Thymidylate synthetase mRNA levels are increased in liver metastases of colorectal cancer patients resistant to fluoropyrimidine-based chemotherapy

BMC Cancer

Volumn 4, Issue , 2004, Pages

  Libra, Massimo ^a,d   Navolanic, Patrick M ^b,d   Talamini, Renato ^a   Cecchin, Erica ^a   Sartor, Franca ^a   Tumolo, Salvatore ^c   Masier, Sara ^a   Travali, Salvatore ^d   Boiocchi, Mauro ^a   Toffoli, Giuseppe ^a  

^a CENTRO DI RIFERIMENTO ONCOLOGICO   (Italy)

^b EAST CAROLINA UNIVERSITY   (United States)

^c S MARIA DEGLI ANGELI HOSPITAL   (Italy)

^d UNIVERSITY OF CATANIA   (Italy)

Author keywords

Colon rectal cancer; FUDR; Liver metastasis; Thymidylate synthetase

Indexed keywords

FLOXURIDINE; FLUOROPYRIMIDINE; FLUOROURACIL; MESSENGER RNA; THYMIDYLATE SYNTHASE; ANTINEOPLASTIC ANTIMETABOLITE; TUMOR PROTEIN;

ADULT; AGED; ARTICLE; CANCER SURVIVAL; CLINICAL ARTICLE; COLORECTAL CANCER; CONTROLLED STUDY; CORRELATION ANALYSIS; DRUG EFFICACY; DRUG RESPONSE; FEMALE; HEPATIC ARTERY; HUMAN; LAPAROTOMY; LIVER METASTASIS; MALE; PROTEIN EXPRESSION; TREATMENT OUTCOME; TUMOR BIOPSY; COLORECTAL TUMOR; DRUG RESISTANCE; ENZYMOLOGY; INTRAARTERIAL DRUG ADMINISTRATION; LIVER TUMOR; METASTASIS; MIDDLE AGED;

ADULT; AGED; ANTIMETABOLITES, ANTINEOPLASTIC; COLORECTAL NEOPLASMS; DRUG RESISTANCE, NEOPLASM; FEMALE; FLOXURIDINE; HUMANS; INFUSIONS, INTRA-ARTERIAL; LIVER NEOPLASMS; MALE; MIDDLE AGED; NEOPLASM PROTEINS; RNA, MESSENGER; THYMIDYLATE SYNTHASE;

EID: 3042840988     PISSN: 14712407     EISSN: None     Source Type: Journal    
DOI: 10.1186/1471-2407-4-11     Document Type: Article

References (21)

