Responding to infection and apoptosis-a task for TH17 cells

Annals of the New York Academy of Sciences

Volumn 1209, Issue 1, 2010, Pages 56-67

  Brereton, Corinna F ^a   Blander, J Magarian ^a  

^a MOUNT SINAI SCHOOL OF MEDICINE   (United States)

Author keywords

Apoptosis; Infection; Phagosome

Indexed keywords

INTERLEUKIN 1 RECEPTOR; INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 17; INTERLEUKIN 17F; INTERLEUKIN 21; INTERLEUKIN 22; INTERLEUKIN 6; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 10; PROSTAGLANDIN E2; THROMBOCYTE ACTIVATING FACTOR; TOLL LIKE RECEPTOR; TOLL LIKE RECEPTOR 1; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 3; TOLL LIKE RECEPTOR 4; TOLL LIKE RECEPTOR 5; TOLL LIKE RECEPTOR 6; TOLL LIKE RECEPTOR 7; TOLL LIKE RECEPTOR 8; TOLL LIKE RECEPTOR 9; TRANSFORMING GROWTH FACTOR BETA;

ANTIGEN PRESENTING CELL; APOPTOSIS; ARTICLE; CELL DIFFERENTIATION; CITROBACTER RODENTIUM; CYTOKINE PRODUCTION; ENTEROBACTERIACEAE INFECTION; EPITHELIUM CELL; ESCHERICHIA COLI; HUMAN; IMMUNE RESPONSE; INFECTION; INFLAMMATION; LYMPHOCYTE DIFFERENTIATION; MACROPHAGE; MONOCYTE; NONHUMAN; PHAGOCYTE; PHAGOSOME; TH17 CELL; CELL LINE; CYTOLOGY; HELPER CELL; IMMUNOLOGY; INNATE IMMUNITY; PHAGOCYTOSIS; SIGNAL TRANSDUCTION;

BACTERIA (MICROORGANISMS); CITROBACTER; CITROBACTER RODENTIUM;

APOPTOSIS; CELL DIFFERENTIATION; CELL LINE; CITROBACTER RODENTIUM; HUMANS; IMMUNITY, INNATE; PHAGOCYTOSIS; SIGNAL TRANSDUCTION; T-LYMPHOCYTES, HELPER-INDUCER;

EID: 78049523518     PISSN: 00778923     EISSN: 17496632     Source Type: Book Series    
DOI: 10.1111/j.1749-6632.2010.05747.x     Document Type: Article

References (93)

