • Araujo D.M., Cherry S.R., Tatsukawa K.J., Toyokuni T., Kornblum H.I. Deficits in striatal dopamine D(2) receptors and energy metabolism detected by in vivo microPET imaging in a rat model of Huntington's disease. Exp Neurol 2000, 166:287-297.
    • (2000) Exp Neurol , vol.166 , pp. 287-297
    • Araujo, D.M.1    Cherry, S.R.2    Tatsukawa, K.J.3    Toyokuni, T.4    Kornblum, H.I.5
  • 3
    • 0032842038 scopus 로고    scopus 로고
    • Dopamine oxidation alters mitochondrial respiration and induces permeability transition in brain mitochondria: implications for Parkinson's disease
    • Berman S.B., Hastings T.G. Dopamine oxidation alters mitochondrial respiration and induces permeability transition in brain mitochondria: implications for Parkinson's disease. J Neurochem 1999, 73:1127-1137.
    • (1999) J Neurochem , vol.73 , pp. 1127-1137
    • Berman, S.B.1    Hastings, T.G.2
  • 4
    • 20144385721 scopus 로고    scopus 로고
    • Neuroprotective effects of atorvastatin against glutamate-induced excitotoxicity in primary cortical neurones
    • Bösel J., Gandor F., Harms C., Synowitz M., Harms U., Djoufack P.C., et al. Neuroprotective effects of atorvastatin against glutamate-induced excitotoxicity in primary cortical neurones. J Neurochem 2005, 92:1386-1398.
    • (2005) J Neurochem , vol.92 , pp. 1386-1398
    • Bösel, J.1    Gandor, F.2    Harms, C.3    Synowitz, M.4    Harms, U.5    Djoufack, P.C.6
  • 5
    • 70349754448 scopus 로고    scopus 로고
    • Mechanism for quinolinic acid cytotoxicity in human astrocytes and neurons
    • Braidy N., Grant R., Adams S., Brew B.J., Guillemin G.J. Mechanism for quinolinic acid cytotoxicity in human astrocytes and neurons. Neurotox Res 2009, 16:77-86.
    • (2009) Neurotox Res , vol.16 , pp. 77-86
    • Braidy, N.1    Grant, R.2    Adams, S.3    Brew, B.J.4    Guillemin, G.J.5
  • 6
    • 77955087261 scopus 로고    scopus 로고
    • Simvastatin stimulates production of the antiapoptotic protein Bcl-2 via endothelin-1 and NFATc3 in SH-SY5Y cells
    • Butterick T.A., Igbavboa U., Eckert G.P., Sun G.Y., Weisman G.A., Müller W.E., et al. Simvastatin stimulates production of the antiapoptotic protein Bcl-2 via endothelin-1 and NFATc3 in SH-SY5Y cells. Mol Neurobiol 2010, 41:384-391.
    • (2010) Mol Neurobiol , vol.41 , pp. 384-391
    • Butterick, T.A.1    Igbavboa, U.2    Eckert, G.P.3    Sun, G.Y.4    Weisman, G.A.5    Müller, W.E.6
  • 8
    • 12144261198 scopus 로고    scopus 로고
    • 3-Hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors attenuate beta-amyloid-induced microglial inflammatory responses
    • Cordle A., Landreth G. 3-Hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors attenuate beta-amyloid-induced microglial inflammatory responses. J Neurosci 2005, 25:299-307.
    • (2005) J Neurosci , vol.25 , pp. 299-307
    • Cordle, A.1    Landreth, G.2
  • 9
    • 33745764469 scopus 로고    scopus 로고
    • The role of pleiotropic effects of statins in dementia
    • Crisby M. The role of pleiotropic effects of statins in dementia. Acta Neurol Scand Suppl 2006, 185:115-118.
    • (2006) Acta Neurol Scand Suppl , vol.185 , pp. 115-118
    • Crisby, M.1
  • 10
    • 49149097118 scopus 로고    scopus 로고
    • Neurotherapeutics in multiple sclerosis: novel agents and emerging treatment strategies
    • DeAngelis T., Lublin F. Neurotherapeutics in multiple sclerosis: novel agents and emerging treatment strategies. Mt Sinai J Med 2008, 75:157-167.
