Drug-induced regulation of target expression

PLoS Computational Biology

Volumn 6, Issue 9, 2010, Pages

  Iskar, Murat ^a   Campillos, Monica ^a   Kuhn, Michael ^a   Jensen, Lars Juhl ^a,b   van Noort, Vera ^a   Bork, Peer ^a,c  

^a EUROPEAN MOLECULAR BIOLOGY LABORATORY   (Germany)

^b University of Copenhagen   (Denmark)

^c MAX DELBRÜCK CENTER FOR MOLECULAR MEDICINE   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CELL CULTURE; DRUG THERAPY; LEAD COMPOUNDS; NUCLEIC ACIDS;

CELL LINES; COMPLEX RESPONSE; DRUG TARGETS; EXPRESSION LEVELS; HUMAN CELLS; MECHANISM SYSTEMS; NEGATIVE FEEDBACK LOOP; POSITIVE FEEDBACK LOOP; TARGET BINDING; TARGET PROTEINS;

GENE EXPRESSION;

BETA TUBULIN; CALMODULIN; CALMODULIN 1; CELL PROTEIN; DNA TOPOISOMERASE (ATP HYDROLYSING); DNA TOPOISOMERASE 2 ALPHA; ENDOPLASMIN; G PROTEIN COUPLED RECEPTOR; MESSENGER RNA; PODOPHYLLOTOXIN; STEROL 14ALPHA DEMETHYLASE; TRICHOSTATIN A; UNCLASSIFIED DRUG; VORINOSTAT;

ARTICLE; CALCULATION; CONTROLLED STUDY; DOWN REGULATION; DRUG TARGETING; FEEDBACK SYSTEM; GENE EXPRESSION REGULATION; HUMAN; HUMAN CELL; REGULATORY MECHANISM; RELIABILITY; SCORING SYSTEM; UPREGULATION;

EID: 78049449443     PISSN: 1553734X     EISSN: 15537358     Source Type: Journal    
DOI: 10.1371/journal.pcbi.1000925     Document Type: Article

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