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Volumn 57, Issue 1, 2010, Pages 85-140

Pediatric Nonalcoholic Fatty Liver Disease: A Comprehensive Review

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MARKER; CYTOKINE;

EID: 78149381906     PISSN: 00653101     EISSN: None     Source Type: Book Series    
DOI: 10.1016/j.yapd.2010.08.006     Document Type: Review
Times cited : (35)

References (230)
  • 1
    • 34248359868 scopus 로고    scopus 로고
    • Pathology of fatty liver disease
    • Brunt E.M. Pathology of fatty liver disease. Mod Pathol 2007, 20(Suppl 1):S40-S48.
    • (2007) Mod Pathol , vol.20 , Issue.SUPPL 1
    • Brunt, E.M.1
  • 2
    • 0033038672 scopus 로고    scopus 로고
    • Nonalcoholic fatty liver disease: a spectrum of clinical and pathological severity
    • Matteoni C.A., Younossi Z.M., Gramlich T., et al. Nonalcoholic fatty liver disease: a spectrum of clinical and pathological severity. Gastroenterology 1999, 116:1413-1419.
    • (1999) Gastroenterology , vol.116 , pp. 1413-1419
    • Matteoni, C.A.1    Younossi, Z.M.2    Gramlich, T.3
  • 3
    • 0035083842 scopus 로고    scopus 로고
    • Nonalcoholic steatohepatitis: definition and pathology
    • Brunt E.M. Nonalcoholic steatohepatitis: definition and pathology. Semin Liver Dis 2001, 21:3-16.
    • (2001) Semin Liver Dis , vol.21 , pp. 3-16
    • Brunt, E.M.1
  • 4
    • 0033200054 scopus 로고    scopus 로고
    • Nonalcoholic steatohepatitis: a proposal for grading and staging the histological lesions
    • Brunt E.M., Janney C.G., Di Bisceglie A.M., et al. Nonalcoholic steatohepatitis: a proposal for grading and staging the histological lesions. Am J Gastroenterol 1999, 94:2467-2474.
    • (1999) Am J Gastroenterol , vol.94 , pp. 2467-2474
    • Brunt, E.M.1    Janney, C.G.2    Di Bisceglie, A.M.3
  • 5
    • 20044374023 scopus 로고    scopus 로고
    • Design and validation of a histological scoring system for nonalcoholic fatty liver disease
    • Kleiner D.E., Brunt E.M., Van Natta M., et al. Design and validation of a histological scoring system for nonalcoholic fatty liver disease. Hepatology 2005, 41:1313-1321.
    • (2005) Hepatology , vol.41 , pp. 1313-1321
    • Kleiner, D.E.1    Brunt, E.M.2    Van Natta, M.3
  • 6
    • 17044392299 scopus 로고    scopus 로고
    • Proposal for a histological scoring and grading system for non-alcoholic fatty liver disease
    • Mendler M.H., Kanel G., Govindarajan S. Proposal for a histological scoring and grading system for non-alcoholic fatty liver disease. Liver Int 2005, 25:294-304.
    • (2005) Liver Int , vol.25 , pp. 294-304
    • Mendler, M.H.1    Kanel, G.2    Govindarajan, S.3
  • 7
    • 1442355447 scopus 로고    scopus 로고
    • A pilot study of pioglitazone treatment for nonalcoholic steatohepatitis
    • Promrat K., Lutchman G., Uwaifo G.I., et al. A pilot study of pioglitazone treatment for nonalcoholic steatohepatitis. Hepatology 2004, 39:188-196.
    • (2004) Hepatology , vol.39 , pp. 188-196
    • Promrat, K.1    Lutchman, G.2    Uwaifo, G.I.3
  • 8
    • 1942454793 scopus 로고    scopus 로고
    • Nonalcoholic steatohepatitis
    • Brunt E.M. Nonalcoholic steatohepatitis. Semin Liver Dis 2004, 24:3-20.
    • (2004) Semin Liver Dis , vol.24 , pp. 3-20
    • Brunt, E.M.1
  • 9
    • 40949141827 scopus 로고    scopus 로고
    • Relationship of steatosis grade and zonal location to histological features of steatohepatitis in adult patients with non-alcoholic fatty liver disease
    • Chalasani N., Wilson L., Kleiner D.E., et al. Relationship of steatosis grade and zonal location to histological features of steatohepatitis in adult patients with non-alcoholic fatty liver disease. J Hepatol 2008, 48:829-834.
    • (2008) J Hepatol , vol.48 , pp. 829-834
    • Chalasani, N.1    Wilson, L.2    Kleiner, D.E.3
  • 10
    • 0025305038 scopus 로고
    • Fine structure of hepatocytes during the etiology of several common pathologies
    • Schaff Z., Lapis K. Fine structure of hepatocytes during the etiology of several common pathologies. J Electron Microsc Tech 1990, 14:179-207.
    • (1990) J Electron Microsc Tech , vol.14 , pp. 179-207
    • Schaff, Z.1    Lapis, K.2
  • 11
    • 40949123364 scopus 로고    scopus 로고
    • Ballooned hepatocytes in steatohepatitis: the value of keratin immunohistochemistry for diagnosis
    • Lackner C., Gogg-Kamerer M., Zatloukal K., et al. Ballooned hepatocytes in steatohepatitis: the value of keratin immunohistochemistry for diagnosis. J Hepatol 2008, 48:821-828.
    • (2008) J Hepatol , vol.48 , pp. 821-828
    • Lackner, C.1    Gogg-Kamerer, M.2    Zatloukal, K.3
  • 12
    • 24144444669 scopus 로고    scopus 로고
    • Histopathology of pediatric nonalcoholic fatty liver disease
    • Schwimmer J.B., Behling C., Newbury R., et al. Histopathology of pediatric nonalcoholic fatty liver disease. Hepatology 2005, 42:641-649.
    • (2005) Hepatology , vol.42 , pp. 641-649
    • Schwimmer, J.B.1    Behling, C.2    Newbury, R.3
  • 13
    • 33747077203 scopus 로고    scopus 로고
    • NAFLD in children: a prospective clinical-pathological study and effect of lifestyle advice
    • Nobili V., Marcellini M., Devito R., et al. NAFLD in children: a prospective clinical-pathological study and effect of lifestyle advice. Hepatology 2006, 44:458-465.
    • (2006) Hepatology , vol.44 , pp. 458-465
    • Nobili, V.1    Marcellini, M.2    Devito, R.3
  • 14
    • 70350077457 scopus 로고    scopus 로고
    • Nonalcoholic steatohepatitis in children: a multicenter clinicopathological study
    • Carter-Kent C., Yerian L.M., Brunt E.M., et al. Nonalcoholic steatohepatitis in children: a multicenter clinicopathological study. Hepatology 2009, 50:1113-1120.
    • (2009) Hepatology , vol.50 , pp. 1113-1120
    • Carter-Kent, C.1    Yerian, L.M.2    Brunt, E.M.3
  • 15
    • 70149120937 scopus 로고    scopus 로고
    • Clinical and histological features of nonalcoholic fatty liver disease in children
    • Ko J.S., Yoon J.M., Yang H.R., et al. Clinical and histological features of nonalcoholic fatty liver disease in children. Dig Dis Sci 2009, 54:2225-2230.
    • (2009) Dig Dis Sci , vol.54 , pp. 2225-2230
    • Ko, J.S.1    Yoon, J.M.2    Yang, H.R.3
  • 16
    • 32044467721 scopus 로고    scopus 로고
    • Histologic spectrum of nonalcoholic fatty liver disease in morbidly obese adolescents
    • Xanthakos S., Miles L., Bucuvalas J., et al. Histologic spectrum of nonalcoholic fatty liver disease in morbidly obese adolescents. Clin Gastroenterol Hepatol 2006, 4:226-232.
    • (2006) Clin Gastroenterol Hepatol , vol.4 , pp. 226-232
    • Xanthakos, S.1    Miles, L.2    Bucuvalas, J.3
  • 17
    • 63349106888 scopus 로고    scopus 로고
    • Portal chronic inflammation in nonalcoholic fatty liver disease (NAFLD): a histologic marker of advanced NAFLD-Clinicopathologic correlations from the nonalcoholic steatohepatitis clinical research network
    • Brunt E.M., Kleiner D.E., Wilson L.A., et al. Portal chronic inflammation in nonalcoholic fatty liver disease (NAFLD): a histologic marker of advanced NAFLD-Clinicopathologic correlations from the nonalcoholic steatohepatitis clinical research network. Hepatology 2009, 49:809-820.
    • (2009) Hepatology , vol.49 , pp. 809-820
    • Brunt, E.M.1    Kleiner, D.E.2    Wilson, L.A.3
  • 18
    • 33745194971 scopus 로고    scopus 로고
    • The role of hepatic biopsy to detect macrovacuolar steatosis during liver procurement
    • Adani G.L., Baccarani U., Sainz-Barriga M., et al. The role of hepatic biopsy to detect macrovacuolar steatosis during liver procurement. Transplant Proc 2006, 38:1404-1406.
    • (2006) Transplant Proc , vol.38 , pp. 1404-1406
    • Adani, G.L.1    Baccarani, U.2    Sainz-Barriga, M.3
  • 19
    • 0037726668 scopus 로고    scopus 로고
    • Diagnosis of fatty liver disease: is biopsy necessary?
    • Joy D., Thava V.R., Scott B.B. Diagnosis of fatty liver disease: is biopsy necessary?. Eur J Gastroenterol Hepatol 2003, 15:539-543.
    • (2003) Eur J Gastroenterol Hepatol , vol.15 , pp. 539-543
    • Joy, D.1    Thava, V.R.2    Scott, B.B.3
  • 20
    • 0029300637 scopus 로고
    • Proton MR spectroscopy in quantitative in vivo determination of fat content in human liver steatosis
    • Longo R., Pollesello P., Ricci C., et al. Proton MR spectroscopy in quantitative in vivo determination of fat content in human liver steatosis. J Magn Reson Imaging 1995, 5:281-285.
    • (1995) J Magn Reson Imaging , vol.5 , pp. 281-285
    • Longo, R.1    Pollesello, P.2    Ricci, C.3
  • 21
    • 29744434720 scopus 로고    scopus 로고
    • Imaging diagnosis and quantification of hepatic steatosis: is it an accepted alternative to needle biopsy?
    • Lupsor M., Badea R. Imaging diagnosis and quantification of hepatic steatosis: is it an accepted alternative to needle biopsy?. Rom J Gastroenterol 2005, 14:419-425.
    • (2005) Rom J Gastroenterol , vol.14 , pp. 419-425
    • Lupsor, M.1    Badea, R.2
  • 22
    • 0026074354 scopus 로고
    • Complications of percutaneous abdominal fine-needle biopsy
    • [review]
    • Smith E.H. Complications of percutaneous abdominal fine-needle biopsy. Radiology 1991, 178:253-258. [review].
    • (1991) Radiology , vol.178 , pp. 253-258
    • Smith, E.H.1
  • 23
    • 0242361733 scopus 로고    scopus 로고
    • Obesity, insulin resistance, and other clinicopathological correlates of pediatric nonalcoholic fatty liver disease
    • Schwimmer J.B., Deutsch R., Rauch J.B., et al. Obesity, insulin resistance, and other clinicopathological correlates of pediatric nonalcoholic fatty liver disease. J Pediatr 2003, 143:500-505.
    • (2003) J Pediatr , vol.143 , pp. 500-505
    • Schwimmer, J.B.1    Deutsch, R.2    Rauch, J.B.3
  • 24
    • 33845262498 scopus 로고    scopus 로고
    • Leptin, free leptin index, insulin resistance and liver fibrosis in children with non-alcoholic fatty liver disease
    • Nobili V., Manco M., Ciampalini P., et al. Leptin, free leptin index, insulin resistance and liver fibrosis in children with non-alcoholic fatty liver disease. Eur J Endocrinol 2006, 155:735-743.
    • (2006) Eur J Endocrinol , vol.155 , pp. 735-743
    • Nobili, V.1    Manco, M.2    Ciampalini, P.3
  • 25
    • 57249103570 scopus 로고    scopus 로고
    • Clinical correlates of histopathology in pediatric nonalcoholic steatohepatitis
    • e1962
    • Patton H.M., Lavine J.E., Van Natta M.L., et al. Clinical correlates of histopathology in pediatric nonalcoholic steatohepatitis. Gastroenterology 2008, 135:1961-1971. e1962.
    • (2008) Gastroenterology , vol.135 , pp. 1961-1971
    • Patton, H.M.1    Lavine, J.E.2    Van Natta, M.L.3
  • 26
    • 67349256422 scopus 로고    scopus 로고
    • Retinol-binding protein 4: a promising circulating marker of liver damage in pediatric nonalcoholic fatty liver disease
    • Nobili V., Alkhouri N., Alisi A., et al. Retinol-binding protein 4: a promising circulating marker of liver damage in pediatric nonalcoholic fatty liver disease. Clin Gastroenterol Hepatol 2009, 7:575-579.
    • (2009) Clin Gastroenterol Hepatol , vol.7 , pp. 575-579
    • Nobili, V.1    Alkhouri, N.2    Alisi, A.3
  • 27
    • 33845207096 scopus 로고    scopus 로고
    • Diagnostic value of biochemical markers (NashTest) for the prediction of non alcoholo steato hepatitis in patients with non-alcoholic fatty liver disease
    • Poynard T., Ratziu V., Charlotte F., et al. Diagnostic value of biochemical markers (NashTest) for the prediction of non alcoholo steato hepatitis in patients with non-alcoholic fatty liver disease. BMC Gastroenterol 2006, 6:34.
    • (2006) BMC Gastroenterol , vol.6 , pp. 34
    • Poynard, T.1    Ratziu, V.2    Charlotte, F.3
  • 28
    • 70349157268 scopus 로고    scopus 로고
    • Serum levels of hyaluronic acid and tissue metalloproteinase inhibitor-1 combined with age predict the presence of nonalcoholic steatohepatitis in a pilot cohort of subjects with nonalcoholic fatty liver disease
    • Miele L., Forgione A., La Torre G., et al. Serum levels of hyaluronic acid and tissue metalloproteinase inhibitor-1 combined with age predict the presence of nonalcoholic steatohepatitis in a pilot cohort of subjects with nonalcoholic fatty liver disease. Transl Res 2009, 154:194-201.