    • (2008) Mt Sinai J Med , vol.75 , pp. 157-167
    • DeAngelis, T.1    Lublin, F.2
  • 11
    • 65249104851 scopus 로고    scopus 로고
    • Molecular mechanisms of excitotoxicity and their relevance to pathogenesis of neurodegenerative diseases
    • Dong X.X., Wang Y., Qin Z.H. Molecular mechanisms of excitotoxicity and their relevance to pathogenesis of neurodegenerative diseases. Acta Pharmacol Sin 2009, 30:379-387.
    • (2009) Acta Pharmacol Sin , vol.30 , pp. 379-387
    • Dong, X.X.1    Wang, Y.2    Qin, Z.H.3
  • 12
    • 67649781671 scopus 로고    scopus 로고
    • Regulation of the brain isoprenoids farnesyl- and geranylgeranylpyrophosphate is altered in male Alzheimer patients
    • Eckert G.P., Hooff G.P., Strandjord D.M., Igbavboa U., Volmer D.A., Müller W.E., et al. Regulation of the brain isoprenoids farnesyl- and geranylgeranylpyrophosphate is altered in male Alzheimer patients. Neurobiol Dis 2009, 35:251-257.
    • (2009) Neurobiol Dis , vol.35 , pp. 251-257
    • Eckert, G.P.1    Hooff, G.P.2    Strandjord, D.M.3    Igbavboa, U.4    Volmer, D.A.5    Müller, W.E.6
  • 13
    • 38949103036 scopus 로고    scopus 로고
    • Excitotoxic neuronal death and the pathogenesis of Huntington's disease
    • Estrada Sánchez A.M., Mejía-Toiber J., Massieu L. Excitotoxic neuronal death and the pathogenesis of Huntington's disease. Arch Med Res 2008, 39:265-276.
    • (2008) Arch Med Res , vol.39 , pp. 265-276
    • Estrada Sánchez, A.M.1    Mejía-Toiber, J.2    Massieu, L.3
  • 15
    • 33744975232 scopus 로고    scopus 로고
    • Time course of oxidative events in the hippocampus following intracerebroventricular infusion of quinolinic acid in mice
    • Ganzella M., Jardim F.M., Boeck C.R., Vendite D. Time course of oxidative events in the hippocampus following intracerebroventricular infusion of quinolinic acid in mice. Neurosci Res 2006, 55:397-402.
    • (2006) Neurosci Res , vol.55 , pp. 397-402
    • Ganzella, M.1    Jardim, F.M.2    Boeck, C.R.3    Vendite, D.4
  • 16
    • 45149107487 scopus 로고    scopus 로고
    • Mechanisms of neurodegeneration in Huntington's disease
    • Gil J.M., Rego A.C. Mechanisms of neurodegeneration in Huntington's disease. Eur J Neurosci 2008, 27:2803-2820.
    • (2008) Eur J Neurosci , vol.27 , pp. 2803-2820
    • Gil, J.M.1    Rego, A.C.2
  • 17
    • 75649132215 scopus 로고    scopus 로고
    • Statins: the drugs for the 21st century?
    • Ginter E., Simko V. Statins: the drugs for the 21st century?. Bratisl Lek Listy 2009, 110:664-668.
    • (2009) Bratisl Lek Listy , vol.110 , pp. 664-668
    • Ginter, E.1    Simko, V.2
  • 18
    • 29744466425 scopus 로고
    • Determination of serum proteins by means of the biuret reaction
    • Gornall A.G., Bardawill C.J., David M.M. Determination of serum proteins by means of the biuret reaction. J Biol Chem 1949, 177:751-766.
    • (1949) J Biol Chem , vol.177 , pp. 751-766
    • Gornall, A.G.1    Bardawill, C.J.2    David, M.M.3
  • 22
    • 19944432452 scopus 로고    scopus 로고
    • Chronic administration of statins alters multiple gene expression patterns in mouse cerebral cortex
    • Johnson-Anuna L.N., Eckert G.P., Keller J.H., Igbavboa U., Franke C., Fechner T., et al. Chronic administration of statins alters multiple gene expression patterns in mouse cerebral cortex. J Pharmacol Exp Ther 2005 Feb, 312(2):786-793.
