Synthesis and biological evaluation of 4-fluoroproline and 4-fluoropyrrolidine-2-acetic acid derivatives as new GABA uptake inhibitors

Bioorganic and Medicinal Chemistry

Volumn 17, Issue 18, 2009, Pages 6540-6546

  Zhuang, Weiping ^a   Zhao, Xueqing ^a   Zhao, Gang ^b   Guo, Lihe ^b   Lian, Yunyang ^a   Zhou, Jingming ^a   Fang, Dongsheng ^a  

^a FUJIAN INSTITUTE OF MICROBIOLOGY   (China)

^b Cell Star Bio Technologies Co Limited   (China)

Author keywords

4 Fluoropyroline; 4 Fluoropyrrolidine 2 acetic acid; GABA uptake inhibitor; GAT 1

Indexed keywords

4 AMINOBUTYRIC ACID UPTAKE PROTEIN 1; 4 FLUOROPROLINE; 4 FLUOROPYRROLIDINE 2 ACETIC ACID DERIVATIVE; PROLINE DERIVATIVE; PROTEIN; TIAGABINE; UNCLASSIFIED DRUG;

ALKALINITY; ARTICLE; DRUG ACTIVITY; DRUG STRUCTURE; ENANTIOMER; MOUSE; NONHUMAN; STRUCTURE ACTIVITY RELATION;

ACETIC ACIDS; ANIMALS; CELL LINE; GABA PLASMA MEMBRANE TRANSPORT PROTEINS; GAMMA-AMINOBUTYRIC ACID; INHIBITORY CONCENTRATION 50; MICE; PROLINE; PYRROLIDINES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 69249132178     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2009.08.010     Document Type: Article

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