Antiplatelet activity of β-carboline alkaloids from Perganum harmala: A possible mechanism through inhibiting PLCγ2 phosphorylation

Vascular Pharmacology

Volumn 50, Issue 5-6, 2009, Pages 147-152

  Im, Ji Hyun ^a   Jin, Yong Ri ^b   Lee, Jung Jin ^a   Yu, Ji Yeon ^a   Han, Xiang Hua ^a   Im, Se Hyuk ^c   Hong, Jin Tae ^a   Yoo, Hwan Soo ^a   Pyo, Myoung Yun ^d   Yun, Yeo Pyo ^a  

^a Chungbuk National University   (South Korea)

^b Maine Medical Center Research Institute   (United States)

^c Chungbuk National University College of Medicine   (South Korea)

^d Sookmyung Women's University   (South Korea)

Author keywords

carboline alkaloids; Antiplatelet activity; Collagen; PLC 2

Indexed keywords

15 HYDROXY 11ALPHA,9ALPHA EPOXYMETHANOPROSTA 5,13 DIENOIC ACID; ALKALOID DERIVATIVE; ARACHIDONIC ACID; BETA CARBOLINE; BETA CARBOLINE DERIVATIVE; CALCIUM; COLLAGEN; DIGITONIN; HARMALINE; HARMALOL; HARMAN; HARMINE; HARMOL; PERGANUM HARMALA EXTRACT; PHOSPHOLIPASE C GAMMA2; PLANT EXTRACT; THROMBIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; ATHEROSCLEROSIS; CALCIUM MOBILIZATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOSOL; DRUG MECHANISM; DRUG POTENCY; DRUG SELECTIVITY; IN VITRO STUDY; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RABBIT; THROMBOCYTE ACTIVATION; THROMBOCYTE AGGREGATION; THROMBOCYTE AGGREGATION INHIBITION; THROMBOSIS;

ALKALOIDS; ANIMALS; ARACHIDONIC ACID; BLOOD PLATELETS; CALCIUM; CARBOLINES; MALE; MOLECULAR STRUCTURE; PEGANUM; PHOSPHOLIPASE C GAMMA; PHOSPHORYLATION; PHOSPHOTYROSINE; PLANT EXTRACTS; PLATELET AGGREGATION; PLATELET AGGREGATION INHIBITORS; RABBITS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 61349171258     PISSN: 15371891     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.vph.2008.11.008     Document Type: Article

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