    • (2005) J Pharmacol Exp Ther , vol.312 , Issue.2 , pp. 786-793
    • Johnson-Anuna, L.N.1    Eckert, G.P.2    Keller, J.H.3    Igbavboa, U.4    Franke, C.5    Fechner, T.6
  • 23
    • 69049108579 scopus 로고    scopus 로고
    • Effect of caffeic acid and rofecoxib and their combination against intrastriatal quinolinic acid induced oxidative damage, mitochondrial and histological alterations in rats
    • Kalonia H., Kumar P., Kumar A., Nehru B. Effect of caffeic acid and rofecoxib and their combination against intrastriatal quinolinic acid induced oxidative damage, mitochondrial and histological alterations in rats. Inflammopharmacology 2009, 17:211-219.
    • (2009) Inflammopharmacology , vol.17 , pp. 211-219
    • Kalonia, H.1    Kumar, P.2    Kumar, A.3    Nehru, B.4
  • 24
    • 77649270021 scopus 로고    scopus 로고
    • Protective effect of rofecoxib and nimesulide against intra-striatal quinolinic acid-induced behavioral, oxidative stress and mitochondrial dysfunctions in rats
    • Kalonia H., Kumar P., Kumar A., Nehru B. Protective effect of rofecoxib and nimesulide against intra-striatal quinolinic acid-induced behavioral, oxidative stress and mitochondrial dysfunctions in rats. Neurotoxicology 2010, 31:195-203.
    • (2010) Neurotoxicology , vol.31 , pp. 195-203
    • Kalonia, H.1    Kumar, P.2    Kumar, A.3    Nehru, B.4
  • 25
    • 20144389219 scopus 로고    scopus 로고
    • Protective effects of ginseng saponins on 3-nitropropionic acid-induced striatal degeneration in rats
    • Kim J.H., Kim S., Yoon I.S., Lee J.H., Jang B.J., Jeong S.M., et al. Protective effects of ginseng saponins on 3-nitropropionic acid-induced striatal degeneration in rats. Neuropharmacology 2005, 48:743-756.
    • (2005) Neuropharmacology , vol.48 , pp. 743-756
    • Kim, J.H.1    Kim, S.2    Yoon, I.S.3    Lee, J.H.4    Jang, B.J.5    Jeong, S.M.6
  • 26
    • 77956999492 scopus 로고
    • Preparations and properties of soluble NADH dehydrogenases from cardiac muscle
    • King T.E., Howard R.L. Preparations and properties of soluble NADH dehydrogenases from cardiac muscle. Methods Enzymol 1967, 10:275-284.
    • (1967) Methods Enzymol , vol.10 , pp. 275-284
    • King, T.E.1    Howard, R.L.2
  • 27
    • 77956987911 scopus 로고
    • Preparation of succinate dehydrogenase and reconstitution of succinate oxidase
    • King T.E. Preparation of succinate dehydrogenase and reconstitution of succinate oxidase. Methods Enzymol 1967, 10:322-331.
    • (1967) Methods Enzymol , vol.10 , pp. 322-331
    • King, T.E.1
  • 28
    • 0017804313 scopus 로고
    • Generation of superoxide radical during auto-oxidation of hydroxylamine and an assay of superoxide dismutase
    • Kono Y. Generation of superoxide radical during auto-oxidation of hydroxylamine and an assay of superoxide dismutase. Arch Biochem Biophys 1978, 186:189-195.
    • (1978) Arch Biochem Biophys , vol.186 , pp. 189-195
    • Kono, Y.1
  • 31
    • 0030986505 scopus 로고    scopus 로고
    • Effects of fluvastatin therapy on lipids, antioxidants, oxidation of low density lipoproteins and trace metals
    • Leonhardt W., Kurktschiev T., Meissner D., Lattke P., Abletshauser C., Weidinger G., et al. Effects of fluvastatin therapy on lipids, antioxidants, oxidation of low density lipoproteins and trace metals. Eur J Clin Pharmacol 1997, 53:65-69.