    • (2009) Transl Res , vol.154 , pp. 194-201
    • Miele, L.1    Forgione, A.2    La Torre, G.3
  • 29
    • 0042165989 scopus 로고    scopus 로고
    • Hepatocyte apoptosis and fas expression are prominent features of human nonalcoholic steatohepatitis
    • Feldstein A.E., Canbay A., Angulo P., et al. Hepatocyte apoptosis and fas expression are prominent features of human nonalcoholic steatohepatitis. Gastroenterology 2003, 125:437-443.
    • (2003) Gastroenterology , vol.125 , pp. 437-443
    • Feldstein, A.E.1    Canbay, A.2    Angulo, P.3
  • 30
    • 0842281645 scopus 로고    scopus 로고
    • Cell death: critical control points
    • Danial N.N., Korsmeyer S.J. Cell death: critical control points. Cell 2004, 116:205-219.
    • (2004) Cell , vol.116 , pp. 205-219
    • Danial, N.N.1    Korsmeyer, S.J.2
  • 31
    • 33745904468 scopus 로고    scopus 로고
    • In vivo assessment of liver cell apoptosis as a novel biomarker of disease severity in nonalcoholic fatty liver disease
    • Wieckowska A., Zein N.N., Yerian L.M., et al. In vivo assessment of liver cell apoptosis as a novel biomarker of disease severity in nonalcoholic fatty liver disease. Hepatology 2006, 44:27-33.
    • (2006) Hepatology , vol.44 , pp. 27-33
    • Wieckowska, A.1    Zein, N.N.2    Yerian, L.M.3
  • 32
    • 70350046669 scopus 로고    scopus 로고
    • Cytokeratin-18 fragment levels as noninvasive biomarkers for nonalcoholic steatohepatitis: a multicenter validation study
    • Feldstein A.E., Wieckowska A., Lopez A.R., et al. Cytokeratin-18 fragment levels as noninvasive biomarkers for nonalcoholic steatohepatitis: a multicenter validation study. Hepatology 2009, 50:1072-1078.
    • (2009) Hepatology , vol.50 , pp. 1072-1078
    • Feldstein, A.E.1    Wieckowska, A.2    Lopez, A.R.3
  • 33
    • 37749032395 scopus 로고    scopus 로고
    • Noninvasive diagnosis of nonalcoholic fatty liver disease using serum biomarkers
    • author reply 2048
    • Mitry R.R., De Bruyne R., Quaglia A., et al. Noninvasive diagnosis of nonalcoholic fatty liver disease using serum biomarkers. Hepatology 2007, 46:2047-2048. author reply 2048.
    • (2007) Hepatology , vol.46 , pp. 2047-2048
    • Mitry, R.R.1    De Bruyne, R.2    Quaglia, A.3
  • 34
    • 59849117801 scopus 로고    scopus 로고
    • Performance of ELF serum markers in predicting fibrosis stage in pediatric non-alcoholic fatty liver disease
    • Nobili V., Parkes J., Bottazzo G., et al. Performance of ELF serum markers in predicting fibrosis stage in pediatric non-alcoholic fatty liver disease. Gastroenterology 2009, 136:160-167.
    • (2009) Gastroenterology , vol.136 , pp. 160-167
    • Nobili, V.1    Parkes, J.2    Bottazzo, G.3
  • 35
    • 0020661702 scopus 로고
    • Ultrasonographical diagnosis of fatty liver: significance of the liver-kidney contrast
    • Yajima Y., Ohta K., Narui T., et al. Ultrasonographical diagnosis of fatty liver: significance of the liver-kidney contrast. Tohoku J Exp Med 1983, 139:43-50.
    • (1983) Tohoku J Exp Med , vol.139 , pp. 43-50
    • Yajima, Y.1    Ohta, K.2    Narui, T.3
  • 36
    • 0028814667 scopus 로고
    • Sonographic diagnosis of diffuse liver disease
    • Zwiebel W.J. Sonographic diagnosis of diffuse liver disease. Semin Ultrasound CT MR 1995, 16:8-15.
    • (1995) Semin Ultrasound CT MR , vol.16 , pp. 8-15
    • Zwiebel, W.J.1
  • 37
    • 33845958189 scopus 로고    scopus 로고
    • Imaging of hepatic steatosis and fatty sparing
    • Karcaaltincaba M., Akhan O. Imaging of hepatic steatosis and fatty sparing. Eur J Radiol 2007, 61:33-43.
    • (2007) Eur J Radiol , vol.61 , pp. 33-43
    • Karcaaltincaba, M.1    Akhan, O.2
  • 38
    • 0036729447 scopus 로고    scopus 로고
    • The utility of radiological imaging in nonalcoholic fatty liver disease
    • Saadeh S., Younossi Z.M., Remer E.M., et al. The utility of radiological imaging in nonalcoholic fatty liver disease. Gastroenterology 2002, 123:745-750.
    • (2002) Gastroenterology , vol.123 , pp. 745-750
    • Saadeh, S.1    Younossi, Z.M.2    Remer, E.M.3
  • 39
    • 33947547651 scopus 로고    scopus 로고
    • MRI and ultrasound for hepatic fat quantification: relationships to clinical and metabolic characteristics of pediatric nonalcoholic fatty liver disease
    • Pacifico L., Celestre M., Anania C., et al. MRI and ultrasound for hepatic fat quantification: relationships to clinical and metabolic characteristics of pediatric nonalcoholic fatty liver disease. Acta Paediatr 2007, 96:542-547.
    • (2007) Acta Paediatr , vol.96 , pp. 542-547
    • Pacifico, L.1    Celestre, M.2    Anania, C.3
  • 40
    • 12944284724 scopus 로고    scopus 로고
    • Quantitative estimation of attenuation in ultrasound video images: correlation with histology in diffuse liver disease
    • Graif M., Yanuka M., Baraz M., et al. Quantitative estimation of attenuation in ultrasound video images: correlation with histology in diffuse liver disease. Invest Radiol 2000, 35:319-324.
    • (2000) Invest Radiol , vol.35 , pp. 319-324
    • Graif, M.1    Yanuka, M.2    Baraz, M.3
  • 41
    • 0025960271 scopus 로고
    • Comparison of liver histology with ultrasonography in assessing diffuse parenchymal liver disease
    • Joseph A.E., Saverymuttu S.H., al-Sam S., et al. Comparison of liver histology with ultrasonography in assessing diffuse parenchymal liver disease. Clin Radiol 1991, 43:26-31.
    • (1991) Clin Radiol , vol.43 , pp. 26-31
    • Joseph, A.E.1    Saverymuttu, S.H.2    al-Sam, S.3
  • 42
    • 0036020536 scopus 로고    scopus 로고
    • Increased liver echogenicity at ultrasound examination reflects degree of steatosis but not of fibrosis in asymptomatic patients with mild/moderate abnormalities of liver transaminases
    • Mathiesen U.L., Franzen L.E., Aselius H., et al. Increased liver echogenicity at ultrasound examination reflects degree of steatosis but not of fibrosis in asymptomatic patients with mild/moderate abnormalities of liver transaminases. Dig Liver Dis 2002, 34:516-522.
    • (2002) Dig Liver Dis , vol.34 , pp. 516-522
    • Mathiesen, U.L.1    Franzen, L.E.2    Aselius, H.3
  • 43
    • 0022645750 scopus 로고
    • Ultrasound scanning in the detection of hepatic fibrosis and steatosis
    • Saverymuttu S.H., Joseph A.E., Maxwell J.D. Ultrasound scanning in the detection of hepatic fibrosis and steatosis. Br Med J (Clin Res Ed) 1986, 292:13-15.
    • (1986) Br Med J (Clin Res Ed) , vol.292 , pp. 13-15
    • Saverymuttu, S.H.1    Joseph, A.E.2    Maxwell, J.D.3
  • 44
    • 67649723378 scopus 로고    scopus 로고
    • New diagnostic and treatment approaches in non-alcoholic fatty liver disease (NAFLD)
    • Ali R., Cusi K. New diagnostic and treatment approaches in non-alcoholic fatty liver disease (NAFLD). Ann Med 2009, 41:265-278.
    • (2009) Ann Med , vol.41 , pp. 265-278
    • Ali, R.1    Cusi, K.2
  • 45
    • 0023882484 scopus 로고
    • Is hepatic ultrasonography a valid alternative tool to liver biopsy? Report on 507 cases studied with both techniques
    • Celle G., Savarino V., Picciotto A., et al. Is hepatic ultrasonography a valid alternative tool to liver biopsy? Report on 507 cases studied with both techniques. Dig Dis Sci 1988, 33:467-471.
    • (1988) Dig Dis Sci , vol.33 , pp. 467-471
    • Celle, G.1    Savarino, V.2    Picciotto, A.3
  • 46
    • 25444490694 scopus 로고    scopus 로고
    • The accuracy of the report of hepatic steatosis on ultrasonography in patients infected with hepatitis C in a clinical setting: a retrospective observational study
    • Hepburn M.J., Vos J.A., Fillman E.P., et al. The accuracy of the report of hepatic steatosis on ultrasonography in patients infected with hepatitis C in a clinical setting: a retrospective observational study. BMC Gastroenterol 2005, 5:14.
    • (2005) BMC Gastroenterol , vol.5 , pp. 14
    • Hepburn, M.J.1    Vos, J.A.2    Fillman, E.P.3
  • 47
    • 0022610211 scopus 로고
    • Sonography of diffuse benign liver disease: accuracy of pattern recognition and grading
    • Needleman L., Kurtz A.B., Rifkin M.D., et al. Sonography of diffuse benign liver disease: accuracy of pattern recognition and grading. AJR Am J Roentgenol 1986, 146:1011-1015.
    • (1986) AJR Am J Roentgenol , vol.146 , pp. 1011-1015
    • Needleman, L.1    Kurtz, A.B.2    Rifkin, M.D.3
  • 48
    • 36448976537 scopus 로고    scopus 로고
    • Interobserver and intraobserver variability in the sonographic assessment of fatty liver
    • Strauss S., Gavish E., Gottlieb P., et al. Interobserver and intraobserver variability in the sonographic assessment of fatty liver. AJR Am J Roentgenol 2007, 189:W320-W323.
    • (2007) AJR Am J Roentgenol , vol.189
    • Strauss, S.1    Gavish, E.2    Gottlieb, P.3
  • 49
    • 0019796098 scopus 로고
    • Computed tomography attenuation values in fatty liver
    • Bydder G.M., Chapman R.W., Harry D., et al. Computed tomography attenuation values in fatty liver. J Comput Tomogr 1981, 5:33-35.
    • (1981) J Comput Tomogr , vol.5 , pp. 33-35
    • Bydder, G.M.1    Chapman, R.W.2    Harry, D.3
  • 50
    • 44949120981 scopus 로고    scopus 로고
    • Liver fat is reproducibly measured using computed tomography in the Framingham Heart Study
    • Speliotes E.K., Massaro J.M., Hoffmann U., et al. Liver fat is reproducibly measured using computed tomography in the Framingham Heart Study. J Gastroenterol Hepatol 2008, 23:894-899.
    • (2008) J Gastroenterol Hepatol , vol.23 , pp. 894-899
    • Speliotes, E.K.1    Massaro, J.M.2    Hoffmann, U.3
  • 51
    • 0347479217 scopus 로고    scopus 로고
    • Macrovesicular hepatic steatosis in living related liver donors: correlation between CT and histologic findings
    • Limanond P., Raman S.S., Lassman C., et al. Macrovesicular hepatic steatosis in living related liver donors: correlation between CT and histologic findings. Radiology 2004, 230:276-280.
    • (2004) Radiology , vol.230 , pp. 276-280
    • Limanond, P.1    Raman, S.S.2    Lassman, C.3
  • 52
    • 34447509617 scopus 로고    scopus 로고
    • Unenhanced CT for assessment of macrovesicular hepatic steatosis in living liver donors: comparison of visual grading with liver attenuation index
    • Lee S.W., Park S.H., Kim K.W., et al. Unenhanced CT for assessment of macrovesicular hepatic steatosis in living liver donors: comparison of visual grading with liver attenuation index. Radiology 2007, 244:479-485.
    • (2007) Radiology , vol.244 , pp. 479-485
    • Lee, S.W.1    Park, S.H.2    Kim, K.W.3
  • 53
    • 34548125265 scopus 로고    scopus 로고
    • Definitive diagnosis and assessment of risk for nonalcoholic fatty liver disease in children and adolescents
    • Schwimmer J.B. Definitive diagnosis and assessment of risk for nonalcoholic fatty liver disease in children and adolescents. Semin Liver Dis 2007, 27:312-318.
    • (2007) Semin Liver Dis , vol.27 , pp. 312-318
    • Schwimmer, J.B.1
  • 54
    • 34247465261 scopus 로고    scopus 로고
    • Fatty liver: imaging patterns and pitfalls
    • Hamer O.W., Aguirre D.A., Casola G., et al. Fatty liver: imaging patterns and pitfalls. Radiographics 2006, 26:1637-1653.
    • (2006) Radiographics , vol.26 , pp. 1637-1653
    • Hamer, O.W.1    Aguirre, D.A.2    Casola, G.3
  • 56
    • 50849087307 scopus 로고    scopus 로고
    • Non-invasive means of measuring hepatic fat content
    • Mehta S.R., Thomas E.L., Bell J.D., et al. Non-invasive means of measuring hepatic fat content. World J Gastroenterol 2008, 14:3476-3483.
    • (2008) World J Gastroenterol , vol.14 , pp. 3476-3483
    • Mehta, S.R.1    Thomas, E.L.2    Bell, J.D.3
  • 57
    • 63049091762 scopus 로고    scopus 로고
    • Fatty liver disease: MR imaging techniques for the detection and quantification of liver steatosis
    • Cassidy F.H., Yokoo T., Aganovic L., et al. Fatty liver disease: MR imaging techniques for the detection and quantification of liver steatosis. Radiographics 2009, 29:231-260.
    • (2009) Radiographics , vol.29 , pp. 231-260
    • Cassidy, F.H.1    Yokoo, T.2    Aganovic, L.3
  • 58
    • 0027585532 scopus 로고
    • Fatty infiltration of the liver. Quantification by 1H localized magnetic resonance spectroscopy and comparison with computed tomography
    • Longo R., Ricci C., Masutti F., et al. Fatty infiltration of the liver. Quantification by 1H localized magnetic resonance spectroscopy and comparison with computed tomography. Invest Radiol 1993, 28:297-302.
