Metallothionein antagonizes aging-induced cardiac contractile dysfunction: Role of PTP1B, insulin receptor tyrosine phosphorylation and Akt

Aging Cell

Volumn 5, Issue 2, 2006, Pages 177-185

  Fang, Cindy X ^a   Doser, Thomas A ^a   Yang, Xiaoping ^a   Sreejayan, Nair ^a   Ren, Jun ^a  

^a UNIVERSITY OF WYOMING   (United States)

Author keywords

Antioxidant; Insulin resistance; Intracellular Ca2+ transients; Myocyte; Shortening

Indexed keywords

ANTIOXIDANT; CALCIUM ION; FURA 2; GLUCOSE; INSULIN; INSULIN RECEPTOR; METALLOTHIONEIN; PROTEIN KINASE B; PROTEIN TYROSINE PHOSPHATASE 1B; PHOSPHOTYROSINE; PROTEIN TYROSINE PHOSPHATASE;

AGING; ANIMAL CELL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; CARDIOMYOPATHY; CONTROLLED STUDY; DISEASE ASSOCIATION; FLUORESCENCE ANALYSIS; GENE EXPRESSION; GENE OVEREXPRESSION; GLUCOSE INTOLERANCE; HEART CONTRACTION; HEART LEFT VENTRICLE MUSCLE; HEART MUSCLE CELL; HEART MUSCLE CONTRACTILITY; HEART MUSCLE RELAXATION; HYPERINSULINEMIA; INSULIN SENSITIVITY; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; TIME; TISSUE SPECIFICITY; TRANSGENIC MOUSE; WESTERN BLOTTING; WILD TYPE; ANIMAL; CALCIUM SIGNALING; ELECTROSTIMULATION; FLUORESCENCE; GENETICS; GLUCOSE TOLERANCE TEST; HEART VENTRICLE; METABOLISM; PATHOLOGY; PHOSPHORYLATION; PHYSIOLOGY;

MUS MUSCULUS;

AGING; ANIMALS; CALCIUM SIGNALING; ELECTRIC STIMULATION; FLUORESCENCE; GLUCOSE TOLERANCE TEST; HEART VENTRICLES; METALLOTHIONEIN; MICE; MICE, TRANSGENIC; MYOCARDIAL CONTRACTION; MYOCYTES, CARDIAC; PHOSPHORYLATION; PHOSPHOTYROSINE; PROTEIN-TYROSINE-PHOSPHATASE; PROTO-ONCOGENE PROTEINS C-AKT; RECEPTOR, INSULIN;

EID: 33646928646     PISSN: 14749718     EISSN: 14749726     Source Type: Journal    
DOI: 10.1111/j.1474-9726.2006.00201.x     Document Type: Article

References (26)