    • (1997) Eur J Clin Pharmacol , vol.53 , pp. 65-69
    • Leonhardt, W.1    Kurktschiev, T.2    Meissner, D.3    Lattke, P.4    Abletshauser, C.5    Weidinger, G.6
  • 32
    • 8644239495 scopus 로고    scopus 로고
    • Statin therapy and risk of dementia in the elderly: a community-based prospective cohort study
    • Li G., Higdon R., Kukull W.A., Peskind E., Van Valen Moore K., Tsuang D., et al. Statin therapy and risk of dementia in the elderly: a community-based prospective cohort study. Neurology 2004, 63:1624-1628.
    • (2004) Neurology , vol.63 , pp. 1624-1628
    • Li, G.1    Higdon, R.2    Kukull, W.A.3    Peskind, E.4    Van Valen Moore, K.5    Tsuang, D.6
  • 33
    • 34548291482 scopus 로고    scopus 로고
    • Statin therapy is associated with reduced neuropathologic changes of Alzheimer disease
    • Li G., Larson E.B., Sonnen J.A., Shofer J.B., Petrie E.C., Schantz A., et al. Statin therapy is associated with reduced neuropathologic changes of Alzheimer disease. Neurology 2007, 69:878-885.
    • (2007) Neurology , vol.69 , pp. 878-885
    • Li, G.1    Larson, E.B.2    Sonnen, J.A.3    Shofer, J.B.4    Petrie, E.C.5    Schantz, A.6
  • 34
    • 41949126549 scopus 로고    scopus 로고
    • Calcium homeostasis and mitochondrial dysfunction in striatal neurons of Huntington disease
    • Lim D., Fedrizzi L., Tartari M., Zuccato C., Cattaneo E., Brini M., et al. Calcium homeostasis and mitochondrial dysfunction in striatal neurons of Huntington disease. J Biol Chem 2008, 283:5780-5789.
    • (2008) J Biol Chem , vol.283 , pp. 5780-5789
    • Lim, D.1    Fedrizzi, L.2    Tartari, M.3    Zuccato, C.4    Cattaneo, E.5    Brini, M.6
  • 35
    • 0030852948 scopus 로고    scopus 로고
    • Mechanisms of cellular 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolinium bromide (MTT) reduction
    • Liu Y., Peterson D.A., Kimura H., Schubert D. Mechanisms of cellular 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolinium bromide (MTT) reduction. J Neurochem 1997, 69:581-593.
    • (1997) J Neurochem , vol.69 , pp. 581-593
    • Liu, Y.1    Peterson, D.A.2    Kimura, H.3    Schubert, D.4
  • 36
    • 0002191974 scopus 로고
    • Catalase
    • Academic Press, New York, H.U. Bergmeyer (Ed.)
    • Luck H. Catalase. Methods of enzymatic analysis 1971, 885-893. Academic Press, New York. H.U. Bergmeyer (Ed.).
    • (1971) Methods of enzymatic analysis , pp. 885-893
    • Luck, H.1
  • 37
    • 0032413345 scopus 로고    scopus 로고
    • 6-Hydroxydopamine injections into the nigrostriatal pathway attenuate striatal malonate and 3-nitropropionic acid lesions
    • Maragos W.F., Jakel R.J., Pang Z., Geddes J.W. 6-Hydroxydopamine injections into the nigrostriatal pathway attenuate striatal malonate and 3-nitropropionic acid lesions. Exp Neurol 1998, 154:637-644.
    • (1998) Exp Neurol , vol.154 , pp. 637-644
    • Maragos, W.F.1    Jakel, R.J.2    Pang, Z.3    Geddes, J.W.4
  • 38
    • 40849089388 scopus 로고    scopus 로고
    • Therapeutic potential of statins in multiple sclerosis: immune modulation, neuroprotection and neurorepair
    • Markovic-Plese S., Singh A.K., Singh I. Therapeutic potential of statins in multiple sclerosis: immune modulation, neuroprotection and neurorepair. Future Neurol 2008, 3:153-167.
    • (2008) Future Neurol , vol.3 , pp. 153-167
    • Markovic-Plese, S.1    Singh, A.K.2    Singh, I.3
  • 39
    • 29444445327 scopus 로고    scopus 로고
    • A rationale for combined therapy with a calcium channel blocker and a statin: evaluation of basic and clinical evidence
    • Mason R.P. A rationale for combined therapy with a calcium channel blocker and a statin: evaluation of basic and clinical evidence. Curr Drug Targets Cardiovasc Haematol Disord 2005 Dec, 5(6):489-501.