    • (1993) Invest Radiol , vol.28 , pp. 297-302
    • Longo, R.1    Ricci, C.2    Masutti, F.3
  • 59
    • 0028347149 scopus 로고
    • Quantification of liver fat using magnetic resonance spectroscopy
    • Thomsen C., Becker U., Winkler K., et al. Quantification of liver fat using magnetic resonance spectroscopy. Magn Reson Imaging 1994, 12:487-495.
    • (1994) Magn Reson Imaging , vol.12 , pp. 487-495
    • Thomsen, C.1    Becker, U.2    Winkler, K.3
  • 60
    • 40449095940 scopus 로고    scopus 로고
    • Comparative MR study of hepatic fat quantification using single-voxel proton spectroscopy, two-point Dixon and three-point IDEAL
    • Kim H., Taksali S.E., Dufour S., et al. Comparative MR study of hepatic fat quantification using single-voxel proton spectroscopy, two-point Dixon and three-point IDEAL. Magn Reson Med 2008, 59:521-527.
    • (2008) Magn Reson Med , vol.59 , pp. 521-527
    • Kim, H.1    Taksali, S.E.2    Dufour, S.3
  • 61
    • 10844240700 scopus 로고    scopus 로고
    • Hepatic triglyceride content and its relation to body adiposity: a magnetic resonance imaging and proton magnetic resonance spectroscopy study
    • Thomas E.L., Hamilton G., Patel N., et al. Hepatic triglyceride content and its relation to body adiposity: a magnetic resonance imaging and proton magnetic resonance spectroscopy study. Gut 2005, 54:122-127.
    • (2005) Gut , vol.54 , pp. 122-127
    • Thomas, E.L.1    Hamilton, G.2    Patel, N.3
  • 62
    • 10644220306 scopus 로고    scopus 로고
    • Prevalence of hepatic steatosis in an urban population in the United States: impact of ethnicity
    • Browning J.D., Szczepaniak L.S., Dobbins R., et al. Prevalence of hepatic steatosis in an urban population in the United States: impact of ethnicity. Hepatology 2004, 40:1387-1395.
    • (2004) Hepatology , vol.40 , pp. 1387-1395
    • Browning, J.D.1    Szczepaniak, L.S.2    Dobbins, R.3
  • 63
    • 12144259379 scopus 로고    scopus 로고
    • Magnetic resonance spectroscopy to measure hepatic triglyceride content: prevalence of hepatic steatosis in the general population
    • Szczepaniak L.S., Nurenberg P., Leonard D., et al. Magnetic resonance spectroscopy to measure hepatic triglyceride content: prevalence of hepatic steatosis in the general population. Am J Physiol Endocrinol Metab 2005, 288:E462-E468.
    • (2005) Am J Physiol Endocrinol Metab , vol.288
    • Szczepaniak, L.S.1    Nurenberg, P.2    Leonard, D.3
  • 64
    • 33846431254 scopus 로고    scopus 로고
    • Relationship among histologic, radiologic, and biochemical assessments of hepatic steatosis: a study of human liver samples
    • Vuppalanchi R., Cummings O.W., Saxena R., et al. Relationship among histologic, radiologic, and biochemical assessments of hepatic steatosis: a study of human liver samples. J Clin Gastroenterol 2007, 41:206-210.
    • (2007) J Clin Gastroenterol , vol.41 , pp. 206-210
    • Vuppalanchi, R.1    Cummings, O.W.2    Saxena, R.3
  • 65
    • 19144365586 scopus 로고    scopus 로고
    • A randomized controlled trial of metformin versus vitamin E or prescriptive diet in nonalcoholic fatty liver disease
    • Bugianesi E., Gentilcore E., Manini R., et al. A randomized controlled trial of metformin versus vitamin E or prescriptive diet in nonalcoholic fatty liver disease. Am J Gastroenterol 2005, 100:1082-1090.
    • (2005) Am J Gastroenterol , vol.100 , pp. 1082-1090
    • Bugianesi, E.1    Gentilcore, E.2    Manini, R.3
  • 66
    • 0036776903 scopus 로고    scopus 로고
    • Effect of rosiglitazone on insulin sensitivity and body composition in type 2 diabetic patients
    • Carey D.G., Cowin G.J., Galloway G.J., et al. Effect of rosiglitazone on insulin sensitivity and body composition in type 2 diabetic patients. Obes Res 2002, 10:1008-1015.
    • (2002) Obes Res , vol.10 , pp. 1008-1015
    • Carey, D.G.1    Cowin, G.J.2    Galloway, G.J.3
  • 67
    • 16444378976 scopus 로고    scopus 로고
    • A phase 2 clinical trial of metformin as a treatment for non-diabetic paediatric non-alcoholic steatohepatitis
    • Schwimmer J.B., Middleton M.S., Deutsch R., et al. A phase 2 clinical trial of metformin as a treatment for non-diabetic paediatric non-alcoholic steatohepatitis. Aliment Pharmacol Ther 2005, 21:871-879.
    • (2005) Aliment Pharmacol Ther , vol.21 , pp. 871-879
    • Schwimmer, J.B.1    Middleton, M.S.2    Deutsch, R.3
  • 68
    • 67650091408 scopus 로고    scopus 로고
    • Effect of PRESS and STEAM sequences on magnetic resonance spectroscopic liver fat quantification
    • Hamilton G., Middleton M.S., Bydder M., et al. Effect of PRESS and STEAM sequences on magnetic resonance spectroscopic liver fat quantification. J Magn Reson Imaging 2009, 30:145-152.
    • (2009) J Magn Reson Imaging , vol.30 , pp. 145-152
    • Hamilton, G.1    Middleton, M.S.2    Bydder, M.3
  • 69
    • 67650287923 scopus 로고    scopus 로고
    • Advanced MRI methods for assessment of chronic liver disease
    • Taouli B., Ehman R.L., Reeder S.B. Advanced MRI methods for assessment of chronic liver disease. AJR Am J Roentgenol 2009, 193:14-27.
    • (2009) AJR Am J Roentgenol , vol.193 , pp. 14-27
    • Taouli, B.1    Ehman, R.L.2    Reeder, S.B.3
  • 70
    • 0021132985 scopus 로고
    • Simple proton spectroscopic imaging
    • Dixon W.T. Simple proton spectroscopic imaging. Radiology 1984, 153:189-194.
    • (1984) Radiology , vol.153 , pp. 189-194
    • Dixon, W.T.1
  • 71
    • 72949123204 scopus 로고    scopus 로고
    • Noninvasive imaging biomarkers for steatosis assessment
    • Sirlin C.B. Noninvasive imaging biomarkers for steatosis assessment. Liver Transpl 2009, 15:1389-1391.
    • (2009) Liver Transpl , vol.15 , pp. 1389-1391
    • Sirlin, C.B.1
  • 73
    • 23044510006 scopus 로고    scopus 로고
    • Hepatic MRI for fat quantitation: its relationship to fat morphology, diagnosis, and ultrasound
    • Fishbein M., Castro F., Cheruku S., et al. Hepatic MRI for fat quantitation: its relationship to fat morphology, diagnosis, and ultrasound. J Clin Gastroenterol 2005, 39:619-625.
    • (2005) J Clin Gastroenterol , vol.39 , pp. 619-625
    • Fishbein, M.1    Castro, F.2    Cheruku, S.3
  • 74
    • 33745146832 scopus 로고    scopus 로고
    • Hepatic macrosteatosis: predicting appropriateness of liver donation by using MR imaging-correlation with histopathologic findings
    • Kim S.H., Lee J.M., Han J.K., et al. Hepatic macrosteatosis: predicting appropriateness of liver donation by using MR imaging-correlation with histopathologic findings. Radiology 2006, 240:116-129.
    • (2006) Radiology , vol.240 , pp. 116-129
    • Kim, S.H.1    Lee, J.M.2    Han, J.K.3
  • 75
    • 27144532730 scopus 로고    scopus 로고
    • Accuracy of liver fat quantification at MR imaging: comparison of out-of-phase gradient-echo and fat-saturated fast spin-echo techniques-initial experience
    • Qayyum A., Goh J.S., Kakar S., et al. Accuracy of liver fat quantification at MR imaging: comparison of out-of-phase gradient-echo and fat-saturated fast spin-echo techniques-initial experience. Radiology 2005, 237:507-511.
    • (2005) Radiology , vol.237 , pp. 507-511
    • Qayyum, A.1    Goh, J.S.2    Kakar, S.3
  • 76
    • 58149359687 scopus 로고    scopus 로고
    • Nonalcoholic fatty liver disease: rapid evaluation of liver fat content with in-phase and out-of-phase MR imaging
    • Borra R.J., Salo S., Dean K., et al. Nonalcoholic fatty liver disease: rapid evaluation of liver fat content with in-phase and out-of-phase MR imaging. Radiology 2009, 250:130-136.
    • (2009) Radiology , vol.250 , pp. 130-136
    • Borra, R.J.1    Salo, S.2    Dean, K.3
  • 77
    • 0030995737 scopus 로고    scopus 로고
    • Introduction of fast MR imaging in the assessment of hepatic steatosis
    • Fishbein M.H., Gardner K.G., Potter C.J., et al. Introduction of fast MR imaging in the assessment of hepatic steatosis. Magn Reson Imaging 1997, 15:287-293.
    • (1997) Magn Reson Imaging , vol.15 , pp. 287-293
    • Fishbein, M.H.1    Gardner, K.G.2    Potter, C.J.3
  • 78
    • 27744582271 scopus 로고    scopus 로고
    • Hepatic fat fraction: MR imaging for quantitative measurement and display-early experience
    • Hussain H.K., Chenevert T.L., Londy F.J., et al. Hepatic fat fraction: MR imaging for quantitative measurement and display-early experience. Radiology 2005, 237:1048-1055.
    • (2005) Radiology , vol.237 , pp. 1048-1055
    • Hussain, H.K.1    Chenevert, T.L.2    Londy, F.J.3
  • 79
    • 40249090380 scopus 로고    scopus 로고
    • Relaxation effects in the quantification of fat using gradient echo imaging
    • Bydder M., Yokoo T., Hamilton G., et al. Relaxation effects in the quantification of fat using gradient echo imaging. Magn Reson Imaging 2008, 26:347-359.
    • (2008) Magn Reson Imaging , vol.26 , pp. 347-359
    • Bydder, M.1    Yokoo, T.2    Hamilton, G.3
  • 80
    • 34547934476 scopus 로고    scopus 로고
    • Fat quantification with IDEAL gradient echo imaging: correction of bias from T(1) and noise
    • Liu C.Y., McKenzie C.A., Yu H., et al. Fat quantification with IDEAL gradient echo imaging: correction of bias from T(1) and noise. Magn Reson Med 2007, 58:354-364.
    • (2007) Magn Reson Med , vol.58 , pp. 354-364
    • Liu, C.Y.1    McKenzie, C.A.2    Yu, H.3
  • 81
    • 64949095273 scopus 로고    scopus 로고
    • Nonalcoholic fatty liver disease: diagnostic and fat-grading accuracy of low-flip-angle multiecho gradient-recalled-echo MR imaging at 1.5 T
    • Yokoo T., Bydder M., Hamilton G., et al. Nonalcoholic fatty liver disease: diagnostic and fat-grading accuracy of low-flip-angle multiecho gradient-recalled-echo MR imaging at 1.5 T. Radiology 2009, 251:67-76.
    • (2009) Radiology , vol.251 , pp. 67-76
    • Yokoo, T.1    Bydder, M.2    Hamilton, G.3
  • 82
    • 0027381629 scopus 로고
    • MR imaging of fat-containing tissues: valuation of two quantitative imaging techniques in comparison with localized proton spectroscopy
    • Brix G., Heiland S., Bellemann M.E., et al. MR imaging of fat-containing tissues: valuation of two quantitative imaging techniques in comparison with localized proton spectroscopy. Magn Reson Imaging 1993, 11:977-991.
    • (1993) Magn Reson Imaging , vol.11 , pp. 977-991
    • Brix, G.1    Heiland, S.2    Bellemann, M.E.3
  • 83
    • 66749106248 scopus 로고    scopus 로고
    • Quantification of hepatic steatosis with MRI: the effects of accurate fat spectral modeling
    • Reeder S.B., Robson P.M., Yu H., et al. Quantification of hepatic steatosis with MRI: the effects of accurate fat spectral modeling. J Magn Reson Imaging 2009, 29:1332-1339.
    • (2009) J Magn Reson Imaging , vol.29 , pp. 1332-1339
    • Reeder, S.B.1    Robson, P.M.2    Yu, H.3
  • 84
    • 55749085613 scopus 로고    scopus 로고
    • Multiecho water-fat separation and simultaneous R2i estimation with multifrequency fat spectrum modeling
    • Yu H., Shimakawa A., McKenzie C.A., et al. Multiecho water-fat separation and simultaneous R2i estimation with multifrequency fat spectrum modeling. Magn Reson Med 2008, 60:1122-1134.
    • (2008) Magn Reson Med , vol.60 , pp. 1122-1134
    • Yu, H.1    Shimakawa, A.2    McKenzie, C.A.3
  • 85
    • 70350462793 scopus 로고    scopus 로고
    • T1 independent, T2i corrected MRI with accurate spectral modeling for quantification of fat: validation in a fat-water-SPIO phantom
    • Hines C.D., Yu H., Shimakawa A., et al. T1 independent, T2i corrected MRI with accurate spectral modeling for quantification of fat: validation in a fat-water-SPIO phantom. J Magn Reson Imaging 2009, 30:1215-1222.
    • (2009) J Magn Reson Imaging , vol.30 , pp. 1215-1222
    • Hines, C.D.1    Yu, H.2    Shimakawa, A.3
  • 86
    • 46049100990 scopus 로고    scopus 로고
    • Magnetic resonance elastography for the noninvasive staging of liver fibrosis
    • Huwart L., Sempoux C., Vicaut E., et al. Magnetic resonance elastography for the noninvasive staging of liver fibrosis. Gastroenterology 2008, 135:32-40.
    • (2008) Gastroenterology , vol.135 , pp. 32-40
    • Huwart, L.1    Sempoux, C.2    Vicaut, E.3
  • 87
    • 9144249563 scopus 로고    scopus 로고
    • Transient elastography: a new noninvasive method for assessment of hepatic fibrosis
    • Sandrin L., Fourquet B., Hasquenoph J.M., et al. Transient elastography: a new noninvasive method for assessment of hepatic fibrosis. Ultrasound Med Biol 2003, 29:1705-1713.
