Imaging of hepatic steatosis and fatty sparing

European Journal of Radiology

Volumn 61, Issue 1, 2007, Pages 33-43

  Karcaaltincaba, Musturay ^a   Akhan, Okan ^a  

^a HACETTEPE UNIVERSITY   (Turkey)

Author keywords

CT; Fat; Fatty infiltration; Fatty sparing; Liver; MRI; Steatosis

Indexed keywords

BIOLOGICAL ORGANS; COMPUTERIZED TOMOGRAPHY; DISEASES; FATTY ACIDS; MAGNETIC RESONANCE IMAGING; NONINVASIVE MEDICAL PROCEDURES; TRANSPLANTATION (SURGICAL); ULTRASONIC IMAGING;

FATTY INFILTRATION; FATTY SPARING; HEPATIC STEATOSIS; LIVER;

MEDICAL IMAGING;

INSULIN;

COMPUTER ASSISTED TOMOGRAPHY; DIABETES MELLITUS; FATTY LIVER; HISTOPATHOLOGY; HUMAN; LIVER CELL CARCINOMA; LIVER TRANSPLANTATION; NUCLEAR MAGNETIC RESONANCE IMAGING; ONCOLOGY; PERITONEAL DIALYSIS; PRIORITY JOURNAL; REVIEW; ULTRASOUND;

ADIPOSE TISSUE; DIAGNOSTIC IMAGING; FATTY LIVER; HUMANS; IMAGE ENHANCEMENT;

EID: 33845958189     PISSN: 0720048X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejrad.2006.11.005     Document Type: Review

References (85)

