A Cyp1a2-luciferase transgenic CD-1 mouse model: Responses to aryl hydrocarbons similar to the humanized AhR mice

Toxicological Sciences

Volumn 82, Issue 1, 2004, Pages 297-307

  Zhang, Weisheng ^a   Moorthy, Bhagavatula ^b   Chen, Min ^a   Muthiah, Kathirvel ^b   Coffee, Richard ^c   Purchio, Anthony F ^a   West, David B ^a  

^a Xenogen Corporation   (United States)

^b BAYLOR COLLEGE OF MEDICINE   (United States)

^c Xenogen Biosciences   (United States)

Author keywords

Aryl hydrocarbon receptor; Cytochrome P450 1A2; Drug metabolism; Gene regulation; Imaging; Luciferase; Reporter; Transgenic mice; Xenobiotics

Indexed keywords

2,3,7,8 TETRACHLORODIBENZO PARA DIOXIN; 3 METHYLCHOLANTHRENE; AROMATIC HYDROCARBON; BENZO[A]PYRENE; BETA NAPHTHOFLAVONE; COMPLEMENTARY DNA; CYTOCHROME P450 1A2; LUCIFERASE; MESSENGER RNA; PHENOBARBITAL;

AMINO ACID SEQUENCE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOLUMINESCENCE; CONCENTRATION (PARAMETERS); CONCENTRATION RESPONSE; CONTROLLED STUDY; EMBRYO; ENZYME ACTIVITY; FEMALE; GENE CONTROL; GENE EXPRESSION; GENE SEQUENCE; GENETIC VARIABILITY; GENOTYPE; MALE; MOUSE; NONHUMAN; NORTHERN BLOTTING; NUCLEOTIDE SEQUENCE; POINT MUTATION; SEQUENCE ANALYSIS; SEX DIFFERENCE; STATISTICAL ANALYSIS; STATISTICAL SIGNIFICANCE; TRANSGENIC MOUSE; WESTERN BLOTTING;

AMINO ACID SEQUENCE; ANIMALS; ANIMALS, OUTBRED STRAINS; CYTOCHROME P-450 CYP1A2; FEMALE; GENE EXPRESSION REGULATION; GENES, REPORTER; HUMANS; HYDROCARBONS, AROMATIC; LUCIFERASES; MALE; MICE; MICE, TRANSGENIC; MODELS, ANIMAL; MOLECULAR SEQUENCE DATA; POLYMORPHISM, GENETIC; RECEPTORS, ARYL HYDROCARBON; RNA, MESSENGER;

MUS MUSCULUS;

EID: 8444237774     PISSN: 10966080     EISSN: None     Source Type: Journal    
DOI: 10.1093/toxsci/kfh260     Document Type: Article

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