    • (2003) Ultrasound Med Biol , vol.29 , pp. 1705-1713
    • Sandrin, L.1    Fourquet, B.2    Hasquenoph, J.M.3
  • 88
    • 0036283787 scopus 로고    scopus 로고
    • Elastic modulus measurements of human liver and correlation with pathology
    • Yeh W.C., Li P.C., Jeng Y.M., et al. Elastic modulus measurements of human liver and correlation with pathology. Ultrasound Med Biol 2002, 28:467-474.
    • (2002) Ultrasound Med Biol , vol.28 , pp. 467-474
    • Yeh, W.C.1    Li, P.C.2    Jeng, Y.M.3
  • 89
    • 41849148981 scopus 로고    scopus 로고
    • Noninvasive assessment of liver fibrosis by measurement of stiffness in patients with nonalcoholic fatty liver disease (NAFLD)
    • Yoneda M., Yoneda M., Mawatari H., et al. Noninvasive assessment of liver fibrosis by measurement of stiffness in patients with nonalcoholic fatty liver disease (NAFLD). Dig Liver Dis 2008, 40:371-378.
    • (2008) Dig Liver Dis , vol.40 , pp. 371-378
    • Yoneda, M.1    Yoneda, M.2    Mawatari, H.3
  • 90
    • 49649105500 scopus 로고    scopus 로고
    • Accuracy and reproducibility of transient elastography for the diagnosis of fibrosis in pediatric nonalcoholic steatohepatitis
    • Nobili V., Vizzutti F., Arena U., et al. Accuracy and reproducibility of transient elastography for the diagnosis of fibrosis in pediatric nonalcoholic steatohepatitis. Hepatology 2008, 48:442-448.
    • (2008) Hepatology , vol.48 , pp. 442-448
    • Nobili, V.1    Vizzutti, F.2    Arena, U.3
  • 91
    • 34247631059 scopus 로고    scopus 로고
    • Reproducibility of transient elastography in the evaluation of liver fibrosis in patients with chronic liver disease
    • Fraquelli M., Rigamonti C., Casazza G., et al. Reproducibility of transient elastography in the evaluation of liver fibrosis in patients with chronic liver disease. Gut 2007, 56:968-973.
    • (2007) Gut , vol.56 , pp. 968-973
    • Fraquelli, M.1    Rigamonti, C.2    Casazza, G.3
  • 92
    • 34247102658 scopus 로고    scopus 로고
    • Transient elastography: a new surrogate marker of liver fibrosis influenced by major changes of transaminases
    • Coco B., Oliveri F., Maina A.M., et al. Transient elastography: a new surrogate marker of liver fibrosis influenced by major changes of transaminases. J Viral Hepat 2007, 14:360-369.
    • (2007) J Viral Hepat , vol.14 , pp. 360-369
    • Coco, B.1    Oliveri, F.2    Maina, A.M.3
  • 93
    • 58149396943 scopus 로고    scopus 로고
    • Liver stiffness is an unreliable marker of liver fibrosis in patients with cardiac insufficiency
    • Lebray P., Varnous S., Charlotte F., et al. Liver stiffness is an unreliable marker of liver fibrosis in patients with cardiac insufficiency. Hepatology 2008, 48:2089.
    • (2008) Hepatology , vol.48 , pp. 2089
    • Lebray, P.1    Varnous, S.2    Charlotte, F.3
  • 94
    • 33845659921 scopus 로고    scopus 로고
    • Accuracy of liver stiffness measurement for the diagnosis of cirrhosis in patients with chronic liver diseases
    • Ganne-Carrie N., Ziol M., de Ledinghen V., et al. Accuracy of liver stiffness measurement for the diagnosis of cirrhosis in patients with chronic liver diseases. Hepatology 2006, 44:1511-1517.
    • (2006) Hepatology , vol.44 , pp. 1511-1517
    • Ganne-Carrie, N.1    Ziol, M.2    de Ledinghen, V.3
  • 96
    • 0036621061 scopus 로고    scopus 로고
    • Magnetic resonance imaging of diffuse liver diseases
    • Martin D.R. Magnetic resonance imaging of diffuse liver diseases. Top Magn Reson Imaging 2002, 13:151-163.
    • (2002) Top Magn Reson Imaging , vol.13 , pp. 151-163
    • Martin, D.R.1
  • 98
    • 33646139892 scopus 로고    scopus 로고
    • Liver fibrosis: noninvasive diagnosis with double contrast material-enhanced MR imaging
    • Aguirre D.A., Behling C.A., Alpert E., et al. Liver fibrosis: noninvasive diagnosis with double contrast material-enhanced MR imaging. Radiology 2006, 239:425-437.
    • (2006) Radiology , vol.239 , pp. 425-437
    • Aguirre, D.A.1    Behling, C.A.2    Alpert, E.3
  • 99
    • 35248881091 scopus 로고    scopus 로고
    • Superparamagnetic iron oxides and low molecular weight gadolinium chelates are synergistic for direct visualization of advanced liver fibrosis
    • Hughes-Cassidy F., Chavez A.D., Schlang A., et al. Superparamagnetic iron oxides and low molecular weight gadolinium chelates are synergistic for direct visualization of advanced liver fibrosis. J Magn Reson Imaging 2007, 26:728-737.
    • (2007) J Magn Reson Imaging , vol.26 , pp. 728-737
    • Hughes-Cassidy, F.1    Chavez, A.D.2    Schlang, A.3
  • 100
    • 77449088122 scopus 로고    scopus 로고
    • MR imaging of liver fibrosis: current state of the art
    • Faria S.C., Ganesan K., Mwangi I., et al. MR imaging of liver fibrosis: current state of the art. Radiographics 2009, 29:1615-1635.
    • (2009) Radiographics , vol.29 , pp. 1615-1635
    • Faria, S.C.1    Ganesan, K.2    Mwangi, I.3
  • 101
    • 0035101962 scopus 로고    scopus 로고
    • Chronic hepatitis: correlation of early patchy and late linear enhancement patterns on gadolinium-enhanced MR images with histopathology initial experience
    • Semelka R.C., Chung J.J., Hussain S.M., et al. Chronic hepatitis: correlation of early patchy and late linear enhancement patterns on gadolinium-enhanced MR images with histopathology initial experience. J Magn Reson Imaging 2001, 13:385-391.
    • (2001) J Magn Reson Imaging , vol.13 , pp. 385-391
    • Semelka, R.C.1    Chung, J.J.2    Hussain, S.M.3
  • 102
    • 0037245116 scopus 로고    scopus 로고
    • Emergence of different macrophage populations in hepatic fibrosis following thioacetamide-induced acute hepatocyte injury in rats
    • Ide M., Yamate J., Machida Y., et al. Emergence of different macrophage populations in hepatic fibrosis following thioacetamide-induced acute hepatocyte injury in rats. J Comp Pathol 2003, 128:41-51.
    • (2003) J Comp Pathol , vol.128 , pp. 41-51
    • Ide, M.1    Yamate, J.2    Machida, Y.3
  • 103
    • 12844288099 scopus 로고    scopus 로고
    • Alcoholic fatty liver: its pathogenesis and mechanism of progression to inflammation and fibrosis
    • Lieber C.S. Alcoholic fatty liver: its pathogenesis and mechanism of progression to inflammation and fibrosis. Alcohol 2004, 34:9-19.
    • (2004) Alcohol , vol.34 , pp. 9-19
    • Lieber, C.S.1
  • 104
    • 0036190040 scopus 로고    scopus 로고
    • Superparamagnetic iron oxide-mediated hepatic signal intensity change in patients with and without cirrhosis: pulse sequence effects and Kupffer cell function
    • Tanimoto A., Yuasa Y., Shinmoto H., et al. Superparamagnetic iron oxide-mediated hepatic signal intensity change in patients with and without cirrhosis: pulse sequence effects and Kupffer cell function. Radiology 2002, 222:661-666.
    • (2002) Radiology , vol.222 , pp. 661-666
    • Tanimoto, A.1    Yuasa, Y.2    Shinmoto, H.3
  • 105
    • 37549002934 scopus 로고    scopus 로고
    • Double-contrast MRI for accurate staging of hepatocellular carcinoma in patients with cirrhosis
    • Hanna R.F., Kased N., Kwan S.W., et al. Double-contrast MRI for accurate staging of hepatocellular carcinoma in patients with cirrhosis. AJR Am J Roentgenol 2008, 190:47-57.
    • (2008) AJR Am J Roentgenol , vol.190 , pp. 47-57
    • Hanna, R.F.1    Kased, N.2    Kwan, S.W.3
  • 106
    • 55749111001 scopus 로고    scopus 로고
    • Measurement of liver stiffness with two imaging techniques: magnetic resonance elastography and ultrasound elastometry
    • Bensamoun S.F., Wang L., Robert L., et al. Measurement of liver stiffness with two imaging techniques: magnetic resonance elastography and ultrasound elastometry. J Magn Reson Imaging 2008, 28:1287-1292.
    • (2008) J Magn Reson Imaging , vol.28 , pp. 1287-1292
    • Bensamoun, S.F.1    Wang, L.2    Robert, L.3
  • 107
    • 33746220381 scopus 로고    scopus 로고
    • MR elastography of the liver: preliminary results
    • Rouviere O., Yin M., Dresner M.A., et al. MR elastography of the liver: preliminary results. Radiology 2006, 240:440-448.
    • (2006) Radiology , vol.240 , pp. 440-448
    • Rouviere, O.1    Yin, M.2    Dresner, M.A.3
  • 108
    • 34748861747 scopus 로고    scopus 로고
    • Assessment of hepatic fibrosis with magnetic resonance elastography
    • e1202
    • Yin M., Talwalkar J.A., Glaser K.J., et al. Assessment of hepatic fibrosis with magnetic resonance elastography. Clin Gastroenterol Hepatol 2007, 5:1207-1213. e1202.
    • (2007) Clin Gastroenterol Hepatol , vol.5 , pp. 1207-1213
    • Yin, M.1    Talwalkar, J.A.2    Glaser, K.J.3
  • 109
    • 38649113882 scopus 로고    scopus 로고
    • Magnetic resonance imaging of hepatic fibrosis: emerging clinical applications
    • Talwalkar J.A., Yin M., Fidler J.L., et al. Magnetic resonance imaging of hepatic fibrosis: emerging clinical applications. Hepatology 2008, 47:332-342.
    • (2008) Hepatology , vol.47 , pp. 332-342
    • Talwalkar, J.A.1    Yin, M.2    Fidler, J.L.3
  • 110
    • 67649361544 scopus 로고    scopus 로고
    • Diagnosis and treatment of pediatric nonalcoholic steatohepatitis and the implications for bariatric surgery
    • Pardee P.E., Lavine J.E., Schwimmer J.B. Diagnosis and treatment of pediatric nonalcoholic steatohepatitis and the implications for bariatric surgery. Semin Pediatr Surg 2009, 18:144-151.
    • (2009) Semin Pediatr Surg , vol.18 , pp. 144-151
    • Pardee, P.E.1    Lavine, J.E.2    Schwimmer, J.B.3
  • 111
    • 0017154704 scopus 로고
    • The syndromes of insulin resistance and acanthosis nigricans. Insulin-receptor disorders in man
    • Kahn C.R., Flier J.S., Bar R.S., et al. The syndromes of insulin resistance and acanthosis nigricans. Insulin-receptor disorders in man. N Engl J Med 1976, 294:739-745.
    • (1976) N Engl J Med , vol.294 , pp. 739-745
    • Kahn, C.R.1    Flier, J.S.2    Bar, R.S.3
  • 112
    • 0025945012 scopus 로고
    • Insulin resistance-mechanisms, syndromes, and implications
    • Moller D.E., Flier J.S. Insulin resistance-mechanisms, syndromes, and implications. N Engl J Med 1991, 325:938-948.
    • (1991) N Engl J Med , vol.325 , pp. 938-948
    • Moller, D.E.1    Flier, J.S.2
  • 113
    • 0028071849 scopus 로고
    • Insulin resistance, hypersecretion of LH, and a dual-defect hypothesis for the pathogenesis of polycystic ovary syndrome
    • Poretsky L., Piper B. Insulin resistance, hypersecretion of LH, and a dual-defect hypothesis for the pathogenesis of polycystic ovary syndrome. Obstet Gynecol 1994, 84:613-621.
    • (1994) Obstet Gynecol , vol.84 , pp. 613-621
    • Poretsky, L.1    Piper, B.2
  • 114
    • 0018242201 scopus 로고
    • Hyperinsulinemia in obesity syndromes: its metabolic consequences and possible etiology
    • Jeanrenaud B. Hyperinsulinemia in obesity syndromes: its metabolic consequences and possible etiology. Metabolism 1978, 27:1881-1892.
    • (1978) Metabolism , vol.27 , pp. 1881-1892
    • Jeanrenaud, B.1
  • 115
    • 33646035836 scopus 로고    scopus 로고
    • Contributions of different fatty acid sources to very low-density lipoprotein-triacylglycerol in the fasted and fed states
    • Barrows B.R., Parks E.J. Contributions of different fatty acid sources to very low-density lipoprotein-triacylglycerol in the fasted and fed states. J Clin Endocrinol Metab 2006, 91:1446-1452.
    • (2006) J Clin Endocrinol Metab , vol.91 , pp. 1446-1452
    • Barrows, B.R.1    Parks, E.J.2
  • 116
    • 18244382304 scopus 로고    scopus 로고
    • Sources of fatty acids stored in liver and secreted via lipoproteins in patients with nonalcoholic fatty liver disease
    • Donnelly K.L., Smith C.I., Schwarzenberg S.J., et al. Sources of fatty acids stored in liver and secreted via lipoproteins in patients with nonalcoholic fatty liver disease. J Clin Invest 2005, 115:1343-1351.
    • (2005) J Clin Invest , vol.115 , pp. 1343-1351
    • Donnelly, K.L.1    Smith, C.I.2    Schwarzenberg, S.J.3
  • 117
    • 57949116523 scopus 로고    scopus 로고
    • Alterations in fatty acid kinetics in obese adolescents with increased intrahepatic triglyceride content
    • Fabbrini E., deHaseth D., Deivanayagam S., et al. Alterations in fatty acid kinetics in obese adolescents with increased intrahepatic triglyceride content. Obesity (Silver Spring) 2009, 17:25-29.