1. Janeway, C.A. Jr. 1989. Approaching the asymptote? Evolution and revolution in immunology. Cold Spring Harb. Symp. Quant. Biol. 54(Pt 1): 1-13.
2. Aderem, A. & D.M. Underhill 1999. Mechanisms of phagocytosis in macrophages. Annu. Rev. Immunol. 17: 593-623.
3. Kinchen, J.M. & K.S. Ravichandran 2008. Phagosome maturation: going through the acid test. Nat. Rev. Mol. Cell Biol. 9: 781-795.
4. Stuart, L.M. & R.A. Ezekowitz 2005. Phagocytosis: elegant complexity. Immunity 22: 539-550.
5. Savina, A. & S. Amigorena 2007. Phagocytosis and antigen presentation in dendritic cells. Immunol. Rev. 219: 143-156.
6. Trombetta, E.S. & I. Mellman 2005. Cell biology of antigen processing in vitro and in vivo. Annu. Rev. Immunol. 23: 975-1028.
7. Mosmann, T.R., H. Cherwinski, M.W. Bond, et al 1986. Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins. J. Immunol. 136: 2348-2357.
8. Langrish, C.L. et al 2004. IL-12 and IL-23: master regulators of innate and adaptive immunity. Immunol. Rev. 202: 96-105.
9. Trinchieri, G. 2003. Interleukin-12 and the regulation of innate resistance and adaptive immunity. Nat. Rev. Immunol. 3: 133-146.
10. Okamura, H. et al 1995. Cloning of a new cytokine that induces IFN-gamma production by T cells. Nature 378: 88-91.
11. Kadowaki, N., S. Antonenko, J.Y. Lau & Y.J. Liu 2000. Natural interferon alpha/beta-producing cells link innate and adaptive immunity. J. Exp. Med. 192: 219-226.
12. Salomon, B. & J.A. Bluestone 1998. LFA-1 interaction with ICAM-1 and ICAM-2 regulates Th2 cytokine production. J. Immunol. 161: 5138-5142.
13. Ohshima, Y. et al 1998. OX40 costimulation enhances interleukin-4 (IL-4) expression at priming and promotes the differentiation of naive human CD4(+) T cells into high IL-4-producing effectors. Blood 92: 3338-3345.
14. Zhu, J., H. Yamane & W.E. Paul 2010. Differentiation of effector CD4 T cell populations. Annu. Rev. Immunol 28: 445-489.
15. Wan, Y.Y. & R.A. Flavell 2009. How diverse--CD4 effector T cells and their functions. J. Mol. Cell Biol. 1: 20-36.
16. + Foxp3(-) effector T cells. Nat. Immunol. 9: 1347-1355.
17. Veldhoen, M. et al 2008. Transforming growth factor-beta 'reprograms' the differentiation of T helper 2 cells and promotes an interleukin 9-producing subset. Nat. Immunol. 9: 1341-1346.
18. Duhen, T., R. Geiger, D. Jarrossay, et al 2009. Production of interleukin 22 but not interleukin 17 by a subset of human skin-homing memory T cells. Nat. Immunol. 10: 857-863.
19. Trifari, S., C.D. Kaplan, E.H. Tran, et al 2009. Identification of a human helper T cell population that has abundant production of interleukin 22 and is distinct from T(H)-17, T(H)1 and T(H)2 cells. Nat. Immunol. 10: 864-871.
20. King, C. 2009. New insights into the differentiation and function of T follicular helper cells. Nat. Rev. Immunol. 9: 757-766.
21. King, C., S.G. Tangye & C.R. Mackay 2008. T follicular helper (TFH) cells in normal and dysregulated immune responses. Annu. Rev. Immunol. 26: 741-766.
22. Nurieva, R.I. et al 2008. Generation of T follicular helper cells is mediated by interleukin-21 but independent of T helper 1, 2, or 17 cell lineages. Immunity 29: 138-149.
23. Vogelzang, A. et al 2008. A fundamental role for interleukin-21 in the generation of T follicular helper cells. Immunity 29: 127-137.
24. Blander, J.M. & R. Medzhitov 2004. Regulation of phagosome maturation by signals from toll-like receptors. Science 304: 1014-1018.
25. Blander, J.M. & R. Medzhitov 2006. On regulation of phagosome maturation and antigen presentation. Nat. Immunol. 7: 1029-1035.
26. Akira, S., S. Uematsu & O. Takeuchi 2006. Pathogen recognition and innate immunity. Cell 124: 783-801.
