Chemical constituents and pharmacologic actions of genus Peganum: Research advances

Journal of International Pharmaceutical Research

Volumn 37, Issue 5, 2010, Pages

  Zhao, Ting ^a   Wang, Chang Hong ^a,b   Wang, Zheng Tao ^a,b  

^a SHANGHAI UNIVERSITY OF TRADITIONAL CHINESE MEDICINE   (China)

^b Shanghai R and D Center for Standardization of Chinese Medicines   (China)

Author keywords

Alkaloids; Bioactivity; Chemical constituents; Peganum

Indexed keywords

15 HYDROXY 11ALPHA,9ALPHA EPOXYMETHANOPROSTA 5,13 DIENOIC ACID; ALKALOID DERIVATIVE;

ALZHEIMER DISEASE; ANTICOAGULATION; ANTIINFLAMMATORY ACTIVITY; ANTIMICROBIAL ACTIVITY; ANTINEOPLASTIC ACTIVITY; ANTIPROTOZOAL ACTIVITY; CHEMICAL COMPOSITION; DIABETES MELLITUS; GENUS; MEDICAL RESEARCH; PAIN; PEGANUM HARMALA; REVIEW;

EID: 78149330948     PISSN: 16740440     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (47)

1. Faskhutdinov MF, Telezhenetskaya MV, Levkovich MG, et al. Alkaloids of Peganum harmala[J]. Chem Nat Compd, 2000, 36(6): 602-605.
2. Ma ZZ, Hano Y, Qiu F, et al. Triterpenoids from Peganum nigellastrum[J]. J Asian Nat Prod Res, 2007, 9(6-8): 575-578.
3. Ma ZZ, Hano Y, Nomura T, et al. Two new pyrrolo quinazolinoquinoline alkaloids from Peganum nigellastrum [J]. Heterocycles, 1997, 46: 541-546.
4. Ma ZZ, Hano Y, Nomura T, et al. Two new quinazolinequinoline alkaloids from Peganum nigellastrum[J]. Heterocycles, 1999,51(8): 1883-1889
5. Ma ZZ, Hano Y, Nomura T, et al. Alkaloids and phenylpropanoids from Peganum nigellastrum [J]. Phytochemistry, 2000, 53(8): 1075-1078.
6. Zheng XY, Zhang ZJ, Chou GX, et al. Alkaloids from seeds of Peganum nigellastrum Bunge by an in vitro TLC-bioautographic assay [J]. Arch Pharm Res, 2009, 32 (9): 1245-1251.
7. Frison G, Favretto D, Zancanaro F, et al. A case of β-carboline alkaloid intoxication following ingestion of Peganum harmala seed extract[J]. Forensic Sci Int, 2008, 179(2/3): e37-e43.
8. + in PC12 cells:insight into potential neurotoxicants in Parkinson's disease[J]. J Neurochem, 1994, 62(4): 1503-1510.
9. O'Hearn E, Molliver ME. Degeneration of Purkinje cells in parasagittal zones of the cerebellar vermis after treatment with ibogaine or harmaline[J]. Neuroscience, 1993, 55(2): 303-310.
10. Moura DJ, Rorig C, Vieira DL, et al. Effects of β-carboline alkaloids on the object recognition task in mice [J]. Life Sci, 2006,79(22): 2099-2104.
11. Splettstoesser F, Bonnet U, Wiemann M, et al. Modulation of voltage-gated channel currents by harmaline and harmane[J]. Br J Pharmacol, 2005, 144(1): 52-58.
12. Lee CS, Han ES, Jang YY, et al. Protective effect of harmalol and harmaline on MPTP neurotoxicity in the mouse and dopamine-induced damage of brain mitochondria and PC12 cells[J]. J Neurochem, 2000, 75(2): 521-531.
13. Moura DJ, Richter MF, Boeira JM, et al. Antioxidant properties of beta-carboline alkaloids are related to their antimutagenic and antigenotoxic activities[J]. Mutagenesis, 2007, 22(4): 293-302.
14. Jahaniani F, Ebrahimi SA, Rahbar-Roshandel N. et al. Xanthomicrol is the main cytotoxic component of Draeocephalum kotschyii and a potential anti-cancer agent [J]. Phytochemistry, 2005, 66(13): 1581-1592.
15. El-Gendy MA, Somayaji V, El-Kadi AO. Peganum harmala L. is a candidate herbal plant for preventing dioxin mediated effects[J]. Planta Med, 2010, 76(7): 671-677.
16. Guan H, Chen H, Peng W, et al. Design of β-carboline derivatives as DNA-targeting antitumor agents[J]. Eur J Med Chem, 2006, 41(10): 1167-1179.
17. Cao R, Chen H, Peng W, et al. Design, synthesis and in vitro and in vivo antitumor activities of novel β-carboline derivatives[J]. Eur J Med Chem, 2005, 40(10) :991-1001.
18. Sobhanim AM, Ebrahimi SA, Mahmoudian M. An in vitro evaluation of human DNA topoisomerase I inhibition by Peganum harmala L. seeds extract and its β-carboline alkaloids [J]. J Pharm Pharmaceut Sci, 2002, 5(1): 19-23.
19. Cagir A, Jones SH, Gao R, et al. A naturally occurring human DNA topoisomerase I poison [J]. J Am Chem Soc, 2003, 125(45): 13628-13629.
20. Rahman AFMM, Kim HD, Lu LJ, et al. Synthesis and biological properties of luotonin A derivatives [J]. Bull Korean Chem Soc, 2008, 29(10): 1988-1992.
21. Ma Z, Hano Y, Nomura T, et al. Novel quinazoline-quinoline alkaloids with cytotoxic and DNA topoisomerase II inhibitory activities [J]. Bioorg Med Chem Lett, 2004, 14(5): 1193-1196.