    • (2009) Obesity (Silver Spring) , vol.17 , pp. 25-29
    • Fabbrini, E.1    deHaseth, D.2    Deivanayagam, S.3
  • 118
    • 29044447292 scopus 로고    scopus 로고
    • Free fatty acids produce insulin resistance and activate the proinflammatory nuclear factor-kappaB pathway in rat liver
    • Boden G., She P., Mozzoli M., et al. Free fatty acids produce insulin resistance and activate the proinflammatory nuclear factor-kappaB pathway in rat liver. Diabetes 2005, 54:3458-3465.
    • (2005) Diabetes , vol.54 , pp. 3458-3465
    • Boden, G.1    She, P.2    Mozzoli, M.3
  • 119
    • 14644427890 scopus 로고    scopus 로고
    • Local and systemic insulin resistance resulting from hepatic activation of IKK-beta and NF-kappaB
    • Cai D., Yuan M., Frantz D.F., et al. Local and systemic insulin resistance resulting from hepatic activation of IKK-beta and NF-kappaB. Nat Med 2005, 11:183-190.
    • (2005) Nat Med , vol.11 , pp. 183-190
    • Cai, D.1    Yuan, M.2    Frantz, D.F.3
  • 120
    • 77952785795 scopus 로고    scopus 로고
    • Non-alcoholic fatty liver disease from pathogenesis to management: an update
    • Musso G., Gambino R., Cassader M. Non-alcoholic fatty liver disease from pathogenesis to management: an update. Obes Rev 2010, 11:430-445.
    • (2010) Obes Rev , vol.11 , pp. 430-445
    • Musso, G.1    Gambino, R.2    Cassader, M.3
  • 121
    • 43949108922 scopus 로고    scopus 로고
    • The lysosomal-mitochondrial axis in free fatty acid-induced hepatic lipotoxicity
    • Li Z., Berk M., McIntyre T.M., et al. The lysosomal-mitochondrial axis in free fatty acid-induced hepatic lipotoxicity. Hepatology 2008, 47:1495-1503.
    • (2008) Hepatology , vol.47 , pp. 1495-1503
    • Li, Z.1    Berk, M.2    McIntyre, T.M.3
  • 122
    • 70449355084 scopus 로고    scopus 로고
    • In liver fibrosis, dendritic cells govern hepatic inflammation in mice via TNF-alpha
    • Connolly M.K., Bedrosian A.S., Mallen-St Clair J., et al. In liver fibrosis, dendritic cells govern hepatic inflammation in mice via TNF-alpha. J Clin Invest 2009, 119:3213-3225.
    • (2009) J Clin Invest , vol.119 , pp. 3213-3225
    • Connolly, M.K.1    Bedrosian, A.S.2    Mallen-St Clair, J.3
  • 123
    • 33845642594 scopus 로고    scopus 로고
    • Oxidative-stress and IL-6 mediate the fibrogenic effects of Kupffer cells on stellate cells
    • Nieto N. Oxidative-stress and IL-6 mediate the fibrogenic effects of Kupffer cells on stellate cells. Hepatology 2006, 44:1487-1501.
    • (2006) Hepatology , vol.44 , pp. 1487-1501
    • Nieto, N.1
  • 124
    • 67650963803 scopus 로고    scopus 로고
    • Kupffer cells mediate leptin-induced liver fibrosis
    • Wang J., Leclercq I., Brymora J.M., et al. Kupffer cells mediate leptin-induced liver fibrosis. Gastroenterology 2009, 137:713-723.
    • (2009) Gastroenterology , vol.137 , pp. 713-723
    • Wang, J.1    Leclercq, I.2    Brymora, J.M.3
  • 125
    • 28844440050 scopus 로고    scopus 로고
    • Decreased serum adiponectin: an early event in pediatric nonalcoholic fatty liver disease
    • Louthan M.V., Barve S., McClain C.J., et al. Decreased serum adiponectin: an early event in pediatric nonalcoholic fatty liver disease. J Pediatr 2005, 147:835-838.
    • (2005) J Pediatr , vol.147 , pp. 835-838
    • Louthan, M.V.1    Barve, S.2    McClain, C.J.3
  • 126
    • 33751519769 scopus 로고    scopus 로고
    • Alanine aminotransferase levels and fatty liver in childhood obesity: associations with insulin resistance, adiponectin, and visceral fat
    • Burgert T.S., Taksali S.E., Dziura J., et al. Alanine aminotransferase levels and fatty liver in childhood obesity: associations with insulin resistance, adiponectin, and visceral fat. J Clin Endocrinol Metab 2006, 91:4287-4294.
    • (2006) J Clin Endocrinol Metab , vol.91 , pp. 4287-4294
    • Burgert, T.S.1    Taksali, S.E.2    Dziura, J.3
  • 127
    • 70349678823 scopus 로고    scopus 로고
    • Adiponectin knockout mice on high fat diet develop fibrosing steatohepatitis
    • Asano T., Watanabe K., Kubota N., et al. Adiponectin knockout mice on high fat diet develop fibrosing steatohepatitis. J Gastroenterol Hepatol 2009, 24:1669-1676.
    • (2009) J Gastroenterol Hepatol , vol.24 , pp. 1669-1676
    • Asano, T.1    Watanabe, K.2    Kubota, N.3
  • 128
    • 67649598622 scopus 로고    scopus 로고
    • Adiponectin prevents progression of steatohepatitis in mice by regulating oxidative stress and Kupffer cell phenotype polarization
    • Fukushima J., Kamada Y., Matsumoto H., et al. Adiponectin prevents progression of steatohepatitis in mice by regulating oxidative stress and Kupffer cell phenotype polarization. Hepatol Res 2009, 39:724-738.
    • (2009) Hepatol Res , vol.39 , pp. 724-738
    • Fukushima, J.1    Kamada, Y.2    Matsumoto, H.3
  • 129
    • 34250356015 scopus 로고    scopus 로고
    • Inhibiting triglyceride synthesis improves hepatic steatosis but exacerbates liver damage and fibrosis in obese mice with nonalcoholic steatohepatitis
    • Yamaguchi K., Yang L., McCall S., et al. Inhibiting triglyceride synthesis improves hepatic steatosis but exacerbates liver damage and fibrosis in obese mice with nonalcoholic steatohepatitis. Hepatology 2007, 45:1366-1374.
    • (2007) Hepatology , vol.45 , pp. 1366-1374
    • Yamaguchi, K.1    Yang, L.2    McCall, S.3
  • 130
    • 52649083729 scopus 로고    scopus 로고
    • The lowering of hepatic fatty acid uptake improves liver function and insulin sensitivity without affecting hepatic fat content in humans
    • Rigazio S., Lehto H.R., Tuunanen H., et al. The lowering of hepatic fatty acid uptake improves liver function and insulin sensitivity without affecting hepatic fat content in humans. Am J Physiol Endocrinol Metab 2008, 295:E413-E419.
    • (2008) Am J Physiol Endocrinol Metab , vol.295
    • Rigazio, S.1    Lehto, H.R.2    Tuunanen, H.3
  • 131
    • 73149107279 scopus 로고    scopus 로고
    • Maternal high-fat feeding primes steatohepatitis in adult mice offspring, involving mitochondrial dysfunction and altered lipogenesis gene expression
    • Bruce K.D., Cagampang F.R., Argenton M., et al. Maternal high-fat feeding primes steatohepatitis in adult mice offspring, involving mitochondrial dysfunction and altered lipogenesis gene expression. Hepatology 2009, 50:1796-1808.
    • (2009) Hepatology , vol.50 , pp. 1796-1808
    • Bruce, K.D.1    Cagampang, F.R.2    Argenton, M.3
  • 132
    • 61749094289 scopus 로고    scopus 로고
    • Maternal high-fat diet triggers lipotoxicity in the fetal livers of nonhuman primates
    • McCurdy C.E., Bishop J.M., Williams S.M., et al. Maternal high-fat diet triggers lipotoxicity in the fetal livers of nonhuman primates. J Clin Invest 2009, 119:323-335.
    • (2009) J Clin Invest , vol.119 , pp. 323-335
    • McCurdy, C.E.1    Bishop, J.M.2    Williams, S.M.3
  • 133
    • 33750002388 scopus 로고    scopus 로고
    • Prevalence of fatty liver in children and adolescents
    • Schwimmer J.B., Deutsch R., Kahen T., et al. Prevalence of fatty liver in children and adolescents. Pediatrics 2006, 118:1388-1393.
    • (2006) Pediatrics , vol.118 , pp. 1388-1393
    • Schwimmer, J.B.1    Deutsch, R.2    Kahen, T.3
  • 134
    • 65249188812 scopus 로고    scopus 로고
    • Heritability of nonalcoholic fatty liver disease
    • Schwimmer J.B., Celedon M.A., Lavine J.E., et al. Heritability of nonalcoholic fatty liver disease. Gastroenterology 2009, 136:1585-1592.
    • (2009) Gastroenterology , vol.136 , pp. 1585-1592
    • Schwimmer, J.B.1    Celedon, M.A.2    Lavine, J.E.3
  • 135
    • 67650496665 scopus 로고    scopus 로고
    • Correlates and heritability of nonalcoholic fatty liver disease in a minority cohort
    • Wagenknecht L.E., Scherzinger A.L., Stamm E.R., et al. Correlates and heritability of nonalcoholic fatty liver disease in a minority cohort. Obesity (Silver Spring) 2009, 17:1240-1246.
    • (2009) Obesity (Silver Spring) , vol.17 , pp. 1240-1246
    • Wagenknecht, L.E.1    Scherzinger, A.L.2    Stamm, E.R.3
  • 136
    • 56749096610 scopus 로고    scopus 로고
    • Genetic variation in PNPLA3 confers susceptibility to nonalcoholic fatty liver disease
    • Romeo S., Kozlitina J., Xing C., et al. Genetic variation in PNPLA3 confers susceptibility to nonalcoholic fatty liver disease. Nat Genet 2008, 40:1461-1465.
    • (2008) Nat Genet , vol.40 , pp. 1461-1465
    • Romeo, S.1    Kozlitina, J.2    Xing, C.3
  • 137
    • 67349174005 scopus 로고    scopus 로고
    • A common variant in PNPLA3, which encodes adiponutrin, is associated with liver fat content in humans
    • Kotronen A., Johansson L.E., Johansson L.M., et al. A common variant in PNPLA3, which encodes adiponutrin, is associated with liver fat content in humans. Diabetologia 2009, 52:1056-1060.
    • (2009) Diabetologia , vol.52 , pp. 1056-1060
    • Kotronen, A.1    Johansson, L.E.2    Johansson, L.M.3
  • 138
    • 69249111667 scopus 로고    scopus 로고
    • A nonsynonymous gene variant in the adiponutrin gene is associated with nonalcoholic fatty liver disease severity
    • Sookoian S., Castano G.O., Burgueno A.L., et al. A nonsynonymous gene variant in the adiponutrin gene is associated with nonalcoholic fatty liver disease severity. J Lipid Res 2009, 50:2111-2116.
    • (2009) J Lipid Res , vol.50 , pp. 2111-2116
    • Sookoian, S.1    Castano, G.O.2    Burgueno, A.L.3
  • 139
    • 33748745960 scopus 로고    scopus 로고
    • Characterization of the human patatin-like phospholipase family
    • Wilson P.A., Gardner S.D., Lambie N.M., et al. Characterization of the human patatin-like phospholipase family. J Lipid Res 2006, 47:1940-1949.
    • (2006) J Lipid Res , vol.47 , pp. 1940-1949
    • Wilson, P.A.1    Gardner, S.D.2    Lambie, N.M.3
  • 140
    • 70449403261 scopus 로고    scopus 로고
    • Genetic evidence for a role of adiponutrin in the metabolism of apolipoprotein B-containing lipoproteins
    • Kollerits B., Coassin S., Beckmann N.D., et al. Genetic evidence for a role of adiponutrin in the metabolism of apolipoprotein B-containing lipoproteins. Hum Mol Genet 2009, 18:4669-4676.
    • (2009) Hum Mol Genet , vol.18 , pp. 4669-4676
    • Kollerits, B.1    Coassin, S.2    Beckmann, N.D.3
  • 141
    • 36549070161 scopus 로고    scopus 로고
    • Prevalence of elevated alanine aminotransferase among US adolescents and associated factors: NHANES 1999-2004
    • Fraser A., Longnecker M.P., Lawlor D.A. Prevalence of elevated alanine aminotransferase among US adolescents and associated factors: NHANES 1999-2004. Gastroenterology 2007, 133:1814-1820.
    • (2007) Gastroenterology , vol.133 , pp. 1814-1820
    • Fraser, A.1    Longnecker, M.P.2    Lawlor, D.A.3
  • 142
    • 0030904688 scopus 로고    scopus 로고
    • The relationship between fatty liver and hyperinsulinemia in obese Japanese children
    • Kawasaki T., Hashimoto N., Kikuchi T., et al. The relationship between fatty liver and hyperinsulinemia in obese Japanese children. J Pediatr Gastroenterol Nutr 1997, 24:317-321.
    • (1997) J Pediatr Gastroenterol Nutr , vol.24 , pp. 317-321
    • Kawasaki, T.1    Hashimoto, N.2    Kikuchi, T.3
  • 143
    • 34547105275 scopus 로고    scopus 로고
    • Nonalcoholic fatty liver disease in overweight children and adolescents
    • Sagi R., Reif S., Neuman G., et al. Nonalcoholic fatty liver disease in overweight children and adolescents. Acta Paediatr 2007, 96:1209-1213.
    • (2007) Acta Paediatr , vol.96 , pp. 1209-1213
    • Sagi, R.1    Reif, S.2    Neuman, G.3
  • 144
    • 59149094374 scopus 로고    scopus 로고
    • Treatment of non-alcoholic fatty liver disease with metformin versus lifestyle intervention in insulin-resistant adolescents
    • Nadeau K.J., Ehlers L.B., Zeitler P.S., et al. Treatment of non-alcoholic fatty liver disease with metformin versus lifestyle intervention in insulin-resistant adolescents. Pediatr Diabetes 2009, 10:5-13.
    • (2009) Pediatr Diabetes , vol.10 , pp. 5-13
    • Nadeau, K.J.1    Ehlers, L.B.2    Zeitler, P.S.3
  • 145
    • 16444367799 scopus 로고    scopus 로고
    • Influence of gender, race, and ethnicity on suspected fatty liver in obese adolescents
    • Schwimmer J.B., McGreal N., Deutsch R., et al. Influence of gender, race, and ethnicity on suspected fatty liver in obese adolescents. Pediatrics 2005, 115:e561-e565.