27. Medzhitov, R. & C. Janeway, Jr. 2000. Innate immunity. N. Engl. J. Med. 343: 338-344.
28. Erwig, L.P. & P.M. Henson 2008. Clearance of apoptotic cells by phagocytes. Cell Death Differ. 15: 243-250.
29. Torchinsky, M.B., J. Garaude, A.P. Martin & J.M. Blander 2009. Innate immune recognition of infected apoptotic cells directs T(H)17 cell differentiation. Nature 458: 78-82.
30. Takeda, K. & S. Akira 2005. Toll-like receptors in innate immunity. Int. Immunol. 17: 1-14.
31. Bowie, A. & L.A. O'Neill 2000. The interleukin-1 receptor/Toll-like receptor superfamily: signal generators for pro-inflammatory interleukins and microbial products. J. Leukoc. Biol. 67: 508-514.
32. O'Neill, L.A. 2006. How Toll-like receptors signal: what we know and what we don't know. Curr. Opin. Immunol. 18: 3-9.
33. Ravichandran, K.S. & U. Lorenz 2007. Engulfment of apoptotic cells: signals for a good meal. Nat. Rev. Immunol. 7: 964-974.
34. Savill, J., I. Dransfield, C. Gregory & C. Haslett 2002. A blast from the past: clearance of apoptotic cells regulates immune responses. Nat. Rev. Immunol. 2: 965-975.
35. Lauber, K. et al 2003. Apoptotic cells induce migration of phagocytes via caspase-3-mediated release of a lipid attraction signal. Cell 113: 717-730.
36. Elliott, M.R. et al 2009. Nucleotides released by apoptotic cells act as a find-me signal to promote phagocytic clearance. Nature 461: 282-286.
37. Fadok, V.A. et al 1992. Exposure of phosphatidylserine on the surface of apoptotic lymphocytes triggers specific recognition and removal by macrophages. J. Immunol. 148: 2207-2216.
38. Gregory, C.D., A. Devitt & O. Moffatt 1998. Roles of ICAM-3 and CD14 in the recognition and phagocytosis of apoptotic cells by macrophages. Biochem. Soc. Trans. 26: 644-649.
39. Moffatt, O.D., A. Devitt, E.D. Bell, et al 1999. Macrophage recognition of ICAM-3 on apoptotic leukocytes. J. Immunol. 162: 6800-6810.
40. Chang, M.K. et al 1999. Monoclonal antibodies against oxidized low-density lipoprotein bind to apoptotic cells and inhibit their phagocytosis by elicited macrophages: evidence that oxidation-specific epitopes mediate macrophage recognition. Proc. Natl. Acad. Sci. USA 96: 6353-6358.
41. Oka, K. et al 1998. Lectin-like oxidized low-density lipoprotein receptor 1 mediates phagocytosis of aged/apoptotic cells in endothelial cells. Proc. Natl. Acad. Sci. USA 95: 9535-9540.
42. Sambrano, G.R. & D. Steinberg 1995. Recognition of oxidatively damaged and apoptotic cells by an oxidized low density lipoprotein receptor on mouse peritoneal macrophages: role of membrane phosphatidylserine. Proc. Natl. Acad. Sci. USA 92: 1396-1400.
43. Hanayama, R. et al 2002. Identification of a factor that links apoptotic cells to phagocytes. Nature 417: 182-187.
44. Anderson, H.A. et al 2003. Serum-derived protein S binds to phosphatidylserine and stimulates the phagocytosis of apoptotic cells. Nat. Immunol. 4: 87-91.
45. Lemke, G. & C.V. Rothlin 2008. Immunobiology of the TAM receptors. Nat. Rev. Immunol. 8: 327-336.
46. Nagata, K. et al 1996. Identification of the product of growth arrest-specific gene 6 as a common ligand for Axl, Sky, and Mer receptor tyrosine kinases. J. Biol. Chem. 271: 30022-30027.
47. Kobayashi, N. et al 2007. TIM-1 and TIM-4 glycoproteins bind phosphatidylserine and mediate uptake of apoptotic cells. Immunity 27: 927-940.
48. Miyanishi, M. et al 2007. Identification of Tim4 as a phosphatidylserine receptor. Nature 450: 435-439.
49. Park, D. et al 2007. BAI1 is an engulfment receptor for apoptotic cells upstream of the ELMO/Dock180/Rac module. Nature 450: 430-434.
50. Park, S.Y. et al 2008. Rapid cell corpse clearance by stabilin-2, a membrane phosphatidylserine receptor. Cell Death Differ. 15: 192-201.
