Deoxyuridine triphosphate incorporation during Somatic hypermutation of mouse VkOx genes after immunization with phenyloxazolone

Journal of Immunology

Volumn 185, Issue 8, 2010, Pages 4777-4782

  Roche, Benjamin ^a   Claës, Aurélie ^a   Rougeon, François ^a  

^a CNRS   (France)

Author keywords

[No Author keywords available]

Indexed keywords

2 PHENYL OXAZOLONE; DEOXYURIDINE TRIPHOSPHATE DERIVATIVE; DEOXYURIDINE TRIPHOSPHATE PYROPHOSPHATASE; DNA POLYMERASE; OXAZOLE DERIVATIVE; UNCLASSIFIED DRUG; URACIL; 2 PHENYLOXAZOLONE; 2-PHENYLOXAZOLONE; DEOXYURIDINE PHOSPHATE; DEOXYURIDINE TRIPHOSPHATE; DRUG DERIVATIVE; IMMUNOGLOBULIN KAPPA CHAIN; OXAZOLONE;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DNA REPLICATION; GENE MUTATION; IMMUNIZATION; MALE; NONHUMAN; PRIORITY JOURNAL; SOMATIC HYPERMUTATION; WILD TYPE; ANIMAL; BAGG ALBINO MOUSE; GENETICS; IMMUNOGLOBULIN GENE; IMMUNOLOGY; MOUSE; POLYMERASE CHAIN REACTION;

ANIMALS; DEOXYURACIL NUCLEOTIDES; GENES, IMMUNOGLOBULIN; IMMUNOGLOBULIN KAPPA-CHAINS; MICE; MICE, INBRED BALB C; OXAZOLONE; POLYMERASE CHAIN REACTION; SOMATIC HYPERMUTATION, IMMUNOGLOBULIN;

EID: 78049516794     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.1001459     Document Type: Article

References (33)