1. Landis SH, Murray T, Bolden S, Wingo PA: Cancer Statistics, 1998. CA Cancer J Clin 1998, 48:6-29.
2. Krook JE, Moertel CG, Gunderson LL, Wieand HS, Collins RT, Beart RW, Kubista TP, Poon MA, Meyers WC, Maillard JA, Twito DI, Morton RF, Veeder MH, Witzig TE, Cha S, Vidyarthi SC: Effective surgical adjuvant therapy for high-risk rectal carcinoma. N Engl J Med 1991, 324:709-715.
3. Allen-Mersh TG, Earlam S, Fordy C, Abrams K, Houghton J: Quality of life and survival with continuous hepatic-artery floxuridine infusion for colorectal liver metastases. Lancet 1994, 344:1255-1260.
4. Peters GJ, Van der Wilt CL, Van Groeningen CJ, Smid K, Meijer S, Pinedo HM: Thymidylate synthase inhibition after administration of fluorouracil with or without leucovorin in colon cancer patients: implications for treatment with fluorouracil. J Clin Oncol 1994, 12:2035-2042.
5. Marsh S, McKay JA, Curran S, Murray GI, Cassidy J, McLeod HL: Primary colorectal tumour is not an accurate predictor of thymidylate synthase in lymph node metastasis. Oncol Rep 2002, 9:231-234.
6. Horikoshi T, Danenberg KD, Stadlbauer THW, Volkenandt M, Shea LLC, Aigner K, Gustavsson B, Leichman L, Frösing R, Ray M, Gibson NW, Spears CP, Danenberg PV: Quantitation of thymidylate synthase, dihydrofolate reductase, and DT-diaphorase gene expression in human tumors using the polymerase chain reaction. Cancer Res 1992, 52:108-116.
7. Lenz H-J, Hill C, Danenberg KD, Leichman LL, Priest DG, Danenberg PV: Rapid quantitative PCR for determination of relative gene expressions in tissue specimens. PCR Methods Appl 1995, 4:305-309.
8. SAS Institute Inc: "Sas User Guide: Language Version 8.1". Cary, NC: SAS; 2000.
9. Kaplan EL, Meier P: Nonparametric estimation from incomplete observations. J Am Stat Assoc 1958, 53:457-481.
10. Cox DR: Regression models and life tables. J R Stat Soc B 1972, 34:187-220.
11. Armitage P, Berry G: Statistical Methods in Medical Research. Oxford: Blackwell Scientific Publication; 1985.
12. Nanni O, Volpi A, Frassineti GL, De Paola F, Granato AM, Dubini A, Zoli W, Scarpi E, Turci D, Oliverio G, Gambi A, Amadori D: Role of biological markers in the clinical outcome of colon cancer. Br J Cancer 2002, 87:868-875.
13. Gonen M, Hummer A, Zervoudakis A, Sullivan D, Fong Y, Banerjee D, Klimstra D, Cordon-Cardo C, Bertino J, Kemeny N: Thymidylate synthase expression in hepatic tumors is a predictor of survival and progression in patients with resecable metastatic colorectal cancer. J Clin Oncol 2003, 21:406-412.
14. Toffoli G, Gafa R, Russo A, Lanza G, Dolcetti R, Sartor F, Libra M, Viel A, Boiocchi M: Methylenetetrahydrofolate reductase 677 C->T polymorphism and risk of proximal colon cancer in north Italy. Clin Cancer Res 2003, 9:743-748.
15. Link KH, Kornmann M, Butzer U, Leder G, Sunelaitis E, Pillasch J, Salonga D, Danenberg KD, Danenberg PV, Beger HG: Thymidylate synthase quantitation and in vitro chemosensitivity testing predicts responses and survival of patients with isolated nonresectable liver tumors receiving hepatic arterial infusion chemotherapy. Cancer 2000, 89:288-296.
16. Kornmann M, Link KH, Lenz HJ, Pillasch J, Metzger R, Butzer U, Leder GH, Weindel M, Safi F, Danenberg KD, Beger HG, Danenberg PV: Thymidylate synthase is a predictor for response and resistance in hepatic artery infusion chemotherapy. Cancer Lett 1997, 18:29-35.
17. Aschele C, Lonardi S, Monfardini S: Thymidylate synthase expression as a predictor of clinical response to fluoropyrimidine-based chemotherapy in advanced colorectal cancer. Cancer Treat Rev 2002, 28:27-47.
18. Peters GJ, Backus HH, Freemantle S, van Tirest B, Codacci-Pisanelli G, van der Wilt CL, Smid K, Lunec J, Calvert AH, Marsh S, McLeod HL, Bloemena E, Jeijer S, Jansen G, van Groeningen CJ, Pinedo HM: Induction of thymidylate synthase as a 5-fluorouracil resistant mechanism. Biochim Biophys Acta 2002, 1587:194-205.
19. Lenz HJ, Leichman CG, Danenberg KD, Danenberg PV, Groshen S, Cohen H, Laine L, Crookes P, Silberman H, Baranda J, Garcia Y, Li J, Leichman L: Thymidylate synthase mRNA level in adenocarcinoma of the stomach: a predictor for primary tumor response and overall survival. J Clin Oncol 1996, 14:176-182.
20. Bathe OF, Franceschi D, Livingstone AS, Moffat FL, Tian E, Ardalan B: Increased thymidylate synthase gene expression in liver metastases from colorectal carcinoma: implications for chemotherapeutic options and survival. Cancer J Sci Am 1999, 5:34-40.
21. Paradiso A, Simone G, Petroni S, Leone B, Vallejo C, Lacava J, Romero A, Machiavelli M, De Lena M, Allegra CJ, Johnston PG: Thymidilate synthase and p53 primary tumour expression as predictive factors for advanced colorectal cancer patients. Br J Cancer 2000, 82:560-567.