51. Voll, R.E. et al 1997. Immunosuppressive effects of apoptotic cells. Nature 390: 350-351.
52. Fadok, V.A. et al 1998. Macrophages that have ingested apoptotic cells in vitro inhibit proinflammatory cytokine production through autocrine/paracrine mechanisms involving TGF-beta, PGE2, and PAF. J. Clin. Invest. 101: 890-898.
53. Cvetanovic, M. & D.S. Ucker 2004. Innate immune discrimination of apoptotic cells: repression of proinflammatory macrophage transcription is coupled directly to specific recognition. J. Immunol. 172: 880-889.
54. Park, D., A. Hochreiter-Hufford & K.S. Ravichandran 2009. The phosphatidylserine receptor TIM-4 does not mediate direct signaling. Curr. Biol. 19: 346-351.
55. Xiao, Y.Q. et al 2008. Transcriptional and translational regulation of TGF-beta production in response to apoptotic cells. J. Immunol. 181: 3575-3585.
56. Gronski, M.A., J.M. Kinchen, I.J. Juncadella, et al 2009. An essential role for calcium flux in phagocytes for apoptotic cell engulfment and the anti-inflammatory response. Cell Death Differ. 16: 1323-1331.
57. Castrillo, A. & P. Tontonoz 2004. Nuclear receptors in macrophage biology: at the crossroads of lipid metabolism and inflammation. Annu. Rev. Cell Dev. Biol. 20: 455-480.
58. Mukundan, L. et al 2009. PPAR-delta senses and orchestrates clearance of apoptotic cells to promote tolerance. Nat. Med. 15: 1266-1272.
59. A-Gonzalez, N. et al 2009. Apoptotic cells promote their own clearance and immune tolerance through activation of the nuclear receptor LXR. Immunity 31: 245-258.
60. Rothlin, C.V., S. Ghosh, E.I. Zuniga, et al 2007. TAM receptors are pleiotropic inhibitors of the innate immune response. Cell 131: 1124-1136.
61. Chen, H.D. & G. Frankel 2005. Enteropathogenic Escherichia coli: unravelling pathogenesis. FEMS Microbiol. Rev. 29: 83-98.
62. Weflen, A.W., N.M. Alto & G.A. Hecht 2009. Tight junctions and enteropathogenic E. coli. Ann. N.Y. Acad. Sci. 1165: 169-174.
63. Abul-Milh, M., Y. Wu, B. Lau, et al 2001. Induction of epithelial cell death including apoptosis by enteropathogenic Escherichia coli expressing bundle-forming pili. Infect. Immun. 69: 7356-7364.
64. Baldwin, T.J., M.B. Lee-Delaunay, S. Knutton & P.H. Williams 1993. Calcium-calmodulin dependence of actin accretion and lethality in cultured HEp-2 cells infected with enteropathogenic Escherichia coli. Infect. Immun. 61: 760-763.
65. Barnett Foster, D., M. Abul-Milh, M. Huesca & C.A. Lingwood 2000. Enterohemorrhagic Escherichia coli induces apoptosis which augments bacterial binding and phosphatidylethanolamine exposure on the plasma membrane outer leaflet. Infect. Immun. 68: 3108-3115.
66. Crane, J.K., S. Majumdar & D.F. Pickhardt, 3rd. 1999. Host cell death due to enteropathogenic Escherichia coli has features of apoptosis. Infect. Immun. 67: 2575-2584.
67. Crane, J.K., R.A. Olson, H.M. Jones & M.E. Duffey 2002. Release of ATP during host cell killing by enteropathogenic E. coli and its role as a secretory mediator. Am. J. Physiol. Gastrointest. Liver Physiol. 283: G74-G86.
68. Malish, H.R. et al 2003. Potential role of the EPEC translocated intimin receptor (Tir) in host apoptotic events. Apoptosis 8: 179-190.
69. McDaniel, T.K., K.G. Jarvis, M.S. Donnenberg & J.B. Kaper 1995. A genetic locus of enterocyte effacement conserved among diverse enterobacterial pathogens. Proc. Natl. Acad. Sci. USA 92: 1664-1668.
70. McDaniel, T.K. & J.B. Kaper 1997. A cloned pathogenicity island from enteropathogenic Escherichia coli confers the attaching and effacing phenotype on E. coli K-12. Mol. Microbiol. 23: 399-407.