1. Mortele K.J., and Ros P.R. Imaging of diffuse liver disease. Semin Liver Dis 21 (2001) 195-212
2. Siegelman E.S., and Rosen M.A. Imaging of hepatic steatosis. Semin Liver Dis 21 (2001) 71-80
3. Danet I.M., Semelka R.C., and Braga L. MR imaging of diffuse liver disease. Radiol Clin N Am 41 (2003) 67-87
4. Farrell G.C., and Larter C.Z. Nonalcoholic fatty liver disease: from steatosis to cirrhosis. Hepatology 43 Suppl. 1 (2006) S99-S112
5. Hashimoto M., Heianna J., Tate E., et al. Small veins entering the liver. Eur Radiol 12 (2002) 2000-2005
6. Quinn S.F., and Gosink B.B. Characteristic sonographic signs of hepatic fatty infiltration. Am J Roentgenol 145 (1985) 753-755
7. Valls C., Iannacconne R., Alba E., et al. Fat in the liver: diagnosis and characterization. Eur Radiol 16 (2006) 2292-2308
8. Mottin C.C., Moretto M., Padoin A.V., et al. The role of ultrasound in the diagnosis of hepatic steatosis in morbidly obese patients. Obes Surg 14 (2004) 635-637
9. Joy D., Thava V.R., and Scott B.B. Diagnosis of fatty liver disease: is biopsy necessary?. Eur J Gastroenterol Hepatol 15 (2003) 539-543
10. Palmentieri B., de Sio I., La Mura V., et al. The role of bright liver echo pattern on ultrasound B-mode examination in the diagnosis of liver steatosis. Dig Liver Dis 38 (2006) 485-489
11. Hepburn M.J., Vos J.A., Fillman E.P., and Lawitz E.J. The accuracy of the report of hepatic steatosis on ultrasonography in patients infected with hepatitis C in a clinical setting: a retrospective observational study. BMC Gastroenterol 5 (2005) 14
12. Mathiesen U.L., Franzen L.E., and Aselius H. Increased liver echogenicity at ultrasound examination reflects degreeof steatosis but not of fibrosis in asymptomatic patients with mild/moderate abnormalities of liver transaminases. Dig Liver Dis 34 (2002) 516-522
13. Joseph A.E.A., Saverymuttu S.H., Al-Sam S., Cook M.G., and Maxwell J.D. Comparison of liver histology with ultrasonography in assessing diffuse parenchymal liver disease. Clin Radiol 43 (1991) 26-31
14. Fishbein M., Castro F., Cheruku S., et al. Hepatic MRI for fat quantitation: its relationship to fat morphology, diagnosis, and ultrasound. J Clin Gastroenterol 39 (2005) 619-625
15. Kim S.H., Lee J.M., Kim J.H., et al. Appropriateness of a donor liver with respect to macrosteatosis: application of artificial neural networks to US images-initial experience. Radiology 234 (2005) 793-803
16. Gaitini D., Lederman M., Baruch Y., et al. Computerised analysis of liver texture with correlation to needle biopsy. Ultraschall Med 26 (2005) 197-202
17. Gaitini D., Baruch Y., Ghersin E., et al. Feasibility study of ultrasonic fatty liver biopsy: texture vs. attenuation and backscatter. Ultrasound Med Biol 30 (2004) 321-327
18. Kawata R., Sakata K., Kunieda T., et al. Quantitative evaluation of fatty liver by computed tomography in rabbits. Am J Roentgenol 142 (1984) 741-746
19. Piekarski J., Goldberg H.I., Royal S.A., Axel L., and Moss A.A. Difference between liver and spleen CT numbers in the normal adult: its usefulness in predicting the presence of diffuse liver disease. Radiology 137 (1980) 727-729
20. Bydder G.M., Kreel L., Chapman R.W., et al. Accuracy of computed tomography in diagnosis of fatty liver. BMJ 281 (1980) 1042
21. Iwasaki M., Takada Y., Hayashi M., et al. Noninvasive evaluation of graft steatosis in living donor liver transplantation. Transplantation 78 (2004) 1501-1505
22. Pamilo M., Sotaniemi E.A., Suramo I., Lahde S., and Arranto A.J. Evaluation of liver steatotic and fibrous content by computerised tomography and ultrasound. Scand J Gastroenterol 18 (1983) 743-747
23. Nishino M., Hayakawa K., Nakamura Y., Morimoto T., and Mukaihara S. Effects of tamoxifen on hepatic fat content and the development of hepatic steatosis in patients with breast cancer: high frequency of involvement and rapid reversal after completion of tamoxifen therapy. Am J Roentgenol 180 (2003) 129-134