    • (2005) Pediatrics , vol.115
    • Schwimmer, J.B.1    McGreal, N.2    Deutsch, R.3
  • 146
    • 33846624735 scopus 로고    scopus 로고
    • Risk for nonalcoholic fatty liver disease in Hispanic youth with BMI > or =95th percentile
    • Quirós-Tejeira R.E., Rivera C.A., Ziba T.T., et al. Risk for nonalcoholic fatty liver disease in Hispanic youth with BMI > or =95th percentile. J Pediatr Gastroenterol Nutr 2007, 44:228-236.
    • (2007) J Pediatr Gastroenterol Nutr , vol.44 , pp. 228-236
    • Quirós-Tejeira, R.E.1    Rivera, C.A.2    Ziba, T.T.3
  • 147
    • 34447262549 scopus 로고    scopus 로고
    • Predictors of non-alcoholic fatty liver disease in obese children
    • Sartorio A., Del Col A., Agosti F., et al. Predictors of non-alcoholic fatty liver disease in obese children. Eur J Clin Nutr 2007, 61:877-883.
    • (2007) Eur J Clin Nutr , vol.61 , pp. 877-883
    • Sartorio, A.1    Del Col, A.2    Agosti, F.3
  • 148
    • 26044470850 scopus 로고    scopus 로고
    • Decreased prevalence of nonalcoholic fatty liver disease in black obese children
    • Louthan M.V., Theriot J.A., Zimmerman E., et al. Decreased prevalence of nonalcoholic fatty liver disease in black obese children. J Pediatr Gastroenterol Nutr 2005, 41:426-429.
    • (2005) J Pediatr Gastroenterol Nutr , vol.41 , pp. 426-429
    • Louthan, M.V.1    Theriot, J.A.2    Zimmerman, E.3
  • 149
    • 73549090807 scopus 로고    scopus 로고
    • Symptoms and quality of life in obese children and adolescents with nonalcoholic fatty liver disease
    • Kistler K.D., Molleston J., Unalp A., et al. Symptoms and quality of life in obese children and adolescents with nonalcoholic fatty liver disease. Aliment Pharmacol Ther 2009, 31:396-406.
    • (2009) Aliment Pharmacol Ther , vol.31 , pp. 396-406
    • Kistler, K.D.1    Molleston, J.2    Unalp, A.3
  • 150
    • 45849133826 scopus 로고    scopus 로고
    • Nonalcoholic fatty liver disease in children: a single center experience
    • Hh A.K., Henderson J., Vanhoesen K., et al. Nonalcoholic fatty liver disease in children: a single center experience. Clin Gastroenterol Hepatol 2008, 6:799-802.
    • (2008) Clin Gastroenterol Hepatol , vol.6 , pp. 799-802
    • Hh, A.K.1    Henderson, J.2    Vanhoesen, K.3
  • 151
    • 32944464107 scopus 로고    scopus 로고
    • Prevalence of recurrent physical symptoms in U.S. adolescents
    • 350
    • Rhee H., Miles M.S., Halpern C.T., et al. Prevalence of recurrent physical symptoms in U.S. adolescents. Pediatr Nurs 2005, 31:314-319. 350.
    • (2005) Pediatr Nurs , vol.31 , pp. 314-319
    • Rhee, H.1    Miles, M.S.2    Halpern, C.T.3
  • 152
    • 28844509166 scopus 로고    scopus 로고
    • Underdiagnosis of pediatric obesity and underscreening for fatty liver disease and metabolic syndrome by pediatricians and pediatric subspecialists
    • Riley M.R., Bass N.M., Rosenthal P., et al. Underdiagnosis of pediatric obesity and underscreening for fatty liver disease and metabolic syndrome by pediatricians and pediatric subspecialists. J Pediatr 2005, 147:839-842.
    • (2005) J Pediatr , vol.147 , pp. 839-842
    • Riley, M.R.1    Bass, N.M.2    Rosenthal, P.3
  • 153
    • 38449095758 scopus 로고    scopus 로고
    • Expert committee recommendations regarding the prevention, assessment, and treatment of child and adolescent overweight and obesity: summary report
    • Barlow S.E. Expert committee recommendations regarding the prevention, assessment, and treatment of child and adolescent overweight and obesity: summary report. Pediatrics 2007, 120(Suppl 4):S164-S192.
    • (2007) Pediatrics , vol.120 , Issue.SUPPL 4
    • Barlow, S.E.1
  • 154
    • 77949816251 scopus 로고    scopus 로고
    • SAFETY study: alanine aminotransferase cutoff values are set too high for reliable detection of pediatric chronic liver disease
    • Schwimmer J.B., Dunn W., Norman G.J., et al. SAFETY study: alanine aminotransferase cutoff values are set too high for reliable detection of pediatric chronic liver disease. Gastroenterology 2010, 138:1357-1364.
    • (2010) Gastroenterology , vol.138 , pp. 1357-1364
    • Schwimmer, J.B.1    Dunn, W.2    Norman, G.J.3
  • 155
    • 50249151997 scopus 로고    scopus 로고
    • Waist circumference correlates with liver fibrosis in children with non-alcoholic steatohepatitis
    • Manco M., Bedogni G., Marcellini M., et al. Waist circumference correlates with liver fibrosis in children with non-alcoholic steatohepatitis. Gut 2008, 57:1283-1287.
    • (2008) Gut , vol.57 , pp. 1283-1287
    • Manco, M.1    Bedogni, G.2    Marcellini, M.3
  • 156
    • 78149386225 scopus 로고    scopus 로고
    • Anthropometry procedures manual. National Health and Nutrition Examination Survey. Center for Disease Control; 2000. Available at: Accessed September 12,
    • Anthropometry procedures manual. National Health and Nutrition Examination Survey. Center for Disease Control; 2000. Available at: Accessed September 12, 2009. http://www.cdc.gov/nchs/data/nhanes/bm.pdf.
    • (2009)
  • 158
    • 0032882085 scopus 로고    scopus 로고
    • A quantitative scale of acanthosis nigricans
    • Burke J.P., Hale D.E., Hazuda H.P., et al. A quantitative scale of acanthosis nigricans. Diabetes Care 1999, 22:1655-1659.
    • (1999) Diabetes Care , vol.22 , pp. 1655-1659
    • Burke, J.P.1    Hale, D.E.2    Hazuda, H.P.3
  • 159
    • 49149114288 scopus 로고    scopus 로고
    • Cardiovascular risk factors and the metabolic syndrome in pediatric nonalcoholic fatty liver disease
    • Schwimmer J.B., Pardee P.E., Lavine J.E., et al. Cardiovascular risk factors and the metabolic syndrome in pediatric nonalcoholic fatty liver disease. Circulation 2008, 118:277-283.
    • (2008) Circulation , vol.118 , pp. 277-283
    • Schwimmer, J.B.1    Pardee, P.E.2    Lavine, J.E.3
  • 160
    • 54549098072 scopus 로고    scopus 로고
    • Cytokines and renin-angiotensin system signaling in hepatic fibrosis
    • ix
    • Moreno M., Bataller R. Cytokines and renin-angiotensin system signaling in hepatic fibrosis. Clin Liver Dis 2008, 12:825-852. ix.
    • (2008) Clin Liver Dis , vol.12 , pp. 825-852
    • Moreno, M.1    Bataller, R.2
  • 161
    • 34548425707 scopus 로고    scopus 로고
    • Management of hypertension in children and adolescents with the metabolic syndrome
    • Puri M., Flynn J.T. Management of hypertension in children and adolescents with the metabolic syndrome. J Cardiometab Syndr 2006, 1:259-268.
    • (2006) J Cardiometab Syndr , vol.1 , pp. 259-268
    • Puri, M.1    Flynn, J.T.2
  • 162
    • 33645523067 scopus 로고    scopus 로고
    • Prevalence of overweight and obesity in the United States, 1999-2004
    • Ogden C.L., Carroll M.D., Curtin L.R., et al. Prevalence of overweight and obesity in the United States, 1999-2004. JAMA 2006, 295:1549-1555.
    • (2006) JAMA , vol.295 , pp. 1549-1555
    • Ogden, C.L.1    Carroll, M.D.2    Curtin, L.R.3
  • 163
    • 0034078045 scopus 로고    scopus 로고
    • Liver steatosis in juvenile obesity: correlations with lipid profile, hepatic biochemical parameters and glycemic and insulinemic responses to an oral glucose tolerance test
    • Guzzaloni G., Grugni G., Minocci A., et al. Liver steatosis in juvenile obesity: correlations with lipid profile, hepatic biochemical parameters and glycemic and insulinemic responses to an oral glucose tolerance test. Int J Obes Relat Metab Disord 2000, 24:772-776.
    • (2000) Int J Obes Relat Metab Disord , vol.24 , pp. 772-776
    • Guzzaloni, G.1    Grugni, G.2    Minocci, A.3
  • 164
    • 0034613642 scopus 로고    scopus 로고
    • Non-alcoholic steatohepatitis in children and adolescents
    • Manton N.D., Lipsett J., Moore D.J., et al. Non-alcoholic steatohepatitis in children and adolescents. Med J Aust 2000, 173:476-479.
    • (2000) Med J Aust , vol.173 , pp. 476-479
    • Manton, N.D.1    Lipsett, J.2    Moore, D.J.3
  • 165
    • 0141510580 scopus 로고    scopus 로고
    • The natural history of nonalcoholic fatty liver disease: a clinical histopathological study
    • Harrison S.A., Torgerson S., Hayashi P.H. The natural history of nonalcoholic fatty liver disease: a clinical histopathological study. Am J Gastroenterol 2003, 98:2042-2047.
    • (2003) Am J Gastroenterol , vol.98 , pp. 2042-2047
    • Harrison, S.A.1    Torgerson, S.2    Hayashi, P.H.3
  • 166
    • 1542515099 scopus 로고    scopus 로고
    • Ursodeoxycholic acid for treatment of nonalcoholic steatohepatitis: results of a randomized trial
    • Lindor K.D., Kowdley K.V., Heathcote E.J., et al. Ursodeoxycholic acid for treatment of nonalcoholic steatohepatitis: results of a randomized trial. Hepatology 2004, 39:770-778.
    • (2004) Hepatology , vol.39 , pp. 770-778
    • Lindor, K.D.1    Kowdley, K.V.2    Heathcote, E.J.3
  • 167
    • 1842480297 scopus 로고    scopus 로고
    • Nonalcoholic fatty liver disease among patients with hypothalamic and pituitary dysfunction
    • Adams L.A., Feldstein A., Lindor K.D., et al. Nonalcoholic fatty liver disease among patients with hypothalamic and pituitary dysfunction. Hepatology 2004, 39:909-914.
    • (2004) Hepatology , vol.39 , pp. 909-914
    • Adams, L.A.1    Feldstein, A.2    Lindor, K.D.3
  • 169
    • 18144405003 scopus 로고    scopus 로고
    • Pediatric nonalcoholic steatohepatitis associated with hypopituitarism
    • Nakajima K., Hashimoto E., Kaneda H., et al. Pediatric nonalcoholic steatohepatitis associated with hypopituitarism. J Gastroenterol 2005, 40:312-315.
    • (2005) J Gastroenterol , vol.40 , pp. 312-315
    • Nakajima, K.1    Hashimoto, E.2    Kaneda, H.3
  • 170
    • 34249699540 scopus 로고    scopus 로고
    • Non-alcoholic steatohepatitis and cancer
    • x-xi
    • Bugianesi E. Non-alcoholic steatohepatitis and cancer. Clin Liver Dis 2007, 11:191-207. x-xi.
    • (2007) Clin Liver Dis , vol.11 , pp. 191-207
    • Bugianesi, E.1
  • 171
    • 16244403652 scopus 로고    scopus 로고
    • Non-alcoholic steatohepatitis (NASH) and hepatocellular carcinoma
    • Cuadrado A., Orive A., Garcia-Suarez C., et al. Non-alcoholic steatohepatitis (NASH) and hepatocellular carcinoma. Obes Surg 2005, 15:442-446.
    • (2005) Obes Surg , vol.15 , pp. 442-446
    • Cuadrado, A.1    Orive, A.2    Garcia-Suarez, C.3
  • 172
    • 34548674927 scopus 로고    scopus 로고
    • Primary liver cancers with nonalcoholic steatohepatitis
    • Hashizume H., Sato K., Takagi H., et al. Primary liver cancers with nonalcoholic steatohepatitis. Eur J Gastroenterol Hepatol 2007, 19:827-834.
    • (2007) Eur J Gastroenterol Hepatol , vol.19 , pp. 827-834
    • Hashizume, H.1    Sato, K.2    Takagi, H.3
  • 173
    • 56649107955 scopus 로고    scopus 로고
    • Hepatic, cardiovascular, and endocrine outcomes of the histological subphenotypes of nonalcoholic fatty liver disease
    • Rubinstein E., Lavine J.E., Schwimmer J.B. Hepatic, cardiovascular, and endocrine outcomes of the histological subphenotypes of nonalcoholic fatty liver disease. Semin Liver Dis 2008, 28:380-385.
    • (2008) Semin Liver Dis , vol.28 , pp. 380-385
    • Rubinstein, E.1    Lavine, J.E.2    Schwimmer, J.B.3
  • 174
    • 33645963121 scopus 로고    scopus 로고
    • Similarities and differences in outcomes of cirrhosis due to nonalcoholic steatohepatitis and hepatitis C
    • Sanyal A.J., Banas C., Sargeant C., et al. Similarities and differences in outcomes of cirrhosis due to nonalcoholic steatohepatitis and hepatitis C. Hepatology 2006, 43:682-689.
    • (2006) Hepatology , vol.43 , pp. 682-689
    • Sanyal, A.J.1    Banas, C.2    Sargeant, C.3
  • 175
    • 4644261918 scopus 로고    scopus 로고
    • Association of non-alcoholic steatohepatitis without significant fibrosis with hepatocellular carcinoma
    • Bullock R.E., Zaitoun A.M., Aithal G.P., et al. Association of non-alcoholic steatohepatitis without significant fibrosis with hepatocellular carcinoma. J Hepatol 2004, 41:685-686.
