Persistent induction of cytochrome P450 (CYP)1A enzymes by 3-methylcholanthrene in vivo in mice is mediated by sustained transcriptional activation of the corresponding promoters

Biochemical and Biophysical Research Communications

Volumn 390, Issue 4, 2009, Pages 1419-1424

  Jiang, Weiwu ^a   Wang, Lihua ^a   Zhang, Weisheng ^b   Coffee, Richard ^b   Fazili, Inayat S ^a   Moorthy, Bhagavatula ^a  

^a BAYLOR COLLEGE OF MEDICINE   (United States)

^b Xenogen Biosciences   (United States)

Author keywords

3 Methylcholanthrene; CYP1A2; Cytochrome P4501A1; Gene regulation; In vivo; Luciferase reporter; Mice; Persistent induction; Promoter; Real time RT PCR; Transcriptional regulation; Transgenic

Indexed keywords

3 METHYLCHOLANTHRENE; CORN OIL; CYTOCHROME P450 1A; CYTOCHROME P450 1A2; LUCIFERASE; MESSENGER RNA; POLYCYCLIC AROMATIC HYDROCARBON;

ANIMAL EXPERIMENT; ARTICLE; BIOLUMINESCENCE; CARCINOGENESIS; CONTROLLED STUDY; ELECTROPHORESIS; ENZYME INDUCTION; EXPERIMENTAL MODEL; GENE EXPRESSION; IN VIVO STUDY; MALE; METABOLIC ACTIVATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; REPORTER GENE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TRANSGENIC MOUSE; WESTERN BLOTTING; WILD TYPE;

ANIMALS; CARCINOGENS; CYTOCHROME P-450 CYP1A1; CYTOCHROME P-450 CYP1A2; HUMANS; MALE; METHYLCHOLANTHRENE; MICE; MICE, TRANSGENIC; PROMOTER REGIONS, GENETIC; TRANSCRIPTIONAL ACTIVATION;

MUS; MUS MUSCULUS; RODENTIA; ZEA MAYS;

EID: 70450257640     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2009.11.021     Document Type: Article

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