1. Di Noia, J. M., and M. S. Neuberger. 2007. Molecular mechanisms of antibody somatic hypermutation. Annu. Rev. Biochem. 76:1-22.
2. Ladner, R. D. 2001. The role of dUTPase and uracil-DNA repair in cancer chemotherapy. Curr. Protein Pept. Sci. 2:361-370.
3. Sousa, M. M., H. E. Krokan, and G. Slupphaug. 2007. DNA-uracil and human pathology. Mol. Aspects Med. 28:276-306.
4. Berger, S. H., D. L. Pittman, and M. D. Wyatt. 2008. Uracil in DNA: consequences for carcinogenesis and chemotherapy. Biochem. Pharmacol. 76:697-706.
5. Andersen, S., T. Heine, R. Sneve, I. König, H. E. Krokan, B. Epe, and H. Nilsen. 2005. Incorporation of dUMP into DNA is a major source of spontaneous DNA damage, while excision of uracil is not required for cytotoxicity of fluoropyrimidines in mouse embryonic fibroblasts. Carcinogenesis 26:547-555.
6. Guillet, M., P. A. Van der Kemp, and S. Boiteux. 2006. dUTPase activity is critical to maintain genetic stability in Saccharomyces cerevisiae. Nucleic Acids Res. 34:2056-2066.
7. Kim, N., and S. Jinks-Robertson. 2009. dUTP incorporation into genomic DNA is linked to transcription in yeast. Nature 459:1150-1153.
8. Ting, H., E. A. Kouzminova, and A. Kuzminov. 2008. Synthetic lethality with the dut defect in Escherichia coli reveals layers of DNA damage of increasing complexity due to uracil incorporation. J. Bacteriol. 190:5841-5854.
9. Faili, A., S. Aoufouchi, Q. Guéranger, C. Zober, A. Léon, B. Bertocci, J. C. Weill, and C. A. Reynaud. 2002. AID-dependent somatic hypermutation occurs as a DNA single-strand event in the BL2 cell line. Nat. Immunol. 3:815-821.
10. Ordinario, E. C., M. Yabuki, R. P. Larson, and N. Maizels. 2009. Temporal regulation of Ig gene diversification revealed by single-cell imaging. J. Immunol. 183:4545-4553.
11. Kaartinen, M., G. M. Griffiths, A. F. Markham, and C. Milstein. 1983. mRNA sequences define an unusually restricted IgG response to 2-phenyloxazolone and its early diversification. Nature 304:320-324.
12. Näkelä, O., M. Kaartinen, J. L. T. Pelkonen, and K. Karjalainen. 1978. Inheritance of antibody specificity V. Anti-2-phenyloxazolone in the mouse. J. Exp. Med. 148:1644-1660.
13. Miller, S. A., D. D. Dykes, and H. F. Polesky. 1988. A simple salting out procedure for extracting DNA from human nucleated cells. Nucleic Acids Res. 16:1215.
14. Muramatsu, M., K. Kinoshita, S. Fagarasan, S. Yamada, Y. Shinkai, and T. Honjo. 2000. Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzyme. Cell 102:553-563.
15. Griffiths, G. M., C. Berek, M. Kaartinen, and C. Milstein. 1984. Somatic mutation and the maturation of immune response to 2-phenyl oxazolone. Nature 312:271-275.
16. Even, J., G. M. Griffiths, C. Berek, and C. Milstein. 1985. Light chain germ-line genes and the immune response to 2-phenyloxazolone. EMBO J. 4 (13 A): 3439-3445.
17. Kobayashi, A., M. Kitaoka, and K. Hayashi. 2005. Novel PCR-mediated mutagenesis employing DNA containing a natural abasic site as a template and translesional Taq DNA polymerase. J. Biotechnol. 116:227-232.
18. Jiang, D., Z. Hatahet, R. J. Melamede, Y. W. Kow, and S. S. Wallace. 1997. Characterization of Escherichia coli endonuclease VIII. J. Biol. Chem. 272:32230-32239.
19. Berek, C., and C. Milstein. 1987. Mutation drift and repertoire shift in the maturation of the immune response. Immunol. Rev. 96:23-41.
20. Neuberger, M. S., J. M. Di Noia, R. C. L. Beale, G. T. Williams, Z. Yang, and C. Rada. 2005. Somatic hypermutation at A. T pairs: polymerase error versus dUTP incorporation. Nat. Rev. Immunol. 5:171-178.
21. Storb, U., H. M. Shen, and D. Nicolae. 2009. Somatic hypermutation: processivity of the cytosine deaminase AID and error-free repair of the resulting uracils. Cell Cycle 8:3097-3101.
22. Imai, K., G. Slupphaug, W. I. Lee, P. Revy, S. Nonoyama, N. Catalan, L. Yel, M. Forveille, B. Kavli, H. E. Krokan, et al. 2003. Human uracil-DNA glycosylase deficiency associated with profoundly impaired immunoglobulin classswitch recombination. Nat. Immunol. 4:1023-1028.
23. Frieder, D., M. Larijani, C. Collins, M. Shulman, and A. Martin. 2009. The concerted action of Msh2 and UNG stimulates somatic hypermutation at A. T base pairs. Mol. Cell. Biol. 29:5148-5157.
24. Kavli, B., O. Sundheim, M. Akbari, M. Otterlei, H. Nilsen, F. Skorpen, P. A. Aas, L. Hagen, H. E. Krokan, and G. Slupphaug. 2002. hUNG2 is the major repair enzyme for removal of uracil from U:A matches, U:G mismatches, and U in single-stranded DNA, with hSMUG1 as a broad specificity backup. J. Biol. Chem. 277:39926-39936.
25. Visnes, T., B. Doseth, H. S. Pettersen, L. Hagen, M. M. L. Sousa, M. Akbari, M. Otterlei, B. Kavli, G. Slupphaug, and H. E. Krokan. 2009. Uracil in DNA and its processing by different DNA glycosylases. Philos. Trans. R. Soc. Lond. B Biol. Sci. 364:563-568.
26. Nilsen, H., K. A. Haushalter, P. Robins, D. E. Barnes, G. L. Verdine, and T. Lindahl. 2001. Excision of deaminated cytosine from the vertebrate genome: role of the SMUG1 uracil-DNA glycosylase. EMBO J. 20:4278-4286.
27. Matsuda, T., K. Bebenek, C. Masutani, I. B. Rogozin, F. Hanaoka, and T. A. Kunkel. 2001. Error rate and specificity of human and murine DNA polymerase h. J. Mol. Biol. 312:335-346.
28. Pavlov, Y. I., I. B. Rogozin, A. P. Galkin, A. Y. Aksenova, F. Hanaoka, C. Rada, and T. A. Kunkel. 2002. Correlation of somatic hypermutation specificity and A-T base pair substitution errors by DNA polymerase h during copying of a mouse immunoglobulin k light chain transgene. Proc. Natl. Acad. Sci. USA 99:9954-9959.
29. Dörner, T., and P. E. Lipsky. 2001. Smaller role for polh? Nat. Immunol. 2:982-984.
30. Phung, Q. H., D. B. Winter, A. Cranston, R. E. Tarone, V. A. Bohr, R. Fishel, and P. J. Gearhart. 1998. Increased hypermutation at G and C nucleotides in immunoglobulin variable genes from mice deficient in the MSH2 mismatch repair protein. J. Exp. Med. 187:1745-1751.
31. Delbos, F., S. Aoufouchi, A. Faili, J. C. Weill, and C. A. Reynaud. 2007. DNA polymerase η is the sole contributor of A/T modifications during immunoglobulin gene hypermutation in the mouse. J. Exp. Med. 204:17-23.
32. Bhattacharya, P., F. Grigera, I. B. Rogozin, T. McCarty, H. C. I. I. I. Morse, III, and A. L. Kenter. 2008. Identification of murine B cell lines that undergo somatic hypermutation focused to A:T and G:C residues. Eur. J. Immunol. 38:227-239.
33. Franklin, A., and R. V. Blanden. 2006. A/T-targeted somatic hypermutation: critique of the mainstream model. Trends Biochem. Sci. 31:252-258.