    • (2005) Curr Drug Targets Cardiovasc Haematol Disord , vol.5 , Issue.6 , pp. 489-501
    • Mason, R.P.1
  • 40
    • 33846450284 scopus 로고    scopus 로고
    • Prevention of stroke and dementia by statin therapy: experimental and clinical evidence of their pleiotropic effects
    • Miida T., Takahashi A., Ikeuchi T. Prevention of stroke and dementia by statin therapy: experimental and clinical evidence of their pleiotropic effects. Pharmacol Ther 2007, 113:378-393.
    • (2007) Pharmacol Ther , vol.113 , pp. 378-393
    • Miida, T.1    Takahashi, A.2    Ikeuchi, T.3
  • 41
    • 33845933438 scopus 로고    scopus 로고
    • Mutant Huntingtin expression induces mitochondrial calcium handling defects in clonal striatal cells: functional consequences
    • Milakovic T., Quintanilla R.A., Johnson G.V. Mutant Huntingtin expression induces mitochondrial calcium handling defects in clonal striatal cells: functional consequences. J Biol Chem 2006, 281:34785-34795.
    • (2006) J Biol Chem , vol.281 , pp. 34785-34795
    • Milakovic, T.1    Quintanilla, R.A.2    Johnson, G.V.3
  • 43
    • 33744527506 scopus 로고    scopus 로고
    • Protective effect of fluvastatin, an inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase, on copper-induced hydroxyl radical generation in the rat heart
    • Obata T. Protective effect of fluvastatin, an inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase, on copper-induced hydroxyl radical generation in the rat heart. Toxicology 2006, 223:175-180.
    • (2006) Toxicology , vol.223 , pp. 175-180
    • Obata, T.1
  • 45
    • 40749115140 scopus 로고    scopus 로고
    • Statins in the spectrum of neurologic disease
    • Orr J.D. Statins in the spectrum of neurologic disease. Curr Atheroscler Rep 2008, 10:11-18.
    • (2008) Curr Atheroscler Rep , vol.10 , pp. 11-18
    • Orr, J.D.1
  • 47
    • 55549136009 scopus 로고    scopus 로고
    • Effects of simvastatin on neuroprotection and modulation of Bcl-2 and BAX in the rat quinolinic acid model of Huntington's disease
    • Patassini S., Giampà C., Martorana A., Bernardi G., Fusco F.R. Effects of simvastatin on neuroprotection and modulation of Bcl-2 and BAX in the rat quinolinic acid model of Huntington's disease. Neurosci Lett 2008, 448:166-169.
    • (2008) Neurosci Lett , vol.448 , pp. 166-169
    • Patassini, S.1    Giampà, C.2    Martorana, A.3    Bernardi, G.4    Fusco, F.R.5
  • 49
    • 0031839233 scopus 로고    scopus 로고
    • Privileged access to mitochondria of calcium influx through N-methyl-d-aspartate receptors
    • Peng T.I., Greenamyre J.T. Privileged access to mitochondria of calcium influx through N-methyl-d-aspartate receptors. Mol Pharmacol 1998, 53:974-980.
    • (1998) Mol Pharmacol , vol.53 , pp. 974-980
    • Peng, T.I.1    Greenamyre, J.T.2
  • 51
    • 67651158798 scopus 로고    scopus 로고
    • Behavioral and quantitative mitochondrial proteome analyses of the effects of simvastatin: implications for models of neural degeneration
    • Pienaar I.S., Schallert T., Hattingh S., Daniels W.M. Behavioral and quantitative mitochondrial proteome analyses of the effects of simvastatin: implications for models of neural degeneration. J Neural Transm 2009, 116:791-806.
    • (2009) J Neural Transm , vol.116 , pp. 791-806
    • Pienaar, I.S.1    Schallert, T.2    Hattingh, S.3    Daniels, W.M.4
  • 52
    • 84984569420 scopus 로고    scopus 로고
    • Ebselen blocks the quinolinic acid-induced production of thiobarbituric acid reactive species but does not prevent the behavioral alterations produced by intra-striatal quinolinic acid administration in the rat
    • Rossato J.I., Zeni G., Mello C.F., Rubin M.A., Rocha J.B. Ebselen blocks the quinolinic acid-induced production of thiobarbituric acid reactive species but does not prevent the behavioral alterations produced by intra-striatal quinolinic acid administration in the rat. Neurosci Lett 2002, 318:137-140.