24. Ricci C., Longo R., Gioulis E., et al. Noninvasive in vivo quantitative assessment of fat content in human liver. J Hepatol 27 (1997) 108-113
25. Johnston R.J., Stamm E.R., Lewin J.M., Hendrick R.E., and Archer P.G. Diagnosis of fatty infiltration of the liver on contrast enhanced CT: limitations of liver-minus-spleen attenuation difference measurements. Abdom Imaging 23 (1998) 409-415
26. Jacobs J.E., Birnbaum B.A., Shapiro M.A., et al. Diagnostic criteria for fatty infiltration of the liver on contrast enhanced helical CT. Am J Roentgenol 171 (1998) 659-664
27. Panicek D.M., Giess C.S., and Schwartz L.H. Qualitative assessment of liver for fatty infiltration on contrast enhanced CT: is muscle a better standard of reference than spleen?. J Comput Assist Tomogr 21 (1997) 699-705
28. Mendler M.H., and Bouillet Le Sidaner A. Dual-energy CT in the diagnosis and quantification of fatty liver: limited clinical value in comparison to ultrasound scan and single energy CT, with special reference to iron overload. J Hepatol 28 (1998) 785-794
29. Wang B., Gao Z., Zou Q., and Li L. Quantitative diagnosis of fatty liver with dual-energy CT. An experimental study in rabbits. Acta Radiol 44 (2003) 92-97
30. Raptopoulos V., Karellas A., Bernstein J., et al. Value of dual-energy CT in differentiating focal fatty infiltration of the liver from low-density masses. Am J Roentgenol 157 (1991) 721-725
31. Kamel I.R., Kruskal J.B., Pomfret E.A., et al. Impact of multidetector CT on donor selection and surgical planning before living adult right lobe liver transplantation. Am J Roentgenol 176 (2001) 193-200
32. Flohr T.G., McCollough C.H., Bruder H., et al. First performance evaluation of a dual-source CT (DSCT) system. Eur Radiol 16 (2006) 256-268
33. Park S.H., Kim P.N., Kim K.W., et al. Macrovesicular hepatic steatosis in living liver donors: use of CT for quantitative and qualitative assessment. Radiology 239 (2006) 105-112
34. Brancatelli G. Science to practice: should biopsy be performed in potential liver donors when unenhanced CT shows an unacceptable degree of steatosis for transplantation?. Radiology 239 (2006) 1-2
35. Limanond P., Raman S.S., Lassman C., et al. Macrovesicular hepatic steatosis in living related liver donors: correlation between CT and histologic findings. Radiology 230 (2004) 276-280
36. Fritz G.A., Schoellnast H., Deutschmann H.A., et al. Density histogram analysis of unenhanced hepatic computed tomography in patients with diffuse liver diseases. J Comput Assist Tomogr 30 (2006) 201-205
37. Levenson H., Greensite F., Hoefs J., et al. Fatty infiltration of the liver: quantification with phase-contrast MR imaging at 1.5 T vs biopsy. Am J Roentgenol 156 (1991) 307-312
38. Mitchell D.G., Kim I., Chang T.S., et al. Fatty liver: chemical shift phase-difference and suppression magnetic resonance imaging techniques in animals, phantoms, and humans. Invest Radiol 26 (1991) 1041-1052
39. Outwater E.K., Blasbalg R., Siegelman E.S., and Vala M. Detection of lipid in abdominal tissues with opposed-phase gradientecho images at 1.5 T: techniques and diagnostic importance. Radiographics 18 (1998) 1465-1480
40. Fishbein M.H., Gardner K.G., Potter C.J., Schmalbrock P., and Smith M.A. Introduction of fast MR imaging in the assessment of hepatic steatosis. Magn Reson Imaging 15 (1997) 287-293
41. Pilleul F., Chave G., Dumortier J., Scoazec J.Y., and Valette P.J. Fatty infiltration of the liver. Detection and grading using dual T1 gradient echo sequences on clinical MR system. Gastroenterol Clin Biol 29 (2005) 1143-1147
42. Kim S.H., Lee J.M., Han J.K., et al. Hepatic macrosteatosis: predicting appropriateness of liver donation by using MR imaging-correlation with histopathologic findings. Radiology 240 (2006) 116-129
43. Rinella M.E., McCarthy R., Thakrar K., et al. Dual-echo, chemical shift gradient-echo magnetic resonance imaging to quantify hepatic steatosis: implications for living liver donation. Liver Transpl 9 (2003) 851-856