    • (2004) J Hepatol , vol.41 , pp. 685-686
    • Bullock, R.E.1    Zaitoun, A.M.2    Aithal, G.P.3
  • 176
    • 0035111170 scopus 로고    scopus 로고
    • Hepatocellular carcinoma arising in non-alcoholic steatohepatitis
    • Zen Y., Katayanagi K., Tsuneyama K., et al. Hepatocellular carcinoma arising in non-alcoholic steatohepatitis. Pathol Int 2001, 51:127-131.
    • (2001) Pathol Int , vol.51 , pp. 127-131
    • Zen, Y.1    Katayanagi, K.2    Tsuneyama, K.3
  • 177
    • 67650912116 scopus 로고    scopus 로고
    • Trends in nonalcoholic fatty liver disease-related hospitalizations in US children, adolescents, and young adults
    • Koebnick C., Getahun D., Reynolds K., et al. Trends in nonalcoholic fatty liver disease-related hospitalizations in US children, adolescents, and young adults. J Pediatr Gastroenterol Nutr 2009, 48:597-603.
    • (2009) J Pediatr Gastroenterol Nutr , vol.48 , pp. 597-603
    • Koebnick, C.1    Getahun, D.2    Reynolds, K.3
  • 178
    • 70350241227 scopus 로고    scopus 로고
    • The natural history of non-alcoholic fatty liver disease in children: a follow-up study for up to 20 years
    • Feldstein A.E., Charatcharoenwitthaya P., Treeprasertsuk S., et al. The natural history of non-alcoholic fatty liver disease in children: a follow-up study for up to 20 years. Gut 2009, 58:1538-1544.
    • (2009) Gut , vol.58 , pp. 1538-1544
    • Feldstein, A.E.1    Charatcharoenwitthaya, P.2    Treeprasertsuk, S.3
  • 179
    • 0037126526 scopus 로고    scopus 로고
    • Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III) final report
    • National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III)
    • National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III) Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III) final report. Circulation 2002, 106:3143-3421.
    • (2002) Circulation , vol.106 , pp. 3143-3421
  • 180
    • 33750606061 scopus 로고    scopus 로고
    • Long-term follow-up of patients with NAFLD and elevated liver enzymes
    • Ekstedt M., Franzen L.E., Mathiesen U.L., et al. Long-term follow-up of patients with NAFLD and elevated liver enzymes. Hepatology 2006, 44:865-873.
    • (2006) Hepatology , vol.44 , pp. 865-873
    • Ekstedt, M.1    Franzen, L.E.2    Mathiesen, U.L.3
  • 181
    • 55549115371 scopus 로고    scopus 로고
    • Intima-media thickness of carotid artery and susceptibility to atherosclerosis in obese children with nonalcoholic fatty liver disease
    • Demircioglu F., Kocyigit A., Arslan N., et al. Intima-media thickness of carotid artery and susceptibility to atherosclerosis in obese children with nonalcoholic fatty liver disease. J Pediatr Gastroenterol Nutr 2008, 47:68-75.
    • (2008) J Pediatr Gastroenterol Nutr , vol.47 , pp. 68-75
    • Demircioglu, F.1    Kocyigit, A.2    Arslan, N.3
  • 182
    • 41349113441 scopus 로고    scopus 로고
    • Nonalcoholic fatty liver disease and carotid atherosclerosis in children
    • Pacifico L., Cantisani V., Ricci P., et al. Nonalcoholic fatty liver disease and carotid atherosclerosis in children. Pediatr Res 2008, 63:423-427.
    • (2008) Pediatr Res , vol.63 , pp. 423-427
    • Pacifico, L.1    Cantisani, V.2    Ricci, P.3
  • 183
    • 41949124892 scopus 로고    scopus 로고
    • Evaluation of metabolic syndrome frequency and carotid artery intima-media thickness as risk factors for atherosclerosis in patients with nonalcoholic fatty liver disease
    • Aygun C., Kocaman O., Sahin T., et al. Evaluation of metabolic syndrome frequency and carotid artery intima-media thickness as risk factors for atherosclerosis in patients with nonalcoholic fatty liver disease. Dig Dis Sci 2008, 53:1352-1357.
    • (2008) Dig Dis Sci , vol.53 , pp. 1352-1357
    • Aygun, C.1    Kocaman, O.2    Sahin, T.3
  • 184
    • 22044438064 scopus 로고    scopus 로고
    • Type 2 diabetes in children is frequently associated with elevated alanine aminotransferase
    • Nadeau K.J., Klingensmith G., Zeitler P. Type 2 diabetes in children is frequently associated with elevated alanine aminotransferase. J Pediatr Gastroenterol Nutr 2005, 41:94-98.
    • (2005) J Pediatr Gastroenterol Nutr , vol.41 , pp. 94-98
    • Nadeau, K.J.1    Klingensmith, G.2    Zeitler, P.3
  • 185
    • 22344452893 scopus 로고    scopus 로고
    • The natural history of nonalcoholic fatty liver disease: a population-based cohort study
    • Adams L.A., Lymp J.F., St Sauver J., et al. The natural history of nonalcoholic fatty liver disease: a population-based cohort study. Gastroenterology 2005, 129:113-121.
    • (2005) Gastroenterology , vol.129 , pp. 113-121
    • Adams, L.A.1    Lymp, J.F.2    St Sauver, J.3
  • 186
    • 34347402532 scopus 로고    scopus 로고
    • Effects of nonalcoholic fatty liver disease on the development of metabolic disorders
    • Fan J.G., Li F., Cai X.B., et al. Effects of nonalcoholic fatty liver disease on the development of metabolic disorders. J Gastroenterol Hepatol 2007, 22:1086-1091.
    • (2007) J Gastroenterol Hepatol , vol.22 , pp. 1086-1091
    • Fan, J.G.1    Li, F.2    Cai, X.B.3
  • 187
    • 34147187336 scopus 로고    scopus 로고
    • Metabolic and nutritional profile of obese adolescents with nonalcoholic fatty liver disease
    • de Piano A., Prado W.L., Caranti D.A., et al. Metabolic and nutritional profile of obese adolescents with nonalcoholic fatty liver disease. J Pediatr Gastroenterol Nutr 2007, 44:446-452.
    • (2007) J Pediatr Gastroenterol Nutr , vol.44 , pp. 446-452
    • de Piano, A.1    Prado, W.L.2    Caranti, D.A.3
  • 188
    • 66749184903 scopus 로고    scopus 로고
    • Lifestyle intervention in obese children with nonalcoholic fatty liver disease: 2-year follow-up study
    • Reinehr T., Schmidt C., Toschke A.M., et al. Lifestyle intervention in obese children with nonalcoholic fatty liver disease: 2-year follow-up study. Arch Dis Child 2009, 94:437-442.
    • (2009) Arch Dis Child , vol.94 , pp. 437-442
    • Reinehr, T.1    Schmidt, C.2    Toschke, A.M.3
  • 189
    • 33750945522 scopus 로고    scopus 로고
    • Nonalcoholic fatty liver disease decrease in obese adolescents after multidisciplinary therapy
    • Tock L., Prado W.L., Caranti D.A., et al. Nonalcoholic fatty liver disease decrease in obese adolescents after multidisciplinary therapy. Eur J Gastroenterol Hepatol 2006, 18:1241-1245.
    • (2006) Eur J Gastroenterol Hepatol , vol.18 , pp. 1241-1245
    • Tock, L.1    Prado, W.L.2    Caranti, D.A.3
  • 190
    • 41549108440 scopus 로고    scopus 로고
    • Effect of lifestyle intervention on non-alcoholic fatty liver disease in Chinese obese children
    • Wang C.L., Liang L., Fu J.F., et al. Effect of lifestyle intervention on non-alcoholic fatty liver disease in Chinese obese children. World J Gastroenterol 2008, 14:1598-1602.
    • (2008) World J Gastroenterol , vol.14 , pp. 1598-1602
    • Wang, C.L.1    Liang, L.2    Fu, J.F.3
  • 191
    • 43049170503 scopus 로고    scopus 로고
    • Fructose consumption as a risk factor for non-alcoholic fatty liver disease
    • Ouyang X., Cirillo P., Sautin Y., et al. Fructose consumption as a risk factor for non-alcoholic fatty liver disease. J Hepatol 2008, 48:993-999.
    • (2008) J Hepatol , vol.48 , pp. 993-999
    • Ouyang, X.1    Cirillo, P.2    Sautin, Y.3
  • 192
    • 67650094664 scopus 로고    scopus 로고
    • Fructose and oxidized low-density lipoprotein in pediatric nonalcoholic fatty liver disease: a pilot study
    • Vos M.B., Weber M.B., Welsh J., et al. Fructose and oxidized low-density lipoprotein in pediatric nonalcoholic fatty liver disease: a pilot study. Arch Pediatr Adolesc Med 2009, 163:674-675.
    • (2009) Arch Pediatr Adolesc Med , vol.163 , pp. 674-675
    • Vos, M.B.1    Weber, M.B.2    Welsh, J.3
  • 193
    • 47149111845 scopus 로고    scopus 로고
    • Metformin use in children with nonalcoholic fatty liver disease: an open-label, 24-month, observational pilot study
    • Nobili V., Manco M., Ciampalini P., et al. Metformin use in children with nonalcoholic fatty liver disease: an open-label, 24-month, observational pilot study. Clin Ther 2008, 30:1168-1176.
    • (2008) Clin Ther , vol.30 , pp. 1168-1176
    • Nobili, V.1    Manco, M.2    Ciampalini, P.3
  • 194
    • 73049090978 scopus 로고    scopus 로고
    • Treatment of nonalcoholic fatty liver disease in children: TONIC trial design
    • Lavine J.E., Schwimmer J.B., Molleston J.P., et al. Treatment of nonalcoholic fatty liver disease in children: TONIC trial design. Contemp Clin Trials 2010, 31:62-70.
    • (2010) Contemp Clin Trials , vol.31 , pp. 62-70
    • Lavine, J.E.1    Schwimmer, J.B.2    Molleston, J.P.3
  • 195
    • 53049101877 scopus 로고    scopus 로고
    • Randomized, placebo-controlled trial of pioglitazone in nondiabetic subjects with nonalcoholic steatohepatitis
    • Aithal G.P., Thomas J.A., Kaye P.V., et al. Randomized, placebo-controlled trial of pioglitazone in nondiabetic subjects with nonalcoholic steatohepatitis. Gastroenterology 2008, 135:1176-1184.
    • (2008) Gastroenterology , vol.135 , pp. 1176-1184
    • Aithal, G.P.1    Thomas, J.A.2    Kaye, P.V.3
  • 196
    • 33751545838 scopus 로고    scopus 로고
    • A placebo-controlled trial of pioglitazone in subjects with nonalcoholic steatohepatitis
    • Belfort R., Harrison S.A., Brown K., et al. A placebo-controlled trial of pioglitazone in subjects with nonalcoholic steatohepatitis. N Engl J Med 2006, 355:2297-2307.
    • (2006) N Engl J Med , vol.355 , pp. 2297-2307
    • Belfort, R.1    Harrison, S.A.2    Brown, K.3
  • 197
    • 46349088361 scopus 로고    scopus 로고
    • Rosiglitazone for nonalcoholic steatohepatitis: one-year results of the randomized placebo-controlled Fatty Liver Improvement with Rosiglitazone Therapy (FLIRT) Trial
    • Ratziu V., Giral P., Jacqueminet S., et al. Rosiglitazone for nonalcoholic steatohepatitis: one-year results of the randomized placebo-controlled Fatty Liver Improvement with Rosiglitazone Therapy (FLIRT) Trial. Gastroenterology 2008, 135:100-110.
    • (2008) Gastroenterology , vol.135 , pp. 100-110
    • Ratziu, V.1    Giral, P.2    Jacqueminet, S.3
  • 198
    • 57549107354 scopus 로고    scopus 로고
    • Pioglitazone versus vitamin E versus placebo for the treatment of non-diabetic patients with non-alcoholic steatohepatitis: PIVENS trial design
    • Chalasani N.P., Sanyal A.J., Kowdley K.V., et al. Pioglitazone versus vitamin E versus placebo for the treatment of non-diabetic patients with non-alcoholic steatohepatitis: PIVENS trial design. Contemp Clin Trials 2009, 30:88-96.
    • (2009) Contemp Clin Trials , vol.30 , pp. 88-96
    • Chalasani, N.P.1    Sanyal, A.J.2    Kowdley, K.V.3
  • 199
    • 77955472640 scopus 로고    scopus 로고
    • A randomized controlled trial of pioglitazone or vitamin E for nonalcoholic steatohepatitis (PIVENS)
    • Sanjay A. A randomized controlled trial of pioglitazone or vitamin E for nonalcoholic steatohepatitis (PIVENS). Hepatology 2009, 50(Suppl 4):90A.
    • (2009) Hepatology , vol.50 , Issue.SUPPL 4
    • Sanjay, A.1
  • 200
    • 0034126755 scopus 로고    scopus 로고
    • Vitamin E treatment of nonalcoholic steatohepatitis in children: a pilot study
    • Lavine J.E. Vitamin E treatment of nonalcoholic steatohepatitis in children: a pilot study. J Pediatr 2000, 136:734-738.
    • (2000) J Pediatr , vol.136 , pp. 734-738
    • Lavine, J.E.1
  • 201
    • 33845491494 scopus 로고    scopus 로고
    • Effect of vitamin E on aminotransferase levels and insulin resistance in children with non-alcoholic fatty liver disease
    • Nobili V., Manco M., Devito R., et al. Effect of vitamin E on aminotransferase levels and insulin resistance in children with non-alcoholic fatty liver disease. Aliment Pharmacol Ther 2006, 24:1553-1561.
    • (2006) Aliment Pharmacol Ther , vol.24 , pp. 1553-1561
    • Nobili, V.1    Manco, M.2    Devito, R.3
  • 202
    • 47149086771 scopus 로고    scopus 로고
    • Lifestyle intervention and antioxidant therapy in children with nonalcoholic fatty liver disease: a randomized, controlled trial
    • Nobili V., Manco M., Devito R., et al. Lifestyle intervention and antioxidant therapy in children with nonalcoholic fatty liver disease: a randomized, controlled trial. Hepatology 2008, 48:119-128.
    • (2008) Hepatology , vol.48 , pp. 119-128
    • Nobili, V.1    Manco, M.2    Devito, R.3
  • 203
    • 0029972267 scopus 로고    scopus 로고
    • Effect of taurine on the fatty liver of children with simple obesity
    • Obinata K., Maruyama T., Hayashi M., et al. Effect of taurine on the fatty liver of children with simple obesity. Adv Exp Med Biol 1996, 403:607-613.
