Prediction of clinical drug efficacy by classification of drug-induced genomic expression profiles in vitro

Proceedings of the National Academy of Sciences of the United States of America

Volumn 100, Issue 16, 2003, Pages 9608-9613

  Gunther, Erik C ^a   Stone, David J ^a   Gerwien, Robert W ^a   Bento, Patricia ^a   Heyes, Melvyn P ^a  

^a CURAGEN CORPORATION   (United States)

Author keywords

Drug screening; Pharmacogenomics; Predictive efficacy

Indexed keywords

3,4 DICHLORO N METHYL N [2 (1 PYRROLIDINYL)CYCLOHEXYL]BENZENEACETAMIDE; 4 [ALPHA (4 ALLYL 2,5 DIMETHYL 1 PIPERAZINYL) 3 HYDROXYBENZYL] N,N DIETHYLBENZAMIDE; AMFEBUTAMONE; AMITRIPTYLINE; ANTIDEPRESSANT AGENT; BIOLOGICAL MARKER; CHLORPROMAZINE; CITALOPRAM; CLOMIPRAMINE; DESIPRAMINE; DOXEPIN; FLUOXETINE; FLUVOXAMINE; IMIPRAMINE; IPRONIAZID; MAPROTILINE; NEUROLEPTIC AGENT; NORTRIPTYLINE; OPIATE; PAROXETINE; PHENELZINE; PROTRIPTYLINE; PSYCHOTROPIC AGENT; SERTRALINE; SPIRADOLINE; TRANYLCYPROMINE; TRAZODONE; TRIFLUOPERAZINE; TRIMIPRAMINE; UNINDEXED DRUG;

ACCURACY; ALGORITHM; ARTICLE; CELL ASSAY; DNA MICROARRAY; DRUG ACTIVITY; DRUG EFFICACY; DRUG SCREENING; GENE EXPRESSION PROFILING; HUMAN; HUMAN CELL; NERVE CELL; PHARMACOGENOMICS; PREDICTION; PRIORITY JOURNAL; STEM CELL;

ALGORITHMS; CLUSTER ANALYSIS; DATABASES, GENETIC; DNA, COMPLEMENTARY; DRUG DESIGN; DRUG EVALUATION, PRECLINICAL; GENE EXPRESSION; HUMANS; MODELS, STATISTICAL; NEURONS; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PHARMACOGENETICS;

EID: 0041421151     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.1632587100     Document Type: Article

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