44. Hussain H.K., Chenevert T.L., Londy F.J., et al. Hepatic fat fraction: MR imaging for quantitative measurement and display-early experience. Radiology 237 (2005) 1048-1055
45. Qayyum A., Goh J.S., Kakar S., et al. Accuracy of liver fat quantification at MR imaging: comparison of out of phase gradient-echo and fat-saturated fast spin-echo technique-initial experience. Radiology 237 (2005) 507-511
46. Longo R., Ricci C., Masutti F., et al. Fatty infiltration of the liver. Quantification by 1H localized magnetic resonance spectroscopy and comparison with computed tomography. Invest Radiol 28 (1993) 297-302
47. Thomsen C., Becker U., Winkler K., et al. Quantification of liver fat using magnetic resonance spectroscopy. Magn Reson Imaging 12 (1994) 487-495
48. Machann J., Thamer C., Schnoedt B., et al. Hepatic lipid accumulation in healthy subjects: a comparative study using spectral fat-selective MRI and volume-localized 1H-MR spectroscopy. Magn Reson Med 55 (2006) 913-917
49. Saadeh S., Younossi Z.M., Remer E.M., et al. The utility of radiological imaging in nonalcoholic fatty liver disease. Gastroenterology 123 (2002) 745-750
50. Duman D.G., Celikel C., Tuney D., et al. Computed tomography in nonalcoholic fatty liver disease: a useful tool for hepatosteatosis assessment?. Dig Dis Sci 51 (2006) 346-351
51. Oliva M.R., Mortele K.J., Segatto E., et al. Computed tomography features of nonalcoholic steatohepatitis with histopathologic correlation. J Comput Assist Tomogr 30 (2006) 37-43
52. Tsushima Y., and Endo K. Spleen enlargement in patients with nonalcoholic fatty liver: correlation between degree of fatty infiltration in liver and size of spleen. Dig Dis Sci 45 (2000) 196-200
53. Mihmanli I., Kantarci F., Yilmaz M.H., et al. Effect of diffuse fatty infiltration of the liver on hepatic artery resistance index. J Clin Ultrasound 33 (2005) 95-99
54. Oguzkurt L., Yildirim T., Torun D., et al. Hepatic vein Doppler waveform in patients with diffuse fatty infiltration of the liver. Eur J Radiol 54 (2005) 253-257
55. Lee V.S., Morgan G.R., Teperman L.W., et al. MR imaging as the sole preoperative imaging modality for right hepatectomy: a prospective study of living adult-to-adult liver donor candidates. Am J Roentgenol 176 (2001) 1475-1482
56. Schroeder T., Malago M., Debatin J.F., et al. "All-in-one" imaging protocols for the evaluation of potential livingliver donors: comparison of magnetic resonance imaging and multidetector computed tomography. Liver Transpl 11 (2005) 776-787
57. Cho J.Y., Suh K.S., Kwon C.H., Yi N.J., and Lee K.U. Mild hepatic steatosis is not a major risk factor for hepatectomy and regenerative power is not impaired. Surgery 139 (2006) 508-515
58. Soejima Y., Shimada M., Suehiro T., et al. Use of steatotic graft in living-donor liver transplantation. Transplantation 76 (2003) 344-348
59. Kemper J., Jung G., and Poll L.W. CT and MRI findings of multifocal hepatic steatosis mimicking malignancy. Abdom Imaging 27 (2002) 708-710
60. Kroncke T.J., Taupitz M., Kivelitz D., et al. Multifocal nodular fatty infiltration of the liver mimicking metastatic disease on CT: imaging findings and diagnosis using MR imaging. Eur Radiol 10 (2000) 1095-1100
61. Kammen B.F., Pacharn P., and Thoeni R.F. Focal fatty infiltration of the liver: analysis of prevalence and CT findings in children and young adults. Am J Roentgenol 177 (2001) 1035-1039
62. Koseoglu K., Ozsunar Y., Taskin F., and Karaman C. Pseudolesions of left liver lobe during helical CT examinations: prevalence and comparison between unenhanced and biphasic CT findings. Eur J Radiol 54 (2005) 388-392
63. Yoshikawa J., Matsui O., Takashima T., et al. Focal fatty change of the liver adjacent to falciform ligament: CT and sonographic findings in five surgically confirmed cases. Am J Roentgenol 149 (1987) 491-494