1. Blendea MC, Jacobs D, Stump CS, McFarlane SI, Ogrin C, Bahtyiar G, Stas S, Kumar P, Sha Q, Ferrario CM, Sowers JR (2005) Abrogation of oxidative stress improves insulin sensitivity in the Ren-2 rat model of tissue angiotensin II overexpression. Am. J. Physiol. Endocrinol. Metab. 288, E353-E359.
2. Cai L, Kang YJ (2001) Oxidative stress and diabetic cardiomyopathy: A brief review. Cardiovasc. Toxicol. 1, 181-193.
3. Cai L, Wang J, Li Y, Sun X, Wang L, Zhou Z, Kang YJ (2005) Inhibition of superoxide generation and associated nitrosative damage is involved in metallothionein prevention of diabetic cardiomyopathy. Diabetes 54, 1829-1837.
4. Couzin J (2005) Physiology. Boosting gene extends mouse life span. Science 309, 1310-1311.
5. Desrois M, Sidell RJ, Gauguier D, Davey CL, Radda GK, Clarke K (2004) Gender differences in hypertrophy, insulin resistance and ischemic injury in the aging type 2 diabetic rat heart. J. Mol. Cell. Cardiol. 37, 547-555.
6. Duan J, Zhang HY, Adkins SD, Ren BH, Norby FL, Zhang X, Benoit JN, Epstein PN, Ren J (2003) Impaired cardiac function and IGF-I response in myocytes from calmodulin-diabetic mice: Role of Akt and RhoA. Am. J. Physiol. Endocrinol. Metab. 284, E366-E376.
7. Dutta K, Podolin DA, Davidson MB, Davidoff AJ (2001) Cardiomyocyte dysfunction in sucrose-fed rats is associated with insulin resistance. Diabetes 50, 1186-1192.
8. Fang CX, Dong F, Ren BH, Epstein PN, Ren J (2005) Metallothionein alleviates cardiac contractile dysfunction induced by insulin resistance: Role of Akt phosphorylation, PTB1B, PPARγ and c-Jun. Diabetologia 48, 2412-2421.
9. Goodyear LJ, Giorgino F, Sherman LA, Carey J, Smith RJ, Dohm GL (1995) Insulin receptor phosphorylation, insulin receptor substrate-1 phosphorylation, and phosphatidylinositol 3-kinase activity are decreased in intact skeletal muscle strips from obese subjects. J. Clin. Invest. 95, 2195-2204.
10. HintZ KK, Ren J (2002) Prediabetic insulin resistance is not permissive to the development of cardiac resistance to insulin-like growth factor I in ventricular myocytes. Diabetes Res. Clin. Pract. 55, 89-98.
11. Iossa S, Mollica MP, Lionetti L, Crescenzo R., Tasso R., Liverini G (2004) A possible link between skeletal muscle mitochondrial efficiency and age-induced insulin resistance. Diabetes 53, 2861-2866.
12. Kamide K, Rakugi H, Nagano M, Nakano N, Ohishi M, Higaki J, Ogihara T (1997) Influence of aging on progression of cardiovascular complications associated with insulin resistance in patients with essential hypertension. Hypertens. Res. 20, 127-132.
13. Kass DA, Shapiro EP, Kawaguchi M, Capriotti AR, Scuteri A, deGroof RC, Lakatta EG (2001) Improved arterial compliance by a novel advanced glycation end-product crosslink breaker. Circulation 104, 1464-1470.
14. Lakatta EG (1999) Cardiovascular aging research: The next horizons. J. Am. Geriatr. Soc. 47, 613-625.
15. Lakatta EG (2000) Cardiovascular aging in health. Clin. Geriatr. Med. 16, 419-444.
16. Lakatta EG, Sollott SJ, Pepe S (2001) The old heart: Operating on the edge. Novartis Found. Symp. 235, 172-196.
17. Li SY, Du M, Dolence EK, Fang CX, Mayer GE, Ceylan-Isik AF, LaCour KH, Yang X, Wilbert CJ, Sreejayan N, Ren J (2005) Aging induces cardiac diastolic dysfunction, oxidative stress, accumulation of advanced glycation endproducts and protein modification. Aging Cell 4, 57-64.
18. Matthaei S, Stumvoll M, Kellerer M, Haring HU (2000) Pathophysiology and pharmacological treatment of insulin resistance. Endocr. Rev. 21, 585-618.
19. Mazumder PK, O'Neill BT, Roberts MW, Buchanan J, Yun UJ, Cooksey RC, Boudina S, Abel ED (2004) Impaired cardiac efficiency and increased fatty acid oxidation in insulin-resistant ob/ob mouse hearts. Diabetes 53, 2366-2374.
20. Meng TC, Buckley DA, Galic S, Tiganis T, Tonks NK (2004) Regulation of insulin signaling through reversible oxidation of the protein-tyrosine phosphatases TC45 and PTP1B. J. Biol. Chem. 279, 37716-37725.
21. Reaven GM (1995) Pathophysiology of insulin resistance in human disease. Physiol. Rev. 75, 473-486.
22. Wang CC, Goalstone ML, Draznin B (2004) Molecular mechanisms of insulin resistance that impact cardiovascular biology. Diabetes 53, 2735-2740.
23. Yang X, Doser TA, Nunn JM, Fang CX, Janardhanan R., Zhu MJ, Sreejayan N, Quinn MT, Ren J (2006) Metallothionein prolongs survival and antagonizes senescence-associated cardiomyocyte diastolic dysfunction: Role of oxidative stress. FASEB J. in press.
24. Yang X, Sreejayan N, Ren J (2005) Views from within and beyond: narratives of cardiac contractile dysfunction under senescence. Endocrine 26, 127-137.
25. Ye G, Metreveli NS, Ren J, Epstein PN (2003) Metallothionein prevents diabetes-induced deficits in cardiomyocytes by inhibiting reactive oxygen species production. Diabetes 52, 777-783.
26. Zabolotny JM, Haj FG, Kim YB, Kim HJ, Shulman GI, Kim JK, Neel BG, Kahn BB (2004) Transgenic overexpression of protein-tyrosine phosphatase 1B in muscle causes insulin resistance, but overexpression with leukocyte antigen-related phosphatase does not additively impair insulin action. J. Biol. Chem. 279, 24844-24851.