Aging is associated with myocardial insulin resistance and mitochondrial dysfunction

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 293, Issue 5, 2007, Pages

  Bhashyam, Siva ^a   Parikh, Pratik ^a   Bolukoglu, Hakki ^a   Shannon, Alexander H ^a   Porter, James H ^a   Shen, You Tang ^b   Shannon, Richard P ^a,c  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b RUTGERS NEW JERSEY MEDICAL SCHOOL   (United States)

^c UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Mitochondria; Myocardium; Uncoupling protein 3

Indexed keywords

FATTY ACID; GLUCOSE; GLUCOSE TRANSPORTER 4; INSULIN; UNCOUPLING PROTEIN 3;

AGING; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ATHEROSCLEROSIS; BODY MASS; CONTROLLED STUDY; CORONARY ARTERY CIRCUMFLEX BRANCH; CORONARY SINUS; DISORDERS OF MITOCHONDRIAL FUNCTIONS; DOG; EXERCISE; GLUCOSE BLOOD LEVEL; GLUCOSE TRANSPORT; HEART LEFT VENTRICLE; HEART MUSCLE; HEART MUSCLE CONTRACTILITY; HEART VENTRICLE REMODELING; HEMODYNAMICS; HYPERINSULINEMIA; INSULIN RESISTANCE; MALE; MITOCHONDRION; NONHUMAN; PRIORITY JOURNAL; SKELETAL MUSCLE;

AGING; ANIMALS; DOGS; HEART; INSULIN RESISTANCE; MYOCARDIAL CONTRACTION; VENTRICULAR FUNCTION, LEFT; VENTRICULAR REMODELING;

EID: 36148983413     PISSN: 03636135     EISSN: 15221539     Source Type: Journal    
DOI: 10.1152/ajpheart.00163.2007     Document Type: Article

References (41)