71. Nagai, T., A. Abe & C. Sasakawa 2005. Targeting of enteropathogenic Escherichia coli EspF to host mitochondria is essential for bacterial pathogenesis: critical role of the 16th leucine residue in EspF. J. Biol. Chem. 280: 2998-3011.
72. Nougayrede, J.P. & M.S. Donnenberg 2004. Enteropathogenic Escherichia coli EspF is targeted to mitochondria and is required to initiate the mitochondrial death pathway. Cell Microbiol. 6: 1097-1111.
73. Blander, J.M. & R. Medzhitov 2006. Toll-dependent selection of microbial antigens for presentation by dendritic cells. Nature 440: 808-812.
74. Mangan, P.R. et al 2006. Transforming growth factor-beta induces development of the T(H)17 lineage. Nature 441: 231-234.
75. Zheng, Y. et al 2008. Interleukin-22 mediates early host defense against attaching and effacing bacterial pathogens. Nat. Med. 14: 282-289.
76. Curtis, M.M. & S.S. Way 2009. Interleukin-17 in host defence against bacterial, mycobacterial and fungal pathogens. Immunology 126: 177-185.
77. Ishigame, H. et al 2009. Differential roles of interleukin-17A and -17F in host defense against mucoepithelial bacterial infection and allergic responses. Immunity 30: 108-119.
78. Korn, T., E. Bettelli, M. Oukka & V.K. Kuchroo 2009. IL-17 and Th17 Cells. Annu. Rev. Immunol. 27: 485-517.
79. Wolk, K. et al 2006. IL-22 regulates the expression of genes responsible for antimicrobial defense, cellular differentiation, and mobility in keratinocytes: a potential role in psoriasis. Eur. J. Immunol. 36: 1309-1323.
80. Wolk, K., E. Witte, K. Witte, et al 2010. Biology of interleukin-22. Semin. Immunopathol. 32: 17-31.
81. Hetz, C., M.R. Bono, L.F. Barros & R. Lagos 2002. Microcin E492, a channel-forming bacteriocin from Klebsiella pneumoniae, induces apoptosis in some human cell lines. Proc. Natl. Acad. Sci. USA 99: 2696-2701.
82. Aujla, S.J. et al 2008. IL-22 mediates mucosal host defense against Gram-negative bacterial pneumonia. Nat. Med. 14: 275-281.
83. Sugimoto, K. et al 2008. IL-22 ameliorates intestinal inflammation in a mouse model of ulcerative colitis. J. Clin. Invest. 118: 534-544.
84. Radaeva, S., R. Sun, H.N. Pan, et al 2004. Interleukin 22 (IL-22) plays a protective role in T cell-mediated murine hepatitis: IL-22 is a survival factor for hepatocytes via STAT3 activation. Hepatology 39: 1332-1342.
85. Pan, H., F. Hong, S. Radaeva & B. Gao 2004. Hydrodynamic gene delivery of interleukin-22 protects the mouse liver from concanavalin A-, carbon tetrachloride-, and Fas ligand-induced injury via activation of STAT3. Cell. Mol. Immunol. 1: 43-49.
86. Zenewicz, L.A. et al 2007. Interleukin-22 but not interleukin-17 provides protection to hepatocytes during acute liver inflammation. Immunity 27: 647-659.
87. Boniface, K. et al 2005. IL-22 inhibits epidermal differentiation and induces proinflammatory gene expression and migration of human keratinocytes. J. Immunol. 174: 3695-3702.
88. Griffiths, C.E. & J.N. Barker 2007. Pathogenesis and clinical features of psoriasis. Lancet 370: 263-271.
89. Sabat, R. et al 2007. Immunopathogenesis of psoriasis. Exp. Dermatol. 16: 779-798.
90. Zheng, Y. et al 2007. Interleukin-22, a T(H)17 cytokine, mediates IL-23-induced dermal inflammation and acanthosis. Nature 445: 648-651.
91. Ma, H.L. et al 2008. IL-22 is required for Th17 cell-mediated pathology in a mouse model of psoriasis-like skin inflammation. J. Clin. Invest. 118: 597-607.
92. Ouyang, W., J.K. Kolls & Y. Zheng 2008. The biological functions of T helper 17 cell effector cytokines in inflammation. Immunity 28: 454-467.
93. Kolls, J.K., P.B. McCray, Jr. & Y.R. Chan 2008. Cytokine-mediated regulation of antimicrobial proteins. Nat. Rev. Immunol. 8: 829-835.