    • (2002) Neurosci Lett , vol.318 , pp. 137-140
    • Rossato, J.I.1    Zeni, G.2    Mello, C.F.3    Rubin, M.A.4    Rocha, J.B.5
  • 53
    • 0021880922 scopus 로고
    • The neurotoxicity of excitatory amino acids is produced by passive chloride influx
    • Rothman S.M. The neurotoxicity of excitatory amino acids is produced by passive chloride influx. J Neurosci 1985, 5:1483-1489.
    • (1985) J Neurosci , vol.5 , pp. 1483-1489
    • Rothman, S.M.1
  • 54
    • 70449710918 scopus 로고    scopus 로고
    • Statin use before and after acute ischemic stroke onset improves neurological outcome
    • Salat D., Ribosa R., Garcia-Bonilla L., Montaner J. Statin use before and after acute ischemic stroke onset improves neurological outcome. Expert Rev Cardiovasc Ther 2009, 7:1219-1230.
    • (2009) Expert Rev Cardiovasc Ther , vol.7 , pp. 1219-1230
    • Salat, D.1    Ribosa, R.2    Garcia-Bonilla, L.3    Montaner, J.4
  • 55
    • 0027180115 scopus 로고
    • MK-801, an N-methyl-d-aspartate receptor antagonist, blocks quinolinic acid-induced lipid peroxidation in rat corpus striatum
    • Santamaría A., Ríos C. MK-801, an N-methyl-d-aspartate receptor antagonist, blocks quinolinic acid-induced lipid peroxidation in rat corpus striatum. Neurosci Lett 1993, 159:51-54.
    • (1993) Neurosci Lett , vol.159 , pp. 51-54
    • Santamaría, A.1    Ríos, C.2
  • 56
    • 0018636340 scopus 로고
    • Calcium dependence of toxic cell death: a final common pathway
    • Schanne F.A., Kane A.B., Young E.E., Farber J.L. Calcium dependence of toxic cell death: a final common pathway. Science 1979, 206:700-702.
    • (1979) Science , vol.206 , pp. 700-702
    • Schanne, F.A.1    Kane, A.B.2    Young, E.E.3    Farber, J.L.4
  • 58
    • 0014059118 scopus 로고
    • An electron-transport system associated with the outer membrane of liver mitochondria. A biochemical and morphological study
    • Sottocasa G.L., Kuylenstierna B., Ernster L., Bergstrand A. An electron-transport system associated with the outer membrane of liver mitochondria. A biochemical and morphological study. J Cell Biol 1967, 32:415-438.
    • (1967) J Cell Biol , vol.32 , pp. 415-438
    • Sottocasa, G.L.1    Kuylenstierna, B.2    Ernster, L.3    Bergstrand, A.4
  • 60
    • 33750448287 scopus 로고    scopus 로고
    • Simvastatin attenuates plaque inflammation: evaluation by fluorodeoxyglucose positron emission tomography
    • Tahara N., Kai H., Ishibashi M., Nakaura H., Kaida H., Baba K., et al. Simvastatin attenuates plaque inflammation: evaluation by fluorodeoxyglucose positron emission tomography. J Am Coll Cardiol 2006, 48:1825-1831.
    • (2006) J Am Coll Cardiol , vol.48 , pp. 1825-1831
    • Tahara, N.1    Kai, H.2    Ishibashi, M.3    Nakaura, H.4    Kaida, H.5    Baba, K.6
  • 61
    • 68149148938 scopus 로고    scopus 로고
    • Simvastatin improves cerebrovascular function and counters soluble amyloid-beta, inflammation and oxidative stress in aged APP mice
    • Tong X.K., Nicolakakis N., Fernandes P., Ongali B., Brouillette J., Quirion R., et al. Simvastatin improves cerebrovascular function and counters soluble amyloid-beta, inflammation and oxidative stress in aged APP mice. Neurobiol Dis 2009, 35:406-414.