    • (1996) Adv Exp Med Biol , vol.403 , pp. 607-613
    • Obinata, K.1    Maruyama, T.2    Hayashi, M.3
  • 204
    • 33845336554 scopus 로고    scopus 로고
    • Randomized placebo-controlled trial of ursodeoxycholic acid with vitamin e in nonalcoholic steatohepatitis
    • Dufour J.F., Oneta C.M., Gonvers J.J., et al. Randomized placebo-controlled trial of ursodeoxycholic acid with vitamin e in nonalcoholic steatohepatitis. Clin Gastroenterol Hepatol 2006, 4:1537-1543.
    • (2006) Clin Gastroenterol Hepatol , vol.4 , pp. 1537-1543
    • Dufour, J.F.1    Oneta, C.M.2    Gonvers, J.J.3
  • 205
    • 33845326443 scopus 로고    scopus 로고
    • Management of fatty liver disease with vitamin E and C compared to ursodeoxycholic acid treatment
    • Ersoz G., Gunsar F., Karasu Z., et al. Management of fatty liver disease with vitamin E and C compared to ursodeoxycholic acid treatment. Turk J Gastroenterol 2005, 16:124-128.
    • (2005) Turk J Gastroenterol , vol.16 , pp. 124-128
    • Ersoz, G.1    Gunsar, F.2    Karasu, Z.3
  • 207
    • 77949875041 scopus 로고    scopus 로고
    • A new therapy for nonalcoholic fatty liver disease and diabetes? INT-747-the first FXR hepatic therapeutic study
    • Sanyal A., Mudaliar S., Henry R. A new therapy for nonalcoholic fatty liver disease and diabetes? INT-747-the first FXR hepatic therapeutic study. Hepatology 2009, 50(Suppl 4):389A.
    • (2009) Hepatology , vol.50 , Issue.SUPPL 4
    • Sanyal, A.1    Mudaliar, S.2    Henry, R.3
  • 208
    • 78149391150 scopus 로고    scopus 로고
    • Identifier: NCT00465751. Available at:, Accessed October 31, 2007, ClinicalTrials.gov
    • ClinicalTrials.gov Effects of FXR activation on hepatic lipid and glucose metabolism Identifier: NCT00465751. Available at:, Accessed October 31, 2007. http://clinicaltrials.gov/ct2/show/NCT00465751.
    • Effects of FXR activation on hepatic lipid and glucose metabolism
  • 209
    • 0037383865 scopus 로고    scopus 로고
    • Probucol in the treatment of non-alcoholic steatohepatitis: a double-blind randomized controlled study
    • Merat S., Malekzadeh R., Sohrabi M.R., et al. Probucol in the treatment of non-alcoholic steatohepatitis: a double-blind randomized controlled study. J Hepatol 2003, 38:414-418.
    • (2003) J Hepatol , vol.38 , pp. 414-418
    • Merat, S.1    Malekzadeh, R.2    Sohrabi, M.R.3
  • 210
    • 0242487635 scopus 로고    scopus 로고
    • N-acetylcysteine in the treatment of non-alcoholic steatohepatitis
    • Pamuk G.E., Sonsuz A. N-acetylcysteine in the treatment of non-alcoholic steatohepatitis. J Gastroenterol Hepatol 2003, 18:1220-1221.
    • (2003) J Gastroenterol Hepatol , vol.18 , pp. 1220-1221
    • Pamuk, G.E.1    Sonsuz, A.2
  • 211
    • 0033731597 scopus 로고    scopus 로고
    • L-Carnitine therapy in non-alcoholic steatohepatitis
    • Uygun A., Kadayifci A., Baĝci S., et al. L-Carnitine therapy in non-alcoholic steatohepatitis. Turk J Gastroenterol 2000, 11:196-201.
    • (2000) Turk J Gastroenterol , vol.11 , pp. 196-201
    • Uygun, A.1    Kadayifci, A.2    Baĝci, S.3
  • 212
    • 55649083505 scopus 로고    scopus 로고
    • Efficacy of atorvastatin for the treatment of nonalcoholic steatohepatitis with dyslipidemia
    • Hyogo H., Tazuma S., Arihiro K., et al. Efficacy of atorvastatin for the treatment of nonalcoholic steatohepatitis with dyslipidemia. Metabolism 2008, 57:1711-1718.
    • (2008) Metabolism , vol.57 , pp. 1711-1718
    • Hyogo, H.1    Tazuma, S.2    Arihiro, K.3
  • 213
    • 74949102941 scopus 로고    scopus 로고
    • A pilot study using simvastatin in the treatment of nonalcoholic steatohepatitis: a randomized placebo-controlled trial
    • Nelson A., Torres D.M., Morgan A.E., et al. A pilot study using simvastatin in the treatment of nonalcoholic steatohepatitis: a randomized placebo-controlled trial. J Clin Gastroenterol 2009, 43:990-994.
    • (2009) J Clin Gastroenterol , vol.43 , pp. 990-994
    • Nelson, A.1    Torres, D.M.2    Morgan, A.E.3
  • 214
    • 48249093075 scopus 로고    scopus 로고
    • Lipid screening and cardiovascular health in childhood
    • Daniels S.R., Greer F.R. Lipid screening and cardiovascular health in childhood. Pediatrics 2008, 122:198-208.
    • (2008) Pediatrics , vol.122 , pp. 198-208
    • Daniels, S.R.1    Greer, F.R.2
  • 215
    • 67349139281 scopus 로고    scopus 로고
    • Systematic review and metaanalysis of statins for heterozygous familial hypercholesterolemia in children: evaluation of cholesterol changes and side effects
    • O'Gorman C.S., Higgins M.F., O'Neill M.B. Systematic review and metaanalysis of statins for heterozygous familial hypercholesterolemia in children: evaluation of cholesterol changes and side effects. Pediatr Cardiol 2009, 30:482-489.
    • (2009) Pediatr Cardiol , vol.30 , pp. 482-489
    • O'Gorman, C.S.1    Higgins, M.F.2    O'Neill, M.B.3
  • 216
    • 52649142138 scopus 로고    scopus 로고
    • Storm over statins-the controversy surrounding pharmacologic treatment of children
    • de Ferranti S., Ludwig D.S. Storm over statins-the controversy surrounding pharmacologic treatment of children. N Engl J Med 2008, 359:1309-1312.
    • (2008) N Engl J Med , vol.359 , pp. 1309-1312
    • de Ferranti, S.1    Ludwig, D.S.2
  • 217
    • 33646483917 scopus 로고    scopus 로고
    • A double-blind randomized placebo-controlled trial of orlistat for the treatment of nonalcoholic fatty liver disease
    • Zelber-Sagi S., Kessler A., Brazowsky E., et al. A double-blind randomized placebo-controlled trial of orlistat for the treatment of nonalcoholic fatty liver disease. Clin Gastroenterol Hepatol 2006, 4:639-644.
    • (2006) Clin Gastroenterol Hepatol , vol.4 , pp. 639-644
    • Zelber-Sagi, S.1    Kessler, A.2    Brazowsky, E.3
  • 218
    • 33646339636 scopus 로고    scopus 로고
    • Gastric bypass surgery improves metabolic and hepatic abnormalities associated with nonalcoholic fatty liver disease
    • Klein S., Mittendorfer B., Eagon J.C., et al. Gastric bypass surgery improves metabolic and hepatic abnormalities associated with nonalcoholic fatty liver disease. Gastroenterology 2006, 130:1564-1572.
    • (2006) Gastroenterology , vol.130 , pp. 1564-1572
    • Klein, S.1    Mittendorfer, B.2    Eagon, J.C.3
  • 219
    • 33644897589 scopus 로고    scopus 로고
    • Non-alcoholic steatohepatitis: effect of Roux-en-Y gastric bypass surgery
    • Barker K.B., Palekar N.A., Bowers S.P., et al. Non-alcoholic steatohepatitis: effect of Roux-en-Y gastric bypass surgery. Am J Gastroenterol 2006, 101:368-373.
    • (2006) Am J Gastroenterol , vol.101 , pp. 368-373
    • Barker, K.B.1    Palekar, N.A.2    Bowers, S.P.3
  • 220
    • 33750571872 scopus 로고    scopus 로고
    • Weight loss and non-alcoholic fatty liver disease: falls in gamma-glutamyl transferase concentrations are associated with histologic improvement
    • Dixon J.B., Bhathal P.S., O'Brien P.E. Weight loss and non-alcoholic fatty liver disease: falls in gamma-glutamyl transferase concentrations are associated with histologic improvement. Obes Surg 2006, 16:1278-1286.
    • (2006) Obes Surg , vol.16 , pp. 1278-1286
    • Dixon, J.B.1    Bhathal, P.S.2    O'Brien, P.E.3
  • 221
    • 67650951419 scopus 로고    scopus 로고
    • Prospective study of the long-term effects of bariatric surgery on liver injury in patients without advanced disease
    • Mathurin P., Hollebecque A., Arnalsteen L., et al. Prospective study of the long-term effects of bariatric surgery on liver injury in patients without advanced disease. Gastroenterology 2009, 137:532-540.
    • (2009) Gastroenterology , vol.137 , pp. 532-540
    • Mathurin, P.1    Hollebecque, A.2    Arnalsteen, L.3
  • 222
    • 26444467171 scopus 로고    scopus 로고
    • Surgically-induced weight loss significantly improves nonalcoholic fatty liver disease and the metabolic syndrome
    • [discussion: 618-20]
    • Mattar S.G., Velcu L.M., Rabinovitz M., et al. Surgically-induced weight loss significantly improves nonalcoholic fatty liver disease and the metabolic syndrome. Ann Surg 2005, 242:610-617. [discussion: 618-20].
    • (2005) Ann Surg , vol.242 , pp. 610-617
    • Mattar, S.G.1    Velcu, L.M.2    Rabinovitz, M.3
  • 223
    • 37349083846 scopus 로고    scopus 로고
    • Short-term outcome in the first 10 morbidly obese adolescent patients in the FDA-approved trial for laparoscopic adjustable gastric banding
    • Holterman A.X., Browne A., Dillard B.E., et al. Short-term outcome in the first 10 morbidly obese adolescent patients in the FDA-approved trial for laparoscopic adjustable gastric banding. J Pediatr Gastroenterol Nutr 2007, 45:465-473.
    • (2007) J Pediatr Gastroenterol Nutr , vol.45 , pp. 465-473
    • Holterman, A.X.1    Browne, A.2    Dillard, B.E.3
  • 224
    • 70350127143 scopus 로고    scopus 로고
    • Laparoscopic adjustable gastric banding for morbidly obese adolescents affects android fat loss, resolution of comorbidities, and improved metabolic status
    • Nadler E.P., Reddy S., Isenalumhe A., et al. Laparoscopic adjustable gastric banding for morbidly obese adolescents affects android fat loss, resolution of comorbidities, and improved metabolic status. J Am Coll Surg 2009, 209:638-644.
    • (2009) J Am Coll Surg , vol.209 , pp. 638-644
    • Nadler, E.P.1    Reddy, S.2    Isenalumhe, A.3
  • 225
    • 38149013861 scopus 로고    scopus 로고
    • An update on 73 US obese pediatric patients treated with laparoscopic adjustable gastric banding: comorbidity resolution and compliance data
    • Nadler E.P., Youn H.A., Ren C.J., et al. An update on 73 US obese pediatric patients treated with laparoscopic adjustable gastric banding: comorbidity resolution and compliance data. J Pediatr Surg 2008, 43:141-146.
    • (2008) J Pediatr Surg , vol.43 , pp. 141-146
    • Nadler, E.P.1    Youn, H.A.2    Ren, C.J.3
  • 226
    • 66149114332 scopus 로고    scopus 로고
    • Best practice updates for pediatric/adolescent weight loss surgery
    • Pratt J.S., Lenders C.M., Dionne E.A., et al. Best practice updates for pediatric/adolescent weight loss surgery. Obesity (Silver Spring) 2009, 17:901-910.
    • (2009) Obesity (Silver Spring) , vol.17 , pp. 901-910
    • Pratt, J.S.1    Lenders, C.M.2    Dionne, E.A.3
  • 227
    • 32944482103 scopus 로고    scopus 로고
    • Relation between elevated serum alanine aminotransferase and metabolic syndrome in Korean adolescents
    • Park H.S., Han J.H., Choi K.M., et al. Relation between elevated serum alanine aminotransferase and metabolic syndrome in Korean adolescents. Am J Clin Nutr 2005, 82:1046-1051.
    • (2005) Am J Clin Nutr , vol.82 , pp. 1046-1051
    • Park, H.S.1    Han, J.H.2    Choi, K.M.3
  • 228
    • 38049120715 scopus 로고    scopus 로고
    • Prevalence of non-alcoholic fatty liver and characteristics in overweight adolescents in the general population
    • Imhof A., Kratzer W., Boehm B., et al. Prevalence of non-alcoholic fatty liver and characteristics in overweight adolescents in the general population. Eur J Epidemiol 2007, 22:889-897.
    • (2007) Eur J Epidemiol , vol.22 , pp. 889-897
    • Imhof, A.1    Kratzer, W.2    Boehm, B.3
  • 229
    • 37649013155 scopus 로고    scopus 로고
    • Prevalence of fatty liver disease and its risk factors in the population of South China
    • Zhou Y.J., Li Y.Y., Nie Y.Q., et al. Prevalence of fatty liver disease and its risk factors in the population of South China. World J Gastroenterol 2007, 13:6419-6424.
    • (2007) World J Gastroenterol , vol.13 , pp. 6419-6424
    • Zhou, Y.J.1    Li, Y.Y.2    Nie, Y.Q.3
  • 230
    • 77249179753 scopus 로고    scopus 로고
    • Prevalence of non-alcoholic fatty liver disease in children and relationship to metabolic syndrome, insulin resistance, and waist circumference
    • Tominaga K., Fujimoto E., Suzuki K., et al. Prevalence of non-alcoholic fatty liver disease in children and relationship to metabolic syndrome, insulin resistance, and waist circumference. Environ Health Prev Med 2009, 14:142-149.
    • (2009) Environ Health Prev Med , vol.14 , pp. 142-149
    • Tominaga, K.1    Fujimoto, E.2    Suzuki, K.3


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