64. Soyer P., Dewine N., Someville E., et al. Hepatic pseudolesion around the falciform ligament: prevalence on CT examination. Abdom Imaging 21 (1996) 324-328
65. Itai Y., and Matsui O. Blood flow and liver imaging. Radiology 202 (1997) 306-314
66. Matsui O., Kadoya M., Takahashi S., et al. Focal sparing of segment IV in fatty livers shown by sonography and CT: correlation with aberrant gastric venous drainage. Am J Roentgenol 164 (1995) 1137-1140
67. Arai K., Matsui O., Takashima T., Ida M., and Nishida Y. Focal spared areas in fatty liver caused by regional decreased portal flow. Am J Roentgenol 151 (1988) 300-302
68. Basaran C., Karcaaltincaba M., Akata D., et al. Fat-containing lesions of the liver: cross-sectional imaging findings with emphasis on MRI. Am J Roentgenol 184 (2005) 1103-1110
69. Sohn J., Siegelman E., and Osiason A. Unusual patterns of hepatic steatosis caused by the local effect of insulin revealed on chemical shift MR imaging. Am J Roentgenol 176 (2001) 471-474
70. Eisenberg L.B., Warshauer D.M., Woosley J.T., et al. CT and MRI of hepatic focal nodular hyperplasia with peripheral steatosis. J Comput Assist Tomogr 19 (1995) 498-500
71. Kallio T., Nevalainen P.I., Lahtela J.T., Mustonen J., and Pasternack A. Hepatic subcapsular steatosis in diabetic CAPD patients treated with intraperitoneal insulin. Description of a typical pattern. Acta Radiol 42 (2001) 323-325
72. Khalili K., Lan F.P., Hanbidge A.E., et al. Hepatic subcapsular steatosis in response to intraperitoneal insulin delivery: CT findings and prevalence. Am J Roentgenol 180 (2003) 1601-1604
73. Prasad S.R., Wang H., Rosas H., et al. Fat-containing lesions of the liver: radiologic-pathologic correlation. Radiographics 25 (2005) 321-331
74. Mortele K.J., Stubbe J., Praet M., et al. Intratumoral steatosis in focal nodular hyperplasia coinciding with diffuse hepatic steatosis: CT and MRI findings with histologic correlation. Abdom Imaging 25 (2000) 179-181
75. Hamer O.W., Aguirre D.A., Casola G., and Sirlin C.B. Imaging features of perivascular fatty infiltration of the liver: initial observations. Radiology 237 (2005) 159-169
76. Salmonson E.C., Lundstedt C., Holmin T., and Hagerstrand I. Focal periportal liver steatosis. Abdom Imaging 18 (1993) 39-41
77. Yoon K.H., Matsui O., Kadoya M., et al. Pseudolesion in segments II and III of the liver on CT during arterial portography caused by aberrant right gastric venous drainage. J Comput Assist Tomogr 23 (1999) 306-309
78. Aubin B., Denys A., Lafortune M., Dery R., and Breton G. Focal sparing of liver parenchyma in steatosis: role of the gallbladder and its vessels. J Ultrasound Med 4 (1995) 77-80
79. Chong V.F., and Fan Y.F. Ultrasonographic hepatic pseudolesions: normal parenchyma mimicking mass lesions in fatty liver. Clin Radiol 49 (1994) 326-329
80. Tom W.W., Yeh B.M., Cheng J.C., et al. Hepatic pseudotumor due to nodular fatty sparing: the diagnostic role of opposed-phase MRI. Am J Roentgenol 183 (2004) 721-724
81. Grossholz M., Terrier F., Rubbia L., et al. Focal sparing in the fatty liver as a sign of an adjacent space-occupying lesion. Am J Roentgenol 171 (1998) 1391-1395
82. Itai Y., Maeda M., Echigo J., et al. Hyperattenuating rim on noncontrast CT of the liver: probable peritumoral sparing of fatty infiltration. Clin Radiol 51 (1996) 406-410
83. Gabata T., Kadoya M., Matsui O., et al. Peritumoral spared area in fatty liver: correlation between opposed-phase gradient-echo MR imaging and CT arteriography. Abdom Imaging 26 (2001) 384-389
84. Chung J.J., Kim M.J., Kim J.H., Lee J.T., and Yoo H.S. Fat sparing of surrounding liver from metastasis in patients with fatty liver: MR imaging with histopathologic correlation. Am J Roentgenol 180 (2003) 1347-1350
85. Marti-Bonmati L., Penaloza F., Villarreal E., and Martinez M.J. Nonspecificity of the fat-sparing ring surrounding focal liver lesion at MR imaging. Acad Radiol 12 (2005) 1551-1556