    • (2009) Neurobiol Dis , vol.35 , pp. 406-414
    • Tong, X.K.1    Nicolakakis, N.2    Fernandes, P.3    Ongali, B.4    Brouillette, J.5    Quirion, R.6
  • 62
    • 21044442392 scopus 로고    scopus 로고
    • Prostaglandins and cyclooxygenases in glial cells during brain inflammation
    • Tzeng S.F., Hsiao H.Y., Mak O.T. Prostaglandins and cyclooxygenases in glial cells during brain inflammation. Curr Drug Targets Inflamm Allergy 2005, 4:335-340.
    • (2005) Curr Drug Targets Inflamm Allergy , vol.4 , pp. 335-340
    • Tzeng, S.F.1    Hsiao, H.Y.2    Mak, O.T.3
  • 63
    • 34548379904 scopus 로고    scopus 로고
    • Cholesterol biosynthesis pathway is disturbed in YAC128 mice and is modulated by Huntingtin mutation
    • Valenza M., Carroll J.B., Leoni V., Bertram L.N., Björkhem I., Singaraja R.R., et al. Cholesterol biosynthesis pathway is disturbed in YAC128 mice and is modulated by Huntingtin mutation. Hum Mol Genet 2007, 16:2187-2198.
    • (2007) Hum Mol Genet , vol.16 , pp. 2187-2198
    • Valenza, M.1    Carroll, J.B.2    Leoni, V.3    Bertram, L.N.4    Björkhem, I.5    Singaraja, R.R.6
  • 65
    • 0041335559 scopus 로고    scopus 로고
    • Minocycline inhibits caspase-independent and -dependent mitochondrial cell death pathways in models of Huntington's disease
    • Wang X., Zhu S., Drozda M., Zhang W., Stavrovskaya I.G., Cattaneo E., et al. Minocycline inhibits caspase-independent and -dependent mitochondrial cell death pathways in models of Huntington's disease. Proc Natl Acad Sci USA 2003, 100:10483-10487.
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 10483-10487
    • Wang, X.1    Zhu, S.2    Drozda, M.3    Zhang, W.4    Stavrovskaya, I.G.5    Cattaneo, E.6
  • 66
    • 30544432853 scopus 로고    scopus 로고
    • The negative cell cycle regulator, Tob (transducer of ErbB-2), is involved in motor skill learning
    • Wang X.M., Gao X., Zhang X.H., Tu Y.Y., Jin M.L., Zhao G.P., et al. The negative cell cycle regulator, Tob (transducer of ErbB-2), is involved in motor skill learning. Biochem Biophy Res Commun 2006, 340:1023-1027.
    • (2006) Biochem Biophy Res Commun , vol.340 , pp. 1023-1027
    • Wang, X.M.1    Gao, X.2    Zhang, X.H.3    Tu, Y.Y.4    Jin, M.L.5    Zhao, G.P.6
  • 67
    • 0013914976 scopus 로고
    • Mechanisms of lipid peroxide formation in animal tissues
    • Wills E.D. Mechanisms of lipid peroxide formation in animal tissues. Biochem J 1966, 99:667-676.
    • (1966) Biochem J , vol.99 , pp. 667-676
    • Wills, E.D.1
  • 68
    • 56149105398 scopus 로고    scopus 로고
    • Calcium ions in neuronal degeneration
    • Wojda U., Salinska E., Kuznicki J. Calcium ions in neuronal degeneration. IUBMB Life 2008, 60:575-590.
    • (2008) IUBMB Life , vol.60 , pp. 575-590
    • Wojda, U.1    Salinska, E.2    Kuznicki, J.3
  • 69
    • 0346749450 scopus 로고    scopus 로고
    • 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors protect cortical neurons from excitotoxicity
    • Zacco A., Togo J., Spence K., Ellis A., Lloyd D., Furlong S., et al. 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors protect cortical neurons from excitotoxicity. J Neurosci 2003, 23:11104-11111.
    • (2003) J Neurosci , vol.23 , pp. 11104-11111
    • Zacco, A.1    Togo, J.2    Spence, K.3    Ellis, A.4    Lloyd, D.5    Furlong, S.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.