1. Barazzoni R. Skeletal muscle mitochondrial protein metabolism and function in ageing and type 2 diabetes. Curr Opin Clin Nutr Metab Care 71: 97-102, 2004.
2. Boehm EA, Jones BE, Radda GK, Veech RL, Clarke K. Increased uncoupling proteins and decreased efficiency in palmitate-perfused hyperthyroid rat heart. Am J Physiol Heart Circ Physiol 280: H977-H983, 2001.
3. Brand MD, Buckingham JA, Esteves TC, Green K, Lambert AJ, Miwa S, Murphy MP, Pakay JL, Talbot DA, Echtay KS. Mitochondrial superoxide and aging: uncoupling-protein activity and superoxide production. Biochem Soc Symp 71: 203-213, 2004.
4. Butler J, Rodondi N, Zhu Y, Figaro K, Fazio S, Vaughan DE, Satterfield S, Newman AB, Goodpaster B, Bauer DC, Holvoet P, Harris TB, de Rekeneire N, Rubin S, Ding J, Kritchevsky SB. Health ABC Study: Metabolic syndrome and the risk of cardiovascular disease in older adults. J Am Coll Cardiol 47: 1595-1602, 2006.
5. Egan BM. Insulin resistance and the sympathetic nervous system. Curr Hypertens Rep 5: 247-254, 2003.
6. Evans WJ. Protein nutrition, exercise and aging. J Am Coll Nutr 23: 601S-609S, 2004.
7. Fagius J. Sympathetic nerve activity in metabolic control-some basic concepts. Acta Physiol Scand 177: 337-343, 2003.
8. Garnier A, Fortin D, Delomenie C, Momken I, Veksler V, Ventura-Clapier R. Depressed mitochondrial transcription factors and oxidative capacity in rat failing cardiac and skeletal muscles. J Physiol 551: 491-501, 2003.
9. Goldberg AP, Coon PJ. Non-insulin-dependent diabetes mellitus in the elderly. Influence of obesity and physical inactivity. Endocrinol Metab Clin North Am 16: 843-865, 1987.
10. Haidet GC. Effect of age on cardiovascular responses to static muscular contraction in beagles. J Appl Physiol 73: 2320-2327, 1992.
11. Haidet GC, Parsons D. Reduced exercise capacity in senescent beagles: an evaluation of the periphery. Am J Physiol Heart Circ Physiol 260: H173-H182, 1991.
12. Haidet GC. Dynamic exercise in senescent beagles: oxygen consumption and hemodynamic responses. Am J Physiol Heart Circ Physiol 257: H1428-H1437, 1989.
13. Harper ME, Bevilacqua L, Hagopian K, Weindruch R, Ramsey JJ. Aging, oxidative stress, and mitochondrial uncoupling. Acta Physiol Scand 182: 321-331, 2004.
14. Harris MI. Epidemiologic studies on the pathogenesis of non-insulin-dependent diabetes mellitus (NIDDM). Clin Invest Med 18: 231-239, 1995.
15. Hoeks J, Hesselink MK, Schrauwen P. Involvement of UCP3 in mild uncoupling and lipotoxicity. Exp Gerontol 41: 658-662, 2006.
16. Holloszy JO, Schultz J, Kusnierkiewicz J, Hagberg JM, Ehsani AA. Effects of exercise on glucose tolerance and insulin resistance. Brief review and some preliminary results. Acta Med Scand Suppl 711: 55-65, 1986.
17. Holvoet P, Kritchevsky SB, Tracy RP, Mertens A, Rubin SM, Butler J, Goodpaster B, Harris TB. The metabolic syndrome, circulating oxidized LDL, and risk of myocardial infarction in well-functioning elderly people in the health, aging, and body composition cohort. Diabetes 53: 1068-1073, 2004.
18. Kim YB, Shulman GI, Kahn BB. Fatty acid infusion selectively impairs insulin action on Akt1 and protein kinase C lambda/zeta but not on glycogen synthase kinase-3. J Biol Chem 277: 32915-32922, 2002.
19. Laemmli UK. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227: 680-685, 1970.
20. Lehman JJ, Barger PM, Kovacs A, Saffitz JE, Medeiros DM, Kelly DP. Peroxisome proliferator-activated receptor gamma coactivator-1 promotes cardiac mitochondrial biogenesis. J Clin Invest 106: 847-856, 2000.
21. Lo YT, Tsao CJ, Liu IM, Liou SS, Cheng JT. Increase of PTEN gene expression in insulin resistance. Horm Metab Res 36: 662-666, 2004.
22. Lowell BB, Shulman GI. Mitochondrial dysfunction and type 2 diabetes. Science 307: 384-387, 2005.
23. Mead F, Williams AJ. Block of the ryanodine receptor channel by neomycin is relieved at high holding potentials. Biophys J 82: 1953-1963, 2002.
24. Morino K, Petersen KF, Dufour S, Befroy D, Frattini J, Shatzkes N, Neschen S, White MF, Bilz S, Sono S, Pypaert M, Shulman GI. Reduced mitochondrial density and increased IRS-1 serine phosphorylation in muscle of insulin-resistant offspring of type 2 diabetic parents. J Clin Invest 115: 3587-3593, 2005.
25. Musi N, Fujii N, Hirshman MF, Ekberg I, Fröberg S, Ljungvist O, Thorell A, Goodyear LJ. AMP-activated protein kinase (AMPK) is activated in muscle of subjects with type 2 diabetes during exercise. Diabetes 50: 921-927, 2001.
26. Nikolaidis LA, Sturzu A, Stolarski C, Elahi D, Shen YT, Shannon RP. The development of myocardial insulin resistance in conscious dogs with advanced dilated cardiomyopathy. Cardiovasc Res 61: 297-306, 2004.
27. Nikolaidis LA, Elahi D, Hentosz T, Doverspike A, Huerbin R, Zourelias L, Stolarski C, Shen YT, Shannon RP. Recombinant glucagon-like peptide-1 increases myocardial glucose uptake and improves left ventricular performance in conscious dogs with pacing-induced dilated cardiomyopathy. Circulation 110: 955-961, 2004.
28. Petersen KF, Befroy D, Dufour S, Dziura J, Ariyan C, Rothman DL, DiPietro L, Cline GW, Shulman GI. Mitochondrial dysfunction in the elderly: possible role in insulin resistance. Science 300: 1140 -1142, 2003.
29. Petersen KF, Dufour S, Befroy D, Garcia R, Shulman GI. Impaired mitochondrial activity in the insulin-resistant offspring of patients with type 2 diabetes. N Engl J Med 350: 664-671, 2004.
30. Reaven GM. Insulin resistance, the insulin resistance syndrome, and cardiovascular disease. Panminerva Med 47: 201-210, 2005.
31. Reznick RM, Shulman GI. The role of AMP-activated protein kinase in mitochondrial biogenesis. J Physiol 574: 33-39, 2006.
32. Ritz P, Elia M. The effect of inactivity on dietary intake and energy homeostasis. Proc Nutr Soc 58: 115-22, 1999.
33. Scheen AJ. Diabetes mellitus in the elderly: insulin resistance and/or impaired insulin secretion? Diabetes Metab 31: 5S27-5S34, 2005.
34. Sitsapesan R, Williams AJ. Mechanisms of caffeine activation of single calcium-release channels of sheep cardiac sarcoplasmic reticulum. J Physiol 423: 425-439, 1990.
35. Tomanek RJ, Aydelotte MR, Torry RJ. Remodeling of coronary vessels during aging in purebred beagles. Circ Res 69: 1068-1074, 1991.
36. Torlinska T, Mackowiak P, Nogowski L, Hryniewiecki T, Witmanowski H, Perz M, Madry E, Nowak KW. Age dependent changes of insulin receptors in rat tissues. J Physiol Pharmacol 51: 871-881, 2000.
37. Towbin H, Staehelin T, Gordon J. Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets. Proc Natl Acad Sci USA 76: 4350-4354, 1979.
38. Wijesekara N, Konrad D, Eweida M, Jefferies C, Liadis N, Giacca A, Crackower M, Suzuki A, Mak TW, Kahn CR, Klip A, Woo M. Muscle-specific Pten deletion protects against insulin resistance and diabetes. Mol Cell Biol 25: 1135-1145, 2005.
39. Wilson PW, Kannel WB. Obesity, diabetes, and risk of cardiovascular disease in the elderly. Am J Geriatr Cardiol 11: 119-123, 2002.
40. Yu C, Chen Y, Cline GW, Zhang D, Zong H, Wang Y, Bergeron R, Kim JK, Cushman SW, Cooney GJ, Atcheson B, White MF, Kraegen EW, Shulman GI. Mechanism by which fatty acids inhibit insulin activation of insulin receptor substrate-1 (IRS-1)-associated phosphatidylinositol 3-kinase activity in muscle. J Biol Chem 277: 50230-50236, 2002.
41. Zong H, Ren JM, Young LH, Pypaert M, Mu J, Birnbaum MJ, Shulman GI. AMP kinase is required for mitochondrial biogenesis in skeletal muscle in response to chronic energy deprivation. Proc Natl Acad Sci USA 99: 15983-15987, 2002.