22. Harayama T, Hori A, Serban G, et al. Concise synthesis of quinazoline alkaloids,luotonins A and B, and rutaecarpine [J]. Tetrahedron, 2004, 60(47): 10645-10649.
23. Cinelli MA, Morrell A, Dexheimer TS, et al. Design,synthesis,and biological evaluation of 14-substituted aromathecins as topoisomerase I inhibitors[J]. J Med Chem, 2008, 51(15): 4609-4619.
24. Mhaske SB, Argade NP. Regioselective quinazolinone-directed ortho lithiation of quinazolinoylquinoline: practical synthesis of naturally occurring human DNA topoisomerase I poison luotonin A and luotonins B and E [J]. J Org Chem, 2004, 69(13): 4563-4566.
25. Song Y, Kesuma D, Wang J, et al. Specific inhibition of cyclin-dependent kinases and cell proliferation by harmine[J]. Biochem Biophys Res Commun, 2004, 317(1): 128-132.
26. Kim H, Sablin SO, Ramsay RR. Inhibition of monoamine oxidase A by β-carboline derivatives[J]. Arch Biochem Biophys, 1997, 337(1): 137-142.
27. 11C-Harmine as a tracer for monoamine oxidase A(MAO-A): in vitro and in vivo studies[J]. Nucl Med Biol, 1997, 24(4): 287-293.
28. 2B receptors and MAO-A in rat tissues:norharman blocks the effect of morphine withdrawal on DOPA/noradrenaline synthesis in the brain[J]. Eur J Pharmacol, 2005, 518(2-3): 234-242.
29. Farzin D, Mansouri N. Antidepressant-like effect of harmane and other β-carbolines in the mouse forced swim test[J]. Eur Neuropsychopharmacol, 2006, 16(5): 324-328.
30. Farouk L, Laroubi A, Aboufatima R, et al. Evaluation of the analgesic effect of alkaloid extract of Peganum harmala L. possible mechanisms involved [J]. J Ethnopharmacol, 2008,115(3): 449-454.
31. Astulla A, Zaima K, Matsuno Y, et al. Alkaloids from the seeds of Peganum harmala showing antiplasmodial and vasorelaxant activities[J]. J Nat Med, 2008, 62(4): 470-472.
32. Berrougui H, Martín-Cordero C, Khalil A, et al. Vasorelaxant effects of harmine and harmaline extracted from Peganum harmala L. seeds in isolated rat aorta [J]. Pharmacol Res, 2006, 54(2): 150-157.
33. Tahraoui A, El-Hilaly J, Israili ZH, et al. Ethnopharmacological survey of plants used in the traditional treatment of hypertension and diabetes in south-eastern Morocco (Errachidia Province) [J]. J Ethnopharmacol, 2007, 110(1): 105-117.
34. Im JH, Jin YR, Lee JJ, et al. Antiplatelet activity of β-carboline alkaloids from Perganum harmala:a possible mechanism through inhibiting PLCγ2 phosphorylation [J]. Vasc Pharmacol, 2009, 50(5-6): 147-152.
35. Waki H, Park KW, Mitro N. The small molecule harmine is an antidiabetic cell-type-specific regulator of PPAR gamma expression[J]. Cell Metab, 2007, 5(5): 357-370.
36. Prashanth D, John S. Antibacterial activity of Peganum harmala [J]. Fitoterapia, 1999, 70(4): 438-439.
37. Arshad N, Neubauer C, Hasnain S, et al. Peganum harmala can minimize Escherichia coli infection in poultry,but long-term feeding may induce side effects [J]. Poult Sci,2008,87(2): 240-249.
38. Arshad N, Zitterl-Eglseer K, Hasnain S, et al. Effect of Peganum harmala or its β-carboline alkaloids on certain antibiotic resistant strains of bacteria and protozoa from poultry[J]. Phytother Res, 2008, 22(11): 1533-1538.
39. Abbassi K, Atay-Kadiri Z, Ghaout S. Biological effects of alkaloids extracted from three plants of Moroccan arid areas on the desert locust[J]. Physiol Entomol, 2003, 28(3): 232-236.
40. Jbilou R, Amri H, Bouayad N, et al. Insecticidal effects of extracts of seven plant species on larval development, α-amylase activity and offspring production of Tribolium castaneum (Herbst) (Insecta: Coleoptera;Tenebrionidae) [J]. Bioresource Technol, 2008, 99(5): 959-964.
41. Derakhshanfar A, Mirzaei M. Effect of Peganum harmala (wild rue) extract on experimental ovine malignant theileriosis: pathological and parasitologic al findings [J]. Onderstepoort J Vet Res, 2008, 75(1): 67-72.
42. Mirzaei M. Treatment of natural tropical theileriosis with the extract of the plant Peganum harmala[J]. Korean J Parasitol, 2007, 45(4): 267-271.
43. Khaliq T, Misra P, Gupta S. Peganine hydrochloride dihydrate an orally active antileishmanial agent [J]. Bioorg Med Chem Lett, 2009, 19(9): 2585-2586.
44. Derakhshanfar A, Oloumi MM, Mirzaie M. Study on the effect of Peganum harmala extract on experimental skin wound healing in rat: pathological and biomechanical findings[J]. Comp Clin Pathol, 2010, 19(2): 169-172.